AR068050A1 - Inhibidores de la polimerasa viral - Google Patents

Inhibidores de la polimerasa viral

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Publication number
AR068050A1
AR068050A1 ARP080103382A ARP080103382A AR068050A1 AR 068050 A1 AR068050 A1 AR 068050A1 AR P080103382 A ARP080103382 A AR P080103382A AR P080103382 A ARP080103382 A AR P080103382A AR 068050 A1 AR068050 A1 AR 068050A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
optionally substituted
independently selected
het
Prior art date
Application number
ARP080103382A
Other languages
English (en)
Inventor
Pierre L Beaulieu
Pasquale Forgione
Cedrickx Godbout
Alexandre Gagnon
Julie Naud
Martin Poirier
Bounkham Thavonekham
Jean Rancourt
Timothy A Stammers
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR068050A1 publication Critical patent/AR068050A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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    • C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
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    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
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    • C07D257/04—Five-membered rings
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    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
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Abstract

Composicion farmacéutica, uso y artículo que comprende la composicion y material de envasado. Estos compuestos son utiles como inhibidores de la polimerasa NS5B del virus de la hepatitis C. Reivindicacion 1: Un compuesto de formula (1) donde R2 es arilo o Het, opcionalmente sustituido con R20, donde R20 es de 1 a 5 sustituyentes, cada uno de ellos seleccionado independientemente entre a) halo; b) R7, donde R7 se selecciona entre H, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-7, arilo y Het; donde el alquilo C1-6 y el cicloalquilo C3-7 están opcionalmente sustituidos con 1 o 2 sustituyentes, cada uno seleccionado independientemente entre -OH, -alquilo C1-6, halo, -haloalquilo C1-6, cicloalquilo C3-7, -O-alquilo C1-6, ciano, COOH, -NH2, -NH-alquilo C1-6, -NH-cicloalquilo C3-7, -N(alquil C1-4)cicloalquilo C3-7, y -N(alquilo C1-4)2; donde cada uno de los grupos arilo y Het está opcionalmente sustituido con 1 a 3 sustituyentes, cada uno independientemente seleccionado de i) halo, ciano, oxo, tioxo, imino, -OH, -O-alquilo C1-6, -O-haloalquilo C1-6, O-cicloalquilo C3-7, cicloalquilo C3-7, haloalquilo C1-4, -C(=O)-alquilo C1-4, -SO2-alquilo C1-6, -C(=O)-NH2, -C(O)-NH-alquilo C1-4, -C(=O)-N(alquilo C1-4)2, -C(=O)-NH-cicloalquilo C3-7, -C(=O)-N(alquil C1-4)cicloalquilo C3-7, -NH2, -NH-alquilo C1-4, -N(alquilo C1-4)2, -NH-cicloalquilo C3-7, -N(alquil C1-4)cicloalquilo C3-7 o -NH-C(O)alquilo C1-4; ii) alquilo C1-6 opcionalmente sustituido con -OH, -O-haloalquilo C1-6 o -O-alquilo C1-6; y iii) arilo o Het, donde cada uno de los grupos arilo y Het está opcionalmente sustituido con halo, alquilo C1-6 o -O-alquilo C1-6; c) -C(=O)-R7, -C(=O)-OR7, -O-R7, -SR7, -SOR7, SO2R7, -alquileno C1-6-R7, -alquileno C1-6-O-R7, -alquileno C1-6-S-R7, -alquileno C1-6-R7 o -alquileno C1-6-SO2R7; donde R7 es como se ha definido anteriormente; y donde el -alquileno C1-6 está opcionalmente sustituido con 1 o 2 sustituyentes, cada uno de ellos seleccionado independientemente entre -OH, -alquilo C1-6, halo, -haloalquilo C1-6, cicloalquilo C3-7, -O-alquilo C1-6, ciano, -COOH, -NH2, -NH-alquilo C1-4, -NH-cicloalquilo C3-7, -N(alquil C1-4)cicloalquilo C3-7 y -N(alquilo C1-4)2; y d) aril-alquilo C1-6 o Het-alquilo C1-6, donde cada uno de los grupos arilo y Het está opcionalmente sustituido con 1 a 3 sustituyentes, cada uno independientemente seleccionado de i) halo, ciano, oxo, tioxo, imino, -OH, -O-alquilo C1-6, -O-haloalquilo C1-6, O-cicloalquilo C3-7, cicloalquilo C3-7, haloalquilo C1-6, -C(=O)-alquilo C1-6, -SO2-alquilo C1-6, -C(=O)-NH2, -C(=O)-NH-alquilo (C1-4), -C(=O)-N(alquilo C1-4)2, -C(=O)-NH-cicloalquilo C3-7, -C(=O)-N(alquil C1-4)cicloalquilo