FR2880023B1 - Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique - Google Patents

Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique

Info

Publication number
FR2880023B1
FR2880023B1 FR0413898A FR0413898A FR2880023B1 FR 2880023 B1 FR2880023 B1 FR 2880023B1 FR 0413898 A FR0413898 A FR 0413898A FR 0413898 A FR0413898 A FR 0413898A FR 2880023 B1 FR2880023 B1 FR 2880023B1
Authority
FR
France
Prior art keywords
thienyl
diphenyl
alkyl
methyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0413898A
Other languages
English (en)
Other versions
FR2880023A1 (fr
Inventor
Francis Barth
Christian Congy
Jean Philippe Ducoux
Carmona Murielle Rinaldi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0413898A priority Critical patent/FR2880023B1/fr
Priority to PE2005001495A priority patent/PE20060770A1/es
Priority to PCT/FR2005/003219 priority patent/WO2006070106A1/fr
Priority to RU2007127864/04A priority patent/RU2007127864A/ru
Priority to JP2007547569A priority patent/JP2008525388A/ja
Priority to ARP050105403A priority patent/AR052655A1/es
Priority to CA002590681A priority patent/CA2590681A1/fr
Priority to CNA2005800471155A priority patent/CN101107239A/zh
Priority to EP05850565A priority patent/EP1833812A1/fr
Priority to BRPI0519291-9A priority patent/BRPI0519291A2/pt
Priority to MX2007007725A priority patent/MX2007007725A/es
Priority to AU2005321171A priority patent/AU2005321171A1/en
Priority to KR1020077014318A priority patent/KR20070094614A/ko
Priority to TW094145965A priority patent/TW200633996A/zh
Priority to UY29302A priority patent/UY29302A1/es
Publication of FR2880023A1 publication Critical patent/FR2880023A1/fr
Application granted granted Critical
Publication of FR2880023B1 publication Critical patent/FR2880023B1/fr
Priority to IL183996A priority patent/IL183996A0/en
Priority to US11/764,378 priority patent/US7674821B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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FR0413898A 2004-12-23 2004-12-23 Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique Expired - Fee Related FR2880023B1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR0413898A FR2880023B1 (fr) 2004-12-23 2004-12-23 Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique
PE2005001495A PE20060770A1 (es) 2004-12-23 2005-12-16 Derivados de n-[(4,5-difenil-3-alquil-2-tienil)metil]amina como antagonistas de los receptores cannabinoides cb1
AU2005321171A AU2005321171A1 (en) 2004-12-23 2005-12-21 N-[(4, 5-diphenyl-3-alkyl-2-thienyl) methyl] amine (amide, sulfonamide, carbamate and urea) derivatives as cannabinoid CB1 receptor antagonists
JP2007547569A JP2008525388A (ja) 2004-12-23 2005-12-21 カンナビノイドｃｂ１受容体アンタゴニストとしてのｎ−［（４，５−ジフェニル−３−アルキル−２−チエニル）メチル］アミン（アミド、スルホンアミド、カルバミン酸及び尿素）誘導体
ARP050105403A AR052655A1 (es) 2004-12-23 2005-12-21 Derivados de n-[(4,5-difenil-3-alquil-2-tienil)metil]amina(amida,sulfonamida,carbamato,urea)
CA002590681A CA2590681A1 (fr) 2004-12-23 2005-12-21 Derives de n- [ (4 , 5-diphenyl-3-alkyl-2-thienyl) methyl] amine (amide, sulfonamide, carbamate et uree) comme antagonists des recepteurs cb1 des cannabinoides
CNA2005800471155A CN101107239A (zh) 2004-12-23 2005-12-21 N-[(4,5-二苯基-3-烷基-2-噻吩基)甲基]胺(酰胺、磺酰胺、氨基甲酸酯和尿素)衍生物作为***化学成分的cb1受体拮抗剂
EP05850565A EP1833812A1 (fr) 2004-12-23 2005-12-21 Dérivés de n-[(4,5-diphenyl-3-alkyl-2-thienyl)methyl]amine (amide, sulfonamide, carbamate et urée) comme antagonistes des récepteurs cb1 des cannabinoïdes
PCT/FR2005/003219 WO2006070106A1 (fr) 2004-12-23 2005-12-21 DERIVES DE N- [ (4 , 5-DIPHENYL-3-ALKYL-2-THIENYL) METHYL] AMINE (AMIDE, SULFONAMIDE, CARBAMATE ET UREE) COMME ANTAGONISTS DES RECEPTEURS CBl DES
MX2007007725A MX2007007725A (es) 2004-12-23 2005-12-21 Derivados de n-[(4,5-difenil-3-alquil-2-tienil)metil]amina (amida, sulfonamida, carbamato y urea), como antagonistas de los receptores cb1 de los cannabinoides.
RU2007127864/04A RU2007127864A (ru) 2004-12-23 2005-12-21 Производные n-[(4, 5-дифенил-3-алкил-2-тиенил)метил]амина (амид, сульфонамид, карбамат и карбамид) в качестве антагонистов рецепторов св1 каннабиноидов
KR1020077014318A KR20070094614A (ko) 2004-12-23 2005-12-21 칸나비노이드 ｃｂ１ 수용체 길항제로서의ｎ-［（４,５-디페닐-３-알킬-２-티에닐）메틸］아민（아미드, 술폰아미드, 카르바메이트 및 우레아） 유도체
BRPI0519291-9A BRPI0519291A2 (pt) 2004-12-23 2005-12-21 derivados de n[(4,5-difenil-3-alquil-2-tienil) metil] amina (amida, sulfonamida, carbamato e urÉia) como antagonistas dos receptores cb1 dos canabinàides
TW094145965A TW200633996A (en) 2004-12-23 2005-12-22 N-[(4,5-diphenyl-3-alkyl-2-thienyl)methyl]amine derivatives, preparation thereof and therapeutic use thereof
UY29302A UY29302A1 (es) 2004-12-23 2005-12-22 Derivados de n-((4,5-difenil-3-alquil-2-tienil)metil)amina, su preparación y su aplicación en terapéutica
IL183996A IL183996A0 (en) 2004-12-23 2007-06-17 N-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl]amine(amide, sulfonamide, carbamate and urea) derivatives as cannabinoid cb1 receptor, antagonists
US11/764,378 US7674821B2 (en) 2004-12-23 2007-06-18 N-[(4,5-diphenyl-3-alkyl-2-thienyl)methyl]amine [amide, sulfonamide, carbamate and urea) derivatives as cannabinoid CB1 receptor antagonists

Applications Claiming Priority (1)

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FR2880890B1 (fr) * 2005-01-19 2007-03-30 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique
FR2881744B1 (fr) * 2005-02-09 2007-04-27 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique
US8841334B2 (en) 2006-05-31 2014-09-23 Abbvie Inc. Compounds as cannabinoid receptor ligands and uses thereof
EP2024349B1 (fr) 2006-05-31 2017-08-02 AbbVie Inc. Composés constituant des ligands de récepteurs cannabinoïdes et utilisations de ces composés
WO2008028094A1 (fr) * 2006-08-31 2008-03-06 Abbott Laboratories Composés utilisés en tant que ligands de récepteurs cannabinoides cb2
WO2008028093A1 (fr) * 2006-08-31 2008-03-06 Abbott Laboratories Nouveaux composés utilisés comme ligands de récepteurs de cannabinoïde
EP2142522A1 (fr) 2007-03-28 2010-01-13 Abbott Laboratories Composés 1,3-thiazol-2(3h)-ylidene en tant que ligands de récepteur cannabinoïde
US7872033B2 (en) 2007-04-17 2011-01-18 Abbott Laboratories Compounds as cannabinoid receptor ligands
JP2010527929A (ja) 2007-05-18 2010-08-19 アボット・ラボラトリーズ カンナビノイド受容体リガンドとしての新規な化合物
US9193713B2 (en) 2007-10-12 2015-11-24 Abbvie Inc. Compounds as cannabinoid receptor ligands
FR2934594B1 (fr) * 2008-08-01 2010-09-10 Sanofi Aventis Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique.
US8846730B2 (en) 2008-09-08 2014-09-30 Abbvie Inc. Compounds as cannabinoid receptor ligands
PE20110804A1 (es) 2008-09-16 2011-11-30 Abbott Lab Compuestos novedosos como ligandos de receptores de cannabinoides
PA8854001A1 (es) 2008-12-16 2010-07-27 Abbott Lab Compuestos novedosos como ligandos de receptores de canabinoides

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GB9012936D0 (en) 1990-06-11 1990-08-01 Fujisawa Pharmaceutical Co Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
FR2665441B1 (fr) 1990-07-31 1992-12-04 Sanofi Sa Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.
FR2713225B1 (fr) 1993-12-02 1996-03-01 Sanofi Sa N-pipéridino-3-pyrazolecarboxamide substitué.
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2714378B1 (fr) 1993-12-24 1996-03-15 Sanofi Sa Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant.
FR2789079B3 (fr) 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
FR2860792B1 (fr) * 2003-10-10 2006-02-24 Sanofi Synthelabo Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique
FR2864958B1 (fr) * 2004-01-12 2006-02-24 Sanofi Synthelabo Derive de n-[(1,5-diphenyl-1h-pyrazol-3-yl)methyl] sulfonamide, leur preparation et leur application en therapeutique.

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US20070270470A1 (en) 2007-11-22
CN101107239A (zh) 2008-01-16
PE20060770A1 (es) 2006-10-03
EP1833812A1 (fr) 2007-09-19
WO2006070106A1 (fr) 2006-07-06
KR20070094614A (ko) 2007-09-20
AR052655A1 (es) 2007-03-28
CA2590681A1 (fr) 2006-07-06
AU2005321171A1 (en) 2006-07-06
TW200633996A (en) 2006-10-01
RU2007127864A (ru) 2009-01-27
FR2880023A1 (fr) 2006-06-30
UY29302A1 (es) 2006-07-31
JP2008525388A (ja) 2008-07-17
US7674821B2 (en) 2010-03-09
IL183996A0 (en) 2007-10-31
BRPI0519291A2 (pt) 2009-01-06
MX2007007725A (es) 2007-08-22

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