DK1848705T3 - EXO- og diastereoselektive synteser af himbacin-analoger - Google Patents

EXO- og diastereoselektive synteser af himbacin-analoger

Info

Publication number
DK1848705T3
DK1848705T3 DK06718069.5T DK06718069T DK1848705T3 DK 1848705 T3 DK1848705 T3 DK 1848705T3 DK 06718069 T DK06718069 T DK 06718069T DK 1848705 T3 DK1848705 T3 DK 1848705T3
Authority
DK
Denmark
Prior art keywords
exo
himbacin
analogs
diastereoselective
syntheses
Prior art date
Application number
DK06718069.5T
Other languages
English (en)
Inventor
Jing Liao
Ngiap Kie Lim
George Wu
Anantha Sudhakar
Tao Wang
Ji Xie
Frank Xing Chen
Marc Poirier
Mingsheng Huang
Vijay Sabesan
Daw-Long Kwok
Jian Cui
Xiaojing Yang
Tiruvettipuram K Thiruvengadam
Ilia Zavialov
Hoa N Nguyen
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK1848705T3 publication Critical patent/DK1848705T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06Preparation of nitro compounds
    • C07C201/10Preparation of nitro compounds by substitution of functional groups by nitro groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06Preparation of nitro compounds
    • C07C201/12Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/55Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/10Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/12Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/08Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing hydroxy groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/606Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom having only or additionally carbon-to-carbon triple bonds as unsaturation in the carboxylic acid moiety
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/64Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92Naphthofurans; Hydrogenated naphthofurans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/58Pyridine rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK06718069.5T 2005-01-14 2006-01-12 EXO- og diastereoselektive synteser af himbacin-analoger DK1848705T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64446405P 2005-01-14 2005-01-14
PCT/US2006/000954 WO2006076415A2 (en) 2005-01-14 2006-01-12 Exo- and diastereo- selective syntheses of himbacine analogs

Publications (1)

Publication Number Publication Date
DK1848705T3 true DK1848705T3 (da) 2010-06-14

Family

ID=36168544

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10001844.9T DK2206697T3 (da) 2005-01-14 2006-01-12 Exo- og diastereo-selektive synteser af himbacinanaloger
DK06718069.5T DK1848705T3 (da) 2005-01-14 2006-01-12 EXO- og diastereoselektive synteser af himbacin-analoger

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK10001844.9T DK2206697T3 (da) 2005-01-14 2006-01-12 Exo- og diastereo-selektive synteser af himbacinanaloger

Country Status (22)

