AR098260A2 - Polimorfo cristalino de una sal de bisulfato de un antagonista del receptor de trombina, proceso para su preparación, composición y forma purificada - Google Patents

Polimorfo cristalino de una sal de bisulfato de un antagonista del receptor de trombina, proceso para su preparación, composición y forma purificada

Info

Publication number
AR098260A2
AR098260A2 ARP140104095A ARP140104095A AR098260A2 AR 098260 A2 AR098260 A2 AR 098260A2 AR P140104095 A ARP140104095 A AR P140104095A AR P140104095 A ARP140104095 A AR P140104095A AR 098260 A2 AR098260 A2 AR 098260A2
Authority
AR
Argentina
Prior art keywords
preparation
antegonist
composition
purified form
compound
Prior art date
Application number
ARP140104095A
Other languages
English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34807453&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR098260(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of AR098260A2 publication Critical patent/AR098260A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Reivindicación 1: Una forma de polimorfo cristalino 1 del compuesto de fórmula (2) que exhibe un patrón de difracción de rayos X en polvo con posiciones de puntos pico característicos a 11,2, 16,4, 19,2 y 21,0 grados 2q. Reivindicación 6: Un proceso para la preparación del compuesto de fórmula (2) a partir del compuesto de fórmula (1) de acuerdo con la reacción, que comprende d) mezclar el compuesto de fórmula (1) en un solvente orgánico para formar una mezcla; e) calentar la mezcla a una temperatura de aproximadamente 40 - 80ºC; y f) agregar ácido sulfúrico a la mezcla.
ARP140104095A 2004-01-09 2014-11-03 Polimorfo cristalino de una sal de bisulfato de un antagonista del receptor de trombina, proceso para su preparación, composición y forma purificada AR098260A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/755,066 US7235567B2 (en) 2000-06-15 2004-01-09 Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist

Publications (1)

Publication Number Publication Date
AR098260A2 true AR098260A2 (es) 2016-05-18

Family

ID=34807453

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP050100037A AR047088A1 (es) 2004-01-09 2005-01-06 Polimorfo cristalino de piridinetilennaftofurano como antagonista del receptor de trombina, metodo de obtencion y composiciones farmaceuticas
ARP140104095A AR098260A2 (es) 2004-01-09 2014-11-03 Polimorfo cristalino de una sal de bisulfato de un antagonista del receptor de trombina, proceso para su preparación, composición y forma purificada

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP050100037A AR047088A1 (es) 2004-01-09 2005-01-06 Polimorfo cristalino de piridinetilennaftofurano como antagonista del receptor de trombina, metodo de obtencion y composiciones farmaceuticas

Country Status (23)

