AR037826A1 - Derivados de piridazina fusionada - Google Patents
Derivados de piridazina fusionadaInfo
- Publication number
- AR037826A1 AR037826A1 ARP020104845A ARP020104845A AR037826A1 AR 037826 A1 AR037826 A1 AR 037826A1 AR P020104845 A ARP020104845 A AR P020104845A AR P020104845 A ARP020104845 A AR P020104845A AR 037826 A1 AR037826 A1 AR 037826A1
- Authority
- AR
- Argentina
- Prior art keywords
- nr4r5
- alkyl
- cycloalkyl
- alkenyl
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Los derivados de piridazina fusionada, que son útiles como inhibidores de CDK se describen en la presente. La presente descrita también incluye métodos para elaborar tales derivados de piridazinas fusionadas así como también métodos para utilizar los mismos en el tratamiento de enfermedades hiperproliferativas. Reivindicación 1: Un compuesto de la fórmula (1) o una sal, solvato o derivado fisiológicamente funcional del mismo, en donde: D es N o CH; R1 es hidrógeno, alquilo C1-6, alquenilo C2-4, alquinilo C2-4, alcoxi C1-3, halógeno, -CF3, hidroxi, ciano, -S(O)yalquilo C1-3, o -NR4R5; y es 0, 1 ó 2; a es 1 ó 2; R2 es hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalquilo C1-6, cicloalquilo C3-7, halógeno, heterociclilo, arilo, heteroarilo, ciano, azido, nitro, -OR8, -OR6R8, -R6R7, -R6R'', -OS(O)2R9, -S(O)yR10, -C(O)R7, -C(O)OR7, -C(O)NR4R5, -N(H)R'C(=NR4)NR4R5, -OC(O)NR4R5, -OC(O)OR7, -C(=NR4)NR4R5, -NR4R5, -OC(O)R7 o -N(R8)C(O)R8; R3 es -(Q)p-(Q1), en donde Q es O, N(R8) o S(O)y, p es 0 ó 1; y es 0, 1 ó 2 y Q1 es alquilo C1-6, cicloalquilo C3-7, haloalquilo C1-6, arilo, arilo sustituido con -C(O)N(H)R6NR4R5 o -OC(H)(OH)R6NR4R6, heteroarilo, aralquilo, o R6NR4R5; R4 y R5 son independientemente hidrógeno, alquilo C1-3, cicloalquilo C3-7, -C(O)R9, o R4 y R5, junto con el átomo de nitrógeno al cual se unen, forman un heterociclilo; R6 es alquenilo, arileno, heteroarileno, cicloalquileno C3-7, alquenileno, cicloalquenileno C3-7, o alquinileno; R7 es hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, -NR4R5, arilo, aralquilo, heteroarilo, cicloalquilo, heterociclilo, -S(O)yR10, -C(O)R8, -C(O)OR8, -C(O)NR4R5, -S(O)2NR4R5, -N(H)R'C(=NR4)NR4R5, -OC(O)NR4R5, -OC(O)OR8, -C(=NR4)NR4R5, -NR4R5, o -N(R8)C(O)R8; R8 es hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, -NR4R5, arilo, aralquilo, heteroarilo, cicloalquilo, heterociclilo, o -S(O)2R9; R9 es alquilo C1-6 o haloalquilo C1-6; R10 es hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, -NR4R5, arilo, aralquilo, heteroarilo, cicloalquilo, heterociclilo, -C(O)R8, -C(O)OR8, -C(O)NR4R5, -N(H)R'C(=NR4)NR4R5, -OC(O)NR4R5, -OC(O)OR8, -C(=NR4)NR4R5, -NR4R5, o -N(R8)C(O)R8; R' es alquileno C1-3 y R'' es -OR7, -OC(O)NR4R5, -OC(O)OR7, o -OC(O)R7.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34179801P | 2001-12-17 | 2001-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR037826A1 true AR037826A1 (es) | 2004-12-09 |
Family
ID=23339081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020104845A AR037826A1 (es) | 2001-12-17 | 2002-12-13 | Derivados de piridazina fusionada |
Country Status (10)
Country | Link |
---|---|
US (1) | US7279473B2 (es) |
EP (1) | EP1463730B1 (es) |
JP (1) | JP2005524609A (es) |
AR (1) | AR037826A1 (es) |
AT (1) | ATE323706T1 (es) |
AU (1) | AU2002357164A1 (es) |
DE (1) | DE60210819T2 (es) |
ES (1) | ES2262899T3 (es) |
TW (1) | TW200301119A (es) |
WO (1) | WO2003051886A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003062236A1 (en) | 2002-01-22 | 2003-07-31 | Warner-Lambert Company Llc | 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d]PYRIMIDIN-7-ONES |
AU2003301302A1 (en) * | 2002-10-15 | 2004-05-04 | Smithkline Beecham Corporation | Pyradazine compounds as gsk-3 inhibitors |
EP1648889B1 (en) * | 2003-07-11 | 2008-10-29 | Warner-Lambert Company LLC | Isethionate salt of a selective cdk4 inhibitor |
