AR053116A1 - Derivados de la n-(( 4,5-difenil-2- tienil)metil)sulfonamida,su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de la n-(( 4,5-difenil-2- tienil)metil)sulfonamida,su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR053116A1 AR053116A1 ARP060100142A ARP060100142A AR053116A1 AR 053116 A1 AR053116 A1 AR 053116A1 AR P060100142 A ARP060100142 A AR P060100142A AR P060100142 A ARP060100142 A AR P060100142A AR 053116 A1 AR053116 A1 AR 053116A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- unsubstituted
- halogen atom
- group
- mono
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Addiction (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedimiento de preparacion y aplicacion en terapéutica. Con afinidad por los receptores de los canabinoides CB1). Reivindicacion 1: Compuesto que responde a la formula (1) en la que R1 representa: un alquilo de (C1-C7) no sustituido o sustituido una o varias veces con un átomo de halogeno; un cicloalquilo de (C3-C7) no sustituido o sustituido una o varias veces con un grupo alquilo de (C1-C3); un cicloalquil de (C3-C7)-metilo no sustituido o sustituido una o varias veces sobre el carbociclo con un alquilo de (C1-C3); un fenilo no sustituido o mono-, di- o trisustituido con sustituyentes elegidos independientemente entre un átomo de halogeno, un alquilo de (C1-C4), un alcoxi de (C1-C4), un ciano, un radical trifluorometilo, un radical trifluorometoxi, un grupo S(O)nAlk, un grupo alquil de (C1-C4)-carbonilo; un fenilo; un bencilo no sustituido o mono- o disustituido sobre el fenilo con sustituyentes elegidos independientemente sobre un átomo de halogeno, un alquilo de (C1-C4), un alcoxi de (C1-C4), un radical trifluorometilo; R2 representa un átomo de hidrogeno o un grupo alquilo de (C1-C3); R3 representa un fenilo no sustituido o mono-, di- o trisustituido con sustituyentes elegidos independientemente entre un átomo de halogeno, un alquilo de (C1-C4), un alcoxi de (C1-C4), un radical trifluorometilo o un grupo S(O)nAlk; R4 representa un fenilo no sustituido o mono-, di- o trisustituido con sustituyentes elegidos independientemente entre un átomo de halogeno, un alquilo de (C1-C4), un alcoxi de (C1-C4), un radical trifluorometilo o un grupo S(O)nAlk; -n representa 0, 1 o 2; Alk representa un alquilo de (C1-C4), así como sus hidratos o sus solvatos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0500570A FR2880890B1 (fr) | 2005-01-19 | 2005-01-19 | Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053116A1 true AR053116A1 (es) | 2007-04-25 |
Family
ID=35197793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100142A AR053116A1 (es) | 2005-01-19 | 2006-01-13 | Derivados de la n-(( 4,5-difenil-2- tienil)metil)sulfonamida,su preparacion y su aplicacion en terapeutica |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7589120B2 (es) |
| EP (1) | EP1841754A1 (es) |
| JP (1) | JP2008527026A (es) |
| KR (1) | KR20070107048A (es) |
| CN (1) | CN101119985A (es) |
| AR (1) | AR053116A1 (es) |
| AU (1) | AU2006207382A1 (es) |
| BR (1) | BRPI0606450A2 (es) |
| CA (1) | CA2595045A1 (es) |
| FR (1) | FR2880890B1 (es) |
| IL (1) | IL184487A0 (es) |
| MX (1) | MX2007008792A (es) |
| RU (1) | RU2007131275A (es) |
| TW (1) | TW200637838A (es) |
| UY (1) | UY29338A1 (es) |
| WO (1) | WO2006077320A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2881744B1 (fr) * | 2005-02-09 | 2007-04-27 | Sanofi Aventis Sa | Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique |
| FR2894579B1 (fr) * | 2005-12-12 | 2008-01-18 | Sanofi Aventis Sa | Derives diaryltriazolmethylamine, leur preparation et leur application en therapeutique. |
| JP5236748B2 (ja) * | 2008-01-08 | 2013-07-17 | パーデュー、ファーマ、リミテッド、パートナーシップ | 疼痛治療のためのカンナビノイド受容体のリガンドとしてのプロリン類似体 |
| FR2934594B1 (fr) * | 2008-08-01 | 2010-09-10 | Sanofi Aventis | Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4302461A (en) * | 1979-08-09 | 1981-11-24 | E. I. Du Pont De Nemours And Company | Antiinflammatory 5-substituted-2,3-diarylthiophenes |
| US4381311A (en) * | 1980-12-29 | 1983-04-26 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-α-(polyhalomethyl)-2-thiophenemethanols |
| JPS57134479A (en) * | 1980-12-29 | 1982-08-19 | Du Pont | Antiinflammatory 4,5-diaryl-alpha,alpha- bis(polyhalomethyl)-2-thiophene methane amines |
| EP0055471A1 (en) * | 1980-12-29 | 1982-07-07 | E.I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-alpha,alpha-bis(polyhalomethyl)-2-thiophenemethanamines |
| US4432974A (en) * | 1982-03-04 | 1984-02-21 | E. I. Du Pont De Nemours And Company | Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes |
| GB9012936D0 (en) * | 1990-06-11 | 1990-08-01 | Fujisawa Pharmaceutical Co | Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
| FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| WO2003007887A2 (en) * | 2001-07-20 | 2003-01-30 | Merck & Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
| AR038966A1 (es) * | 2002-03-18 | 2005-02-02 | Solvay Pharm Bv | Derivados de tiazol que tienen actividad antagonista, agonista o agonista parcial de cb1 |
| FR2860792B1 (fr) * | 2003-10-10 | 2006-02-24 | Sanofi Synthelabo | Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique |
| FR2864958B1 (fr) * | 2004-01-12 | 2006-02-24 | Sanofi Synthelabo | Derive de n-[(1,5-diphenyl-1h-pyrazol-3-yl)methyl] sulfonamide, leur preparation et leur application en therapeutique. |
| FR2880023B1 (fr) * | 2004-12-23 | 2007-02-23 | Sanofi Aventis Sa | Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique |
-
2005
- 2005-01-19 FR FR0500570A patent/FR2880890B1/fr not_active Expired - Fee Related
-
2006
- 2006-01-13 AR ARP060100142A patent/AR053116A1/es unknown
- 2006-01-18 UY UY29338A patent/UY29338A1/es not_active Application Discontinuation
- 2006-01-18 WO PCT/FR2006/000115 patent/WO2006077320A1/fr active Application Filing
- 2006-01-18 JP JP2007551704A patent/JP2008527026A/ja active Pending
- 2006-01-18 AU AU2006207382A patent/AU2006207382A1/en not_active Abandoned
- 2006-01-18 KR KR1020077018890A patent/KR20070107048A/ko not_active Application Discontinuation
- 2006-01-18 EP EP06709122A patent/EP1841754A1/fr not_active Withdrawn
- 2006-01-18 TW TW095101890A patent/TW200637838A/zh unknown
- 2006-01-18 CA CA002595045A patent/CA2595045A1/fr not_active Abandoned
- 2006-01-18 MX MX2007008792A patent/MX2007008792A/es not_active Application Discontinuation
- 2006-01-18 RU RU2007131275/04A patent/RU2007131275A/ru not_active Application Discontinuation
- 2006-01-18 BR BRPI0606450-7A patent/BRPI0606450A2/pt not_active Application Discontinuation
- 2006-01-18 CN CNA2006800049789A patent/CN101119985A/zh active Pending
-
2007
- 2007-07-08 IL IL184487A patent/IL184487A0/en unknown
- 2007-07-10 US US11/775,557 patent/US7589120B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FR2880890A1 (fr) | 2006-07-21 |
| FR2880890B1 (fr) | 2007-03-30 |
| TW200637838A (en) | 2006-11-01 |
| CN101119985A (zh) | 2008-02-06 |
| MX2007008792A (es) | 2007-09-11 |
| JP2008527026A (ja) | 2008-07-24 |
| US20070287744A1 (en) | 2007-12-13 |
| AU2006207382A1 (en) | 2006-07-27 |
| RU2007131275A (ru) | 2009-02-27 |
| IL184487A0 (en) | 2007-10-31 |
| BRPI0606450A2 (pt) | 2009-06-30 |
| UY29338A1 (es) | 2006-08-31 |
| KR20070107048A (ko) | 2007-11-06 |
| WO2006077320A1 (fr) | 2006-07-27 |
| CA2595045A1 (fr) | 2006-07-27 |
| EP1841754A1 (fr) | 2007-10-10 |
| US7589120B2 (en) | 2009-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |