AR040406A1 - Antagonistas de histamina h3 de benzimidazolona - Google Patents
Antagonistas de histamina h3 de benzimidazolonaInfo
- Publication number
- AR040406A1 AR040406A1 AR20030101341A ARP030101341A AR040406A1 AR 040406 A1 AR040406 A1 AR 040406A1 AR 20030101341 A AR20030101341 A AR 20030101341A AR P030101341 A ARP030101341 A AR P030101341A AR 040406 A1 AR040406 A1 AR 040406A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently selected
- aryl
- group
- alkoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
También se describen composiciones farmacéuticas que comprenden los compuestos de la fórmula (1). Asimismo se describen métodos para el tratamiento de varias enfermedades o trastornos, tales como por ejemplo la alergia, afecciones de las vías respiratorias inducidas por alergia, y congestión (por ejemplo, congestión nasal) usando los compuestos de la fórmula (1). Asimismo se describen métodos para el tratar varias enfermedades o trastornos, tales como por ejemplo la alergia, afecciones de las vías respiratorias inducidas por alergia, y congestión (por ejemplo, congestión nasal) mediante el uso de los compuestos de fórmula (1) en combinación con un antagonista de H1. Reivindicación 1: Un compuesto que está representado por la fórmula estructural (1) o una sal o solvato de los mismos farmacéuticamente aceptable, en los cuales: la línea de puntos representa un doble enlace opcional; a es 0 a 3; b es 0 a 3; n es 1, 2 o 3; p es 1, 2 o 3 con la condición de que cuando M2 es N, entonces p no es 1; r es 1, 2, o 3 con la condición de que cuando r es 2 o 3, entonces M2 es C(R3) y p es 2 o 3; A es un enlace o alquileno C1-6; M1 es C(R3) o N; M2 es C (R3) o N; Y es -C(=O)-, -C(=S)-, -(CH2)q-, -NR4C(=O)-, -C(=O)NR4-, -C(=O)CH2-, -CH2(C=O)-, -SO1-2-, -NH-C(=N-CN)- o -C(=N-CN)-NH-; con la condición de que cuando M1 es N, I no es -NR4C(=O)- o -NH-C(=N-CN)- ; y cuando M2 es N, Y no es -C(=O)NR4- o -C(=N-CN)-NH- ; q es 1 a 5, con la condición de que cuando M1 y M2 son ambos N, q no es 1; Z es un enlace, alquileno C1-6, alquenileno C1-6, -C(=O)-, -CH(CN)-, o -CH2-C(=O)NR4-; R1 es un resto seleccionado del grupo de fórmulas (2); k es 0, 1, 2, 3 o 4; k1 es 0, 1, 2 o 3; k2 es 0, 1 o 2; R es H, alquilo C1-6, hidroxialquilo C2-6-, haloalquilo C1-6-, haloalcoxi C1-6-alquilo C1-6-, R29-O-C(O)-alquilo C1-6-, alcoxi C1-6-alquilo C1-6-, N (R30)(R31)-alquilo C1-6-, alcoxi C1-6-alcoxi C1-6-alquilo C1-6-, R32-arilo, R32-arilalquilo C1-6-, R32-ariloxialquilo C1-6-, R32-heteroarilo, R32-heteroarilalquilo C1-6-, cicloalquilo C3-6, cicloalquil C3-6 alquilo C1-6-, N(R30)(R31)-C(O)-alquilo C1-6-, o heterocicloalquilalquilo C1-6-; R2 es un anillo heteroarilo de seis miembros que tiene 1 o 2 heteroátomos independientemente seleccionados entre N o N-O, siendo los átomos de anillo remanentes carbono; un anillo heteroarilo de cinco miembros que tiene 1, 2, 3 o 4 heteroátomos independientemente seleccionados entre N, O o S, siendo el resto de los anillos carbono; R32-quinolilo ; R32-arilo; heterocicloalquilo ; cicloalquilo C3-6; alquilo C1-6; hidrógeno; o de fórmulas (3), (4) y (5) donde dicho anillo heteroarilo de seis miembros o dicho anillo heteroarilo de cinco miembros está opcionalmente substituido con R6; X es CH o N; Q es un enlace o alquileno C1-6; Q1 es un enlace alquileno C1-6 o -N(R4)-; R3 es H, halógeno, alquilo C1-6, -OH o alcoxi C1-6; R4 está independientemente seleccionado del grupo que consiste en hidrógeno, alquilo C1-6, cicloalquilo C3-6, cicloalquil (C3-6)alquilo C1-6, R33-arilo, R33-arilalquilo C1-6, y R32-heteroarilo ;R5 es hidrogeno, alquilo C1-6, -C(O)R20, -C(O)2R20, -C(O)N(R20)2 o alquilo C1-6 -SO2-; o R4 y