AR069417A1 - Piperidinas heteroaril - sustituidas - Google Patents
Piperidinas heteroaril - sustituidasInfo
- Publication number
- AR069417A1 AR069417A1 ARP080105089A ARP080105089A AR069417A1 AR 069417 A1 AR069417 A1 AR 069417A1 AR P080105089 A ARP080105089 A AR P080105089A AR P080105089 A ARP080105089 A AR P080105089A AR 069417 A1 AR069417 A1 AR 069417A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- alkyl
- substituted
- cycloalkyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se refiere a piperidinas heteroaril-sustituidas, a procedimientos para su preparacion, a su uso para el tratamiento y/o la profilaxis de enfermedades y a su uso para preparar medicamentos para el tratamiento y/o la profilaxis de enfermedades, en particular de enfermedades cardiovasculares y enfermedades tumorales. Reivindicacion 1: Compuestos de la formula (1) en la que: A representa un grupo de las formulas (2) donde es el punto de anclaje al anillo de piperidina, y * es el punto de anclaje a R2; R1representa fenilo, donde fenilo puede estar sustituido con 1 a 3 sustituyentes seleccionados independientemente unos de otros del grupo constituido por monofluorometilo, difluorometilo, trifluorometilo, monofluorometoxi, difluorometoxi, trifluorometoxi, monofluorometilsulfanilo, difluorometilsulfanilo, trifluorometilsulfanilo, metilsulfonilo, alquilo C1-4, alcoxi C1-4, alcoxi C1-4-carbonilo y cicloalquilo C3-6, donde alcoxi C2-4 puede estar sustituido con un sustituyente seleccionado a partir del grupo constituido por metoxi y etoxi, y donde cicloalquilo puede estar sustituido con 1 a 3 sustituyentes independientemente uno del otro seleccionados del grupo constituido por halogeno y alquilo C1-4, R2 representa hidrogeno, trifluorometilo, aminometilo, alquilo C1-6, alquenilo C2-6, alcoxicarbonilo C1-4, cicloalquilo C3-6, ciclopentenilo, heterociclilo de 4 a 6 miembros, fenilo, 1,3-benzodioxolilo, heteroarilo de 5 o 6 miembros o piridilaminocarbonilo, donde cicloalquilo, heterociclilo, fenilo y heteroarilo pueden estar sustituidos con 1 a 3 sustituyentes seleccionados independientemente uno del otro del grupo constituido por halogeno, ciano, amino, monofluorometilo, difluorometilo, trifluorometilo. monofluorometoxi, difluorometoxi, trifluorometoxi, monofluorometilsulfanilo, difluorometilsulfanilo, trifluorometilsulfanilo, alquilo C1-4, alcoxi C1-4, alquilamino C1-6, alcoxi C1-4-carbonilamino, cicloalquilo C3-6, heterociclilo de 4 a 6 miembros, fenilo y heteroarilo de 5 o 6 miembros, donde alquilamino puede estar sustituido con un sustituyente seleccionado del grupo constituido por alcoxi C1-4 y alquilamino C1-6, y donde alquilo C1-4 puede estar sustituido con un sustituyente seleccionado del grupo constituido por halogeno, hidroxilo, amino, aminocarbonilo, alcoxi C1-4, alquil C1-6-amino, alquiltio C1-4, alquil C1-4-carbonilo, alquil C1-4-carboniloxi, alquil C1-4-sulfonilo, alcoxi C1-4-carbonilo, alcoxi C1-4-carbonilamino, cicloalquilo C3-6, cicloalquil C3-6-amino, heterociclilo de 4 a 6 miembros, fenilo, fenoxi, heteroarilo de 5 o 6 miembros y heteroariltio de 5 o 6 