AR039826A1 - Composiciones y metodo para el tratamiento de infeccion en ganado vacuno y porcino - Google Patents

Composiciones y metodo para el tratamiento de infeccion en ganado vacuno y porcino

Info

Publication number
AR039826A1
AR039826A1 ARP030101735A ARP030101735A AR039826A1 AR 039826 A1 AR039826 A1 AR 039826A1 AR P030101735 A ARP030101735 A AR P030101735A AR P030101735 A ARP030101735 A AR P030101735A AR 039826 A1 AR039826 A1 AR 039826A1
Authority
AR
Argentina
Prior art keywords
group
halogen
treatment
phenyl
flunixin
Prior art date
Application number
ARP030101735A
Other languages
English (en)
Original Assignee
Schering Plough Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Plough Ltd filed Critical Schering Plough Ltd
Publication of AR039826A1 publication Critical patent/AR039826A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Formulaciones que combinan una droga antiinflamatoria no esteroide (NSAID) tal como flunixina, con un antibiótico derivado de tianfenicol o cloranfenicol fluorado, tal como florfenicol. Se describen también métodos para el uso de dichas formulaciones en el tratamiento y prevención de enfermedades infecciosas de bovinos y porcinos, incluyendo enfermedad respiratoria bovina y enfermedad respiratoria porcina. Reivindicación 1: Una composición para el tratamiento de infección microbial en un animal, que comprende flunixina o una de sus sales farmacéuticamente aceptables y un compuesto de fórmula (1), en donde: R es un miembro seleccionado entre el grupo que consiste en metilo o etilo, o un derivado halogenado de los mismos, dihalogendeuteriometilo, 1-halogen-1-deuterioetilo, 1,2-dihalogen-1-dueterioetilo, azidometilo y metilsulfonilmetilo; cada X y X' es un miembro seleccionado en forma independiente entre el grupo que consiste en NO2, SO2R1, SOR1, SR1, SONH2, SO2NH2, SONHR1, SO2NHR1, COR1, OR1, R1, CN, halógeno, hidrógeno, fenilo y fenilo sustituido con halógeno, NO2, R1, PO2R1, CONHR1, NHR1, NR1R2, CONR1R2, OCOR1, u OR1, en donde cada uno de R1 y R2 es un miembro seleccionado en forma independiente entre el grupo que consiste en metilo, etilo, n-propilo, isopropilo, butilo, t-butilo, isobutilo y fenilo; y Z es hidrógeno o un grupo acilo de un ácido hidrocarboncarboxílico que tiene hasta 16 átomos de carbono, o un grupo de acilo de un ácido aminohidrocarboncarboxílico que tiene hasta 12 átomos de carbono; y las sales farmacéuticamente aceptables de dichos grupos acilo.
ARP030101735A 2002-05-20 2003-05-19 Composiciones y metodo para el tratamiento de infeccion en ganado vacuno y porcino AR039826A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38201502P 2002-05-20 2002-05-20

Publications (1)

Publication Number Publication Date
AR039826A1 true AR039826A1 (es) 2005-03-02

Family

ID=29550174

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101735A AR039826A1 (es) 2002-05-20 2003-05-19 Composiciones y metodo para el tratamiento de infeccion en ganado vacuno y porcino

Country Status (29)

Country Link
US (3) US6790867B2 (es)
EP (1) EP1505975B1 (es)
JP (2) JP4772324B2 (es)
KR (1) KR101102176B1 (es)
CN (1) CN100563655C (es)
AR (1) AR039826A1 (es)
AU (1) AU2003228042B2 (es)
BR (1) BRPI0311126B1 (es)
CA (1) CA2485491C (es)
CY (1) CY1107176T1 (es)
DE (1) DE60317662T2 (es)
DK (1) DK1505975T3 (es)
EC (1) ECSP045442A (es)
ES (1) ES2295583T3 (es)
HK (1) HK1072547A1 (es)
IL (2) IL165252A0 (es)
MX (1) MXPA04011516A (es)
MY (1) MY135791A (es)
NO (1) NO20045547L (es)
NZ (1) NZ536476A (es)
PE (1) PE20040041A1 (es)
PL (1) PL213975B1 (es)
PT (1) PT1505975E (es)
RU (2) RU2330662C2 (es)
SI (1) SI1505975T1 (es)
TW (1) TWI355266B (es)
UA (1) UA81629C2 (es)
WO (1) WO2003097054A1 (es)
ZA (1) ZA200409296B (es)

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Also Published As

Publication number Publication date
RU2330662C2 (ru) 2008-08-10
US6790867B2 (en) 2004-09-14
DE60317662T2 (de) 2008-10-30
ZA200409296B (en) 2005-07-27
CY1107176T1 (el) 2012-10-24
JP2005526849A (ja) 2005-09-08
RU2466726C2 (ru) 2012-11-20
US8044102B2 (en) 2011-10-25
HK1072547A1 (en) 2005-09-02
PT1505975E (pt) 2008-01-31
US20030220302A1 (en) 2003-11-27
KR20050010818A (ko) 2005-01-28
ES2295583T3 (es) 2008-04-16
CN1652783A (zh) 2005-08-10
MXPA04011516A (es) 2005-02-14
WO2003097054A1 (en) 2003-11-27
AU2003228042B2 (en) 2006-09-21
IL165252A0 (en) 2005-12-18
TWI355266B (en) 2012-01-01
CA2485491A1 (en) 2003-11-27
IL165252A (en) 2011-11-30
NO20045547L (no) 2004-12-17
NZ536476A (en) 2008-10-31
RU2004137273A (ru) 2005-07-10
DE60317662D1 (de) 2008-01-03
PE20040041A1 (es) 2004-01-24
PL213975B1 (pl) 2013-05-31
US20030216447A1 (en) 2003-11-20
KR101102176B1 (ko) 2012-01-02
TW200307536A (en) 2003-12-16
DK1505975T3 (da) 2008-01-14
RU2008107582A (ru) 2009-09-10
BR0311126A (pt) 2005-03-08
SI1505975T1 (sl) 2008-06-30
EP1505975B1 (en) 2007-11-21
BRPI0311126B1 (pt) 2016-11-08
EP1505975A1 (en) 2005-02-16
JP2006213731A (ja) 2006-08-17
PL374575A1 (en) 2005-10-31
UA81629C2 (ru) 2008-01-25
ECSP045442A (es) 2005-01-03
CA2485491C (en) 2012-12-04
MY135791A (en) 2008-06-30
CN100563655C (zh) 2009-12-02
AU2003228042A1 (en) 2003-12-02
US20050288261A1 (en) 2005-12-29
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