R5, conjuntamente con el nitrógeno al cual están unidos, forman un anillo azetidinilo, pirrolidinilo, piperidinilo, piperazinilo o morfolinilo; R6 representa de1 a 3 substituyentes independientemente seleccionados del grupo que consiste en -OH, halógeno, alquilo C1-6-, alcoxi C1-6, alquil C1-6tio, -CF3, -NR4R5, NO2, -CO2R4, -CON(R4)2, -CH2-NR4R5, -CN, o de fórmulas (6), (7) y (8), o 2 substituyentes R6 conjuntamente en el mismo carbono son =O; R12 está independientemente seleccionado del grupo que consiste en alquilo C1-6, hidroxi, alcoxi C1-6, o flúor, con la condición de que cuando R12 es hidroxi o flúor, entonces R12 no está unido a un carbono adyacente a un nitrógeno; o dos substituyentes R12 conjuntamente forman un puente alquilo C1 a C2 de un carbono de anillo a otro carbono de anillo no adyacente; o R12 es =O; R13 está independientemente seleccionado del grupo que consiste en alquilo C1-6, hidroxi, alcoxi C1-6, o flúor, con la condición de que cuando R13 es hidroxi o flúor entonces R13 no están unido a un carbono adyacente a un nitrógeno; o dos substituyentes R13 conjuntamente forman un puente alquilo C1 a C2 de un carbono de anillo a otro carbono de anillo no adyacente; o R13 es =O; R20 está independientemente seleccionado del grupo que consiste en hidrogeno, alquilo C1-6, o arilo, donde dicho grupo arilo está opcionalmente substituido con 1 a 3 grupos independientemente seleccionados de halógeno, -CF3, -OCF3, hidroxi, o metoxi; o cuando dos grupos R20 están presentes, dichos dos grupos R20 tomados conjuntamente con el nitrógeno al cual están unidos pueden formar un anillo heterocíclico de cinco o seis miembros; R22 es alquilo C1-6, R34-arilo o heterocicloalquilo; R24 es H, alquilo C1-6, -SO2R22 o R34-arilo; R25 está independientemente seleccionado del grupo que consiste en alquilo C1-6, -CN, -NO2, halógeno, -CF3, -OH, alcoxi C1-6, alquil C1-6-C(O)-, aril-C(O)-, N(R4)(R5)-C(O)-, N(R4)(R5)-S(O)1-2-, halo-alquilo C1-6- o halo-alcoxi C1-6-alquilo C1-6-; R29 es H, alquilo C1-6, R35-arilo o R35-arilalquilo C1-6-; R30 es H, alquilo C1-6 -, R35-arilo o R35-arilalquilo C1-6-; R31 es H, alquilo C1-6-, R35-arilo, R35-arilalquilo C1-6 -, alquilo C1-6-C(O)-, R35- aril-C(O)-, N(R4)(R5)-C(O)-, alquilo C1-6-S(O)2- o R35-aril-S(O)2-; o R30 y R31 conjuntamente son -(CH2)4-5-, -(CH2)2-O-(CH2)2- o -(CH2)2-N(R29)-(CH2)2- y forman un anillo con el nitrógeno al cual están unidos; R32 representa de 1 a 3 substituyentes independientemente seleccionados del grupo que consiste en H, -OH, halógeno, alquilo C1-6, alcoxi C1-6, -SR22, -CF3, -OCF3, -OCHF2, -NR37R38, -NO2, -CO2R37, -CON(R37)2, -S(O)2R22, -S(O)2N(R20)2, -N(R24)S(O)2R22, -CN, hidroxialquilo C1-6- y -OCH2CH2OR22; R33 representa de 1 a 3 substituyentes independientemente seleccionados del grupo que consiste en alquilo C1-6, halógeno, -CN, -NO2, -OCHF2 y -O-alquilo C1-6; R34 representa de 1 a 3 substituyentes independientemente seleccionados del grupo que consiste en H, halógeno, -CF3, -OCF3, -OH y -OCH3; R35 representa de 1 a 3 substituyentes independientemente seleccionados de hidrogeno, halo, alquil C1-6, hidroxi, alcoxi C1-6, fenoxi, -CF3, -N (R36)2, -COOR20 y -NO2; R36 está independientemente seleccionado del grupo que consiste en H y alquilo C1-6; R37 está independientemente seleccionado del grupo que consiste en hidrogeno, alquilo C1-6, cicloalquilo C3-6, cicloalquil C3-6alquilo C1-6, R33-arilo, R33-arilalquilo C1-6, y R32-heteroarilo; y R38 es hidrogeno, alquilo C1-6, -C(O)R20, -C(O)2R20, -C(O)N(R2)2 o alquil C1-6 -SO2-; o R37 y R38, conjuntamente con el nitrógeno al cual están unidos forman un anillo azetidinilo, pirrolidinilo, piperidinilo, piperazinilo o morfolinilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37346702P | 2002-04-18 | 2002-04-18 |
Publications (1)
Publication Number | Publication Date |
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AR040406A1 true AR040406A1 (es) | 2005-04-06 |
Family
ID=29736058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20030101341A AR040406A1 (es) | 2002-04-18 | 2003-04-16 | Antagonistas de histamina h3 de benzimidazolona |
Country Status (17)
Country | Link |
---|---|
US (1) | US7220735B2 (es) |
EP (1) | EP1494671B1 (es) |
JP (2) | JP4563800B2 (es) |
KR (1) | KR20040099449A (es) |
CN (1) | CN100360130C (es) |
AR (1) | AR040406A1 (es) |
AT (1) | ATE529112T1 (es) |
AU (1) | AU2003223631B2 (es) |
CA (1) | CA2482551C (es) |
IL (1) | IL164583A (es) |
MX (1) | MXPA04010172A (es) |
MY (1) | MY132566A (es) |
NZ (1) | NZ535764A (es) |
PE (1) | PE20040464A1 (es) |
TW (1) | TW200305409A (es) |
WO (1) | WO2003103669A1 (es) |
ZA (1) | ZA200407985B (es) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
US7220735B2 (en) * | 2002-04-18 | 2007-05-22 | Schering Corporation | Benzimidazolone histamine H3 antagonists |
DE60319813T2 (de) * | 2002-04-18 | 2009-04-23 | Schering Corporation | 1-(4-piperidinyl)benzimidazole als histamin h3 antagonisten |
WO2004002983A2 (en) * | 2002-06-28 | 2004-01-08 | Euro-Celtique, S.A. | Therapeutic piperazine derivatives useful for treating pain |
US7332508B2 (en) | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
DK1615909T3 (da) | 2003-04-23 | 2008-11-17 | Glaxo Group Ltd | Piperazin-derivater og deres anvendelse til behandling af neurologiske og psykiatriske sygdomme |
US20050119266A1 (en) * | 2003-10-01 | 2005-06-02 | Yan Shi | Pyrrolidine and piperidine derivatives as factor Xa inhibitors |
US7820673B2 (en) * | 2003-12-17 | 2010-10-26 | Takeda Pharmaceutical Company Limited | Urea derivative, process for producing the same, and use |
US7622579B2 (en) | 2004-06-28 | 2009-11-24 | Janssen Pharmaceutica Nv | Hetero isonipecotic modulators of vanilloid VR1 receptor |
TW200633990A (en) * | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
EP1853610A1 (en) * | 2005-03-03 | 2007-11-14 | Sirtris Pharmaceuticals, Inc. | N-phenyl benzamide derivatives as sirtuin modulators |
KR20080021082A (ko) * | 2005-06-20 | 2008-03-06 | 쉐링 코포레이션 | 히스타민 h3 길항제로서 유용한 피페리딘 유도체 |
WO2007002057A1 (en) * | 2005-06-20 | 2007-01-04 | Schering Corporation | Carbon-linked substituted piperidines and derivatives thereof useful as histamine h3 antagonists |
AU2006275568A1 (en) * | 2005-08-02 | 2007-02-08 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
US7855289B2 (en) * | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
AU2006278397B2 (en) | 2005-08-04 | 2013-01-17 | Sirtris Pharmaceuticals, Inc. | Oxazolopyridine derivatives as sirtuin modulators |
US8088928B2 (en) * | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8093401B2 (en) * | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
JP4860700B2 (ja) * | 2005-09-20 | 2012-01-25 | シェーリング コーポレイション | ヒスタミンH3アンタゴニストとして有用な、1−[[1−[(2−アミノ−6−メチル−4−ピリジニル)メチル]−4−フルオロ−4−ピペリジニル]カルボニル]−4−[2−(2−ピリジニル)−3H−イミダゾ[4,5−b]ピリジン−3−イル]ピペリジン |
CA2634847A1 (en) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Substituted aniline derivatives useful as histamine h3 antagonists |
WO2007075702A2 (en) * | 2005-12-21 | 2007-07-05 | Schering Corporation | Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and h3 receptor antagonist/inverse agonist |
PE20071162A1 (es) * | 2005-12-21 | 2007-11-30 | Schering Corp | Combinacion de un antagonista/agonista inverso de h3 y un supresor del apetito |
CN101426777A (zh) * | 2005-12-21 | 2009-05-06 | 先灵公司 | 用作组胺h3拮抗剂的苯氧基哌啶及其类似物 |
