AR063357A1 - Derivados de pirimidinas como inhibidores de mapk/erk quinasa. procesos de obtencion y composiciones farmaceuticas. - Google Patents
Derivados de pirimidinas como inhibidores de mapk/erk quinasa. procesos de obtencion y composiciones farmaceuticas.Info
- Publication number
- AR063357A1 AR063357A1 ARP070104689A ARP070104689A AR063357A1 AR 063357 A1 AR063357 A1 AR 063357A1 AR P070104689 A ARP070104689 A AR P070104689A AR P070104689 A ARP070104689 A AR P070104689A AR 063357 A1 AR063357 A1 AR 063357A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- heterocycloalkyl
- cycloalkyl
- bicycloaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
Procesos de obtencion de los compuestos descriptos y composiciones farmacéuticas que los comprenden. Reivindicacion 1: Un compuesto caracterizado porque tiene la formula (1) en donde Q está seleccionado de CR7R8, CO y CS; R1 está seleccionado del grupo que consiste en cicloalquilo C3-12, heterocicloalquilo C3-12, bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-1), heteroarilo C1-10, bicicloarilo C9-12 y heterobicicloarilo C4-12, cada uno sustituido o no sustituido, R2 es hidrogeno o un sustituyente convertible in vivo en hidrogeno, R3 está seleccionado del grupo que consiste en amino, alquil C1-10- amino, alcoxiamino, sulfonamido, imino, sulfonilo, sulfinilo, alquilo C2-10, haloalquilo C1-10, carbonilalquilo C1-3, tiocarbonilalquilo C1-3, oxaalquilo C1-6, oxialquil C1-4-oxialquilo C1-4, sulfonilalquilo C1-3, sulfinilalquilo C1-3, aminoalquilo C1-10, iminoalquilo C1-3, cicloalquil C3-12-alquilo C1-5, heterocicloalquil C3-12-alquilo C1-5, arilalquilo C1-10, heteroarilalquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12-alquilo C1-5, cicloalquilo C3-12, heterocicloalquilo C3-12, bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-12, heteroarilo C1-10, bicicloarilo C9-12 y heterobicicloarilo C4-12, cada uno sustituido o no sustituido; R4 y R5 están seleccionados cada uno, de modo independiente, del grupo que consiste en hidrogeno, oxi, hidroxi, carboniloxi, alcoxi, ariloxi, heteroariloxi, carbonilo, oxicarbonilo, amino, alquil C1-10-amino, sulfonamido, imino, sulfonilo. sulfinilo, alquilo C1-10, haloalquilo C1-10, carbonilalquilo C1-3, tiocarbonilalquilo C1-3, sulfonilalquilo C1-3, sulfinilalquilo C1-3, aminoalquilo C1-10, iminoalquilo C1-3, cicloalquil C3- 12-alquilo C1-5, heterocicloalquil C3-12-alquilo C1-5, arilalquilo C1-10, heteroarilalquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12-alquilo C1-5, cicloalquiIo C3-12, heterocicloalquilo C3-12, bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-12, heteroarilo C1-10, bicicloarilo C9-12 y heterobicicloarilo C4-12, cada uno sustituido o no sustituido, siempre que R4 y R5 estén cada uno, de modo independiente, ausentes cuando los átomos a los que están unidos forman parte de un enlace doble; R6 está seleccionado del grupo que consiste en hidrogeno. heteroariloxi, amino, alquil C1-10-amino, sulfonamido, imino, sulfonilo, sulfinilo, alquilo C1-10, haloalquilo C1-10, carbonilalquilo C1-3, tiocarbonilalquilo C1-3, sulfonilalquilo C1-3, sulfinilalquilo C1-3, aminoalquilo C1-10, iminoalquilo C1-3, cicloalquil C3-12-alquilo C1-5, heterocicloalquil C3-12-alquilo C1-5), arilalquilo C1-10, heteroarilalquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12-alquilo C1-5, cicloalquilo C3-12, heterocicloalquilo C3-12, arilo C4-12 y heteroarilo C1-10, cada uno sustituido o no sustituido, siempre que R6 esté ausente cuando el átomo al que está unido forma