AR046600A1 - Diazaespiroalcanos y su uso como tratamiento para enfermedades mediadas por ccr8 - Google Patents

Diazaespiroalcanos y su uso como tratamiento para enfermedades mediadas por ccr8

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Publication number
AR046600A1
AR046600A1 ARP040103863A ARP040103863A AR046600A1 AR 046600 A1 AR046600 A1 AR 046600A1 AR P040103863 A ARP040103863 A AR P040103863A AR P040103863 A ARP040103863 A AR P040103863A AR 046600 A1 AR046600 A1 AR 046600A1
Authority
AR
Argentina
Prior art keywords
alkyl
phenyl
halogen
optionally substituted
alkoxy
Prior art date
Application number
ARP040103863A
Other languages
English (en)
Inventor
Hakan Bladh
Annea Lisius
Hazel Joan Dyke
Den Heuvel Marco Van
Stephen Price
Stephen Connolly
Igor Shamovsky
Original Assignee
Astrazeneca Ab
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29546627&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR046600(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR046600A1 publication Critical patent/AR046600A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P27/16—Otologicals
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

Compuestos de fórmula general (1), en donde A, B, W, X, Y, Z, D, E, R1 y n tienen los valores definidos en la memoria descriptiva, procesos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia. Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula (1) y sales aceptables para uso farmacéutico, solvatos o N-óxidos de los mismos, en donde: w, x, y y z son en forma independiente 1, 2 ó 3; A es fenilo, bencilo, alquilo, cicloalquilo C3-6 saturado o parcialmente insaturado, un anillo cicloheteroalquilo de 6 miembros que contiene 1 ó 2 heteroátomos seleccionados entre O ó N, alquil-arilo, naftilo, un anillo heteroaromático de 6 a 7 miembros que contiene entre 1 y 3 heteroátomos, un anillo heteroaromático bicíclico de 9 a 10 miembros que contiene entre 1 y 4 heteroátomos, un cicloheteroalquilo fusionado a un fenilo de 5 ó 6 miembros que contiene al menos un heteroátomo seleccionado entre O, S o N, o piridona; donde A está optativamente sustituido por uno o más grupos seleccionados entre: halógeno, ciano, CF3, OCF3, alcoxi C1-6, hidroxi, alquilo C1-6, tioalquilo C1-6, SO2alquilo C1-6, NR2R3, amida, alcoxicarbonilo C1-6, -NO2, acilamino C1-6, -CO2H, carboxialquilo, morfolina; fenoxi optativamente sustituido con uno o más grupos seleccionados entre halógeno, alcoxi C1-6, alquilo C1-6; fenilo o difenilo, estando dichos fenilo y difenilo sustituidos optativamente en forma independiente con uno o más grupos seleccionados en forma independiente entre halógeno, alcoxi C1-6, alquilo C1-6 o -COOH; benciloxi optativamente sustituido con uno o más grupos seleccionados entre halógeno, alcoxi C1-6, alquilo C1-6; o un anillo heteroaromático de 5 a 7 miembros que contiene entre 1 y 4 heteroátomos seleccionados entre O, S o N optativamente sustituido con uno o más grupos seleccionados en forma independiente entre halógeno, alcoxi C1-6, alquilo C1-6; R2 y R3 son en forma independiente halógeno o alquilo C1- 6, o R2 y R3 junto con el nitrógeno al cual están unidos forman un anillo saturado de 6 miembros que contiene optativamente un heteroátomo adicional; B es un grupo R4-R5 donde: R4 es un enlace, -N(R6)-, -R7-N(R8)-, -N(R9)-R10-, O, alquilo C1-4 optativamente interrumpido por N(R11) ó O, alquenilo C2-4 o 1,3-butadienilo, o -SO2-N(R12)-; R5 es C=O o SO2; R6, R8, R11, y R12 son cada uno en forma independiente H o alquilo C1-6; R9 es H, alquilo C1-6 o carboxialquilo C1-6; R7 y R10 son en forma independiente alquilo C1-4 o cicloalquilo C3-5; D es alquilo C1-4; E es fenilo, o un anillo aromático de 5 ó 6 miembros que contiene uno o dos heteroátomos; cada R1 representa en forma independiente alcoxi C1-6 optativamente sustituido con uno o más halógenos, cicloalquilalcoxi C4-6, alqueniloxi C2-6, halógeno, OCH2CN, COalquilo C1-6, OR11, OCH2R11, o -S-R12; R11 es un fenilo o aromático saturado o aromático de 5 ó 6 miembros que contiene uno o dos heteroátomos y cada uno está optativamente sustituido por uno o más grupos seleccionados entre alquilo C1-6, halógeno, alcoxi C1-6, CF3; o ciano; R12 es alquilo C1-6 o R12 es fenilo optativamente sustituido con uno o más halógenos; y n es 0, 1, 2, 3 ó 4; con la salvedad de que cuando E es fenilo, w + x es mayor que 2 y n es 1 entonces R1 no es un grupo fenoxi en la posición meta del anillo fenilo E, y con la salvedad de que cuando A-B es acetilo, tosilo o butoxi-carbonilo terciario (t-boc), entonces D-E-(R1)n no es bencilo.
ARP040103863A 2003-10-23 2004-10-22 Diazaespiroalcanos y su uso como tratamiento para enfermedades mediadas por ccr8 AR046600A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0302811A SE0302811D0 (sv) 2003-10-23 2003-10-23 Novel compounds

Publications (1)

Publication Number Publication Date
AR046600A1 true AR046600A1 (es) 2005-12-14

Family

ID=29546627

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040103863A AR046600A1 (es) 2003-10-23 2004-10-22 Diazaespiroalcanos y su uso como tratamiento para enfermedades mediadas por ccr8

Country Status (17)

Country Link
US (1) US20070249648A1 (es)
EP (1) EP1678178A1 (es)
JP (1) JP2007509141A (es)
KR (1) KR20060088557A (es)
CN (1) CN1898239A (es)
AR (1) AR046600A1 (es)
AU (1) AU2004284028B2 (es)
BR (1) BRPI0415613A (es)
CA (1) CA2542226A1 (es)
IL (1) IL174698A0 (es)
MX (1) MXPA06004300A (es)
NO (1) NO20062335L (es)
SE (1) SE0302811D0 (es)
TW (1) TW200528451A (es)
UY (1) UY28572A1 (es)
WO (1) WO2005040167A1 (es)
ZA (1) ZA200603174B (es)

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