AR079687A1 - Formulaciones adecuadas para el diagnostico por imagenes con pet - Google Patents
Formulaciones adecuadas para el diagnostico por imagenes con petInfo
- Publication number
- AR079687A1 AR079687A1 ARP100104866A ARP100104866A AR079687A1 AR 079687 A1 AR079687 A1 AR 079687A1 AR P100104866 A ARP100104866 A AR P100104866A AR P100104866 A ARP100104866 A AR P100104866A AR 079687 A1 AR079687 A1 AR 079687A1
- Authority
- AR
- Argentina
- Prior art keywords
- radiolabel
- formulation
- ethoxy
- phenyl
- alcohol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Formulaciones de derivados basados en el ligando beta amiloide lipofílico de estilbeno y más particularmente formulaciones que se pueden administrar por vía parental, por ejemplo intravenosa, en donde el derivado basado en el ligando beta amiloide lipofílico estilbeno es un radiofármaco marcado con 19F o 18F del mismo. Método de filtracion estéril de dicha formulacion adecuada. Reivindicacion 1: Una formulacion, caracterizada porque comprende un derivado basado en el ligando beta amiloide lipofílico estilbeno, un alcohol y un poliéter. Reivindicacion 7: Un método para la preparacion de la formulacion de acuerdo con la reivindicacion 1, caracterizado porque comprende una radiomarca obtenida mediante un dispositivo automático para uso radiofarmacéutico que comprende los pasos de: obtener una radiomarca, purificar la radiomarca usando cartuchos o columnas para una extraccion en fase solida, en donde la radiomarca es eluída con alcohol, agregar el eluato de alcohol al poliéter para obtener la formulacion de la presente y someter la formulacion a filtracion estéril sobre un filtro estéril; en donde la radiomarca es un derivado basado en el ligando beta amiloide lipofílico estilbeno. Reivindicacion 8: La formulacion de acuerdo con las reivindicaciones 1 o 2, caracterizada porque comprende el compuesto (1) Metil- [4-((F)-2-(4-[2-(2-propoxi-etoxi)-etoxi]-fenil)-vinil)-fenil]-amina o el compuesto (2) Metil-[4-((F18)-2-(4-[2-(2-propoxi-etoxi)-etoxi]-fenil)-vinil)-fenil]-amina o mezclas de los mismos, un alcohol, un poliéter y un agente para ajustar el pH.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09075568 | 2009-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079687A1 true AR079687A1 (es) | 2012-02-15 |
Family
ID=43797709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100104866A AR079687A1 (es) | 2009-12-23 | 2010-12-22 | Formulaciones adecuadas para el diagnostico por imagenes con pet |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20120328521A1 (es) |
| EP (1) | EP2515948A1 (es) |
| JP (1) | JP5774023B2 (es) |
| KR (1) | KR20120098914A (es) |
| CN (1) | CN102762229B9 (es) |
| AR (1) | AR079687A1 (es) |
| AU (1) | AU2010334929B2 (es) |
| BR (1) | BR112012015369A2 (es) |
| CA (1) | CA2785576C (es) |
| EA (1) | EA022447B1 (es) |
| HK (1) | HK1178064A1 (es) |
| IL (1) | IL220569A0 (es) |
| MX (1) | MX336896B (es) |
| SG (1) | SG181903A1 (es) |
| TW (1) | TW201138833A (es) |
| UY (1) | UY33152A (es) |
| WO (1) | WO2011076825A1 (es) |
| ZA (1) | ZA201204683B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013126898A1 (en) * | 2012-02-24 | 2013-08-29 | Case Western Reserve University | Molecular probes for detecting lipids |
| RU2623867C2 (ru) * | 2011-06-21 | 2017-06-29 | Пирамаль Имэджинг Са | Композиции фторированного стильбена, пригодные для пэт визуализации |
| JP6207588B2 (ja) * | 2012-04-10 | 2017-10-04 | ランセウス メディカル イメージング， インコーポレイテッド | 放射性薬剤合成方法 |
| US10765763B2 (en) | 2016-03-09 | 2020-09-08 | Case Western Reserve University | Radioligands for myelin |
| TW201906818A (zh) * | 2017-05-31 | 2019-02-16 | 美商５１１製藥公司 | 新穎氘取代之正子發射斷層掃描（ｐｅｔ）顯影劑及其藥理應用 |
| WO2019145293A1 (en) * | 2018-01-24 | 2019-08-01 | Ac Immune Sa | Diagnostic compositions for pet imaging, a method for manufacturing the diagnostic composition and its use in diagnostics |
