AR074529A2 - Derivados de ciclohexano espirociclicos - Google Patents
Derivados de ciclohexano espirociclicosInfo
- Publication number
- AR074529A2 AR074529A2 ARP090103322A AR074529A2 AR 074529 A2 AR074529 A2 AR 074529A2 AR P090103322 A ARP090103322 A AR P090103322A AR 074529 A2 AR074529 A2 AR 074529A2
- Authority
- AR
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- Prior art keywords
- substituted
- unsubstituted
- unsaturated
- saturated
- alkyl
- Prior art date
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract
Derivados de ciclohexano espirocíclicos que poseen la fórmula general (1) en la que: R1 y R2 son en forma independiente entre sí para H; alquilo C1-5 respectivamente saturado o no saturado, ramificado o no ramificado, sustituido en forma simple o múltiple o no sustituido, o CHO; o los restos R1 y R2 son juntos para CH2CH2OCH2CH2, CH2CH2NR11CH2CH2 o (CH2)3-6, donde R11 significa H; alquilo C1-5, respectivamente saturado o no saturado, ramificado o no ramificado, sustituido en forma simple o múltiple o no sustituido; cicloalquilo C3-8, respectivamente saturado o no saturado, sustituido en forma simple o múltiple o no sustituido; arilo-, o heteroarilo, respectivamente sustituido en forma simple o múltiple o no sustituido; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, respectivamente sustituido en forma simple o múltiple o no sustituido; R3 es para alquilo C1-5, respectivamente saturado o no saturado, ramificado o no ramificado, sustituido en forma simple o múltiple o no sustituido; cicloalquilo C3-8, respectivamente saturado o no saturado, sustituido en forma simple o múltiple o no sustituido; arilo, respectivamente no sustituido o sustituido en forma simple o múltiple; arilo, o cicloalquilo C3-8 unido por el grupo alquilo C1-3, saturado o no saturado, ramificado o no ramificado, respectivamente no sustituido o sustituido en forma simple o múltiple; W es NR4 O ó S; y R4 es para H; alquilo C1-5, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; arilo, o heteroarilo, respectivamente sustituido o no sustituido; arilo, heteroarilo o cicloalquilo unido por el grupo alquilo C1-3, saturado o no saturado, ramificado o no ramificado, respectivamente sustituido en forma simple o múltiple o no sustituido; COR12; SO2R12, donde R12 significa H; alquilo C1-5, respectivamente saturado o no saturado, ramificado o no ramificado, sustituido en forma simple o múltiple o no sustituido; cicloalquilo C3-8, respectivamente saturado o no saturado, sustituido en forma simple o múltiple o no sustituido; arilo-, o heteroarilo, respectivamente sustituido en forma simple o múltiple o no sustituido; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, respectivamente sustituido en forma simple o múltiple o no sustituido; OR13; NR14R15; R5 es para =O; H; COOR13, CONR13, OR13; alquilo C1-5, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; cicloalquilo C3-8, saturado o no saturado, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; R6 es para H; F, Cl, NO2, CF3, OR13, SR13, SO2R13, SO2OR13, CN, COOR13, NR14R15; alquilo C1-5, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; cicloalquilo C3-8, saturado o no saturado, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; o R5 y R6 significan juntos (CH2)n con n = 2, 3, 4, 5 ó 6, donde los átomos de hidrógeno individuales pueden estar reemplazados también por F, Cl, Br, I, NO2, CF3, OR13, CN o alquilo C1-5; R7, R8, R9 y R10 son en forma independiente entre sí para H, F, Cl, Br, I, NO2, CF3, OR13, SR13, SO2R13,SO2OR13, SO2NH2, CN, COOR13, NR14R15; alquilo C1-5, cicloalquilo C3-8, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; donde R13 significa H; alquilo C1-5 respectivamente saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; cicloalquilo C3-8, respectivamente saturado o no saturado, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; R14 y R15 significan en forma independiente entre sí H; alquilo C1-5, respectivamente saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; o cicloalquilo C3-8, respectivamente saturado o no saturado, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; o R14 y R15 forman juntos CH2CH2OCH2CH2, CH2CH2NR16CH2CH2 o (CH2)3-6, donde R16 significa H; alquilo C1-5 saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; X representa NR17; R17 es para H, alquilo C1-5, saturado o no saturado, ramificado o no ramificado; COR12 o SO2R12; en la forma del racemato; de los enantiómeros, diastereómeros, mezclas de los enantiómeros o diastereómeros o de un enantiómero o diastereómero individual; de las bases y/o sales de ácidos o cationes fisiológicamente compatibles. Un procedimiento para su elaboración, medicamentos que contienen estos compuestos y el uso de los derivados de ciclohexano espirocíclicos para elaborar medicamentos.
Applications Claiming Priority (1)
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DE2002152667 DE10252667A1 (de) | 2002-11-11 | 2002-11-11 | Spirocyclische Cyclohexan-Derivate |
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AR074529A2 true AR074529A2 (es) | 2011-01-26 |
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ARP030104135 AR041932A1 (es) | 2002-11-11 | 2003-11-11 | Derivados de ciclohexano espirociclicos, preparacion de los mismos, su uso en la fabricacion de medicamentos y dichos medicamentos. |
ARP090103322 AR074529A2 (es) | 2002-11-11 | 2009-08-28 | Derivados de ciclohexano espirociclicos |
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ARP030104135 AR041932A1 (es) | 2002-11-11 | 2003-11-11 | Derivados de ciclohexano espirociclicos, preparacion de los mismos, su uso en la fabricacion de medicamentos y dichos medicamentos. |
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EP (4) | EP2116544B1 (es) |
JP (4) | JP4728645B2 (es) |
KR (2) | KR101075817B1 (es) |
CN (2) | CN101693714B (es) |
AR (2) | AR041932A1 (es) |
AT (1) | ATE441650T1 (es) |
AU (2) | AU2003296563B2 (es) |
BR (2) | BRPI0315296B8 (es) |
CA (1) | CA2505555C (es) |
CO (1) | CO5580765A2 (es) |
CY (2) | CY1110558T1 (es) |
DE (2) | DE10252667A1 (es) |
DK (2) | DK1560835T3 (es) |
EC (1) | ECSP055786A (es) |
ES (4) | ES2333956T3 (es) |
HK (3) | HK1080478A1 (es) |
IL (2) | IL168473A (es) |
MX (1) | MXPA05004959A (es) |
NO (2) | NO331818B1 (es) |
NZ (1) | NZ540575A (es) |
PE (1) | PE20040830A1 (es) |
PL (2) | PL215227B1 (es) |
PT (2) | PT1560835E (es) |
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