AR084412A1 - Compuestos de piridina fusionados, utiles como inhibidores de caseina quinasa, y las composiciones farmaceuticas que los contienen - Google Patents
Compuestos de piridina fusionados, utiles como inhibidores de caseina quinasa, y las composiciones farmaceuticas que los contienenInfo
- Publication number
- AR084412A1 AR084412A1 ARP110104787A ARP110104787A AR084412A1 AR 084412 A1 AR084412 A1 AR 084412A1 AR P110104787 A ARP110104787 A AR P110104787A AR P110104787 A ARP110104787 A AR P110104787A AR 084412 A1 AR084412 A1 AR 084412A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- cycloalkyl
- heterocycloalkyl
- membered
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
También composiciones farmacéuticas, métodos de tratamiento, métodos de síntesis e intermediarios correspondientes. Útiles para enfermedades neurológicas y psiquiátricas.Reivindicación 1: Compuestos de piridina fusionados, útiles como inhibidores de caseína quinasa, caracterizados porque tienen la fórmula (1), en donde X e Y son independientemente =N-, -NR1-, CR1 o -S-, siempre que, al menos, uno de X e Y sea CR1; el anillo A es un cicloalquilo o heterocicloalquilo de 4 a 7 miembros o un heteroarilo de 5 a 6 miembros, en donde hasta 2 átomos de carbono se reemplazan por un heteroátomo seleccionado de =N-, -NR2-, -O-, -S, y cualquier átomo de carbono restante puede sustituirse con R3, según lo permita la valencia; cada R1 es independientemente H, alquilo C1-4, cicloalquilo C3-6, -CF3, -(CH2)1-3CF3, heterocicloalquilo de 4 a 10 miembros, en donde dicho heterocicloalquilo puede sustituirse con hasta 2 sustituyentes seleccionados independientemente de halógeno, OH, oxo, ciano, alquilo C1-6 o alquil C1-6-O-alquilo C1-6; cada R2 es independientemente H, alquilo C1-6, bicicloalquilo C4-10, -(CH2)t-CN, -SO2-alquilo C1-6, -SO2(CH2)t-cicloalquilo C3-6, -alquil C1-6-O-alquilo C1-6, -alquil C1-6-C(O)O-alquilo C1-6, -cicloalquil C3-6-C(O)O-alquilo C1-6, -C(O)-(O)u-alquilo C1-6, -C(O)-alquil C1-6-O-alquilo C1-6, -C(O)-(O)u-(CH2)t-(arilo C6-10), -(CH2)t-(arilo C6-10), -C(O)-(O)u-(CH2)t-(heteroarilo de 5 a 10 miembros), -(CH2)t-C(O)-NR5R6, -(CH2)t-(heteroarilo de 5 a 10 miembros), -C(O)-(O)u-(CH2)t-(heterocicloalquilo de 3 a 10 miembros), -(CH2)t-(heterocicloalquilo de 4 a 10 miembros), -C(O)-(O)u-(CH2)t-(cicloalquilo de 3 a 10 miembros) o -(CH2)t-(cicloalquilo de 3 a 10 miembros), en donde arilo, heteroarilo, cicloalquilo y heterocicloalquilo de R2 pueden sustituirse con hasta 2 sustituyentes seleccionados independientemente de halógeno, OH, ciano, alquilo C1-6 o alquil C1-6-O-alquilo C1-6, y en donde cualquier alquilo, cicloalquilo y heterocicloalquilo de R2 puede sustituirse también con oxo, según lo permita la valencia; cada R3 independientemente está ausente, es alquilo C1-3, halógeno, oxo, -NR5R6 u -OR5; cada R4 es independientemente halógeno, -CF3, alquilo C1-3, -(CH2)t-cicloalquilo C3-4, -(CH2)t-O-alquilo C1-3, -(CH2)t-ciano o -(CH2)t-hidroxi; cada R5 es independientemente H o alquilo C1-6; cada R6 es independientemente H o alquilo C1-6; R7 es H, halógeno o alquilo C1-3; n es 0, 1 ó 2; cada t es independientemente 0, 1 ó 2; y cada u es independientemente 0 ó 1; o una sal de estos aceptable desde el punto de vista farmacéutico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061425213P | 2010-12-20 | 2010-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084412A1 true AR084412A1 (es) | 2013-05-15 |