| WO2020202831A1 (ja) * | 2019-03-29 | 2020-10-08 | 国立研究開発法人量子科学技術研究開発機構 | 放射性医薬の製造方法及び放射性医薬 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11505526A (ja) * | 1995-05-01 | 1999-05-21 | ユニヴァーシティ・オヴ・ピッツバーグ | アルツハイマー病の死前診断ならびにアミロイド沈着のイン・ビボのイメージ化及び予防のためのアゾ化合物 |
| DE10012120A1 (de) * | 2000-03-13 | 2001-09-27 | Ktb Tumorforschungs Gmbh | Therapeutische und diagnostische Ligandensysteme mit Transportmolekülbindenden Eigenschaften und diese enthaltende Arzneimittel |
| JP2004536026A (ja) * | 2000-11-28 | 2004-12-02 | トランスフォーム ファーマシューティカルズ，インコーポレーティッド． | パクリタキセル、その誘導体、および薬剤として許容される塩を含む医薬品製剤 |
| JP4436928B2 (ja) * | 2001-08-27 | 2010-03-24 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | スチルベン誘導体、およびアミロイド斑の結合および画像化のためのその使用 |
| CA2463902A1 (en) * | 2001-10-26 | 2003-05-01 | Oxigene, Inc. | Functionalized stilbene derivatives as improved vascular targeting agents |
| CN101123995B (zh) * | 2004-12-17 | 2011-11-16 | 宾夕法尼亚大学理事会 | 茋衍生物及其用于结合和成像淀粉样蛋白斑的用途 |
| SI2213652T1 (sl) | 2004-12-17 | 2015-03-31 | The Trustees Of The University Of Pennsylvania | Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov |
| PL2363392T3 (pl) * | 2006-03-30 | 2017-10-31 | Univ Pennsylvania | Styrylopirydynowe pochodne i ich zastosowanie do wiązania i obrazowania płytek amyloidowych |
| EP2214722A1 (en) * | 2007-11-07 | 2010-08-11 | GE Healthcare BV | Stabilization of radiopharmaceuticals |
| US20100310456A1 (en) * | 2009-06-04 | 2010-12-09 | General Electric Company | Imaging of myelin basic protein |
-
2010
- 2010-12-22 EP EP10795010A patent/EP2515948A1/en not_active Withdrawn
- 2010-12-22 CN CN201080059126.6A patent/CN102762229B9/zh active Active
- 2010-12-22 EA EA201200940A patent/EA022447B1/ru not_active IP Right Cessation
- 2010-12-22 TW TW099145355A patent/TW201138833A/zh unknown
- 2010-12-22 KR KR1020127019237A patent/KR20120098914A/ko not_active Application Discontinuation
- 2010-12-22 BR BR112012015369A patent/BR112012015369A2/pt not_active Application Discontinuation
- 2010-12-22 UY UY33152A patent/UY33152A/es not_active Application Discontinuation
- 2010-12-22 SG SG2012046710A patent/SG181903A1/en unknown
- 2010-12-22 CA CA2785576A patent/CA2785576C/en active Active
- 2010-12-22 WO PCT/EP2010/070455 patent/WO2011076825A1/en active Application Filing
- 2010-12-22 US US13/518,197 patent/US20120328521A1/en not_active Abandoned
- 2010-12-22 JP JP2012545313A patent/JP5774023B2/ja active Active
- 2010-12-22 AR ARP100104866A patent/AR079687A1/es unknown
- 2010-12-22 AU AU2010334929A patent/AU2010334929B2/en active Active
- 2010-12-22 MX MX2012007431A patent/MX336896B/es active IP Right Grant
-
2012
- 2012-06-21 IL IL220569A patent/IL220569A0/en unknown
- 2012-06-22 ZA ZA2012/04683A patent/ZA201204683B/en unknown
-
2013
- 2013-04-29 HK HK13105159.1A patent/HK1178064A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20120328521A1 (en) | 2012-12-27 |
| TW201138833A (en) | 2011-11-16 |
| IL220569A0 (en) | 2012-08-30 |
| SG181903A1 (en) | 2012-07-30 |
| CA2785576C (en) | 2017-12-05 |
| AU2010334929A1 (en) | 2012-07-05 |
| KR20120098914A (ko) | 2012-09-05 |
| CN102762229B (zh) | 2014-11-12 |
| MX2012007431A (es) | 2012-10-15 |
| MX336896B (es) | 2016-02-05 |
| CN102762229B9 (zh) | 2020-12-01 |
| BR112012015369A2 (pt) | 2018-01-23 |
| ZA201204683B (en) | 2013-04-24 |
| EA201200940A1 (ru) | 2013-02-28 |
| WO2011076825A1 (en) | 2011-06-30 |
| CA2785576A1 (en) | 2011-06-30 |
| JP5774023B2 (ja) | 2015-09-02 |
| JP2013515694A (ja) | 2013-05-09 |
| EP2515948A1 (en) | 2012-10-31 |
| UY33152A (es) | 2011-07-29 |
| CN102762229A (zh) | 2012-10-31 |
| EA022447B1 (ru) | 2016-01-29 |
| HK1178064A1 (en) | 2013-09-06 |
| AU2010334929B2 (en) | 2015-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |