AR077371A1 - DERIVADOS DE PIRAZOL, SU PREPARACIoN Y SU APLICACIoN EN LA TERAPIA DEL CÁNCER - Google Patents
DERIVADOS DE PIRAZOL, SU PREPARACIoN Y SU APLICACIoN EN LA TERAPIA DEL CÁNCERInfo
- Publication number
- AR077371A1 AR077371A1 ARP100102366A ARP100102366A AR077371A1 AR 077371 A1 AR077371 A1 AR 077371A1 AR P100102366 A ARP100102366 A AR P100102366A AR P100102366 A ARP100102366 A AR P100102366A AR 077371 A1 AR077371 A1 AR 077371A1
- Authority
- AR
- Argentina
- Prior art keywords
- application
- derivatives
- preparation
- pirazol
- cancer therapy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de pirazoles de la formula general (1) en la que: en donde X representa cloro o fluor en el estado de base o sal de adicion de ácido. Procedimiento de preparacion y aplicacion en terapéutica del cáncer. Reivindicacion 5: Compuesto de formula 1: en donde X representa cloro o fluor. Reivindicacion 6: Compuesto de formula 2: en donde X representa cloro o fluor.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0903270A FR2947546B1 (fr) | 2009-07-03 | 2009-07-03 | Derives de pyrazoles, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
AR077371A1 true AR077371A1 (es) | 2011-08-24 |
Family
ID=41695643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100102366A AR077371A1 (es) | 2009-07-03 | 2010-07-02 | DERIVADOS DE PIRAZOL, SU PREPARACIoN Y SU APLICACIoN EN LA TERAPIA DEL CÁNCER |
Country Status (31)
Country | Link |
---|---|
US (1) | US8367715B2 (es) |
EP (1) | EP2448924B1 (es) |
JP (1) | JP5680640B2 (es) |
KR (1) | KR20120037967A (es) |
CN (1) | CN102471280B (es) |
AR (1) | AR077371A1 (es) |
AU (1) | AU2010267824A1 (es) |
BR (1) | BR112012000104A2 (es) |
CA (1) | CA2767096A1 (es) |
CL (1) | CL2012000013A1 (es) |
CO (1) | CO6480992A2 (es) |
CR (1) | CR20110701A (es) |
DO (1) | DOP2012000001A (es) |
EA (1) | EA020364B1 (es) |
EC (2) | ECSP12011569A (es) |
FR (1) | FR2947546B1 (es) |
HK (1) | HK1169387A1 (es) |
IL (1) | IL217300A0 (es) |
MA (1) | MA33500B1 (es) |
MX (1) | MX2012000267A (es) |
MY (1) | MY155829A (es) |
NI (1) | NI201200001A (es) |
NZ (1) | NZ597578A (es) |
PE (1) | PE20120917A1 (es) |
SG (1) | SG177463A1 (es) |
TN (1) | TN2011000658A1 (es) |
TW (1) | TWI471312B (es) |
UA (1) | UA106500C2 (es) |
UY (1) | UY32757A (es) |
WO (1) | WO2011001122A2 (es) |
ZA (1) | ZA201200027B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2908409B1 (fr) | 2006-11-10 | 2009-01-09 | Sanofi Aventis Sa | Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation |
US9394256B2 (en) * | 2012-01-09 | 2016-07-19 | X-Chem, Inc. | Benzhydrol-pyrazole derivatives having kinase inhibitory activity and uses thereof |
AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
CN106660997B (zh) | 2014-08-18 | 2019-05-21 | 卫材R&D管理有限公司 | 单环吡啶衍生物的盐及其晶体 |
CN107619388A (zh) * | 2016-07-13 | 2018-01-23 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
CN107840842A (zh) | 2016-09-19 | 2018-03-27 | 北京天诚医药科技有限公司 | 炔代杂环化合物、其制备方法及其在医药学上的应用 |
MX2020008610A (es) | 2018-03-28 | 2020-09-21 | Eisai R&D Man Co Ltd | Agente terapeutico para carcinoma hepatocelular. |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6331541B1 (en) * | 1998-12-18 | 2001-12-18 | Soo S. Ko | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