miembros, donde cicloalquilo, heterociclilo, fenilo, fenoxi, heteroarilo y heteroariltio pueden estar sustituidos con 1 a 3 sustituyentes seleccionados independientemente uno del otro del grupo constituido por halogeno, ciano, hidroximetilo, monofluorometilo, difluorometilo, trifluorometilo, monofluorometoxi. difluorometoxi, trifluorometoxi, monofluorometilsulfanilo, difluorometilsulfanilo, trifluorometilsulfanilo alquilo C1-4 alcoxi C1-4, cicloalquilo C3-6, heterociclilo de 4 a 6 miembros, fenilo y heteroarilo de 5 o 6 miembros, R3 representa alquilo C1-6, alcoxi C1-6, alquil C1-6-amino, cicloalquilo C3-7, heterociclilo de 4 a 6 miembros, fenilo o heteroarilo de 5 o 6 miembros, donde alquilo, alcoxi C2-6 y alquilamino pueden estar sustituidos con un sustituyente seleccionado del grupo constituido por hidroxilo, amino, ciano y alcoxi C1-4, y donde cicloalquilo, heterociclilo, fenilo y heteroarilo pueden estar sustituidos con 1 a 3 sustituyentes seleccionados independientemente unos de otros del grupo constituido por halogeno, ciano, nitro, oxo, hidroxilo, amino, aminometilo, monofluorometilo, difluorometilo, trifluorometilo, monofluorometoxi, difluorometoxi, trifluorometoxi, monofluorometilsulfanilo, difluorometilsulfanilo, trifluorometilsulfanilo, hidroxicarbonilo, aminocarbonilo, alquilo C1-4, alcoxi C1-4, alquil C1-6-amino, alcoxi C1-4-carbonilo y alquil C1-4-aminocarbonilo, o una de sus sales, de sus solvatos o de los solvatos de sus sales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007057718A DE102007057718A1 (de) | 2007-11-30 | 2007-11-30 | Heteroaryl-substituierte Piperidine |
| DE102008010221A DE102008010221A1 (de) | 2008-02-20 | 2008-02-20 | Heteroaryl-substituierte Piperidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR069417A1 true AR069417A1 (es) | 2010-01-20 |
Family
ID=40580130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105089A AR069417A1 (es) | 2007-11-30 | 2008-11-24 | Piperidinas heteroaril - sustituidas |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8119663B2 (es) |
| EP (1) | EP2227466B1 (es) |
| JP (1) | JP5450435B2 (es) |
| KR (1) | KR20100114018A (es) |
| CN (1) | CN101932577B (es) |
| AR (1) | AR069417A1 (es) |
| AT (1) | ATE506359T1 (es) |
| CA (1) | CA2706991A1 (es) |
| CL (1) | CL2008003473A1 (es) |
| DE (1) | DE502008003324D1 (es) |
| DK (1) | DK2227466T3 (es) |
| HK (1) | HK1152311A1 (es) |
| HR (1) | HRP20110510T1 (es) |
| PA (1) | PA8805201A1 (es) |
| PE (1) | PE20091026A1 (es) |
| PL (1) | PL2227466T3 (es) |
| PT (1) | PT2227466E (es) |
| TW (1) | TW200936135A (es) |
| UY (1) | UY31484A1 (es) |
| WO (1) | WO2009068214A2 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009014484A1 (de) | 2009-03-23 | 2010-09-30 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022896A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022897A1 (de) * | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022895A1 (de) * | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022894A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| EP2585441A4 (en) * | 2010-06-28 | 2013-10-09 | Hetero Research Foundation | PROCESS FOR OLMESARTAN MEDOXOMIL |
| EP2595988B1 (en) | 2010-07-22 | 2014-12-17 | Zafgen, Inc. | Tricyclic compounds and methds of making and using same |
| AU2011316550A1 (en) | 2010-10-12 | 2013-05-02 | Zafgen, Inc | Sulphonamide compounds and methods of making and using same |
| TW201300380A (zh) * | 2010-10-19 | 2013-01-01 | Comentis Inc | 抑制β－分泌酶活性之噁二唑化合物及其使用方法 |
| BR112013018771A2 (pt) | 2011-01-26 | 2019-09-17 | Zafgen Inc | compostos de tetrazol e métodos para fazer e usar os mesmos |
| JP5941981B2 (ja) | 2011-05-06 | 2016-06-29 | ザフゲン，インコーポレイテッド | 三環式スルホンアミド化合物ならびにその製造および使用方法 |
| US9242997B2 (en) | 2011-05-06 | 2016-01-26 | Zafgen, Inc. | Tricyclic pyrazole sulphonamide compunds and methods of making and using same |
| US9290472B2 (en) | 2011-05-06 | 2016-03-22 | Zafgen, Inc. | Partially saturated tricyclic compounds and methods of making and using same |
| MX2014008706A (es) | 2012-01-18 | 2015-03-05 | Zafgen Inc | Compuestos tricíclicos de sulfonamida y métodos para elaborarlos y usarlos. |
| CN104169268A (zh) | 2012-01-18 | 2014-11-26 | 扎夫根股份有限公司 | 三环砜化合物及其制备和使用方法 |
| KR20150079951A (ko) | 2012-11-05 | 2015-07-08 | 자프겐 인크. | 간 질환의 치료 방법 |
| KR20150079952A (ko) | 2012-11-05 | 2015-07-08 | 자프겐 인크. | 트리시클릭 화합물 및 그의 제조 및 사용 방법 |
| BR112015010223A2 (pt) | 2012-11-05 | 2017-07-11 | Zafgen Inc | compostos tricíclicos para o uso no tratamento e/ou controle de obesidade |
| CN103965095A (zh) * | 2013-02-04 | 2014-08-06 | 艾琪康医药科技（上海）有限公司 | 1-r1-3-r2-4-氟哌啶及其衍生物的制备方法 |
| CN104341590A (zh) * | 2013-08-01 | 2015-02-11 | 韩冰 | 一种树枝状高分子化合物及其制备和用途 |
| WO2020179859A1 (ja) | 2019-03-06 | 2020-09-10 | 第一三共株式会社 | ピロロピラゾール誘導体 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA951618B (en) * | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
| US5767144A (en) * | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
| WO1997030045A1 (en) * | 1996-02-13 | 1997-08-21 | Abbott Laboratories | Novel benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists |
| AU2722297A (en) * | 1996-04-03 | 1997-10-22 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
| US6403612B2 (en) * | 2000-01-31 | 2002-06-11 | Merck & Co., Inc. | Thrombin receptor antagonists |
| EP2385039B1 (en) * | 2001-04-19 | 2014-03-12 | Eisai R&D Management Co., Ltd. | 2-Iminoisoindolinone derivatives as thrombin receptor antagonists |
| BR0213325A (pt) * | 2001-10-15 | 2004-10-13 | Janssen Pharmaceutica Nv | Derivados de 4-fenil-4-[1h-imidazol-2-il]-piperidina substituìda para a redução de dano isquêmico |
| US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
| JP2008504278A (ja) | 2004-06-24 | 2008-02-14 | インサイト・コーポレイション | アミド化合物およびその医薬としての使用 |
| JP2008504279A (ja) | 2004-06-24 | 2008-02-14 | インサイト・コーポレイション | アミド化合物およびその医薬としての使用 |
| US8071624B2 (en) * | 2004-06-24 | 2011-12-06 | Incyte Corporation | N-substituted piperidines and their use as pharmaceuticals |
| EA200700251A1 (ru) | 2004-08-10 | 2007-08-31 | Инсайт Корпорейшн | Амидосоединения и их применение в качестве фармацевтических средств |
| DE102004045796A1 (de) * | 2004-09-22 | 2006-03-23 | Merck Patent Gmbh | Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung |
| WO2006051623A1 (ja) * | 2004-11-09 | 2006-05-18 | Eisai Co., Ltd. | トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤 |
| WO2007038138A2 (en) | 2005-09-21 | 2007-04-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| TW200804341A (en) | 2006-01-31 | 2008-01-16 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| WO2007101270A1 (en) | 2006-03-02 | 2007-09-07 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
| EP2013163A1 (en) * | 2006-05-01 | 2009-01-14 | Incyte Corporation | Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1 |
-
2008
- 2008-11-20 PT PT08854224T patent/PT2227466E/pt unknown
- 2008-11-20 DK DK08854224.6T patent/DK2227466T3/da active
- 2008-11-20 WO PCT/EP2008/009792 patent/WO2009068214A2/de active Application Filing
- 2008-11-20 CN CN2008801260263A patent/CN101932577B/zh not_active Expired - Fee Related
- 2008-11-20 CA CA2706991A patent/CA2706991A1/en not_active Abandoned
- 2008-11-20 DE DE502008003324T patent/DE502008003324D1/de active Active
- 2008-11-20 JP JP2010535272A patent/JP5450435B2/ja not_active Expired - Fee Related
- 2008-11-20 PL PL08854224T patent/PL2227466T3/pl unknown
- 2008-11-20 KR KR1020107014447A patent/KR20100114018A/ko not_active Application Discontinuation
- 2008-11-20 EP EP08854224A patent/EP2227466B1/de not_active Not-in-force
- 2008-11-20 AT AT08854224T patent/ATE506359T1/de active
- 2008-11-21 CL CL2008003473A patent/CL2008003473A1/es unknown
- 2008-11-24 UY UY31484A patent/UY31484A1/es not_active Application Discontinuation
- 2008-11-24 PE PE2008001960A patent/PE20091026A1/es not_active Application Discontinuation
- 2008-11-24 AR ARP080105089A patent/AR069417A1/es unknown
- 2008-11-25 PA PA20088805201A patent/PA8805201A1/es unknown
- 2008-11-25 US US12/323,454 patent/US8119663B2/en not_active Expired - Fee Related
- 2008-11-28 TW TW097146090A patent/TW200936135A/zh unknown
-
2011
- 2011-06-23 HK HK11106516.9A patent/HK1152311A1/xx not_active IP Right Cessation
- 2011-07-07 HR HR20110510T patent/HRP20110510T1/hr unknown
-
2012
- 2012-02-20 US US13/400,491 patent/US20120214788A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK2227466T3 (da) | 2011-08-08 |
| US8119663B2 (en) | 2012-02-21 |
| JP2011504889A (ja) | 2011-02-17 |
| CA2706991A1 (en) | 2009-06-04 |
| ATE506359T1 (de) | 2011-05-15 |
| JP5450435B2 (ja) | 2014-03-26 |
| KR20100114018A (ko) | 2010-10-22 |
| EP2227466A2 (de) | 2010-09-15 |
| HRP20110510T1 (hr) | 2011-08-31 |
| CN101932577A (zh) | 2010-12-29 |
| TW200936135A (en) | 2009-09-01 |
| DE502008003324D1 (de) | 2011-06-01 |
| EP2227466B1 (de) | 2011-04-20 |
| PA8805201A1 (es) | 2010-02-12 |
| PT2227466E (pt) | 2011-07-01 |
| PE20091026A1 (es) | 2009-07-26 |
| US20120214788A1 (en) | 2012-08-23 |
| PL2227466T3 (pl) | 2011-09-30 |
| WO2009068214A3 (de) | 2009-08-20 |
| US20090306139A1 (en) | 2009-12-10 |
| UY31484A1 (es) | 2009-07-17 |
| CN101932577B (zh) | 2013-07-17 |
| WO2009068214A2 (de) | 2009-06-04 |
| CL2008003473A1 (es) | 2009-08-14 |
| HK1152311A1 (en) | 2012-02-24 |
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