AR046982A1 - Derivados de 1-piperazin- y 1-homopiperazin-carboxilatos, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de 1-piperazin- y 1-homopiperazin-carboxilatos, su preparacion y su aplicacion en terapeutica

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Publication number
AR046982A1
AR046982A1 ARP040104843A ARP040104843A AR046982A1 AR 046982 A1 AR046982 A1 AR 046982A1 AR P040104843 A ARP040104843 A AR P040104843A AR P040104843 A ARP040104843 A AR P040104843A AR 046982 A1 AR046982 A1 AR 046982A1
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Argentina
Prior art keywords
group
cycloalkyl
alkylene
atom
alkyl
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ARP040104843A
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English (en)
Inventor
Ahmed Abouabdellah
Garcia Antonio Almario
Christian Hoornaert
Adrien Tak Li
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Sanofi Aventis
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Publication of AR046982A1 publication Critical patent/AR046982A1/es

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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  • Pain & Pain Management (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

Compuesto que responde a la formula general (1) en la cual m representa un numero entero igual a 1 o 2; R1 representa un grupo de tipo arilo o heteroarilo, eventualmente constituido por uno o varios grupos R3 o R4; R2 representa un grupo de formula general CHR5CONHR6, R3 representa un átomo de halogeno o un grupo hidroxi, ciano, nitro, alquilo C1-6, alcoxi C1-6, tioalquilo C1-6, fluoroalquilo C1-6, fluoroalcoxi C1-6, -O-(alquileno C2-3)-, -O-(alquileno C1-3)-O-, fluorotioalquilo C1-6, cicloalquilo C3-7, cicloalquilo C3-7-alquileno C1-3, piperidinilo benciloxi, piperazinilo, pirrolidinilo, morfolinilo, feniloxi, NR7R8, NHCOR7, NHSO2R7, COR7, CO2R7, CONR7R8, SO2R7 o SO2NR7R8, R4 representa un grupo arilo o heteroarilo; el o los grupos R4 pueden sustituirse por uno o varios grupos R3 idénticos o diferentes entre sí; R5 representa un átomo de H o un grupo alquilo C1-3; R6 representa un átomo de H o un grupo alquilo C1-6, cicloalquilo C3-7 o cicloalquilo C3-7-alquileno C1-3; R7 y R8 representan, independientemente entre sí, un átomo de H, un grupo alquilo C1-3 o un grupo fenilo; en estado de base, de sal de adicion con un ácido, de hidrato o de solvato. Aplicacion en terapéutica.
ARP040104843A 2003-12-23 2004-12-22 Derivados de 1-piperazin- y 1-homopiperazin-carboxilatos, su preparacion y su aplicacion en terapeutica AR046982A1 (es)

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FR0315248A FR2864080B1 (fr) 2003-12-23 2003-12-23 Derives de 1-piperazine-et-1-homopiperazine-carboxylates, leur preparation et leur application en therapeutique

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AR046982A1 true AR046982A1 (es) 2006-01-04

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US7269708B2 (en) * 2004-04-20 2007-09-11 Rambus Inc. Memory controller for non-homogenous memory system
TW200633990A (en) 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
TWI385152B (zh) 2005-02-17 2013-02-11 Astellas Pharma Inc Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivatives (I)
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