GB0317127D0 (en) * | 2003-07-22 | 2003-08-27 | Astex Technology Ltd | Pharmaceutical compounds |
JP2008528469A (ja) * | 2005-01-21 | 2008-07-31 | アステックス・セラピューティクス・リミテッド | ピラゾールキナーゼ阻害剤およびさらなる抗癌剤の組合せ剤 |
WO2007064931A2 (en) * | 2005-12-02 | 2007-06-07 | Bayer Healthcare Llc | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
EP1959947A2 (en) * | 2005-12-15 | 2008-08-27 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
US20070208000A1 (en) * | 2005-12-15 | 2007-09-06 | Morgan Bradley P | Certain chemical entities, compositions and methods |
FR2908409B1 (fr) * | 2006-11-10 | 2009-01-09 | Sanofi Aventis Sa | Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation |
EA200900783A1 (ru) * | 2006-12-11 | 2009-12-30 | Айрм Ллк | Соединения и композиции в качестве ингибиторов киназы |
-
2009
- 2009-07-03 FR FR0903270A patent/FR2947546B1/fr not_active Expired - Fee Related
-
2010
- 2010-07-02 CA CA2767096A patent/CA2767096A1/fr not_active Abandoned
- 2010-07-02 EA EA201270128A patent/EA020364B1/ru not_active IP Right Cessation
- 2010-07-02 AR ARP100102366A patent/AR077371A1/es unknown
- 2010-07-02 BR BR112012000104A patent/BR112012000104A2/pt not_active IP Right Cessation
- 2010-07-02 TW TW99121891A patent/TWI471312B/zh not_active IP Right Cessation
- 2010-07-02 CN CN201080036552.8A patent/CN102471280B/zh not_active Expired - Fee Related
- 2010-07-02 KR KR1020127002905A patent/KR20120037967A/ko not_active Application Discontinuation
- 2010-07-02 MY MYPI2011006394A patent/MY155829A/en unknown
- 2010-07-02 MX MX2012000267A patent/MX2012000267A/es active IP Right Grant
- 2010-07-02 JP JP2012518123A patent/JP5680640B2/ja not_active Expired - Fee Related
- 2010-07-02 PE PE2012000008A patent/PE20120917A1/es not_active Application Discontinuation
- 2010-07-02 AU AU2010267824A patent/AU2010267824A1/en not_active Abandoned
- 2010-07-02 EP EP10742179.4A patent/EP2448924B1/fr active Active
- 2010-07-02 UA UAA201201093A patent/UA106500C2/uk unknown
- 2010-07-02 UY UY0001032757A patent/UY32757A/es not_active Application Discontinuation
- 2010-07-02 WO PCT/FR2010/051394 patent/WO2011001122A2/fr active Application Filing
- 2010-07-02 MA MA34592A patent/MA33500B1/fr unknown
- 2010-07-02 SG SG2011097821A patent/SG177463A1/en unknown
- 2010-07-02 NZ NZ597578A patent/NZ597578A/xx not_active IP Right Cessation
-
2011
- 2011-12-21 CR CR20110701A patent/CR20110701A/es unknown
- 2011-12-22 TN TNP2011000658A patent/TN2011000658A1/fr unknown
- 2011-12-23 US US13/336,253 patent/US8367715B2/en active Active
- 2011-12-29 IL IL217300A patent/IL217300A0/en unknown
-
2012
- 2012-01-02 DO DO2012000001A patent/DOP2012000001A/es unknown
- 2012-01-03 ZA ZA2012/00027A patent/ZA201200027B/en unknown
- 2012-01-03 EC EC2012011569A patent/ECSP12011569A/es unknown
- 2012-01-03 CL CL2012000013A patent/CL2012000013A1/es unknown
- 2012-01-03 CO CO12000505A patent/CO6480992A2/es active IP Right Grant
- 2012-01-03 EC ECSP12011659 patent/ECSP12011659A/es unknown
- 2012-01-05 NI NI201200001A patent/NI201200001A/es unknown
- 2012-10-08 HK HK12109827.6A patent/HK1169387A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |