AR069692A1 - Peptidilnitrilos y sus usos como inhibidores de la dipeptidil peptidasa - Google Patents
Peptidilnitrilos y sus usos como inhibidores de la dipeptidil peptidasaInfo
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- AR069692A1 AR069692A1 ARP080105431A ARP080105431A AR069692A1 AR 069692 A1 AR069692 A1 AR 069692A1 AR P080105431 A ARP080105431 A AR P080105431A AR P080105431 A ARP080105431 A AR P080105431A AR 069692 A1 AR069692 A1 AR 069692A1
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- Prior art keywords
- alkyl
- cycloalkyl
- saturated
- independently represent
- attached form
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Abstract
Un proceso para su preparacion, composiciones farmacéuticas que contienen a los mismos y su uso en el tratamiento del asma, enfermedad pulmonar obstructiva cronica o rinitis alérgica. Reivindicacion 1: Un compuesto caracterizado porque es de la formula (1) donde n representa de manera independiente 0, 1, 2, 3 o 4; X1 representa un grupo metileno; y representa 0, 1 o 2; cada R1 representa de manera independiente halogeno, hidroxilo, carboxilo, ciano, alquilo C1-6, alcoxi C1-6, trifluorometilo, NR6R7, C(O)NR6R7, NR6aC(O)R7a, SO2NR6R7, NR6aSO2R7a o S(O)mR8 y R1 se sustituye opcionalmente con hidroxi, halogeno o alcoxi C1-6; R2 representa un átomo de hidrogeno o un grupo alquilo C1-6 opcionalmente sustituido con por lo menos un sustituyente seleccionado entre halogeno, hidroxilo, carboxilo, ciano, trifluorometilo, alquilo C1-6, cicloalquilo C3-6, NR9R10, C(O)NR11R12, NR13C(O)R14, SO2NR15R16, NR17SO2R18 y S(O)pR19; R3 representa un átomo de hidrogeno o un grupo alquilo C1-6 opcionalmente sustituido con por lo menos un sustituyente seleccionado entre halogeno, hidroxilo, carboxilo, ciano, trifluorometilo, alquilo C1-6, cicloalquilo C3-6, NR20R21, C(O)NR22R23, NR24C(O)R25, SO2NR26R27, NR28SO2R29 y S(O)pR30; R4 representa un átomo de hidrogeno o un grupo alquilo C1-6 opcionalmente sustituido con por lo menos un sustituyente seleccionado entre halogeno, hidroxilo, carboxilo, ciano, trifluorometilo, alquilo C1-6, cicloalquilo C3-6, NR31R32, C(O)NR33R34, NR35C(O)R36, SO2NR37R38, NR39SO2R40 y S(O)rR41, R5 representa un átomo de hidrogeno o un grupo alquilo C1-6 opcionalmente sustituido con por lo menos un sustituyente seleccionado entre halogeno, hidroxilo, carboxilo, ciano, trifluorometilo, alquilo C1-6, cicloalquilo C3-6, NR42R43, C(O)NR44R45, NR46C(O)R47, SO2NR48R49, NR50SO2R51 y S(O)tR52, o R3 y R4 junto con los átomos de carbono a los cuales están unidos representan un anillo ciclopropilo, o R4 y R5 junto con el átomo de carbono al cual están unidos forman un anillo carbocíclico o heterocíclico saturado o insaturado, de 3 a 6 miembros cuyo anillo se puede sustituir opcionalmente con por lo menos un sustituyente seleccionado entre halogeno, hidroxilo, carboxilo y alquilo C1-6; A y B representan, cada uno de manera independiente, un sistema de anillos aromático de 5 a 10 miembros que comprende opcionalmente por lo menos un heteroátomo del anillo seleccionado entre nitrogeno, oxígeno y azufre, el sistema de anillos está sustituido opcionalmente con por lo menos un sustituyente seleccionado entre halogeno, carboxilo, hidroxilo, oxo, nitro, ciano, mercapto, cicloalquilo C3-6, alquenilo C2-6, trifluorometilo, alcoxi C1-6, alquilcarbonilo C1-6, alquilcarboniloxi C1-6, alcoxicarbonilo C1-6, -NR53R54, -C(O)NR55R56, NR57C(O)R58, SO2NR59R60, NR61SO2R62, S(O)vR63, heterocicliloxi de 4 a 7 miembros saturado, benciloxi, alquilpiperazinilo C1-6y un grupo alquilo C1-6 (el mismo sustituido opcionalmente con hidroxilo, NR64R65, fenilo o morfolinilo); m, p, q, r, t y v representan, cada uno de manera independiente, 0, 1 o 2; X2 representa una union, un átomo de oxígeno o azufre, SO, SO2, NR66, C(O)NR66, NR66C(O), SO2NR66, NR66SO2, alquilo