Family
ID=45446116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110104787A AR084412A1 (es) | 2010-12-20 | 2011-12-19 | Compuestos de piridina fusionados, utiles como inhibidores de caseina quinasa, y las composiciones farmaceuticas que los contienen |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8536164B2 (es) |
| EP (2) | EP2654750B1 (es) |
| JP (2) | JP5684923B2 (es) |
| KR (1) | KR101590236B1 (es) |
| CN (1) | CN103260622B (es) |
| AR (1) | AR084412A1 (es) |
| AU (1) | AU2011346733C1 (es) |
| CA (1) | CA2819961C (es) |
| CY (2) | CY1118772T1 (es) |
| DK (2) | DK3181133T3 (es) |
| ES (2) | ES2744099T3 (es) |
| HK (1) | HK1188145A1 (es) |
| HR (2) | HRP20170484T1 (es) |
| HU (2) | HUE032405T2 (es) |
| IL (1) | IL226948A (es) |
| LT (2) | LT3181133T (es) |
| MX (1) | MX338551B (es) |
| PL (2) | PL3181133T3 (es) |
| PT (2) | PT3181133T (es) |
| RS (2) | RS55897B1 (es) |
| SG (1) | SG190802A1 (es) |
| SI (2) | SI3181133T1 (es) |
| WO (1) | WO2012085721A1 (es) |
| ZA (1) | ZA201303453B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2493876B1 (en) * | 2009-10-28 | 2014-02-12 | Pfizer Inc | Imidazole derivatives as casein kinase inhibitors |
| US9938269B2 (en) * | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| CN104837844B (zh) * | 2012-12-21 | 2017-08-29 | 百时美施贵宝公司 | 作为酪蛋白激酶1 d/e抑制剂的吡唑取代的咪唑并哌嗪 |
| WO2015163446A1 (ja) * | 2014-04-25 | 2015-10-29 | 協和発酵キリン株式会社 | イミダゾール化合物の製造方法 |
| JP2017222576A (ja) * | 2014-10-31 | 2017-12-21 | 石原産業株式会社 | 有害生物防除剤 |
| CN107365315A (zh) * | 2016-05-11 | 2017-11-21 | 国药集团国瑞药业有限公司 | 一种吡唑类化合物、其晶型及其制备方法 |
| US10973820B2 (en) | 2017-12-13 | 2021-04-13 | Facio Intellectual Property B.V. | Compounds for treatment of diseases related to DUX4 expression |
| TW202112368A (zh) * | 2019-06-13 | 2021-04-01 | 荷蘭商法西歐知識產權股份有限公司 | 用於治療有關dux4表現之疾病的抑制劑組合 |
| WO2021190616A1 (en) * | 2020-03-27 | 2021-09-30 | Gritscience Biopharmaceuticals Co., Ltd. | Methods for inhibiting casein kinases |
| EP4126878A1 (en) * | 2020-03-27 | 2023-02-08 | Gritscience Biopharmaceuticals Co., Ltd. | Compounds as casein kinase inhibitors |
| CN111808102B (zh) * | 2020-08-03 | 2021-12-31 | 南通大学 | 一种3-甲氧基-6,7-二氢-5H-吡咯并[3,4-b]吡啶盐酸盐及其合成方法 |
| WO2022058920A1 (en) * | 2020-09-17 | 2022-03-24 | Janssen Pharmaceutica Nv | Casein kinase 1 delta modulators |
| CN116490503A (zh) * | 2020-09-17 | 2023-07-25 | 詹森药业有限公司 | 酪蛋白激酶1δ调节剂 |
| CN116888126A (zh) * | 2020-12-15 | 2023-10-13 | 北京原基华毅生物科技有限公司 | 一种酪蛋白激酶抑制剂的化合物 |
| US20230053307A1 (en) * | 2021-07-19 | 2023-02-16 | Buddhist Tzu Chi Medical Foundation | Method for preventing or treating skin disorders and conditions |
| WO2023241552A1 (en) * | 2022-06-14 | 2023-12-21 | Gritscience Biopharmaceuticals Co., Ltd | Salt and/or crystal form for compounds as casein kinase inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0151962A3 (en) | 1984-01-25 | 1985-10-02 | Beecham Group Plc | Pyrazolopyridine derivatives |
| EA003925B1 (ru) * | 1997-05-22 | 2003-10-30 | Дж.Д.Сирл Энд Ко | ЗАМЕЩЕННЫЕ ПИРАЗОЛЫ, КАК ИНГИБИТОРЫ p 38 КИНАЗЫ |