WO2007130712A1 (en) * | 2006-01-31 | 2007-11-15 | Janssen Pharmaceutica, Nv | Substituted dipiperidine as ccr2 antagonists for the treatment of inflammatory diseases |
US7728031B2 (en) * | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
AR063275A1 (es) * | 2006-10-12 | 2009-01-14 | Epix Delaware Inc | Compuestos de carboxamida, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la activacion de ccr2. |
MX2009009416A (es) * | 2007-03-02 | 2009-09-11 | Schering Corp | Derivados de bencimidazol y sus metodos de uso. |
TW200916472A (en) * | 2007-06-20 | 2009-04-16 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
BRPI0819093A2 (pt) * | 2007-11-01 | 2017-05-02 | Sirtris Pharmaceuticals Inc | compostos moduladores de sirtuína |
EP2217606A1 (en) * | 2007-11-08 | 2010-08-18 | Sirtris Pharmaceuticals, Inc. | Solubilized thiazolopyridines |
WO2009076512A1 (en) | 2007-12-11 | 2009-06-18 | Epix Delaware, Inc. | Carboxamidξ compounds and their use as chemokine receptor agonists |
WO2009089134A1 (en) * | 2008-01-04 | 2009-07-16 | Src, Inc. | Methods for measuring a patint response upon administration of a drug and compositions thereof |
SG171835A1 (en) | 2008-12-19 | 2011-07-28 | Sirtris Pharmaceuticals Inc | Thiazolopyridine sirtuin modulating compounds |
NZ604035A (en) | 2010-06-04 | 2015-02-27 | Albany Molecular Res Inc | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
JP2014114212A (ja) * | 2011-03-29 | 2014-06-26 | Dainippon Sumitomo Pharma Co Ltd | 新規ベンズイミダゾール誘導体 |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
WO2016144936A1 (en) | 2015-03-09 | 2016-09-15 | Bristol-Myers Squibb Company | Lactams as inhibitors of rock |
JP7281469B2 (ja) * | 2018-01-19 | 2023-05-25 | イドーシア ファーマシューティカルズ リミテッド | C5a受容体調節剤 |
CN114072407A (zh) | 2019-04-02 | 2022-02-18 | 阿里戈斯治疗公司 | 靶向prmt5的化合物 |
US10639315B1 (en) | 2019-05-21 | 2020-05-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating Alzheimer's disease |
US10966989B2 (en) | 2019-04-12 | 2021-04-06 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating mental, behavioral, cognitive disorders |
US10898493B2 (en) | 2019-04-12 | 2021-01-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for psychiatric symptoms of patients with Alzheimer's disease |
US11690849B2 (en) | 2019-04-12 | 2023-07-04 | LA PharmaTech Inc. | Method of treating dementia |
US11318144B2 (en) | 2019-04-12 | 2022-05-03 | LA PharmaTech Inc. | Compositions and methods for treating Alzheimer's disease and Parkinson's disease |
US10639314B1 (en) | 2019-04-30 | 2020-05-05 | LA PharmaTech Inc. | Method of treating Alzheimer's disease |
US11744833B2 (en) | 2019-04-12 | 2023-09-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of insomnia |
US11938139B2 (en) | 2019-04-12 | 2024-03-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders |
US11389458B2 (en) | 2019-04-12 | 2022-07-19 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating parkinson's and huntington's disease |
AU2019443520A1 (en) * | 2019-04-30 | 2021-12-23 | La Pharma Tech Inc. | A method of treating mental, behavioral, cognitive disorders |
CN110105263A (zh) * | 2019-05-13 | 2019-08-09 | 常州大学 | 一种阿米卡星中间体的合成方法 |
IL299845A (en) | 2020-07-15 | 2023-03-01 | Schabar Res Associates Llc | Oral unit dose compounds consisting of ibuprofen and famotidine for the treatment of acute pain and to reduce the severity and/or risk of heartburn |
CA3124579A1 (en) | 2020-07-15 | 2022-01-15 | Schabar Research Associates Llc | Unit oral dose compositions composed of naproxen sodium and famotidine for the treatment of acute pain and the reduction of the severity of heartburn and/or the risk of heartburn |