C3-7, -NH2, -NH-alquilo C1-4, -N(alquilo (C1-4)2, -NH-cicloalquilo C3-7, -N(alquil C1-4)cicloalquilo C3-7 o -NH-C(=O)alquilo C1-4; ii) alquilo C1-6, opcionalmente sustituido con -OH, -O-haloalquilo C1-6 o -O-alquilo C1-6; y iii) arilo o Het, donde cada uno de los grupos arilo y Het está opcionalmente sustituido con halo, alquilo C1-6 o -O-alquilo C1-6; donde la porcion -alquilo C1-6 del aril-alquilo C1-6 o Het-alquilo C1-6 está opcionalmente sustituida con 1 o 2 sustituyentes, cada uno seleccionado independientemente entre -OH, -alquilo C1-6, halo-haloalquilo C1-6, cicloalquilo C3-7, O-alquilo C1-6, ciano, COOH, -NH2, -NH-alquilo C1-4, -NH-cicloalquilo C3-7, -N(alquil C1-4)cicloalquilo C3-7 y -N(alquilo C1-4)2; e) -N(R8)R9, -C(=O)-N(R8)R9, -SO2-N(R8)R9 o -alquileno C1-6-N(R8)R9 donde el -alquileno C1-6 está opcionalmente sustituido con 1 o 2 sustituyentes, cada uno de ellos seleccionado independientemente entre -OH, -alquilo C1-6, halo, -haloalquilo C1-6, cicloalquilo C3-7, -O-alquilo C1-6, ciano, -COOH, -NH2, -NH-alquilo C1-6, -NH-cicloalquilo C3-7, -N(alquil C1-4)cicloalquilo C3-7 y -N(alquilo (C1-4)2; R8 en cada caso, se selecciona independientemente de H, alquilo C1-6 y cicloalquilo C3-7; y R9 en cada caso, se selecciona independientemente entre R7, -O-alquilo C1-6, -alquileno C1-6-R7, -cicloalquil C3-7-alquilo C1-6, -C(=O)-R10, -C(=O)OR10 y -C(=O)NHR10; donde R7 es como se ha definido anteriormente; donde el -alquileno C1-6 está opcionalmente sustituido con 1 o 2 sustituyentes, cada uno de ellos seleccionado independientemente entre -OH, -alquilo C1-6, halo, -haloalquilo C1-6, cicloalquilo C3-7, -O-alquilo C1-6, ciano, -COOH, -NH2, -NH-alquilo C1-4, -NH-cicloalquilo C3-7, -N(alquil C1-4)cicloalquilo C3-7 y -N(alquilo (C1-4)2 donde el alquilo C1-6 está opcionalmente sustituido con 1 o 2 sustituyentes, cada uno de ellos seleccionado independientemente entre -COOH, -NH2, -NH-alquilo C1-4 y -N(alquilo C1-4)2 y donde R10, en cada caso, se selecciona independientemente entre alquilo C1-6, y Het, donde dicho Het está opcionalmente sustituido con alquilo C1-6; o R8 y R9, junto con el N al que están unidos, se unen para formar un heterociclo de 4 a 7 miembros que contiene opcionalmente además de 1 a 3 heteroátomos, cada uno de ellos seleccionado independientemente entre N, O y S, donde cada heteroátomo S puede, independientemente y cuando sea posible, existir en un estado oxidado de tal forma que se una a uno o dos átomos de oxigeno para formar los grupos SO o SO2; donde el heterociclo está opcionalmente sustituido con 1 a 3 sustituyentes, cada uno de ellos seleccionado independientemente entre alquilo C1-6, haloalquilo C1-6, halo, oxo, -OH, SH, -O-alquilo C1-6, -S-alquilo C1-6, cicloalquilo C3-7, -NH2, -NH-alquilo C1-6, -N(alquilo C1-6)2, NH-cicloalquilo C3-7, -N(alquil C1-4)cicloalquilo C3-7, -C(O)alquilo C1-6 y -NHC(=O)-alquilo C1-6; R5 se selecciona entre H, alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-6 y Het; estando el alquilo C1-6 y Het cada uno opcionalmente sustituido con 1 a 4 sustituyentes cada uno seleccionado independientemente entre alquilo C1-6, -OH, -COOH, -C(=O)-alquilo C1-6, -C(=O)-O-alquilo C1-6, -C(=O)-NH-alquilo C1-6, -C(=O)-N(alquilo C1-6)2 y -SO2-alquilo C1-6; y R6 se selecciona entre cicloalquilo C3-7 y arilo; cada uno de los grupos cicloalquilo C3-7 y arilo está opcionalmente sustituido con 1 a 5 sustituyentes, cada uno de ellos seleccionado independientemente entre halogeno, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-7, -OH, -SH, -O-alquilo C1-4 y -S-alquilo C1-4; donde Het es un heterociclo de 4 a 7 miembros saturado, insaturado o aromático que tiene de 1 a 4 heteroátomos, cada uno de ellos seleccionado independientemente entre O, N y S, o un heteropoliciclo de 7 a 14 miembros, saturado, insaturado o aromático que tiene, siempre que sea posible, de 1 a 5 heteroátomos, cada uno de ellos seleccionado independientemente entre O, N y S; o una de sus sales o ésteres.
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