DE10344223A1 (de) * | 2003-09-24 | 2005-04-21 | Merck Patent Gmbh | 1,3-Benzoxazolylderivate als Kinase-Inhibitoren |
US7855205B2 (en) | 2004-10-29 | 2010-12-21 | Janssen Pharmaceutica Nv | Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders |
EP1928237A4 (en) | 2005-09-02 | 2011-03-09 | Abbott Lab | NEW HETEROCYCLES BASED ON IMIDAZO |
AU2007328981B2 (en) * | 2006-12-08 | 2013-07-11 | F. Hoffmann-La Roche Ag | Substituted pyrimidines and their use as JNK modulators |
CA2707989A1 (en) * | 2007-12-07 | 2009-06-11 | Novartis Ag | Pyrazole derivatives and use thereof as inhibitors of cyclin dependent kinases |
NZ587589A (en) | 2008-02-15 | 2012-10-26 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases |
ES2538135T3 (es) * | 2008-06-30 | 2015-06-17 | Janssen Pharmaceutica N.V. | Proceso para la preparación de derivados sustituidos de pirimidina |
AR074870A1 (es) * | 2008-12-24 | 2011-02-16 | Palau Pharma Sa | Derivados de pirazolo (1,5-a ) piridina |
JP5959537B2 (ja) * | 2011-01-28 | 2016-08-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換ピリジニル−ピリミジン及び医薬としてのその使用 |
US20150203812A1 (en) * | 2014-01-20 | 2015-07-23 | Francesco Tombola | Inhibitors of Voltage Gated Ion Channels |
GB201605126D0 (en) * | 2016-03-24 | 2016-05-11 | Univ Nottingham | Inhibitors and their uses |
CN106699608A (zh) * | 2016-12-26 | 2017-05-24 | 常州大学 | 一种含有强吸电子基团的苯胍及其盐的制备方法 |
GB201715342D0 (en) | 2017-09-22 | 2017-11-08 | Univ Nottingham | Compounds |
US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
WO2020180959A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
CN116348458A (zh) | 2019-08-14 | 2023-06-27 | 因赛特公司 | 作为cdk2抑制剂的咪唑基嘧啶基胺化合物 |
US11851426B2 (en) | 2019-10-11 | 2023-12-26 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU622330B2 (en) * | 1989-06-23 | 1992-04-02 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides |
JP2002501532A (ja) * | 1997-05-30 | 2002-01-15 | メルク エンド カンパニー インコーポレーテッド | 新規血管形成阻害薬 |
YU11900A (sh) * | 1997-09-05 | 2002-11-15 | Glaxo Group Limited | Derivati 2,3-diaril-pirazolo (1,5-b) piridazina, njihovo dobijanje i njihova upotreba kao inhibitora ciklooksigenaze 2(cox-2) |
AU3352899A (en) | 1997-12-11 | 1999-07-12 | American Home Products Corporation | 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
SK9892001A3 (en) | 1999-11-10 | 2002-04-04 | Ortho Mcneil Pharm Inc | Substituted 2-aryl-3-(heteroaryl)-imidazo[1,2-a]pyrimidines, and related pharmaceutical compositions and methods |
AU2001292670A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
-
2002
- 2002-12-11 AU AU2002357164A patent/AU2002357164A1/en not_active Abandoned
- 2002-12-11 JP JP2003552768A patent/JP2005524609A/ja active Pending
- 2002-12-11 ES ES02805104T patent/ES2262899T3/es not_active Expired - Lifetime
- 2002-12-11 EP EP02805104A patent/EP1463730B1/en not_active Expired - Lifetime
- 2002-12-11 AT AT02805104T patent/ATE323706T1/de not_active IP Right Cessation
- 2002-12-11 US US10/499,179 patent/US7279473B2/en not_active Expired - Fee Related
- 2002-12-11 DE DE60210819T patent/DE60210819T2/de not_active Expired - Fee Related
- 2002-12-11 WO PCT/US2002/039672 patent/WO2003051886A1/en active IP Right Grant
- 2002-12-13 TW TW091136132A patent/TW200301119A/zh unknown
- 2002-12-13 AR ARP020104845A patent/AR037826A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2002357164A8 (en) | 2003-06-30 |
EP1463730B1 (en) | 2006-04-19 |
DE60210819D1 (en) | 2006-05-24 |
WO2003051886A8 (en) | 2004-08-19 |
AU2002357164A1 (en) | 2003-06-30 |
WO2003051886A1 (en) | 2003-06-26 |
US7279473B2 (en) | 2007-10-09 |
DE60210819T2 (de) | 2007-04-19 |
ES2262899T3 (es) | 2006-12-01 |
US20050090507A1 (en) | 2005-04-28 |
ATE323706T1 (de) | 2006-05-15 |
TW200301119A (en) | 2003-07-01 |
JP2005524609A (ja) | 2005-08-18 |
EP1463730A1 (en) | 2004-10-06 |
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