Country Link
US (2) US7235567B2 (es)
EP (2) EP2277879B1 (es)
JP (2) JP4652342B2 (es)
KR (3) KR20060113758A (es)
CN (2) CN1910176B (es)
AR (2) AR047088A1 (es)
AU (1) AU2005206489B2 (es)
BR (1) BRPI0506761A (es)
CA (1) CA2552786C (es)
CL (1) CL2010000436A1 (es)
EC (1) ECSP066688A (es)
ES (1) ES2622953T3 (es)
HK (1) HK1151285A1 (es)
IL (1) IL176726A (es)
MX (1) MXPA06007830A (es)
MY (1) MY139399A (es)
NO (1) NO20063583L (es)
NZ (1) NZ548156A (es)
PE (1) PE20050761A1 (es)
RU (1) RU2355689C9 (es)
TW (1) TWI295291B (es)
WO (1) WO2005070923A1 (es)
ZA (1) ZA200605550B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US7488742B2 (en) * 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
US20020164322A1 (en) * 2001-01-25 2002-11-07 Alfred Schaufler Suspension comprising fibrinogen, thrombin and alcohol, a method for preparing such a suspension, a method for coating a carrier with such a suspension, a method of drying a coating of a carrier, and a coated collagen sponge
EP1778652A2 (en) * 2004-08-20 2007-05-02 EntreMed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
CN101137647A (zh) * 2005-01-14 2008-03-05 先灵公司 Himbacine类似物的合成
US7541471B2 (en) * 2005-01-14 2009-06-02 Schering Corporation Synthesis of himbacine analogs
AR056262A1 (es) * 2005-01-14 2007-10-03 Schering Corp Preparacion de alcoholes propargilicos y esteres intermediarios de analogos de himbacina
CN101137636A (zh) 2005-01-14 2008-03-05 先灵公司 Himbacine类似物的外型选择性合成
DK1848705T3 (da) 2005-01-14 2010-06-14 Schering Corp EXO- og diastereoselektive synteser af himbacin-analoger
US8101799B2 (en) * 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
WO2007075808A2 (en) * 2005-12-20 2007-07-05 Schering Corporation Methods for preventing and/or treating a cell proliferative disorder
JP2009521472A (ja) * 2005-12-22 2009-06-04 シェーリング コーポレイション 心肺手術の合併症の予防としてのトロンビンレセプターアンタゴニスト
PE20080183A1 (es) * 2006-04-06 2008-03-10 Schering Corp Terapias de combinacion de tra
JP2009542677A (ja) * 2006-06-30 2009-12-03 シェーリング コーポレイション トロンビン受容体拮抗薬の固形製剤
AR061727A1 (es) * 2006-06-30 2008-09-17 Schering Corp Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato
TWI367112B (en) * 2006-06-30 2012-07-01 Schering Corp Immediate-release tablet formulations of a thrombin receptor antagonist
TWI343262B (en) * 2006-09-26 2011-06-11 Schering Corp Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist
CA2673228A1 (en) * 2006-12-22 2008-07-03 Schering Corporation Disintegration promoters in solid dose wet granulation formulations
JP2010522169A (ja) * 2007-03-23 2010-07-01 シェーリング コーポレイション トロンビン受容体アンタゴニストの使用による、経皮的インターベンション後の有害事象の低減
US8227412B2 (en) * 2007-03-29 2012-07-24 Tsopanoglou Nikos E Bioactive parstatin peptides and methods of use
EP2591783A1 (en) 2007-04-13 2013-05-15 Millennium Pharmaceuticals, Inc. Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor
WO2008128038A2 (en) * 2007-04-13 2008-10-23 The Scripps Research Institute Methods and compositions for treating cardiac dysfunctions
PT2146705E (pt) 2007-05-02 2014-05-23 Portola Pharm Inc Terapia de combinação com um composto que atua como inibidor do recetor de adp de plaquetas