parte de un enlace doble; y R7 y R8 están seleccionados cada uno, de modo independiente, del grupo que consiste en hidrogeno, ciano, heteroariloxi, carbonilo, oxicarbonilo, aminocarbonilo, amino, alquil C1-10-amino, sulfonamido, imino, sulfonilo, sulfinilo, alquilo C1- 10, haloalquilo C1-10, carbonilalquilo C1-3, tiocarbonilalquilo C1-3, sulfonilalquilo C1-3, sulfinilalquilo C1-3, aminoalquilo C1-10, iminoalquilo C1-3, cicloalquil C3-12-alquilo C1-5, heterocicloalquil C3-12-alquilo C1-5, arilalquilo C1-10, heteroarilalquilo C1-5, bicicloaril C9-12-alquilo C1-5, heterobicicloaril C8-12-alquilo C1-5, cicloalquilo C3-12, heterocicloalquilo C3-12, bicicloalquilo C9-12, heterobicicloalquilo C3-12, arilo C4-12, heteroarilo C1-10, bicicloarilo C9-12 y heterobicicloarilo C4-12, cada uno sustituido o no sustituido, o R7 y R5 se toman juntos para formar un anillo sustituido o no sustituido, siempre que R8 esté ausente cuando el átomo al que está unido forma parte de un enlace doble, con la condicion de que: (a) cuando R6 está ausente, Q es CO, R1 es fenilo no sustituido, y R2 es hidrogeno, entonces R3 no sea -CH2CN; (b) cuando R6 está ausente Q es CO, R1 es un triacetato de tetrahidro-2H-piran-3,4,5-triilo, y R2 es hidrogeno, entonces R3 no sea -CH2CI; (c) cuando R6 está ausente, Q es CO, R1 es 2,2,6,6- tetrametilpiperidin-1-ol, y R2 es hidrogeno, entonces R3 no sea -CH=CH=Ph; y (d) cuando R6 está ausente, Q es CO, R1 es un fenilo sustituido o no sustituido, R2 es hidrogeno, y R4 y R5 son cada uno, de modo independiente, hidrogeno o metilo, entonces R3 no sea -NH-R10, donde R10 es piridin-2-ilo o un fenilo sustituido o no sustituido.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86256906P | 2006-10-23 | 2006-10-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR063357A1 true AR063357A1 (es) | 2009-01-21 |
Family
ID=39954277
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070104689A AR063357A1 (es) | 2006-10-23 | 2007-10-23 | Derivados de pirimidinas como inhibidores de mapk/erk quinasa. procesos de obtencion y composiciones farmaceuticas. |
Country Status (25)
Country | Link |
---|---|
US (4) | US20100204471A1 (es) |
EP (1) | EP2091941B1 (es) |
JP (1) | JP5249939B2 (es) |
KR (1) | KR20090071666A (es) |
CN (1) | CN101563338A (es) |
AR (1) | AR063357A1 (es) |
AU (1) | AU2007353385A1 (es) |
BR (1) | BRPI0717374A2 (es) |
CA (1) | CA2667447A1 (es) |
CL (1) | CL2007003041A1 (es) |
CO (1) | CO6180442A2 (es) |
CR (1) | CR10818A (es) |
DO (1) | DOP2009000089A (es) |
EA (1) | EA200970407A1 (es) |
EC (1) | ECSP099354A (es) |
IL (1) | IL198254A0 (es) |
MA (1) | MA30889B1 (es) |
MX (1) | MX2009004269A (es) |
NO (1) | NO20091999L (es) |
NZ (1) | NZ577047A (es) |
PE (1) | PE20081468A1 (es) |
TN (1) | TN2009000151A1 (es) |
TW (1) | TW200831100A (es) |
WO (1) | WO2008140553A2 (es) |
ZA (1) | ZA200903274B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2007353385A1 (en) * | 2006-10-23 | 2008-11-20 | Takeda Pharmaceutical Company Limited | MAPK/ERK kinase inhibitors |
JO2985B1 (ar) | 2006-12-20 | 2016-09-05 | Takeda Pharmaceuticals Co | مثبطات كينازmapk/erk |
US8022057B2 (en) * | 2007-11-12 | 2011-09-20 | Takeda Pharmaceutical Company Limited | MAPK/ERK kinase inhibitors |
US8980254B2 (en) | 2008-08-21 | 2015-03-17 | Alvine Pharmaceuticals, Inc. | Formulation for oral administration of proteins |
WO2013151877A1 (en) * | 2012-04-03 | 2013-10-10 | Bristol-Myers Squibb Company | Pyrimidinedione carboxamide inhibitors of endothelial lipase |
