FR2881744B1 - Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique - Google Patents

Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique

Info

Publication number
FR2881744B1
FR2881744B1 FR0501366A FR0501366A FR2881744B1 FR 2881744 B1 FR2881744 B1 FR 2881744B1 FR 0501366 A FR0501366 A FR 0501366A FR 0501366 A FR0501366 A FR 0501366A FR 2881744 B1 FR2881744 B1 FR 2881744B1
Authority
FR
France
Prior art keywords
thienyl
diphenyl
methyl
preparation
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0501366A
Other languages
English (en)
Other versions
FR2881744A1 (fr
Inventor
Francis Barth
Christian Congy
Jean Philippe Ducoux
Carmona Murielle Rinaldi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0501366A priority Critical patent/FR2881744B1/fr
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to PCT/FR2006/000219 priority patent/WO2006084975A1/fr
Priority to JP2007554591A priority patent/JP4823236B2/ja
Priority to CA002596613A priority patent/CA2596613A1/fr
Priority to RU2007133602/04A priority patent/RU2007133602A/ru
Priority to EP06709212A priority patent/EP1858872A1/fr
Priority to BRPI0606942-8A priority patent/BRPI0606942A2/pt
Priority to AU2006212162A priority patent/AU2006212162A1/en
Priority to CNA2006800044183A priority patent/CN101128451A/zh
Priority to MX2007009439A priority patent/MX2007009439A/es
Priority to KR1020077020475A priority patent/KR20070115941A/ko
Priority to ARP060100424A priority patent/AR052898A1/es
Priority to UY29366A priority patent/UY29366A1/es
Priority to TW095104263A priority patent/TW200639160A/zh
Publication of FR2881744A1 publication Critical patent/FR2881744A1/fr
Application granted granted Critical
Publication of FR2881744B1 publication Critical patent/FR2881744B1/fr
Priority to US11/832,162 priority patent/US7687537B2/en
Priority to IL185035A priority patent/IL185035A0/en
Priority to US12/701,887 priority patent/US20100137402A1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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FR0501366A 2005-02-09 2005-02-09 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique Expired - Fee Related FR2881744B1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR0501366A FR2881744B1 (fr) 2005-02-09 2005-02-09 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique
MX2007009439A MX2007009439A (es) 2005-02-09 2006-02-01 Derivados de la n-[(4,5-difenil-2-tienil)metil]amina, su preparacion y su aplicacion en terapeutica.
CA002596613A CA2596613A1 (fr) 2005-02-09 2006-02-01 Derives de n-[(4, 5-diphenyl-3 -alkyl-2-thienyl) methyl] amine (amide , thiouree et uree) comme antagonistes des recepteurs cb1 des cannabinoides
RU2007133602/04A RU2007133602A (ru) 2005-02-09 2006-02-01 Производные n-[(4,5-дифенил-2-тиенил)метил]амина, их получение и применение в терапии
EP06709212A EP1858872A1 (fr) 2005-02-09 2006-02-01 Dérivés de n-[(4,5-diphenyl-3-alkyl-2-thienyl)methyl]amine (amide, thiourée et urée) comme antagonistes des récepteurs cb1 des cannabinoïdes
BRPI0606942-8A BRPI0606942A2 (pt) 2005-02-09 2006-02-01 derivados de n-[(4,5-difenil-2-tienil)metil]amina, o respectivo processo e a respectiva aplicação em terapêutica
AU2006212162A AU2006212162A1 (en) 2005-02-09 2006-02-01 Derivatives of N-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine (amide, thiourea and urea) as cannabinoid CB1 receptor antagonists
CNA2006800044183A CN101128451A (zh) 2005-02-09 2006-02-01 N-[(4,5-二苯基-2-噻吩基)甲基]胺衍生物、它们的制备与治疗用途
PCT/FR2006/000219 WO2006084975A1 (fr) 2005-02-09 2006-02-01 Derives de n-[(4, 5-diphenyl-3 -alkyl-2-thienyl) methyl] amine (amide , thiouree et uree) comme antagonistes des recepteurs cb1 des cannabinoides
KR1020077020475A KR20070115941A (ko) 2005-02-09 2006-02-01 칸나비노이드 ｃｂ1 수용체 길항제로서의ｎ-[(4,5-디페닐-3-알킬-2-티에닐)메틸]아민（아미드,티오우레아 및 우레아) 유도체
JP2007554591A JP4823236B2 (ja) 2005-02-09 2006-02-01 カンナビノイドｃｂ１受容体拮抗薬としてのｎ−［（４，５−ジフェニル−３−アルキル−２−チエニル）メチル］アミン（アミド、チオウレアおよびウレア）誘導体
ARP060100424A AR052898A1 (es) 2005-02-09 2006-02-07 Derivados de la n-[(4,5-difenil -2-tienil) metil] amina, su preparacion, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para enfermedades mediadas por los receptores canabinoides cb1
UY29366A UY29366A1 (es) 2005-02-09 2006-02-08 Derivados de la n-(4,5-difenil-2-tienil)metilamina, su preparacion y su aplicación en terapéutica
TW095104263A TW200639160A (en) 2005-02-09 2006-02-08 N-[(4, 5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application
US11/832,162 US7687537B2 (en) 2005-02-09 2007-08-01 N-[(4,5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application
IL185035A IL185035A0 (en) 2005-02-09 2007-08-02 Derivatives of n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine
US12/701,887 US20100137402A1 (en) 2005-02-09 2010-02-08 N-[(4,5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0501366A FR2881744B1 (fr) 2005-02-09 2005-02-09 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2881744A1 FR2881744A1 (fr) 2006-08-11
FR2881744B1 true FR2881744B1 (fr) 2007-04-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
FR0501366A Expired - Fee Related FR2881744B1 (fr) 2005-02-09 2005-02-09 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique

Country Status (16)

Country Link
US (2) US7687537B2 (fr)
EP (1) EP1858872A1 (fr)
JP (1) JP4823236B2 (fr)
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Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
FR2881744B1 (fr) * 2005-02-09 2007-04-27 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique
AU2006227199A1 (en) 2005-03-22 2006-09-28 Azevan Pharmaceuticals, Inc. Beta-lactamylalkanoic acids for treating premenstrual disorders
FR2894579B1 (fr) * 2005-12-12 2008-01-18 Sanofi Aventis Sa Derives diaryltriazolmethylamine, leur preparation et leur application en therapeutique.
US20100016274A1 (en) * 2006-09-14 2010-01-21 Koppel Gary A Beta-lactam cannabinoid receptor modulators
FR2908766B1 (fr) * 2006-11-20 2009-01-09 Sanofi Aventis Sa Derives de pyrrole,leur preparation et leur utilisation en therapeutique.
EP1939181A1 (fr) * 2006-12-27 2008-07-02 sanofi-aventis Carboxamides hétérocycliques et leur utilisation pour la stimulation de l'expression de la NO synthase
EP3162798B1 (fr) 2007-09-28 2021-04-14 Takeda Pharmaceutical Company Limited Nouveaux composés hétérocycliques à 5 chaînons
JP5345140B2 (ja) * 2007-09-28 2013-11-20 武田薬品工業株式会社 プロトンポンプ阻害剤としての５員複素環化合物
FR2934594B1 (fr) * 2008-08-01 2010-09-10 Sanofi Aventis Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique.
FR2943672B1 (fr) * 2009-03-27 2011-03-25 Sanofi Aventis Derives de 3-alcoxy-4,5-diarylthiophene-2-carboxamide,leur preparation et leur application en therapeutique.
WO2011062955A2 (fr) * 2009-11-18 2011-05-26 University Of Massachusetts Composés pour la modulation de tlr2
RU2623209C9 (ru) 2010-07-01 2018-01-22 Азеван Фармасьютикалз, Инк. Способы лечения посттравматического стрессового расстройства
DK3122743T3 (da) 2014-03-28 2023-02-20 Azevan Pharmaceuticals Inc Sammensætninger og fremgangsmåder til behandling af neurodegenerative sygdomme
CN111295373A (zh) 2017-09-15 2020-06-16 阿泽凡药物公司 用于治疗脑损伤的组合物和方法
US20220332695A1 (en) * 2019-06-28 2022-10-20 Rti International Urea derivatives as cb1 allosteric modulators

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302461A (en) 1979-08-09 1981-11-24 E. I. Du Pont De Nemours And Company Antiinflammatory 5-substituted-2,3-diarylthiophenes
EP0055471A1 (fr) 1980-12-29 1982-07-07 E.I. Du Pont De Nemours And Company 4,5-Diaryl-alpha,alpha-bis-(polyhalométhyl)-2-thiophène-méthan-amines anti-inflammatoires
US4381311A (en) 1980-12-29 1983-04-26 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α-(polyhalomethyl)-2-thiophenemethanols
US4432974A (en) 1982-03-04 1984-02-21 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes
US5571810A (en) * 1990-06-11 1996-11-05 Fujisawa Pharmaceutical Co., Ltd. Thiophene derivatives
GB9012936D0 (en) 1990-06-11 1990-08-01 Fujisawa Pharmaceutical Co Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2713225B1 (fr) 1993-12-02 1996-03-01 Sanofi Sa N-pipéridino-3-pyrazolecarboxamide substitué.
FR2789079B3 (fr) 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
FR2860792B1 (fr) * 2003-10-10 2006-02-24 Sanofi Synthelabo Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique
FR2864958B1 (fr) * 2004-01-12 2006-02-24 Sanofi Synthelabo Derive de n-[(1,5-diphenyl-1h-pyrazol-3-yl)methyl] sulfonamide, leur preparation et leur application en therapeutique.
FR2880023B1 (fr) * 2004-12-23 2007-02-23 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique
FR2880890B1 (fr) * 2005-01-19 2007-03-30 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique
FR2881744B1 (fr) * 2005-02-09 2007-04-27 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique

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EP1858872A1 (fr) 2007-11-28
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US20080009543A1 (en) 2008-01-10
KR20070115941A (ko) 2007-12-06
CN101128451A (zh) 2008-02-20
BRPI0606942A2 (pt) 2009-07-28
FR2881744A1 (fr) 2006-08-11
US20100137402A1 (en) 2010-06-03
WO2006084975A1 (fr) 2006-08-17
JP2008530060A (ja) 2008-08-07
MX2007009439A (es) 2008-03-06
AR052898A1 (es) 2007-04-11
AU2006212162A1 (en) 2006-08-17
IL185035A0 (en) 2007-12-03
US7687537B2 (en) 2010-03-30
CA2596613A1 (fr) 2006-08-17
RU2007133602A (ru) 2009-03-20
UY29366A1 (es) 2006-10-02

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