EP2175885B1 (en) * 2007-07-30 2016-10-12 Ardea Biosciences, Inc. Combinations of mek inhibitors and raf kinase inhibitors and uses thereof
KR20150091434A (ko) * 2007-07-30 2015-08-10 아디아 바이오사이언스즈 인크. 다형체를 포함하는, ｍｅｋ의 억제제로서의 ｎ-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법
JP5457373B2 (ja) 2008-02-22 2014-04-02 コヴィディエン リミテッド パートナーシップ 血流回復のための装置
US8044240B2 (en) 2008-03-06 2011-10-25 Ardea Biosciences Inc. Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof
US8148363B2 (en) 2008-05-19 2012-04-03 Schering Corporation Heterocyclic compounds as factor IXA inhibitors
JP5789256B2 (ja) 2009-06-04 2015-10-07 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． トロンビン受容体アンタゴニストの活性代謝物
AU2010259003A1 (en) 2009-06-08 2011-11-10 Merck Sharp & Dohme Corp. A thrombin receptor antagonist and clopidogrel fixed dose tablet
TWI393716B (zh) 2009-08-04 2013-04-21 Merck Sharp & Dohme 作為ｉｘａ因子抑制劑之雜環化合物
WO2011128421A1 (de) 2010-04-16 2011-10-20 Sanofi Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren
PL2558462T3 (pl) 2010-04-16 2015-03-31 Sanofi Sa Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1
EP2822557B1 (en) 2012-03-06 2017-08-23 Merck Sharp & Dohme Corp. Preparation and use of bicyclic himbacine derivatives as par-receptor antagonists
US9604971B2 (en) 2013-07-22 2017-03-28 Aralez Pharmaceuticals Trading Dac Co-crystal of the PAR-1 receptor antagonists vorapaxar and aspirin
US9808473B2 (en) 2013-08-22 2017-11-07 Merck Sharp & Dohme Corp. Preparation and use of 3-pyridyl substituted-6,6-difluoro bicyclic himbacine derivatives as par-1 receptor antagonists
EP3035929A4 (en) 2013-08-22 2017-03-15 Merck Sharp & Dohme Corp. 7a-amide substituted-6,6-difluoro bicyclic himbacine derivatives
EP3035930A4 (en) 2013-08-22 2017-03-08 Merck Sharp & Dohme Corp. 7a-heterocycle substituted- 6, 6-difluoro bicyclic himbacine derivatives
US9969724B2 (en) 2014-04-16 2018-05-15 Merck Sharp & Dohme Corp. Factor IXa inhibitors
CN106478608A (zh) * 2015-09-01 2017-03-08 博瑞生物医药（苏州）股份有限公司 沃拉帕沙的硫酸盐的结晶多晶型物
TR201601548A2 (tr) 2016-02-05 2018-03-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Vorapaksar ve metoprololün bi̇r farmasöti̇k kompozi̇syonu
WO2017134200A1 (en) 2016-02-05 2017-08-10 Sanovel Ilac Sanayi Ve Ticaret A.S. A novel pharmaceutical composition of vorapaxar and metoprolol
CN110407819B (zh) * 2019-08-02 2020-06-26 牡丹江医学院 一种作为预防外科手术并发症的凝血酶受体拮抗剂
CN110530924A (zh) * 2019-08-08 2019-12-03 西安交通大学 一种可施加电场的dsc电极***
EP4185587A1 (en) 2020-07-22 2023-05-31 JANSSEN Pharmaceutica NV Compounds useful as factor xia inhibitors
US11845748B2 (en) 2021-03-18 2023-12-19 Janssen Pharmaceutica Nv Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11814364B2 (en) 2021-03-18 2023-11-14 Janssen Pharmaceutica Nv Pyridine N-oxide derivatives useful as factor XIa inhibitors
US11919881B2 (en) 2021-03-18 2024-03-05 Janssen Pharmaceutica Nv Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11897880B2 (en) 2021-04-30 2024-02-13 Janssen Pharmaceutica Nv 7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives useful as a factor XIa inhibitors
US11958856B2 (en) 2021-07-22 2024-04-16 Janssen Pharmaceutica Nv Substituted 1,2,3,8,9,9a-hexahydro-5H-pyrrolo[1,2-a]azepin-5-ones as factor XIa inhibitors

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2691974A (en) * 1952-05-20 1954-10-19 Erlo C Nelson Automatic arrow holder
US2743716A (en) * 1953-01-19 1956-05-01 Peter M Wendt Archery arrow retaining device
US2777435A (en) * 1953-09-28 1957-01-15 Wendell R Brooks Bow with automatic arrow holder
US2975780A (en) * 1958-11-17 1961-03-21 Joseph C Fisher Archer's bow
US3158145A (en) * 1962-03-06 1964-11-24 Raymond L Handy Bow arrow holder
US3342173A (en) * 1965-01-04 1967-09-19 Eugene L Ferguson Bow with magnetic retractable arrow rest
US3618586A (en) * 1969-11-03 1971-11-09 George C Current Arrow sight and bowstring tension control
JPS4812480Y1 (es) * 1970-09-14 1973-04-04
US3760788A (en) * 1971-09-03 1973-09-25 Remington Arms Co Inc Archery bow arrow rest
US3867920A (en) * 1971-11-22 1975-02-25 Kenneth M Westphal Bow drawing indicator
US3769956A (en) * 1972-01-13 1973-11-06 M Simo Arrow rest for archery bow
US4075674A (en) * 1972-12-18 1978-02-21 Texas Instruments Incorporated Expandable electronic protection system
US3788299A (en) * 1973-02-16 1974-01-29 Honeywell Inc Automatically releasable arrow holding device for a crossbow
US3890951A (en) * 1973-11-12 1975-06-24 Jennings Compound Bow Inc Adjustable arrow rest
US3865096A (en) * 1973-12-28 1975-02-11 Jr Fernando Troncoso Archery bow arrow rest
US4061107A (en) * 1976-11-11 1977-12-06 Smith Wilbur J Clicker for indicating position of arrow
US4071014A (en) * 1977-03-07 1978-01-31 Trotter George H Arrow positioning device
US4183346A (en) * 1977-11-03 1980-01-15 Troncoso Fernando V Jr Archery bow in combination with an adjustable draw check
US4236497A (en) * 1979-01-11 1980-12-02 Troncoso Jr Fernando V Archery bow with arrow rest
US4343286A (en) * 1979-04-06 1982-08-10 Thacker Bobby J Archery bow
US4318390A (en) * 1980-05-15 1982-03-09 Trotter George H Arrow retainer
US4287868A (en) * 1980-06-16 1981-09-08 Schiff Charles M Retracting arrow rest
US4454858A (en) * 1981-11-06 1984-06-19 Henry Thomas J Draw length indicator for hunting bow
US4407261A (en) * 1981-12-24 1983-10-04 Elliott Kenneth L Arrow lock
US4453528A (en) * 1982-09-27 1984-06-12 William Eckert Arrow rest
US4881515A (en) * 1983-04-05 1989-11-21 Simo Miroslav A Laterally adjustable replaceable arrow rest
US4898145A (en) * 1983-08-01 1990-02-06 Simo Miroslav A Arrow rest and holder
US4579101A (en) * 1984-03-16 1986-04-01 Bateman Iii Earle W Swinging arm arrow rest
US4577612A (en) * 1984-06-18 1986-03-25 John T. Zell Arrow holder
US4542732A (en) * 1984-07-02 1985-09-24 Troncoso Vincent F Compound archery bow assembly
US4632087A (en) * 1984-09-17 1986-12-30 Cline Darrell W Archery arrow support device
US4676220A (en) * 1985-02-19 1987-06-30 Pietraszek Mitchell E Arrow rest
US4685439A (en) * 1985-08-19 1987-08-11 Cosentino Jr Victor A Automatically-released arrow holder
US4693228A (en) * 1986-02-13 1987-09-15 Kidde Recreation Products, Inc. Crossbow trigger mechanism
US4741320A (en) * 1986-03-14 1988-05-03 Wiard Arthur R Archery training aid
US4703745A (en) * 1986-10-03 1987-11-03 Hammond David R Arrow retention attachment for bow
US4862867A (en) * 1987-02-02 1989-09-05 Schmidt John M Arrow retainer for archery
US4796598A (en) * 1987-03-06 1989-01-10 Jones Robert L Retractable arrow launch ramp with compound crossbow
US5107819A (en) * 1987-07-23 1992-04-28 Pugh Gregory E Arrow holding and loading device for archery bows
US4823762A (en) * 1987-07-23 1989-04-25 Pugh Gregory E Arrow holding and loading device for archery bows
US4865008A (en) * 1988-04-29 1989-09-12 Golden Key-Futura, Inc. Disappearing archery arrow guide
US5025773A (en) * 1988-09-26 1991-06-25 Kurt Hintze Archery arrow support
US5161515A (en) * 1989-01-31 1992-11-10 Hammonds David R Reversible archery arrow holder and arrow rest device
US4865007A (en) * 1989-03-03 1989-09-12 Saunders Archery Co. Fall-away arrow rest assembly
US5146908A (en) * 1990-03-21 1992-09-15 Browning Hold-back system for bowstring
US5009215A (en) * 1990-07-02 1991-04-23 Ludwig James E Arrow rest and holder apparatus
US5156138A (en) * 1990-09-19 1992-10-20 Roger Grover Apparatus for drawing, holding and releasing bowstring
US5161514A (en) * 1990-11-01 1992-11-10 Cary John W Arrow rest
US5243959A (en) * 1991-05-24 1993-09-14 Savage Systems, Inc. Archery apparatus and method
US5243957A (en) * 1991-11-20 1993-09-14 Savage Systems, Inc. Archery apparatus
IL106197A (en) 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them
US5341789A (en) * 1993-04-30 1994-08-30 John Paglia Arrow rest with integrated arrow holder
US5415154A (en) * 1993-10-12 1995-05-16 A Design, Inc. Dropaway arrow rest and overdraw assembly
US5394858A (en) * 1993-11-18 1995-03-07 David R. Laliberte Arrow safety positioning apparatus
US5413084A (en) * 1993-12-01 1995-05-09 Haggard; Alan Combined archery sight and arrow rest
US5462041A (en) * 1993-12-20 1995-10-31 Solecki; Dennis Adjustable arrow guide
US5490492A (en) * 1994-01-27 1996-02-13 Savage Systems, Inc. Retracting arrow rest for archery bow
US5503136A (en) * 1994-04-29 1996-04-02 Cavalier Equipment Company, Inc. Arrow rest with retracting arm
US5632263A (en) * 1994-05-03 1997-05-27 Sartain; John K. Automatic arrow positioning device
US5555875A (en) * 1994-10-13 1996-09-17 Martin Archery Inc. Handle riser for an archery bow
US5606961A (en) * 1994-10-20 1997-03-04 Basik; Ronald Arrow rest assembly
US5553597A (en) * 1994-12-29 1996-09-10 Sparks; Rodney L. Overdraw for a compound bow
US5603309A (en) * 1995-09-18 1997-02-18 Sheliga; Douglas J. Manually operated arrow holder and replacer
US5669146A (en) * 1996-02-27 1997-09-23 Kenneth Robertson Changeable insert peep sight
US5676121A (en) * 1996-08-08 1997-10-14 Bizier; Wayne T. Fork tamer
US5671723A (en) * 1997-01-03 1997-09-30 Jerry A. Goff Archery drawlock
US5722381A (en) * 1997-02-27 1998-03-03 New Archery Products Corp. Apparatus for adjustably mounting a pivotal arrow rest
CO4990946A1 (es) 1997-11-25 2000-12-26 Schering Corp Antagonistas del receptor de trombina
US6063847A (en) 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
US6044832A (en) * 1998-08-10 2000-04-04 Piersons, Jr.; Donald W. Fall away arrow rest assembly
US6021769A (en) * 1998-11-30 2000-02-08 Troncoso; Freddie Archery bow arrow rest
US6202635B1 (en) * 1999-05-17 2001-03-20 Daniel L. Evans Arrow launcher apparatus
US6035842A (en) * 1999-06-10 2000-03-14 Bradley; Michael M. Arrow stabilizing mechanism for bow and arrow
AU5895500A (en) 1999-06-29 2001-01-31 Cor Therapeutics, Inc. Novel indazole peptidomimetics as thrombin receptor antagonists
US6630451B1 (en) 1999-06-29 2003-10-07 Orthomcneil Pharmaceutical, Inc. Benzimidazolone peptidometics as thrombin receptor antagonist
US6858577B1 (en) 1999-06-29 2005-02-22 Ortho-Mcneil Pharmaceutical, Inc. Indole peptidomimetics as thrombin receptor antagonists
US6082348A (en) * 1999-07-22 2000-07-04 Savage; Huey P. Arrow west
KR100604742B1 (ko) * 2000-06-15 2006-07-26 쉐링 코포레이션 트롬빈 수용체 길항제
US20040192753A1 (en) 2000-06-15 2004-09-30 Samuel Chackalamannil Methods of use of thrombin receptor antagonists
WO2002071847A1 (en) 2001-03-08 2002-09-19 Emory University Treatment of neurodegenerative diseases and conditions using pari antagonists
US20040242627A1 (en) 2001-04-19 2004-12-02 Shuichi Suzuki 2-Iminoimidazole derivatives (1)
EP1436298B1 (en) * 2001-10-18 2011-09-21 Schering Corporation Himbacine analogues as thrombin receptor antagonists
US6595195B1 (en) * 2002-01-18 2003-07-22 Montana Black Gold Arrow rest device
US6681753B2 (en) * 2002-04-11 2004-01-27 Abbas Ben Afshari Shaft clamping arrow rest
ATE494284T1 (de) * 2002-04-16 2011-01-15 Schering Corp Tricyclischer thrombinrezeptorantagonist
US6782881B2 (en) * 2003-01-16 2004-08-31 New Archery Products Corp. Move-away arrow rest

Also Published As

Publication number Publication date
MY139399A (en) 2009-09-30
NO20063583L (no) 2006-10-06
BRPI0506761A (pt) 2007-05-22
AU2005206489A1 (en) 2005-08-04
EP1701953A1 (en) 2006-09-20
CL2010000436A1 (es) 2011-03-25
TWI295291B (en) 2008-04-01
CA2552786A1 (en) 2005-08-04
ECSP066688A (es) 2006-10-31
JP4652342B2 (ja) 2011-03-16
TW200530225A (en) 2005-09-16
ES2622953T3 (es) 2017-07-10
US20070203193A1 (en) 2007-08-30
RU2006128779A (ru) 2008-02-20
RU2355689C9 (ru) 2010-07-10
US7235567B2 (en) 2007-06-26
KR20110039402A (ko) 2011-04-15
KR20060113758A (ko) 2006-11-02
PE20050761A1 (es) 2005-10-18
CN1910176A (zh) 2007-02-07
RU2355689C2 (ru) 2009-05-20
EP2277879A1 (en) 2011-01-26
CA2552786C (en) 2009-11-24
AU2005206489B2 (en) 2011-09-01
IL176726A0 (en) 2006-10-31
WO2005070923A1 (en) 2005-08-04
IL176726A (en) 2012-08-30
US20040176418A1 (en) 2004-09-09
EP1701953B1 (en) 2014-11-19
HK1151285A1 (zh) 2012-01-27
CN101899039A (zh) 2010-12-01
CN101899039B (zh) 2012-11-28
KR20080100497A (ko) 2008-11-18
KR101039973B1 (ko) 2011-06-09
AR047088A1 (es) 2006-01-04
JP2007517804A (ja) 2007-07-05
ZA200605550B (en) 2007-12-27
JP2010189425A (ja) 2010-09-02
CN1910176B (zh) 2010-06-23
MXPA06007830A (es) 2006-09-01
NZ548156A (en) 2010-07-30
EP2277879B1 (en) 2017-03-08

Similar Documents

Publication Publication Date Title
AR098260A2 (es) Polimorfo cristalino de una sal de bisulfato de un antagonista del receptor de trombina, proceso para su preparación, composición y forma purificada
BRPI0516911A (pt) método para a preparação de um composto e composto de anilina
BRPI0509595B8 (pt) processos para a preparação de cristais de forma a e de material de padrão c de bissulfato de atazanavir
UA100125C2 (ru) Способ выделения и очистки монтелукаста
ECSP10010192A (es) 5-[(3,3,3-trifluoro-2-hidroxi-1-arilpropil)amino]-1h-quinolin-2-onas, un proceso para su producción y su uso como agentes antiinflamatorios
WO2010032259A3 (en) Process for the preparation of efavirenz
BRPI0708291B8 (pt) forma cristalina beta de sal de arginina de perindopril, processo para sua preparação, composições farmacêuticas que a contêm e seus usos
CO6700138A1 (es) Procedimiento de preparación de sal de l-arginina de perindoprilo
AR058187A1 (es) Sintesis de un intermediario y formas polimorficas del mismo que se utilizan para la preparacion de clorhidrato de donepezilo.
ATE547418T1 (de) Organische elektrolumineszenzvorrichtung
ZA201003751B (en) Process for the synthesis of propargylated aminoindan derivatives
PE20110163A1 (es) Proceso para la preparacion de derivados de pirimidina sustituidos
ITMI20050550A1 (it) Procedimento per la preparazione di adapalene
EA200900008A1 (ru) Новые хиральные промежуточные продукты, способ их получения и их применение в производстве толтеродина, фезотеродина или их активных метаболитов
MX2012006525A (es) Procedimiento de sintesis y forma cristalina del hidrocloruro de 4-{3-[cis-hexahidrociclopenta[c]pirrol-2(1h)-il]propoxi}benzamida asi como las composiciones farmaceuticas que las contienen.
RU2016134404A (ru) КРИСТАЛЛИЧЕСКАЯ ФОРМА α МОНОБЕНЗОАТА СОЕДИНЕНИЯ А, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И СОДЕРЖАЩАЯ ЕЕ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
IL200323A0 (en) Synthesis of glyt-1 inhibitors
BR0315671A (pt) Processo para a preparação de um composto
AR074151A1 (es) Un derivado de benzoilbencenoacetamida, proceso de preparacion del mismo, forma polimorfica b de dicho compuesto, proceso de obtencion de dicha forma polimorfica b y su uso
CL2012001528A1 (es) Proceso para preparar la forma cristalina a de ilaprazol a partir de una sal inorganica de ilaprazol y posterior neutralizacion de la sal con un acido en un solvente de reaccion; y proceso para preparar la forma cristalina b de ilaprazol en la forma cristalina a de ilaprazol.
WO2008022918A3 (de) Verbindungen und ihre verwendung zur herstellung von leder und als dispergiermittel
WO2009134297A3 (en) Method of synthesis of proton conducting materials
JP2007521303A5 (es)
AR052865A1 (es) Preparacion de compuestos farmaceuticos derivados de sales de piperazina
AR062623A1 (es) Proceso quimico

Legal Events

Date Code Title Description
FB Suspension of granting procedure