US9145387B2 (en) | 2013-02-08 | 2015-09-29 | Celgene Avilomics Research, Inc. | ERK inhibitors and uses thereof |
US10005760B2 (en) | 2014-08-13 | 2018-06-26 | Celgene Car Llc | Forms and compositions of an ERK inhibitor |
DE102015117207A1 (de) | 2015-10-08 | 2017-04-13 | Silas Mehmet Aslan | Verfahren zur Herstellung von polythiophenhaltigen Fluiden |
IL259810A (en) | 2018-06-04 | 2018-07-31 | Yeda Res & Dev | Mitogen-activated protein kinase kinase 7 inhibitors |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58152890A (ja) * | 1982-03-08 | 1983-09-10 | Takeda Chem Ind Ltd | イソキサゾロピリミジン誘導体 |
US6251943B1 (en) | 1997-02-28 | 2001-06-26 | Warner-Lambert Company | Method of treating or preventing septic shock by administering a MEK inhibitor |
ES2274572T3 (es) | 1997-07-01 | 2007-05-16 | Warner-Lambert Company Llc | Derivados de acido 2-(4-bromo- o 4-yodo-fenilamino) benzoico y su uso como inhibidor de mek. |
WO1999001426A1 (en) | 1997-07-01 | 1999-01-14 | Warner-Lambert Company | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors |
BR9916857A (pt) | 1999-01-13 | 2001-12-04 | Warner Lambert Co | 4 heteroaril diarilaminas |
AU5316900A (en) | 1999-06-03 | 2000-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) |
AU2001273498B2 (en) | 2000-07-19 | 2006-08-24 | Warner-Lambert Company | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids |
WO2005000818A1 (en) * | 2003-06-27 | 2005-01-06 | Warner-Lambert Company Llc | 5-substituted-4-`(substituted phenyl)!amino!-2-pyridone deviatives for use as mek inhibitors |
US7538120B2 (en) * | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
AU2004293019B2 (en) * | 2003-11-19 | 2010-10-28 | Array Biopharma Inc. | Bicyclic inhibitors of MEK and methods of use thereof |
CA2587178A1 (en) | 2004-11-24 | 2006-06-01 | Laboratoires Serono S.A. | Novel 4-arylamino pyridone derivatives as mek inhibitors for the treatment of hyperproliferative disorders |
US20060223807A1 (en) * | 2005-03-29 | 2006-10-05 | University Of Massachusetts Medical School, A Massachusetts Corporation | Therapeutic methods for type I diabetes |
TWI441637B (zh) | 2005-05-18 | 2014-06-21 | Array Biopharma Inc | Mek雜環抑制劑及其使用方法 |
AU2007353385A1 (en) * | 2006-10-23 | 2008-11-20 | Takeda Pharmaceutical Company Limited | MAPK/ERK kinase inhibitors |
JO2985B1 (ar) * | 2006-12-20 | 2016-09-05 | Takeda Pharmaceuticals Co | مثبطات كينازmapk/erk |
US8022057B2 (en) | 2007-11-12 | 2011-09-20 | Takeda Pharmaceutical Company Limited | MAPK/ERK kinase inhibitors |
US20090246198A1 (en) * | 2008-03-31 | 2009-10-01 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors and methods of use thereof |
-
2007
- 2007-10-22 AU AU2007353385A patent/AU2007353385A1/en not_active Abandoned
- 2007-10-22 WO PCT/US2007/082138 patent/WO2008140553A2/en active Application Filing
- 2007-10-22 EA EA200970407A patent/EA200970407A1/ru unknown
- 2007-10-22 MX MX2009004269A patent/MX2009004269A/es active IP Right Grant
- 2007-10-22 CN CNA2007800471578A patent/CN101563338A/zh active Pending
- 2007-10-22 EP EP07874225A patent/EP2091941B1/en active Active
- 2007-10-22 NZ NZ577047A patent/NZ577047A/en not_active IP Right Cessation
- 2007-10-22 CA CA002667447A patent/CA2667447A1/en not_active Abandoned
- 2007-10-22 US US12/446,974 patent/US20100204471A1/en not_active Abandoned
- 2007-10-22 US US11/876,635 patent/US7696218B2/en active Active
- 2007-10-22 BR BRPI0717374-1A patent/BRPI0717374A2/pt not_active IP Right Cessation
- 2007-10-22 KR KR1020097010570A patent/KR20090071666A/ko not_active Application Discontinuation
