AR037230A1 - Solvatos de clorhidrato de metil 1,1-n-trimetil-n-(3,3-difenil-propil)-2-aminoetil 1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)piridin-3,5-dicarboxilato (lercanidipina) con cloruro de metileno, acetona, anisol, tetrahidrofuran, metil-terbutil-ester, isopropanol, 2-butanol, heptano, metil-etil-cetona y a - Google Patents
Solvatos de clorhidrato de metil 1,1-n-trimetil-n-(3,3-difenil-propil)-2-aminoetil 1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)piridin-3,5-dicarboxilato (lercanidipina) con cloruro de metileno, acetona, anisol, tetrahidrofuran, metil-terbutil-ester, isopropanol, 2-butanol, heptano, metil-etil-cetona y aInfo
- Publication number
- AR037230A1 AR037230A1 ARP020102957A ARP020102957A AR037230A1 AR 037230 A1 AR037230 A1 AR 037230A1 AR P020102957 A ARP020102957 A AR P020102957A AR P020102957 A ARP020102957 A AR P020102957A AR 037230 A1 AR037230 A1 AR 037230A1
- Authority
- AR
- Argentina
- Prior art keywords
- methyl
- lercanidipine
- solvates
- nitrophenyl
- trimethyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente describe solvatos de clorhidrato de metil 1,1 N-trimetil-N-(3,3-difenil-propil)-2-aminoetil 1,4 dihidro-2,6-dimetil-4(3-nitrofenil)piridin-3,5 dicarboxilato (lercanidipina) con solventes orgánicos, nuevas formas cristalinas (III) y (IV) de clorhidrato de lercanidipina que se obtienen a partir de dichos solvatos mediante la eliminación de los solventes de solvatación y describe, también, composiciones farmacéuticas antihipertensivas que contienen por lo menos una de dichas formas cristalinas (III) y (IV) de clorhidrato de lercanidipina, como agente activo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001MI001727A ITMI20011727A1 (it) | 2001-08-06 | 2001-08-06 | Solvati della lercanidipina cloridrato e nuove forme cristalline della lercanidipina cloridrato ottenute da essi |
Publications (1)
Publication Number | Publication Date |
---|---|
AR037230A1 true AR037230A1 (es) | 2004-11-03 |
Family
ID=11448246
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020102957A AR037230A1 (es) | 2001-08-06 | 2002-08-02 | Solvatos de clorhidrato de metil 1,1-n-trimetil-n-(3,3-difenil-propil)-2-aminoetil 1,4-dihidro-2,6-dimetil-4-(3-nitrofenil)piridin-3,5-dicarboxilato (lercanidipina) con cloruro de metileno, acetona, anisol, tetrahidrofuran, metil-terbutil-ester, isopropanol, 2-butanol, heptano, metil-etil-cetona y a |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1423367B1 (es) |
JP (1) | JP2005502648A (es) |
KR (1) | KR100912664B1 (es) |
CN (1) | CN100494175C (es) |
AR (1) | AR037230A1 (es) |
AT (1) | ATE294162T1 (es) |
AU (1) | AU2002331390B2 (es) |
BR (1) | BR0211738A (es) |
DE (1) | DE60203919D1 (es) |
EA (1) | EA200400279A1 (es) |
ES (1) | ES2209684T1 (es) |
HR (1) | HRP20040157A2 (es) |
HU (1) | HUP0401161A3 (es) |
IL (2) | IL153916A0 (es) |
IT (1) | ITMI20011727A1 (es) |
MX (1) | MXPA04001073A (es) |
NO (1) | NO20040479L (es) |
PE (1) | PE20030350A1 (es) |
PL (1) | PL369449A1 (es) |
UY (1) | UY27409A1 (es) |
WO (1) | WO2003014085A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100651212B1 (ko) | 2004-10-27 | 2006-12-01 | 제일약품주식회사 | 무정형 레르카니디핀의 제조방법 |
AR052918A1 (es) | 2005-02-25 | 2007-04-11 | Recordati Ireland Ltd | Clorhidrato de lercanidipina amorfo |
BRPI0616169B8 (pt) | 2005-09-16 | 2021-05-25 | Glenmark Pharmaceuticals Ltd | cloridrato de lercanidipina na forma polimorfa v, composição farmacêutica compreendendo dito composto e processos para preparação de cloridrato de lercanidipina |