Country Link
US (4) US7605275B2 (da)
EP (4) EP1848705B1 (da)
JP (3) JP4681616B2 (da)
CN (2) CN102757423B (da)
AR (1) AR056919A1 (da)
AT (2) ATE458726T1 (da)
CA (2) CA2594871C (da)
CY (2) CY1109896T1 (da)
DE (1) DE602006012450D1 (da)
DK (2) DK2206697T3 (da)
ES (3) ES2412981T3 (da)
HK (1) HK1108893A1 (da)
HR (2) HRP20100218T1 (da)
ME (1) ME01967B (da)
MX (1) MX2007008665A (da)
PL (2) PL2206697T3 (da)
PT (2) PT1848705E (da)
RS (2) RS52117B (da)
SG (2) SG158888A1 (da)
SI (2) SI2206697T1 (da)
WO (1) WO2006076415A2 (da)
ZA (1) ZA200706711B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7488742B2 (en) * 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
WO2006076564A1 (en) * 2005-01-14 2006-07-20 Schering Corporation Synthesis of himbacine analogs
US7772276B2 (en) * 2005-01-14 2010-08-10 Schering Corporation Exo-selective synthesis of himbacine analogs
PL2206697T3 (pl) 2005-01-14 2012-03-30 Merck Sharp & Dohme Egzo- oraz diastereoselektywna synteza analogów himbacyny
EP1971336A2 (en) * 2005-12-22 2008-09-24 Shering Corporation Thrombin receptor antagonists as phophylaxis to complications from cardiopulmonary surgery
AR061727A1 (es) * 2006-06-30 2008-09-17 Schering Corp Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato
CA2656241A1 (en) * 2006-06-30 2008-01-10 Schering Corporation Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof
CA2672268A1 (en) * 2006-12-15 2008-06-26 Schering Corporation Bisulfite purification of an alpha-keto amide
EP2197461B1 (en) 2007-10-08 2018-02-21 Aurinia Pharmaceuticals Inc. Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors
CN101910148B (zh) * 2007-10-24 2014-06-04 默沙东公司 制备十二氢-萘并-呋喃基-氨基甲酸酯中间体的高纯度合成方法
US9120935B2 (en) * 2011-06-21 2015-09-01 Bluestar Silicones France Sas Hydrosilylation reaction inhibitors, and use thereof for preparing stable curable silicone compositions
CN105330689B (zh) * 2014-08-08 2018-08-17 博瑞生物医药(苏州)股份有限公司 制备Himbacine类似物中间体的制备方法
CN105985303B (zh) * 2015-02-13 2020-08-14 上海彩迩文生化科技有限公司 抗凝血剂的制备方法、中间体及其制备方法
CN105348241B (zh) * 2015-12-11 2017-09-05 南京华威医药科技开发有限公司 一种硫酸沃拉帕沙中间体的合成方法
US11247940B2 (en) 2016-10-26 2022-02-15 The Regents Of The University Of California Efficient integration of manufacturing of upcycled concrete product into power plants
CN106749138B (zh) * 2016-12-07 2019-08-16 扬子江药业集团四川海蓉药业有限公司 一种硫酸沃拉帕沙中间体醛的制备方法
CN106866450B (zh) * 2017-01-13 2019-01-11 阜阳欣奕华材料科技有限公司 硫酸沃拉帕沙中间体的制备方法
CN108658910B (zh) * 2017-03-29 2020-11-03 北京新领先医药科技发展有限公司 一种沃拉帕沙中间体1-α的制备方法
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
US11230473B2 (en) 2017-06-30 2022-01-25 The Regents Of The University Of California CO2 mineralization in produced and industrial effluent water by pH-swing carbonation
US11339094B2 (en) 2017-08-14 2022-05-24 The Regents Of The University Of California Mitigation of alkali-silica reaction in concrete using readily-soluble chemical additives
WO2019057946A1 (en) 2017-09-25 2019-03-28 F. Hoffmann-La Roche Ag MULTI-CYCLIC AROMATIC COMPOUNDS AS D-FACTOR INHIBITORS
US11384029B2 (en) 2019-03-18 2022-07-12 The Regents Of The University Of California Formulations and processing of cementitious components to meet target strength and CO2 uptake criteria

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE133799A1 (es) * 1997-11-25 2000-01-10 Schering Corp Antagonistas del receptor de trombina
US6063847A (en) 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
PL191095B1 (pl) * 1998-05-05 2006-03-31 Lilly Co Eli Sposób wytwarzania adduktu wodorosiarczynowego 4'-chloro-4-bifenylokarboksyaldehydu, sposób oczyszczania 4'-chloro-4-bifenylokarboksyaldehydu oraz addukt wodorosiarczynowy 4'-chloro-4-bifenylokarboksyaldehydu
US20040192753A1 (en) 2000-06-15 2004-09-30 Samuel Chackalamannil Methods of use of thrombin receptor antagonists
US7235567B2 (en) 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
CA2410177C (en) 2000-06-15 2010-05-11 Schering Corporation Thrombin receptor antagonists
US7488742B2 (en) * 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
US8124625B2 (en) * 2001-09-14 2012-02-28 Shionogi & Co., Ltd. Method of enhancing the expression of apolipoprotein AI using olefin derivatives
MXPA04003610A (es) * 2001-10-18 2004-07-27 Schering Corp Analogos de himbacina como antagonistas del receptor de trombina.
ATE378330T1 (de) * 2002-04-16 2007-11-15 Schering Corp Trizyklische thrombin rezeptor antagonisten
ATE406366T1 (de) * 2004-05-28 2008-09-15 Schering Corp Gehinderte himbacinanaloga als thrombinrezeptorantagonisten
US7772276B2 (en) * 2005-01-14 2010-08-10 Schering Corporation Exo-selective synthesis of himbacine analogs
WO2006076564A1 (en) * 2005-01-14 2006-07-20 Schering Corporation Synthesis of himbacine analogs
PL2206697T3 (pl) 2005-01-14 2012-03-30 Merck Sharp & Dohme Egzo- oraz diastereoselektywna synteza analogów himbacyny
US7541471B2 (en) * 2005-01-14 2009-06-02 Schering Corporation Synthesis of himbacine analogs