C1-3, etenilo o etinilo; R6 y R7 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R6 y R7 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R9 y R10 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R9 y R10 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R11 y R12 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R11 y R12 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R15 y R16 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R15 y R16 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R20 y R21 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R20 y R21 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R22 y R23 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R22 y R23 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R26 y R27 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R26 y R27 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R31 y R32 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R31 y R32 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R33 y R34 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R33 y R34 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R37 y R38 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R37 y R38 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R42 y R43 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R42 y R43 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R44 y R45 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R44 y R45 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R48 y R49 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R48 y R49 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R53 y R54 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R53 y R54 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R55 y R56 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R55 y R56 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R59 y R60 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R59 y R60 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; R64 y R65 representan, cada uno de manera independiente, hidrogeno, alquilo C1-6 o cicloalquilo C3-6, o R64 y R65 junto con el átomo de nitrogeno al cual están unidos forman un anillo heterocíclico saturado de 4 a 7 miembros; cada grupo R6a, R7a, R8, R13, R14, R17, R18, R19, R24, R25, R28, R29, R30, R35, R36, R39, R40, R41, R46, R47, R50, R51, R52, R57, R58, R61, R62 y R63 representa de manera independiente un átomo de hidrogeno o un grupo alquilo C1-6 o cicloalquilo C3-6; y R66 representa un átomo de hidrogeno o un grupo alquilo C1-6; o una sal aceptable para uso farmacéutico del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1297207P | 2007-12-12 | 2007-12-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR069692A1 true AR069692A1 (es) | 2010-02-10 |
Family
ID=40364478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080105431A AR069692A1 (es) | 2007-12-12 | 2008-12-12 | Peptidilnitrilos y sus usos como inhibidores de la dipeptidil peptidasa |
Country Status (22)
Country | Link |
---|---|
US (2) | US7902181B2 (es) |
EP (1) | EP2231597A1 (es) |
JP (1) | JP2011506421A (es) |
KR (1) | KR20100098683A (es) |
CN (1) | CN101945851B (es) |
AR (1) | AR069692A1 (es) |
AU (1) | AU2008334444B2 (es) |
BR (1) | BRPI0820665A2 (es) |
CA (1) | CA2706679A1 (es) |
CL (1) | CL2008003694A1 (es) |
CO (1) | CO6280399A2 (es) |
CR (1) | CR11492A (es) |
DO (1) | DOP2010000178A (es) |
EA (1) | EA201000958A1 (es) |
EC (1) | ECSP10010245A (es) |
IL (1) | IL205873A0 (es) |
MX (1) | MX2010006110A (es) |
PE (1) | PE20091100A1 (es) |
TW (1) | TW200932725A (es) |
UY (1) | UY31524A1 (es) |
WO (1) | WO2009074829A1 (es) |
ZA (1) | ZA201004091B (es) |
Families Citing this family (38)
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SI1976828T1 (sl) | 2005-12-29 | 2017-07-31 | Celtaxsys, Inc. | Diaminski derivati kot inhibitorji levkotrien A4 hidrolaze |
