PE20040041A1 - Composicion farmaceutica que comprende flunixina - Google Patents

Composicion farmaceutica que comprende flunixina

Info

Publication number
PE20040041A1
PE20040041A1 PE2003000481A PE2003000481A PE20040041A1 PE 20040041 A1 PE20040041 A1 PE 20040041A1 PE 2003000481 A PE2003000481 A PE 2003000481A PE 2003000481 A PE2003000481 A PE 2003000481A PE 20040041 A1 PE20040041 A1 PE 20040041A1
Authority
PE
Peru
Prior art keywords
halogen
acid
phenyl
flunixin
deuterioethyl
Prior art date
Application number
PE2003000481A
Other languages
English (en)
Inventor
Kanwal J Varma
Abu Huq
Raul E Kohan
Robert D Simmons
Keith A Freehauf
Original Assignee
Schering Plough Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Plough Ltd filed Critical Schering Plough Ltd
Publication of PE20040041A1 publication Critical patent/PE20040041A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

QUE COMPRENDE: a)FLUNIXINA O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES; b)UN COMPUESTO DE FORMULA (I); Y, c)UN SOLVENTE POLAR APROTICO, SELECCIONADO DE: PIRROLIDONA, N,N-DIMETILACETAMIDA, N,N-DIMETILFORMAMIDA, DMSO, ACETONA, Y GLICEROL FORMAL; Y COMBINACIONES DE LOS MISMOS. DONDE, R ES SELECCIONADO DE METILO O ETILO, O UN DERIVADO HALOGENADO DE LOS MISMOS, DIHALOGENDEUTERIOMETILO, 1-HALOGEN-1-DEUTERIOETILO, 1,2-DIHALOGEN-1-DEUTERIOETILO, AZIDOMETILO Y METILSULFONILMETILO; CADA X Y X' ES SELECCIONADO DE MANERA INDEPENDIENTE DE: NO2, SO2R1, SOR1, SR1, SONH2, SO2NH2, SONHR1, SO2NHR1, COR1, OR1, R1, CN, HALOGENO, H, FENILO Y FENILO SUSTITUIDO CON HALOGENO, NO2, R1, PO2R1, CONHR1, NHR1, NR1R2, CONR1R2, OCOR1, u OR1 EN DONDE CADA UNO DE R1 Y R2 ES SELECCIONADO EN FORMA INDEPENDIENTE DE METILO, ETILO, n-PROPILO, ISOPROPILO, BUTILO, t-BUTILO, ISOBUTILO Y FENILO; Y, Z ES H O UN GRUPO ACILO DE UN ACIDO HIDROCARBONCARBOXILICO QUE TIENE HASTA 16 ATOMOS DE CARBONO, O UN GRUPO ACILO DE UN ACIDO AMINOHIDROCARBONCARBOXILICO QUE TIENE HASTA 12 ATOMOS DE CARBONO Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE DICHOS GRUPOS ACILO. LA COMPOSICION DESCRITA TIENE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES COMO ENFERMEDADES RESPIRATORIAS BOVINAS, PORCINAS, PODODERMATITIS, MASTITIS AGUDA, CONJUNTIVITIS INFECCIOSA AGUDA, METRITIS Y ENTERITIS EN UN ANIMAL
PE2003000481A 2002-05-20 2003-05-19 Composicion farmaceutica que comprende flunixina PE20040041A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38201502P 2002-05-20 2002-05-20

Publications (1)

Publication Number Publication Date
PE20040041A1 true PE20040041A1 (es) 2004-01-24

Family

ID=29550174

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000481A PE20040041A1 (es) 2002-05-20 2003-05-19 Composicion farmaceutica que comprende flunixina

Country Status (29)

Country Link
US (3) US6790867B2 (es)
EP (1) EP1505975B1 (es)
JP (2) JP4772324B2 (es)
KR (1) KR101102176B1 (es)
CN (1) CN100563655C (es)
AR (1) AR039826A1 (es)
AU (1) AU2003228042B2 (es)
BR (1) BRPI0311126B1 (es)
CA (1) CA2485491C (es)
CY (1) CY1107176T1 (es)
DE (1) DE60317662T2 (es)
DK (1) DK1505975T3 (es)
EC (1) ECSP045442A (es)
ES (1) ES2295583T3 (es)
HK (1) HK1072547A1 (es)
IL (2) IL165252A0 (es)
MX (1) MXPA04011516A (es)
MY (1) MY135791A (es)
NO (1) NO20045547L (es)
NZ (1) NZ536476A (es)
PE (1) PE20040041A1 (es)
PL (1) PL213975B1 (es)
PT (1) PT1505975E (es)
RU (2) RU2330662C2 (es)
SI (1) SI1505975T1 (es)
TW (1) TWI355266B (es)
UA (1) UA81629C2 (es)
WO (1) WO2003097054A1 (es)
ZA (1) ZA200409296B (es)

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CN104208062A (zh) * 2013-06-03 2014-12-17 中国农业科学院兰州畜牧与兽药研究所 一种高浓度复方氟苯尼考注射液及其制备方法和应用
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USD890925S1 (en) 2018-06-15 2020-07-21 James T. Doubet Syringe adapter for medication
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Also Published As

Publication number Publication date
TWI355266B (en) 2012-01-01
KR101102176B1 (ko) 2012-01-02
PL374575A1 (en) 2005-10-31
TW200307536A (en) 2003-12-16
DK1505975T3 (da) 2008-01-14
US20030220302A1 (en) 2003-11-27
SI1505975T1 (sl) 2008-06-30
RU2004137273A (ru) 2005-07-10
EP1505975A1 (en) 2005-02-16
RU2330662C2 (ru) 2008-08-10
KR20050010818A (ko) 2005-01-28
US20050288261A1 (en) 2005-12-29
ECSP045442A (es) 2005-01-03
US6790867B2 (en) 2004-09-14
UA81629C2 (ru) 2008-01-25
DE60317662D1 (de) 2008-01-03
AU2003228042A1 (en) 2003-12-02
AR039826A1 (es) 2005-03-02
HK1072547A1 (en) 2005-09-02
CA2485491A1 (en) 2003-11-27
BRPI0311126B1 (pt) 2016-11-08
ES2295583T3 (es) 2008-04-16
JP4772324B2 (ja) 2011-09-14
RU2466726C2 (ru) 2012-11-20
ZA200409296B (en) 2005-07-27
DE60317662T2 (de) 2008-10-30
CN100563655C (zh) 2009-12-02
BR0311126A (pt) 2005-03-08
MY135791A (en) 2008-06-30
NZ536476A (en) 2008-10-31
PL213975B1 (pl) 2013-05-31
US8044102B2 (en) 2011-10-25
JP2005526849A (ja) 2005-09-08
CY1107176T1 (el) 2012-10-24
PT1505975E (pt) 2008-01-31
IL165252A0 (en) 2005-12-18
CA2485491C (en) 2012-12-04
CN1652783A (zh) 2005-08-10
MXPA04011516A (es) 2005-02-14
RU2008107582A (ru) 2009-09-10
EP1505975B1 (en) 2007-11-21
US20030216447A1 (en) 2003-11-20
IL165252A (en) 2011-11-30
AU2003228042B2 (en) 2006-09-21
WO2003097054A1 (en) 2003-11-27
JP2006213731A (ja) 2006-08-17
NO20045547L (no) 2004-12-17

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