| AU2728201A (en) * | 1999-12-21 | 2001-07-03 | Sugen, Inc. | 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors |
| EA017278B9 (ru) | 2005-06-22 | 2013-01-30 | Кемосентрикс, Инк. | Соединения азаиндазола и способы применения |
| US7897595B2 (en) | 2006-05-26 | 2011-03-01 | Forest Laboratories Holdings Limited | Pyridoazepine derivatives |
| EP2308866A1 (de) * | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| EP2493876B1 (en) * | 2009-10-28 | 2014-02-12 | Pfizer Inc | Imidazole derivatives as casein kinase inhibitors |
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2011
- 2011-12-06 PL PL17151228T patent/PL3181133T3/pl unknown
- 2011-12-06 PT PT17151228T patent/PT3181133T/pt unknown
- 2011-12-06 EP EP11805210.9A patent/EP2654750B1/en active Active
- 2011-12-06 AU AU2011346733A patent/AU2011346733C1/en active Active
- 2011-12-06 ES ES17151228T patent/ES2744099T3/es active Active
- 2011-12-06 HU HUE11805210A patent/HUE032405T2/en unknown
- 2011-12-06 DK DK17151228.8T patent/DK3181133T3/da active
- 2011-12-06 RS RS20170387A patent/RS55897B1/sr unknown
- 2011-12-06 ES ES11805210.9T patent/ES2623387T3/es active Active
- 2011-12-06 CA CA2819961A patent/CA2819961C/en active Active
- 2011-12-06 JP JP2013545540A patent/JP5684923B2/ja active Active
- 2011-12-06 EP EP17151228.8A patent/EP3181133B1/en active Active
- 2011-12-06 PL PL11805210T patent/PL2654750T3/pl unknown
- 2011-12-06 LT LTEP17151228.8T patent/LT3181133T/lt unknown
- 2011-12-06 SG SG2013036934A patent/SG190802A1/en unknown
- 2011-12-06 SI SI201131784T patent/SI3181133T1/sl unknown
- 2011-12-06 KR KR1020137015822A patent/KR101590236B1/ko active IP Right Grant
- 2011-12-06 WO PCT/IB2011/055489 patent/WO2012085721A1/en active Application Filing
- 2011-12-06 DK DK11805210.9T patent/DK2654750T3/en active
- 2011-12-06 MX MX2013005833A patent/MX338551B/es active IP Right Grant
- 2011-12-06 HU HUE17151228A patent/HUE047089T2/hu unknown
- 2011-12-06 SI SI201131141A patent/SI2654750T1/sl unknown
- 2011-12-06 RS RS20191036A patent/RS59098B1/sr unknown
- 2011-12-06 PT PT118052109T patent/PT2654750T/pt unknown
- 2011-12-06 LT LTEP11805210.9T patent/LT2654750T/lt unknown
- 2011-12-06 CN CN201180061257.2A patent/CN103260622B/zh active Active
- 2011-12-13 US US13/323,883 patent/US8536164B2/en active Active
- 2011-12-19 AR ARP110104787A patent/AR084412A1/es not_active Application Discontinuation
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2013
- 2013-05-13 ZA ZA2013/03453A patent/ZA201303453B/en unknown
- 2013-06-13 IL IL226948A patent/IL226948A/en active IP Right Grant
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2014
- 2014-02-14 HK HK14101403.3A patent/HK1188145A1/xx unknown
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2015
- 2015-01-14 JP JP2015005142A patent/JP5876596B2/ja active Active
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2017
- 2017-03-22 HR HRP20170484TT patent/HRP20170484T1/hr unknown
- 2017-03-27 CY CY20171100378T patent/CY1118772T1/el unknown
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2019
- 2019-08-14 HR HRP20191469 patent/HRP20191469T1/hr unknown
- 2019-08-21 CY CY20191100892T patent/CY1122062T1/el unknown
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