CA2706679A1 (en) * | 2007-12-12 | 2009-06-18 | Astrazeneca Ab | Novel compounds 010 |
WO2010142985A1 (en) * | 2009-06-10 | 2010-12-16 | Astrazeneca Ab | Substituted n-[1-cyano-2-(phenyl)ethyl]piperidin-2-ylcarboxmide compounds 761 |
US8633322B2 (en) | 2009-10-29 | 2014-01-21 | Janssen Pharmaceutica Nv | Alkynyl derivatives useful as DPP-1 inhibitors |
US8552032B2 (en) * | 2009-12-18 | 2013-10-08 | Janssen Pharmaceutica Nv | Bicyclic derivatives useful as inhibitors of DPP-1 |
US8481547B2 (en) * | 2009-12-18 | 2013-07-09 | Janssen Pharmaceutica Nv | Substituted benzothiazole and benzoxazole derivatives useful as inhibitors of DPP-1 |
JP5764148B2 (ja) * | 2010-03-10 | 2015-08-12 | ヤンセン ファーマシューティカ エヌ.ベー. | ジペプチジルペプチダーゼ−1(dpp−1)の阻害剤として有用な4,4−二置換されたピペリジン誘導体 |
US8686152B2 (en) | 2010-03-10 | 2014-04-01 | Janssen Pharmaceutica Nv | 4,4-disubstituted piperidine derivatives useful as inhibitors of dipeptidyl peptidase-1 (DPP-1) |
WO2011140190A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Tetrazolones as inhibitors of fatty acid synthase |
WO2011154677A1 (en) | 2010-06-09 | 2011-12-15 | Astrazeneca Ab | Substituted n-[1-cyano-2-(phenyl)ethyl] 1-aminocycloalk-1-ylcarboxamide compounds - 760 |
US20140113898A1 (en) * | 2010-11-08 | 2014-04-24 | Zalicus Pharmaceuticals Ltd. | Bisarylsulfone and dialkylarylsulfone compounds as calcium channel blockers |
WO2012119941A1 (en) | 2011-03-04 | 2012-09-13 | Prozymex A/S | Peptidyl nitrilcompounds as peptidase inhibitors |
WO2012130299A1 (en) * | 2011-03-30 | 2012-10-04 | Prozymex A/S | Peptidase inhibitors |
US8999975B2 (en) | 2011-09-19 | 2015-04-07 | Boehringer Ingelheim International Gmbh | Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C |
AU2014249168B2 (en) | 2013-03-12 | 2018-07-12 | Celltaxis, Llc | Methods of inhibiting leukotriene A4 hydrolase |
WO2014140078A1 (en) * | 2013-03-14 | 2014-09-18 | Boehringer Ingelheim International Gmbh | Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (cyano-methyl)-amides inhibitors of cathepsin c |
JP6441831B2 (ja) * | 2013-03-14 | 2018-12-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | カテプシンcの置換2−アザ−ビシクロ[2.2.2]オクタン−3−カルボン酸(ベンジル−シアノ−メチル)−アミド阻害剤 |
WO2014140081A1 (en) * | 2013-03-14 | 2014-09-18 | Boehringer Ingelheim International Gmbh | Substituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c |
BR112015022226A2 (pt) | 2013-03-14 | 2017-07-18 | Celtaxsys Inc | inibidores de leucotrieno a4 hidrolase |
RU2678196C2 (ru) | 2013-03-14 | 2019-01-24 | Селтакссис, Инк. | Производные 2-фениламино-3-цианопиразоло[1,5-а]пиримидина, полезные в качестве ингибитора лейкотриен-a4-гидролазы |
BR112015022227A2 (pt) | 2013-03-14 | 2017-07-18 | Celtaxsys Inc | inibidores de leucotrieno a4 hidrolase |
EP2970283B1 (en) | 2013-03-14 | 2020-11-11 | Boehringer Ingelheim International GmbH | Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c |
CN105612149A (zh) * | 2013-09-09 | 2016-05-25 | 普罗技迈克斯公司 | 作为二肽基肽酶i抑制剂的肽基腈化合物 |
NO2699580T3 (es) * | 2014-01-24 | 2018-02-24 | ||
WO2016016242A1 (en) | 2014-08-01 | 2016-02-04 | Boehringer Ingelheim International Gmbh | Substituted oxetanes and their use as inhibitors of cathepsin c |
LT3191487T (lt) | 2014-09-12 | 2019-10-10 | Boehringer Ingelheim International Gmbh | Katepsino c spirocikliniai inhibitoriai |
DK3239143T3 (da) | 2014-12-24 | 2023-04-11 | Lg Chemical Ltd | Biarylderivat som gpr120-agonist |
WO2016139355A1 (en) | 2015-03-05 | 2016-09-09 | Prozymex A/S | N-substituted 3,3'-(biphenyl-4,4'-diyl)bis-2-aminopropanenitriles as dppi inhibitors |
DK3265452T3 (en) | 2015-03-05 | 2020-06-08 | Neuprozyme Therapeutics ApS | Peptidyl nitril compounds as dipeptidyl peptidase i inhibitors |
TWI691486B (zh) * | 2016-01-29 | 2020-04-21 | 日商東麗股份有限公司 | 環狀胺衍生物及其醫藥用途 |