Also Published As

Publication number Publication date
EP2206697B1 (en) 2011-10-26
JP5911447B2 (ja) 2016-04-27
EP1848705A2 (en) 2007-10-31
ATE530516T1 (de) 2011-11-15
EP2196468B1 (en) 2013-04-10
CN102757423B (zh) 2016-04-20
WO2006076415A2 (en) 2006-07-20
SG158888A1 (en) 2010-02-26
DE602006012450D1 (de) 2010-04-08
ATE458726T1 (de) 2010-03-15
CY1109896T1 (el) 2014-09-10
SI1848705T1 (sl) 2010-06-30
ZA200706711B (en) 2014-01-29
US8618314B2 (en) 2013-12-31
SI2206697T1 (sl) 2012-02-29
EP2196454A3 (en) 2010-09-22
WO2006076415A3 (en) 2006-11-16
DK2206697T3 (da) 2012-02-13
HRP20100218T1 (hr) 2010-05-31
HRP20110963T1 (hr) 2012-01-31
CN101193880B (zh) 2012-08-22
ES2374379T3 (es) 2012-02-16
ES2339696T3 (es) 2010-05-24
HK1108893A1 (en) 2008-05-23
ES2412981T3 (es) 2013-07-15
CA2594871A1 (en) 2006-07-20
US7605275B2 (en) 2009-10-20
US20060247450A1 (en) 2006-11-02
JP2008526972A (ja) 2008-07-24
EP2196454A2 (en) 2010-06-16
US7989653B2 (en) 2011-08-02
CN101193880A (zh) 2008-06-04
CA2594871C (en) 2015-04-07
US20110251392A1 (en) 2011-10-13
RS52117B (en) 2012-08-31
EP2196454B1 (en) 2014-08-27
US8258319B2 (en) 2012-09-04
ME01967B (me) 2012-08-31
US20090281321A1 (en) 2009-11-12
CA2875768A1 (en) 2006-07-20
SG192505A1 (en) 2013-08-30
MX2007008665A (es) 2008-03-04
AR056919A1 (es) 2007-11-07
PT2206697E (pt) 2012-01-10
CA2875768C (en) 2018-03-06
US20120296093A1 (en) 2012-11-22
CY1112371T1 (el) 2015-12-09
PT1848705E (pt) 2010-05-10
EP2206697A1 (en) 2010-07-14
RS51315B (sr) 2010-12-31
JP2013177407A (ja) 2013-09-09
EP1848705B1 (en) 2010-02-24
JP5388231B2 (ja) 2014-01-15
PL1848705T3 (pl) 2010-07-30
PL2206697T3 (pl) 2012-03-30
JP2011098967A (ja) 2011-05-19
EP2196468A1 (en) 2010-06-16
CN102757423A (zh) 2012-10-31
JP4681616B2 (ja) 2011-05-11

Similar Documents

Publication Publication Date Title
DK1848705T3 (da) EXO- og diastereoselektive synteser af himbacin-analoger
DK1778618T3 (da) Syntese af triethylentetraminer
DK2377869T3 (da) Syntese af Bortezomib
DK1802579T3 (da) Derivater af 3-arylaminopyridin
DK1937071T3 (da) Krystallinske modifikationer af pyraclostrobin
DK2167523T3 (da) Syntese og anvendelse af anti-reverse phosphorothioatanaloger af messenger-rna-cappen
DK1917227T3 (da) Krystalformer af astaxanthin
CY2013035I1 (el) Μεθοδοι χρησης συνθεσεων αμινοπυριδινης παρατεταμενης αποδεσμευσης
ATE500249T1 (de) Synthese von himbacinanaloga
DE602006004463D1 (de) Kristallform von asenapinmaleat
CY2013046I1 (el) Καινοτομος χρηση των αντισωματων αντι il-1bhta
DK1879844T3 (da) Fremstilling af natriumdiformiat
NO20055643D0 (no) Preparation of lodixanol
FI20050195A (fi) Metalliseoksen käyttö
DK2081675T3 (da) Syntese af biodiesel
FI20055133A0 (fi) Iskulaite
DE602006006853D1 (de) Synthese von neuem Dihydrobenzoxazin
DK1730109T3 (da) Syntese af pyrrol-2-carbonitriler
FR2885985B1 (fr) Bague de traversee de cloison
DK1591434T3 (da) Nye 1-methoxy-2-phenyl-ethener anvendelig til fremstiling af 5-carboxaldehyd-2-3-dihydrobenzoxepiner
UA11794S (uk) Комплект етикеток
UA12681S (uk) Комплект етикеток
UA12074S (uk) Комплект етикеток
UA13674S (uk) Комплект етикеток
UA12624S (uk) Комплект етикеток