AR093805A1 - Derivados de piridina agonistas del receptor 2 de cannabinoides - Google Patents

Derivados de piridina agonistas del receptor 2 de cannabinoides

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Publication number
AR093805A1
AR093805A1 ARP130104505A ARP130104505A AR093805A1 AR 093805 A1 AR093805 A1 AR 093805A1 AR P130104505 A ARP130104505 A AR P130104505A AR P130104505 A ARP130104505 A AR P130104505A AR 093805 A1 AR093805 A1 AR 093805A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
halogen
hydrogen
attached
Prior art date
Application number
ARP130104505A
Other languages
English (en)
Inventor
Kimbara Atsushi
Rombach Didier
Rogers-Evans Mark
Ricklin Fabienne
Nettekoven Matthias
Roever Stephan
Grether Uwe
Westphal Matthias
Schulz-Gasch Tanja
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR093805A1 publication Critical patent/AR093805A1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

El compuesto de la fórmula 1 puede utilizarse como medicamento. Reivindicación 1: Un compuesto de la fórmula (1), en la que: R¹ es halógeno, halofenilo, cicloalquilalcoxi, halofenilalquilo, oxetaniloxi, haloalcoxi, halofenilalcoxi o alquiloxetanilalcoxi; R² es halógeno, cicloalquilo, haloazetidinilo, halopirrolidinilo, hidroxioxetanilo, cicloalquenilo, halocicloalquilo o halooxetanilo; uno de R³ y R⁴ es hidrógeno o alquilo y el otro es -(CR⁵R⁶)-(CR⁷R⁸)ₙ-R⁹; o R³ y R⁴ junto con el átomo de nitrógeno, al que están unidos, forman un 2-oxo-5-aza-espiro[3.4]octilo, haloazetidinilo o halopirrolidinilo; R⁵ y R⁶ se eligen con independencia entre hidrógeno, alquilo, cicloalquilalquilo, haloalquilo, cicloalquilo, alquilsulfonilalquilo, fenilalcoxialquilo, hidroxialquilo, haloazetidinilalquilo, haloazetidinilcarbonilo, 2-oxa-6-azaespiro[3.3]-heptanilcarbonilo, alquilaminocarbonilo, dialquilaminocarbonilo, aminocarbonilo, azetidinilcarbonilo, oxetanilalquilo y alquiloxetanilo; o R⁵ y R⁶ junto con el átomo de carbono, al que están unidos, forman un cicloalquilo, oxetanilo, oxanilo o dioxotietanilo; R⁷ y R⁸ se eligen con independencia entre hidrógeno, alquilo y cicloalquilo; o R⁷ y R⁸ junto con el átomo de carbono, al que están unidos, forman un cicloalquilo; R⁹ es alquilo, alcoxicarbonilo, hidroxilo, hidroxialquilo, aminocarbonilo, ciano, piridinilo, alquilaminocarbonilo, tiazol-2-ilo, oxazol-2-ilo, 5-alquil-[1,2,4]oxadiazol-3-ilo, alquiltetrazolilo, alquiltiazol-2-ilo, 1H-tetrazolilo, 5-amino-[1,2,4]-oxadiazol-3-ilo, 5-alquil-[1,3,4]-oxadiazol-2-ilo, azetidinilcarbonilo, haloazetidinilcarbonilo, 6-oxa-1-azaespiro[3.3]heptanilo, 5-fenil-[1,3,4]-oxadiazol-2-ilo o haloalquilaminocarbonilo; y n es el número 0 ó 1; con la condición de que si R³ y R⁴ son ambos alquilo al mismo tiempo, entonces R¹ y R² no sean ambos halógeno al mismo tiempo; o una sal o un éster farmacéuticamente aceptable del mismo.
ARP130104505A 2012-12-07 2013-12-05 Derivados de piridina agonistas del receptor 2 de cannabinoides AR093805A1 (es)

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AR093805A1 true AR093805A1 (es) 2015-06-24

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WO2015190564A1 (ja) * 2014-06-13 2015-12-17 武田薬品工業株式会社 含窒素複素環化合物
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JP7454512B2 (ja) 2018-06-27 2024-03-22 エフ． ホフマン－ラ ロシュ アーゲー 優先的カンナビノイド２アゴニストとしてのピリジン及びピラジン誘導体
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