JP7386815B2 (ja) | 2018-05-31 | 2023-11-27 | セルタクシー、エルエルシー | 呼吸器疾患患者の肺増悪を軽減する方法 |
CN115996923A (zh) | 2020-08-26 | 2023-04-21 | 四川海思科制药有限公司 | 一种作为二肽基肽酶1抑制剂的腈衍生物及其用途 |
JP2023551488A (ja) | 2020-12-04 | 2023-12-08 | 瑞石生物医薬有限公司 | カテプシンcの小分子阻害剤及びその医薬的使用 |
JP2024505715A (ja) * | 2021-02-05 | 2024-02-07 | メッドシャイン ディスカバリー インコーポレイテッド | 1,4-オキサゼパンを含む縮合環誘導体 |
WO2023160541A1 (zh) * | 2022-02-22 | 2023-08-31 | 四川海思科制药有限公司 | 一种含氮杂环化合物的制备方法 |
WO2023160542A1 (zh) * | 2022-02-22 | 2023-08-31 | 四川海思科制药有限公司 | 二肽基肽酶抑制剂化合物的盐及晶型 |
WO2024008680A1 (en) * | 2022-07-06 | 2024-01-11 | Chiesi Farmaceutici S.P.A. | Azetidine derivatives and use thereof as dipeptidyl peptidase 1 inhibitors |
WO2024026433A2 (en) * | 2022-07-28 | 2024-02-01 | Insmed Incorporated | Novel dpp1 inhibitors and uses thereof |
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CO5150173A1 (es) * | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
CA2379747C (en) | 1999-07-30 | 2008-09-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Novel succinate derivative compounds useful as cysteine protease inhibitors |
WO2001047886A1 (en) * | 1999-12-24 | 2001-07-05 | F. Hoffmann-La Roche Ag | Nitrile derivatives as cathepsin k inhibitors |
JP4357293B2 (ja) | 2001-06-27 | 2009-11-04 | スミスクライン ビーチャム コーポレーション | ジペプチジルペプチダーゼ阻害剤としてのフルオロピロリジン類 |
ATE374181T1 (de) | 2001-06-27 | 2007-10-15 | Smithkline Beecham Corp | Fluorpyrrolidine als dipeptidylpeptidaseinhibitoren |
ES2298543T3 (es) * | 2002-04-30 | 2008-05-16 | Ucb Pharma, S.A. | Derivados de 2,6-quinolino y 2,6-naftilo y su uso en el tratamiento de enfermedades dependientes de vla-4. |
US20070099958A1 (en) | 2003-06-18 | 2007-05-03 | Prozymex A/S | Protease inhibitors |
CA2555594A1 (en) * | 2004-02-10 | 2005-08-25 | Janssen Pharmaceutica N.V. | Pyridazinones as antagonists of a4 integrins |
US7504413B2 (en) | 2004-05-06 | 2009-03-17 | Cytokinetics, Inc. | N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases |
CA2706679A1 (en) * | 2007-12-12 | 2009-06-18 | Astrazeneca Ab | Novel compounds 010 |
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- 2008-12-10 MX MX2010006110A patent/MX2010006110A/es not_active Application Discontinuation
- 2008-12-10 BR BRPI0820665A patent/BRPI0820665A2/pt not_active IP Right Cessation
- 2008-12-10 US US12/331,719 patent/US7902181B2/en not_active Expired - Fee Related
- 2008-12-10 EP EP08860193A patent/EP2231597A1/en not_active Withdrawn
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- 2008-12-10 EA EA201000958A patent/EA201000958A1/ru unknown
- 2008-12-10 AU AU2008334444A patent/AU2008334444B2/en not_active Ceased
- 2008-12-10 CN CN2008801266467A patent/CN101945851B/zh not_active Expired - Fee Related
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- 2008-12-10 JP JP2010537526A patent/JP2011506421A/ja active Pending
- 2008-12-11 UY UY31524A patent/UY31524A1/es unknown
- 2008-12-11 TW TW097148183A patent/TW200932725A/zh unknown
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CO6280399A2 (es) | 2011-05-20 |
TW200932725A (en) | 2009-08-01 |
US20090306042A1 (en) | 2009-12-10 |
EA201000958A1 (ru) | 2010-12-30 |
PE20091100A1 (es) | 2009-08-29 |
CN101945851B (zh) | 2012-10-31 |
IL205873A0 (en) | 2010-11-30 |
CN101945851A (zh) | 2011-01-12 |
WO2009074829A1 (en) | 2009-06-18 |
AU2008334444A1 (en) | 2009-06-18 |
US7902181B2 (en) | 2011-03-08 |
DOP2010000178A (es) | 2010-09-15 |
CA2706679A1 (en) | 2009-06-18 |
KR20100098683A (ko) | 2010-09-08 |
ZA201004091B (en) | 2011-11-30 |
UY31524A1 (es) | 2009-08-03 |
BRPI0820665A2 (pt) | 2018-05-29 |
EP2231597A1 (en) | 2010-09-29 |
US20110201581A1 (en) | 2011-08-18 |
ECSP10010245A (es) | 2010-07-30 |
AU2008334444B2 (en) | 2011-12-15 |
MX2010006110A (es) | 2010-06-25 |
JP2011506421A (ja) | 2011-03-03 |
CR11492A (es) | 2010-07-15 |
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