AR044614A1 - Composiciones de sulfonamida que modulan la actividad del receptor de quinioquinas (ccr4) - Google Patents

Composiciones de sulfonamida que modulan la actividad del receptor de quinioquinas (ccr4)

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Publication number
AR044614A1
AR044614A1 ARP040101943A ARP040101943A AR044614A1 AR 044614 A1 AR044614 A1 AR 044614A1 AR P040101943 A ARP040101943 A AR P040101943A AR P040101943 A ARP040101943 A AR P040101943A AR 044614 A1 AR044614 A1 AR 044614A1
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AR
Argentina
Prior art keywords
alkyl
optionally substituted
hydroxy
halogen
ring
Prior art date
Application number
ARP040101943A
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English (en)
Inventor
Antonio Mete
Richard Harrison
Barry Teobald
Iain Walters
Original Assignee
Astrazeneca Ab
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Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR044614A1 publication Critical patent/AR044614A1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

Compuestos de sulfonamida, procesos e intermediarios utilizados en su preparación, composiciones farmacéuticas que los contienen y su uso para fines terapéuticos. Reivindicación 1: Un compuesto es caracterizado porque es de fórmula (1), o una sal aceptable para uso farmacéutico del mismo, donde: Ar1 es fenilo o tienilo, cada uno de los cuales está opcionalmente sustituido con entre uno y tres sustituyentes R1, R2 y R3 seleccionados entre halógeno, ciano, CF3, OCF3, O(C1-6) alquilo o C1-6 alquilo; R4 es C1-6 alcoxi donde el grupo alquilo puede formar un anillo saturado de entre 3 y 6 miembros o puede estar sustituido con entre 1 y 3 átomos de flúor o un grupo ciano; o O(C1-6)alquilR11, o O(C2-6)alquil-X-R11 donde el grupo alquilo puede formar un anillo saturado de entre 3 y 6 miembros y está sustituido opcionalmente con entre 1 y 3 grupos seleccionados entre hidroxi, halógeno, NR14R15, SR13, S(O)2R13, S(O)RB o COR13; uno de R5 o R6 es XCH2(C1-4)alquilo donde el grupo alquilo está sustituido en cualquier posición con los dos grupos R11 y NR1415 o hidroxi, o R5/R6 es XR16 donde R16 es un anillo de entre 4 y 8 miembros que contiene entre 1 y 3 heteroátomos seleccionados entre nitrógeno, oxígeno o azufre y está opcionalmente sustituido con entre 1 y 3 grupos seleccionados entre hidroxi, ciano, halógeno y =O, y R16 está sustituido con R11; y el otro es hidrógeno, halógeno, amino, NH(C1-6)alquilo, N((C1-6)alquil)2, C1-6 alcoxi o C1-6 alquilo opcionalmente sustituido con uno o más grupos flúor o hidroxilo; X es NR13, O, S, S(O), S(O)2, o un enlace; R11 es un grupo arilo o un anillo heteroaromático de entre 5 y 7 miembros que contiene entre 1 y 4 heteroátomos seleccionados entre nitrógeno, oxígeno o azufre, donde el grupo arilo o el anillo heteroaromático pueden estar opcionalmente sustituidos con entre 1 y 3 grupos seleccionados entre halógeno, C(O)NR14R15, C(O)OR12, hidroxi, =O, =S,CN, NO2, COR13NR14R15X(CH2)qNR14R15, (CH2)nNR14R15, (CH2)nOH, SR13, S(O)R13, S(O)2R13 (C1-6)alquil-X-(C1-6)alquilo, C1-6 alquilo o C1-6 alcoxi donde el grupo alquilo puede formar un anillo de entre 3 y 6 miembros o está sustituido opcionalmente con entre 1 y 3 grupos seleccionados entre hidroxi, halógeno, NR14R15, SR13, S(O)RB, S(O)2R13; o R11 es C(O)NR14R15, C(O)OR12, CH2OR12; R12 y R13 son en forma independiente hidrógeno o C1-6 alquilo donde el grupo alquilo puede estar sustituido con entre 1 y 3 átomos de flúor o puede formar un anillo saturado de entre 3 y 6 miembros; R14 y R15 son en forma independiente hidrógeno, C1-6 alquilo, C3-6 cicloalquilo, (CH2)gOH o (CH2)gNH2; o R14 y R15 junto con el átomo de nitrógeno al cual están unidos forman un anillo de entre 4 y 8 miembros que contiene 1 y 3 heteroátomos seleccionados entre nitrógeno, oxígeno y azufre y está opcionalmente sustituido con C1-6 alquilo, (C1-6)alquil-OH, o hidroxi; y n es 1, 2, 3, 4 ó 5; y q es 2, 3, 4, 5 ó 6, con la condición de que donde X es un enlace, entonces R5/R6 no es XCH2(C1-4)alquilR11.
ARP040101943A 2003-06-05 2004-06-04 Composiciones de sulfonamida que modulan la actividad del receptor de quinioquinas (ccr4) AR044614A1 (es)

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SE0301653A SE0301653D0 (sv) 2003-06-05 2003-06-05 Novel compounds

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AR044614A1 true AR044614A1 (es) 2005-09-21

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US (1) US20060122195A1 (es)
EP (1) EP1633729B1 (es)
JP (1) JP2006526618A (es)
AR (1) AR044614A1 (es)
AT (1) ATE402928T1 (es)
DE (1) DE602004015451D1 (es)
ES (1) ES2309539T3 (es)
SE (1) SE0301653D0 (es)
TW (1) TW200505875A (es)
UY (1) UY28348A1 (es)
WO (1) WO2004108692A1 (es)

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TWI328007B (en) * 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
SE0301650D0 (sv) * 2003-06-04 2003-06-04 Astrazeneca Ab Novel compounds
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US20060122195A1 (en) 2006-06-08

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