WO2008107797A2 (en) * | 2007-03-05 | 2008-09-12 | Actavis Group Ptc Ehf | Lercanidipine hydrochloride polymorphs and an improved process for preparation of 1,1,n-trimethyl-n-(3,3-diphenylpropyl)-2-aminoethyl acetoacetate |
WO2008136394A1 (ja) * | 2007-04-27 | 2008-11-13 | Ajinomoto Co., Inc. | ラクタム化合物の製造方法及びその製造中間体 |
EP2585051B2 (en) | 2010-06-23 | 2020-04-08 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical oral dosage forms comprising lercanidipine and enalapril and their pharmaceutically acceptable salts |
WO2012085249A2 (en) | 2010-12-24 | 2012-06-28 | Krka, D.D., Novo Mesto | Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8403866D0 (en) * | 1984-02-14 | 1984-03-21 | Recordati Chem Pharm | Diphenylalkylaminoalkyl esters |
US5912351A (en) * | 1995-05-12 | 1999-06-15 | Recordati, S.A. Chemical And Pharmaceutical Company | Anhydrous 1,4-Dihydropyridines and salts thereof |
-
2001
- 2001-08-06 IT IT2001MI001727A patent/ITMI20011727A1/it unknown
-
2002
- 2002-08-02 AR ARP020102957A patent/AR037230A1/es not_active Application Discontinuation
- 2002-08-05 KR KR1020047001791A patent/KR100912664B1/ko not_active IP Right Cessation
- 2002-08-05 IL IL15391602A patent/IL153916A0/xx unknown
- 2002-08-05 CN CNB028155114A patent/CN100494175C/zh not_active Expired - Fee Related
- 2002-08-05 BR BR0211738-0A patent/BR0211738A/pt not_active IP Right Cessation
- 2002-08-05 AU AU2002331390A patent/AU2002331390B2/en not_active Ceased
- 2002-08-05 AT AT02767318T patent/ATE294162T1/de not_active IP Right Cessation
- 2002-08-05 EA EA200400279A patent/EA200400279A1/ru unknown
- 2002-08-05 EP EP02767318A patent/EP1423367B1/en not_active Expired - Lifetime
- 2002-08-05 ES ES02767318T patent/ES2209684T1/es active Pending
- 2002-08-05 PL PL02369449A patent/PL369449A1/xx unknown
- 2002-08-05 WO PCT/EP2002/008700 patent/WO2003014085A1/en active IP Right Grant
- 2002-08-05 DE DE60203919T patent/DE60203919D1/de not_active Expired - Lifetime
- 2002-08-05 HU HU0401161A patent/HUP0401161A3/hu unknown
- 2002-08-05 MX MXPA04001073A patent/MXPA04001073A/es not_active Application Discontinuation
- 2002-08-05 JP JP2003519035A patent/JP2005502648A/ja active Pending
- 2002-08-06 PE PE2002000716A patent/PE20030350A1/es not_active Application Discontinuation
- 2002-08-06 UY UY27409A patent/UY27409A1/es not_active Application Discontinuation
-
2003
- 2003-01-13 IL IL153916A patent/IL153916A/en unknown
-
2004
- 2004-02-03 NO NO20040479A patent/NO20040479L/no not_active Application Discontinuation
- 2004-02-18 HR HR20040157A patent/HRP20040157A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PL369449A1 (en) | 2005-04-18 |
UY27409A1 (es) | 2003-03-31 |
NO20040479L (no) | 2004-02-03 |
ITMI20011727A1 (it) | 2003-02-06 |
MXPA04001073A (es) | 2005-02-17 |
JP2005502648A (ja) | 2005-01-27 |
KR20040030932A (ko) | 2004-04-09 |
EA200400279A1 (ru) | 2004-06-24 |
ATE294162T1 (de) | 2005-05-15 |
KR100912664B1 (ko) | 2009-08-17 |
CN100494175C (zh) | 2009-06-03 |
HRP20040157A2 (en) | 2004-08-31 |
EP1423367A1 (en) | 2004-06-02 |
HUP0401161A3 (en) | 2009-04-28 |
EP1423367B1 (en) | 2005-04-27 |
AU2002331390B2 (en) | 2008-06-05 |
PE20030350A1 (es) | 2003-06-06 |
ES2209684T1 (es) | 2004-07-01 |
WO2003014085A1 (en) | 2003-02-20 |
BR0211738A (pt) | 2004-09-28 |
ITMI20011727A0 (it) | 2001-08-06 |
IL153916A0 (en) | 2003-07-31 |
DE60203919D1 (de) | 2005-06-02 |
HUP0401161A2 (hu) | 2004-09-28 |
IL153916A (en) | 2008-07-08 |
CN1538958A (zh) | 2004-10-20 |
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