CA3219597A1 (en) * | 2021-06-23 | 2022-12-29 | F. Hoffmann-La Roche Ag | Novel process |
US11351179B1 (en) | 2021-08-05 | 2022-06-07 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of psychiatric disorders |
WO2024133610A1 (en) * | 2022-12-23 | 2024-06-27 | F. Hoffmann-La Roche Ag | Proccesses for the preparation of an nlrp3 inhibitor |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0730037B2 (ja) | 1987-03-13 | 1995-04-05 | 第一製薬株式会社 | ピリミジニルプロピオン酸誘導体 |
JP2807577B2 (ja) * | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | 環状アミド誘導体 |
JP3859738B2 (ja) * | 1993-05-26 | 2006-12-20 | 大日本住友製薬株式会社 | キナゾリノン誘導体 |
FR2725986B1 (fr) * | 1994-10-21 | 1996-11-29 | Adir | Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5574044A (en) * | 1994-10-27 | 1996-11-12 | Merck & Co., Inc. | Muscarine antagonists |
CA2200468A1 (en) * | 1994-10-27 | 1996-05-09 | Wayne J. Thompson | Muscarine antagonists |
GB9521781D0 (en) * | 1995-10-24 | 1996-01-03 | Merck Sharp & Dohme | Therapeutic agents |
US6211199B1 (en) * | 1995-11-17 | 2001-04-03 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
DE69626321T2 (de) * | 1995-11-17 | 2003-08-14 | Aventis Pharmaceuticals Inc., Bridgewater | Substituierte 4-(1h-benzimidazol-2-yl-amino)piperidine zur behandlung allergischer erkrankungen |
TR199900326T2 (xx) | 1996-08-16 | 1999-05-21 | Schering Corporation | �st solunum yollar� alerjik tepkisinin histamin resept�r antagonistlerin bir birle�imi ile tedavisi. |
US5869479A (en) * | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
DE19952146A1 (de) * | 1999-10-29 | 2001-06-07 | Boehringer Ingelheim Pharma | Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
EP1318994B1 (en) * | 2000-09-20 | 2008-02-27 | Schering Corporation | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists |
PE20020507A1 (es) | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
US6849621B2 (en) | 2001-03-13 | 2005-02-01 | Schering Corporation | Piperidine compounds |
EP1386920A4 (en) * | 2001-04-20 | 2005-09-14 | Banyu Pharma Co Ltd | DERIVATIVES OF BENZIMIDAZOLONE |
US7220735B2 (en) * | 2002-04-18 | 2007-05-22 | Schering Corporation | Benzimidazolone histamine H3 antagonists |
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- 2003-04-16 WO PCT/US2003/011696 patent/WO2003103669A1/en active Application Filing
- 2003-04-16 KR KR10-2004-7016552A patent/KR20040099449A/ko not_active Application Discontinuation
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- 2003-04-16 AR AR20030101341A patent/AR040406A1/es unknown
- 2003-04-16 PE PE2003000387A patent/PE20040464A1/es not_active Application Discontinuation
- 2003-04-16 EP EP03719770A patent/EP1494671B1/en not_active Expired - Lifetime
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- 2003-04-16 CN CNB038137801A patent/CN100360130C/zh not_active Expired - Fee Related
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MY132566A (en) | 2007-10-31 |
PE20040464A1 (es) | 2004-07-24 |
JP2006206603A (ja) | 2006-08-10 |
JP4563800B2 (ja) | 2010-10-13 |
AU2003223631A1 (en) | 2003-12-22 |
TW200305409A (en) | 2003-11-01 |
US20040048843A1 (en) | 2004-03-11 |
AU2003223631B2 (en) | 2006-07-20 |
KR20040099449A (ko) | 2004-11-26 |
EP1494671A1 (en) | 2005-01-12 |
CA2482551A1 (en) | 2003-12-18 |
IL164583A (en) | 2010-05-17 |
CN1658875A (zh) | 2005-08-24 |
CA2482551C (en) | 2009-08-11 |
ATE529112T1 (de) | 2011-11-15 |
ZA200407985B (en) | 2005-10-19 |
EP1494671B1 (en) | 2011-10-19 |
JP2005529161A (ja) | 2005-09-29 |
MXPA04010172A (es) | 2005-02-03 |
CN100360130C (zh) | 2008-01-09 |
US7220735B2 (en) | 2007-05-22 |
IL164583A0 (en) | 2005-12-18 |
WO2003103669A1 (en) | 2003-12-18 |
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