AR076687A1 - Isoxazolinas como inhibidores de la amidahidrolasa de acidos grasos y com-posiciones farmaceuticas que los contienen - Google Patents

Isoxazolinas como inhibidores de la amidahidrolasa de acidos grasos y com-posiciones farmaceuticas que los contienen

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Publication number
AR076687A1
AR076687A1 ARP100101710A ARP100101710A AR076687A1 AR 076687 A1 AR076687 A1 AR 076687A1 AR P100101710 A ARP100101710 A AR P100101710A AR P100101710 A ARP100101710 A AR P100101710A AR 076687 A1 AR076687 A1 AR 076687A1
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Argentina
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nrf
alkyl
nrfre
ore
independently selected
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Infinity Pharmaceuticals Inc
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    • C07D498/14—Ortho-condensed systems

Abstract

La presenten también provee composiciones farmacéuticas que comprenden un compuesto de la formula (1) y un excipiente farmacéuticamente aceptable. Reivindicacion 1: Un compuesto de la formula (1): o una de sus formas farmacéuticamente aceptables, donde: (i) cada uno de Ra, Rb y Rc está seleccionado, de modo independiente, de H, alquilo C1-10 y perhaloalquilo C1-10, Rd es el grupo -L-Z y Z está seleccionado de arilo C6-14: (ii) cada uno de Ra, Rb y Rc está seleccionado, de modo independiente, de -H, alquilo C1-10 y perhaloalquilo C1-10, Rd es el grupo -L-Z y Z está seleccionado de heterociclilo de 3-14 miembros y heteroarilo de 5-14 miembros; (iii) Ra y Rd se unen para formar un carbociclilo C3-10 o anillo fusionado con heterociclilo de 3-14 miembros y Rb y Rc están seleccionados, de modo independiente, de -H, alquilo C1-10 y perhaloalquilo C1-10; o (iv) Rc y Rd se unen para formar un carbociclilo C3-10 o anillo espirofusionado heterociclilo de 3-14 miembros y Ra y Rb están seleccionados, de modo independiente, de -H, alquilo C1-10 y perhaloalquilo C1-10; L es un enlace covalente o un grupo hidrocarbonado C1-6 divalente, donde una, dos o tres unidades de metileno de L están reemplazadas, de manera opcional e independiente, con uno o varios átomos de oxigeno nitrogeno; G está seleccionado de -CN, -NO2, -S(=O)Re, .-SO2Re, -SO2NRfRe, -PO2Re, -PO2ORe, -PO2NRfRe, -(C=O)Re, -(C=O)ORe, -(C=O)NRfRe, -Br, -I, -F, -CI, -ORe, -ONRfRe, -ONRf(C=O)Re, -ONRfSO2Re, -ONRfPO2Re, -ONRfPO2ORe, -SRe, -OSO2Re, -NRfSO2Re, -OPO2Re, -OPO2ORe, -NRfPO2Re, -NRfPO2ORe, -OPO2NRfRe, -O(C=O)Re, -O(C=O)ORe, -NRfRe, -NRf(C=O)Re,-NRf(C=O)ORe, -O(C=O)NRfRe, -NRf(C=NRf)NRfRe, -O(C=NRf)NRfRe, -NRf(C=NRf)ORe, -[N(Rf)2Re]+X- donde X- es un contraion; y cada Re está seleccionado de alquilo C1-10, alquenilo C2-10, alquinilo C2-10, carbociclo C3-10, arilo C6-14, heterociclilo de 3-14 miembros y heteroarilo de 5-14 miembros; cada Rf unido a un átomo de nitrogeno está seleccionado, de modo independiente, de -H, alquilo C1-10 o un grupo protector amino; o Re y Rf se unen para formar un anillo heterociclilo de 3-14 miembros o un anillo heteroarilo de 5-14 miembros.
ARP100101710A 2009-05-18 2010-05-17 Isoxazolinas como inhibidores de la amidahidrolasa de acidos grasos y com-posiciones farmaceuticas que los contienen AR076687A1 (es)

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US17928309P 2009-05-18 2009-05-18
US17928009P 2009-05-18 2009-05-18
US17928509P 2009-05-18 2009-05-18

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EP (1) EP2432771A4 (es)
JP (1) JP2012527467A (es)
KR (1) KR20120042766A (es)
CN (1) CN102459202B (es)
AR (1) AR076687A1 (es)
AU (1) AU2010249674A1 (es)
BR (1) BRPI1011049A2 (es)
CA (1) CA2762527A1 (es)
IL (1) IL216420A0 (es)
MX (1) MX2011012263A (es)
NZ (2) NZ619076A (es)
RU (1) RU2539595C2 (es)
SG (2) SG10201402443PA (es)
TW (1) TW201043620A (es)
WO (1) WO2010135360A1 (es)
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RU2011151635A (ru) 2013-06-27
CN102459202B (zh) 2015-11-25
MX2011012263A (es) 2012-01-30
RU2539595C2 (ru) 2015-01-20
EP2432771A1 (en) 2012-03-28
SG176168A1 (en) 2011-12-29
KR20120042766A (ko) 2012-05-03
NZ596585A (en) 2014-01-31
NZ619076A (en) 2015-07-31
AU2010249674A1 (en) 2011-12-15
TW201043620A (en) 2010-12-16
ZA201108657B (en) 2013-01-30
BRPI1011049A2 (pt) 2019-09-24
IL216420A0 (en) 2012-03-01
CA2762527A1 (en) 2010-11-25
WO2010135360A1 (en) 2010-11-25
EP2432771A4 (en) 2013-06-05

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