AR040574A1 - Empleo de compuestos del 2- fenil-3-dimetilamino-propano en la terapia de sintomaticas depresivas - Google Patents
Empleo de compuestos del 2- fenil-3-dimetilamino-propano en la terapia de sintomaticas depresivasInfo
- Publication number
- AR040574A1 AR040574A1 AR20030102542A ARP030102542A AR040574A1 AR 040574 A1 AR040574 A1 AR 040574A1 AR 20030102542 A AR20030102542 A AR 20030102542A AR P030102542 A ARP030102542 A AR P030102542A AR 040574 A1 AR040574 A1 AR 040574A1
- Authority
- AR
- Argentina
- Prior art keywords
- cyclohexyl
- dimethylaminomethyl
- phenyl
- phenol
- cyclohexylmethyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C305/00—Esters of sulfuric acids
- C07C305/22—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings
- C07C305/24—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se relaciona con metabolitos de la [2-(3-metoxifenil)-ciclohexilmetil]-dimetilamina, en forma de bases libres y/o en forma de sales fisiológicamente admisibles, los medicamentos correspondientes, y también el uso de la [2-(3-metoxifenil)-ciclohexilmetil]-dimetilamina y sus metabolitos para preparar un medicamento para el tratamiento de las depresiones y un procedimiento para el tratamiento de las depresiones. Reivindicación 1: empleo de 3-(2-dimetilaminometil-ciclohexil)-fenol; (1R,2R)-3-(2-dimetilaminometil-ciclohexil)-fenol; [2-(3-metoxifenil)-ciclohexilmetil]-dimetilamina; (1R,2R)-[2-(3-metoxifenil)-ciclohexilmetil]-dimetilamina; éster sulfúrico de mono-[3-(2-dimetilaminometil-ciclohexil)-fenilo]; éster sulfúrico de mono-(1R,2R)-[3-(2-dimetilaminometil-ciclohexil)-fenilo]; 3-(2-metilaminometil-ciclohexil)-fenol; (1R,2R)-3-(2-metilaminometil-ciclohexil)-fenol; N-óxido de 3-(2-dimetilaminometil-ciclohexil)-fenol; N-óxido de (1R,2R)-3-(2-dimetilaminometil-ciclohexil)-fenol; ácido 6-[3-(2-dimetilaminometil-ciclohexil)-fenoxi]-3,4,5-trihidroxi-tetrahidropiran-2-carboxílico; ácido 6-[(1R,2R)-3-(2-dimetilaminometil-ciclohexil)-fenoxi]-3,4,5-trihidroxi-tetrahidropiran-2-carboxílico; 4-(2-dimetilaminometil-ciclohexil)-catecol; (1R,2R)-4-(2-dimetilaminometil-ciclohexil)-catecol; 3-(2-aminometil-ciclohexil)-fenol; (1R,2R)-3-(2-aminometil-ciclohexil)-fenol; 4-(2-dimetilaminometil-ciclohexil)-bencen-1,2-diol; (1R,2R)-4-(2-dimetilaminometil-ciclohexil)-bencen-1,2-diol; C-[2-(3-metoxi-fenil)-ciclohexil]-metilamina; (1R,2R)- C-[2-(3-metoxi-fenil)-ciclohexil]-metilamina; [2-(3-metoxi-fenil)-ciclohexilmetil]-metil-amina; (1R,2R)-[2-(3-metoxi-fenil)-ciclohexilmetil]-metil-amina; N-óxido de [2-(3-metoxi-fenil)-ciclohexilmetil]-dimetil-amina; o N-óxido de (1R,2R)-[2-(3-metoxi-fenil)-ciclohexilmetil]-dimetil-amina; según el caso, en forma de sus racematos, de sus estereoisómeros puros, en especial los enantiómeros o diastereómeros, o en forma de mezclas de los estereoisómeros, en especial de los enantiómeros o diastereómeros, en cualquier relación de mezcla; en forma aislada o en forma de sus ácidos o de sus bases, o en forma de sus sales, en especial las sales fisiológicamente admisibles, o en forma de sus solvatos, en especial del hidrato; para preparar un medicamento para el tratamiento de las depresiones. Reivindicación 3: Metabolitos del 3-(2-dimetilaminometil-ciclohexil)-fenol, seleccionados entre: éster sulfúrico del mono-[3-(2-dimetilaminometil-ciclohexil)-fenilo; éster sulfúrico del mono-(1R,2R)- [3-(2-dimetilaminometil-ciclohexil)-fenilo; 3-(2-metilaminometil-ciclohexil)-fenol; (1R,2R)- 3-(2-metilaminometil-ciclohexil)-fenol; N-óxido de 3-(2-dimetilaminometil-ciclohexil)-fenol; N-óxido de (1R,2R)-3-(2-dimetilaminometil-ciclohexil)-fenol; ácido 6-[3-(2-dimetilaminometil-ciclohexil)-fenoxi]-3,4,5-trihidroxi-tetrahidropiran-2-carboxílico; ácido 6-[(1R,2R)-3-(2-dimetilaminometil-ciclohexil)-fenoxi]-3,4,5-trihidroxi-tetrahidropiran-2-carboxílico; 4-(2-dimetilaminometil-ciclohexil)-catecol; (1R,2R)-4-(2-dimetilaminometil-ciclohexil)-catecol; 3-(2-aminometil-ciclohexil)-fenol; (1R,2R)-3-(2-aminometil-ciclohexil)-fenol; 4-(2-dimetilaminometil-ciclohexil)-bencen-1,2-diol; (1R,2R)-4-(2-dimetilaminometil-ciclohexil)-bencen-1,2-diol; C-[2-(3-metoxi-fenil)-ciclohexil]-metilamina; (1R,2R)-C-[2-(3-metoxi-fenil)-ciclohexil]-metilamina; [2-(3-metoxi-fenil)-ciclohexilmetil]-metil-amina; (1R,2R)-[2-(3-metoxi-fenil)-ciclohexilmetil]-metil-amina; N-óxido de [2-(3-metoxi-fenil)-ciclohexilmetil]-dimetil-amina; o N-óxido de (1R,2R)-[2-(3-metoxi-fenil)-ciclohexilmetil]-dimetil-amina; según el caso en forma de sus racematos, sus estereoisómeros puros, en especial los enantiómeros o diastereómeros, o en forma de mezclas de enantiómeros o diastereómeros, en cualquier relación de mezcla; en forma aislada o en forma de sus ácidos o de sus bases, o en forma de sus sales, en especial de sales fisiológicamente admisibles, o en forma de sus solvatos, en especial de los hidratos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10233048A DE10233048A1 (de) | 2002-07-19 | 2002-07-19 | Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken |
Publications (1)
Publication Number | Publication Date |
---|---|
AR040574A1 true AR040574A1 (es) | 2005-04-13 |
Family
ID=29796483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20030102542A AR040574A1 (es) | 2002-07-19 | 2003-07-15 | Empleo de compuestos del 2- fenil-3-dimetilamino-propano en la terapia de sintomaticas depresivas |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP1530462B1 (es) |
JP (1) | JP4616644B2 (es) |
KR (1) | KR101056343B1 (es) |
CN (1) | CN1697651B (es) |
AR (1) | AR040574A1 (es) |
AT (1) | ATE491442T1 (es) |
AU (1) | AU2003263179B2 (es) |
BR (1) | BR0312854A (es) |
CA (1) | CA2492876C (es) |
CO (1) | CO5680411A2 (es) |
CY (1) | CY1111607T1 (es) |
DE (2) | DE10233048A1 (es) |
DK (1) | DK1530462T3 (es) |
EC (1) | ECSP055583A (es) |
ES (1) | ES2357947T3 (es) |
HK (1) | HK1075843A1 (es) |
IL (2) | IL166363A (es) |
MX (1) | MXPA05000791A (es) |
NO (1) | NO333812B1 (es) |
PE (1) | PE20050126A1 (es) |
PL (1) | PL214703B1 (es) |
PT (1) | PT1530462E (es) |
RU (1) | RU2387446C2 (es) |
SI (1) | SI1530462T1 (es) |
WO (1) | WO2004009067A1 (es) |
ZA (1) | ZA200501428B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI1685829T1 (sl) * | 2002-11-22 | 2008-08-31 | Gruenenthal Gmbh | Uporaba (1RS,3RS,6RS)-6-dimetilaminometil-1- (3-metoksi-fenil)-cikloheksan-1, 3-diola za zdravljenje vnetne bolečine |
DE10356362A1 (de) * | 2003-11-28 | 2005-06-23 | Grünenthal GmbH | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen |
JP2008514689A (ja) * | 2004-10-01 | 2008-05-08 | ニューロキュア リミテッド | Adhd、cfs、fmおよび鬱病の処置のためのロフェプラミンの薬学的な組成物の使用 |
EP2336103A3 (de) * | 2005-07-22 | 2011-07-20 | Grünenthal GmbH | HCL-Polymorphe von 3-[2-(Dimethylamino)methyl-(cyclohex-1-yl)]phenol |
DE102005034973A1 (de) * | 2005-07-22 | 2007-02-15 | Grünenthal GmbH | Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen |
NZ580429A (en) | 2007-05-31 | 2012-04-27 | Sepracor Inc | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
EP2085081A1 (de) * | 2008-02-04 | 2009-08-05 | Grünenthal GmbH | 3-(2-Dimethylaminomethyl-cyclohexyl)-phenol gegen polyneuropathischen Schmerz |
WO2011147576A1 (en) * | 2010-05-28 | 2011-12-01 | Grünenthal GmbH | Process for the preparation of substituted 1-aminomethyl-2-phenyl-cyclohexane compounds |
WO2012100423A1 (en) * | 2011-01-27 | 2012-08-02 | Eli Lilly And Company | Analgesic compounds, methods, and formulations |
WO2013016840A1 (zh) | 2011-07-29 | 2013-02-07 | 安徽省新星药物开发有限责任公司 | 用于合成他喷他多或其类似物的新中间体 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
PE20010623A1 (es) * | 1999-10-05 | 2001-07-07 | Gruenenthal Chemie | Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria |
JP2001233762A (ja) * | 2000-02-21 | 2001-08-28 | Gruenenthal Gmbh | O−デスメチル−n−モノ−デスメチル−トラマドールの使用方法 |
DE10059411A1 (de) * | 2000-11-30 | 2002-06-13 | Gruenenthal Gmbh | Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
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2002
- 2002-07-19 DE DE10233048A patent/DE10233048A1/de not_active Ceased
-
2003
- 2003-07-15 AR AR20030102542A patent/AR040574A1/es unknown
- 2003-07-16 DE DE50313329T patent/DE50313329D1/de not_active Expired - Lifetime
- 2003-07-16 EP EP03765006A patent/EP1530462B1/de not_active Expired - Lifetime
- 2003-07-16 JP JP2004522472A patent/JP4616644B2/ja not_active Expired - Fee Related
- 2003-07-16 AU AU2003263179A patent/AU2003263179B2/en not_active Ceased
- 2003-07-16 BR BR0312854-7A patent/BR0312854A/pt not_active IP Right Cessation
- 2003-07-16 PT PT03765006T patent/PT1530462E/pt unknown
- 2003-07-16 AT AT03765006T patent/ATE491442T1/de active
- 2003-07-16 KR KR1020057001008A patent/KR101056343B1/ko not_active IP Right Cessation
- 2003-07-16 DK DK03765006.6T patent/DK1530462T3/da active
- 2003-07-16 CA CA2492876A patent/CA2492876C/en not_active Expired - Fee Related
- 2003-07-16 WO PCT/EP2003/007720 patent/WO2004009067A1/de active Application Filing
- 2003-07-16 ES ES03765006T patent/ES2357947T3/es not_active Expired - Lifetime
- 2003-07-16 PL PL375629A patent/PL214703B1/pl not_active IP Right Cessation
- 2003-07-16 SI SI200331941T patent/SI1530462T1/sl unknown
- 2003-07-16 RU RU2005104821/04A patent/RU2387446C2/ru not_active IP Right Cessation
- 2003-07-16 CN CN038218631A patent/CN1697651B/zh not_active Expired - Fee Related
- 2003-07-16 MX MXPA05000791A patent/MXPA05000791A/es active IP Right Grant
- 2003-07-17 PE PE2003000715A patent/PE20050126A1/es not_active Application Discontinuation
-
2005
- 2005-01-18 IL IL166363A patent/IL166363A/en not_active IP Right Cessation
- 2005-01-18 CO CO05003430A patent/CO5680411A2/es not_active Application Discontinuation
- 2005-02-01 EC EC2005005583A patent/ECSP055583A/es unknown
- 2005-02-17 NO NO20050861A patent/NO333812B1/no not_active IP Right Cessation
- 2005-02-17 ZA ZA200501428A patent/ZA200501428B/en unknown
- 2005-11-10 HK HK05110027.1A patent/HK1075843A1/xx not_active IP Right Cessation
-
2010
- 2010-12-06 IL IL209789A patent/IL209789A0/en unknown
-
2011
- 2011-02-08 CY CY20111100144T patent/CY1111607T1/el unknown
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