- 2007-10-22 JP JP2009534802A patent/JP5249939B2/ja active Active
- 2007-10-22 ZA ZA200903274A patent/ZA200903274B/xx unknown
- 2007-10-23 TW TW096139723A patent/TW200831100A/zh unknown
- 2007-10-23 PE PE2007001430A patent/PE20081468A1/es not_active Application Discontinuation
- 2007-10-23 CL CL200703041A patent/CL2007003041A1/es unknown
- 2007-10-23 AR ARP070104689A patent/AR063357A1/es not_active Application Discontinuation
-
2009
- 2009-04-21 IL IL198254A patent/IL198254A0/en unknown
- 2009-04-22 TN TNP2009000151A patent/TN2009000151A1/fr unknown
- 2009-04-23 DO DO2009000089A patent/DOP2009000089A/es unknown
- 2009-05-13 MA MA31870A patent/MA30889B1/fr unknown
- 2009-05-21 EC EC2009009354A patent/ECSP099354A/es unknown
- 2009-05-21 CR CR10818A patent/CR10818A/es not_active Application Discontinuation
- 2009-05-22 CO CO09053035A patent/CO6180442A2/es not_active Application Discontinuation
- 2009-05-22 NO NO20091999A patent/NO20091999L/no not_active Application Discontinuation
-
2010
- 2010-01-05 US US12/652,570 patent/US7943626B2/en active Active
-
2011
- 2011-04-07 US US13/082,259 patent/US8088783B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR063357A1 (es) | Derivados de pirimidinas como inhibidores de mapk/erk quinasa. procesos de obtencion y composiciones farmaceuticas. | |
CO6230984A2 (es) | Inhibidores de cinasa mapk/erk | |
CO6321274A2 (es) | Compuestos de pirazol acetamida n-sustituida como activadores de glucoquinasa | |
CO6241101A2 (es) | Derivados de quinolina como inhibidores de la p13 quinasa | |
AR086590A1 (es) | Compuestos de ciclohexanona y herbicidas que los comprenden | |
AR085615A1 (es) | Derivados de fluoropiridinona utiles como agentes antibacterianos y composiciones farmaceuticas que los contienen | |
ES2613538T3 (es) | Derivados de arilamida como bloqueadores de TTX-S | |
AR045455A1 (es) | Derivados de pirimidina como inhibidores de dipeptidil peptidasa | |
AR069462A1 (es) | Inhibidores de mapk/ erk quinasa | |
CO6241119A2 (es) | Compuestos de pirido 2,3-d pirimidina-7-ona como inhibidores de pi3k-alfa para el tratamiento del cancer | |
AR069740A1 (es) | Compuestos nucleosidos antivirales | |
CO6140056A2 (es) | Compuestos amino -5-4(difluorometoxi)fenil sustituido-5-fenilimidazolona como inhibidores de beta -secretasa | |
AR072936A1 (es) | Derivados piridazin y pirimidin condensados con heterociclos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos como agentes anticancer. | |
AR068140A1 (es) | Amidas heterociclicas y metodos de uso de las mismas | |
AR079334A1 (es) | Derivados de oxazin amino | |
CO6160231A2 (es) | Compuestos de isoindolina 5-substituidos | |
NO20076006L (no) | Acetylenderivater | |
AR063988A1 (es) | Derivados heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
AR071729A1 (es) | Inhibidores de quinasas simil polo (plk) | |
RU2008130878A (ru) | Описание терапевтического средства против диабета | |
AR049861A1 (es) | Derivados de bencimidazol, procesos de preparacion y composiciones farmaceuticas que los co0ntienen. | |
MX2010004293A (es) | Derivados de 6-aril/heteroalquiloxi benzotiazol y bencimidazol, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nuevo uso principalmente como inhibidores de cmet. | |
EP2634174A3 (en) | Nitrogen-containing hetercyclic derivate having 2-imino group and pest control agent including the same | |
AR066605A1 (es) | Derivados de heteroarilamida pirimidona | |
AR063232A1 (es) | Pirido (2,3) indoles como inhibidores de quinasas.composiciones farmaceuticas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |