AR036231A1 - Derivados de 4-diarilamino piperidina,procedimiento para su preparacion, empleo de estos derivados para la fabricacion de medicamentos, composicion farmaceutica y compuestos intermediarios - Google Patents
Derivados de 4-diarilamino piperidina,procedimiento para su preparacion, empleo de estos derivados para la fabricacion de medicamentos, composicion farmaceutica y compuestos intermediariosInfo
- Publication number
- AR036231A1 AR036231A1 ARP020101818A ARP020101818A AR036231A1 AR 036231 A1 AR036231 A1 AR 036231A1 AR P020101818 A ARP020101818 A AR P020101818A AR P020101818 A ARP020101818 A AR P020101818A AR 036231 A1 AR036231 A1 AR 036231A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- medicines
- procedure
- manufacture
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Derivados de 4-diarilamino piperidina de la fórmula general (1) donde R1 se selecciona de cualquiera de fenilo, piridinilo, tienilo, furanilo, imidazolilo, pirrolilo, triazolilo, tiazolilo y piridil-N-óxido; en la cual cada anillo de fenilo de R1 y cada anillo heteroaromático de R1 puede estar además opcional e independientemente sustituido con 1, 2 ó 3 sustituyentes independientemente seleccionados de alquilo C1-6 recto y ramificado, NO2, CF3, alcoxilo C1-6, cloro, flúor, bromo y yodo, así como también sales de los mismos. Las sustituciones en el anillo de fenilo y en el anillo heteroaromático pueden tener lugar en cualquier posición en dichos sistemas anulares. Estos compuestos son útiles en terapia, en particular en el control del dolor, ansiedad y trastornos gastrointestinales funcionales. Procedimiento para su preparación, empleo de estos derivados para la fabricación de medicamentos, composición farmacéutica y compuestos intermediarios.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101773A SE0101773D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036231A1 true AR036231A1 (es) | 2004-08-25 |
Family
ID=20284176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020101818A AR036231A1 (es) | 2001-05-18 | 2002-05-16 | Derivados de 4-diarilamino piperidina,procedimiento para su preparacion, empleo de estos derivados para la fabricacion de medicamentos, composicion farmaceutica y compuestos intermediarios |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7008952B2 (es) |
| EP (1) | EP1395557A1 (es) |
| JP (1) | JP2005508291A (es) |
| KR (1) | KR20040000472A (es) |
| CN (1) | CN1527818A (es) |
| AR (1) | AR036231A1 (es) |
| BG (1) | BG108334A (es) |
| BR (1) | BR0209665A (es) |
| CA (1) | CA2446516A1 (es) |
| CO (1) | CO5540320A2 (es) |
| CZ (1) | CZ20033093A3 (es) |
| EE (1) | EE200300526A (es) |
| HU (1) | HUP0401610A2 (es) |
| IL (1) | IL158700A0 (es) |
| IS (1) | IS7033A (es) |
| MX (1) | MXPA03010444A (es) |
| NO (1) | NO20035119D0 (es) |
| PL (1) | PL367246A1 (es) |
| RU (1) | RU2003131963A (es) |
| SE (1) | SE0101773D0 (es) |
| SK (1) | SK13992003A3 (es) |
| WO (1) | WO2002094785A1 (es) |
| ZA (1) | ZA200308642B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ593444A (en) | 2003-10-01 | 2012-12-21 | Adolor Corp | 4-[(2-N,N-diethylaminocarbonyl)pyrid-5-yl]-spiro[1,2-dihydronaphthalene-2,4'-piperidine] and methods of its use |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| CN113979997A (zh) * | 2021-11-12 | 2022-01-28 | 中国科学院昆明植物研究所 | N,n-(4-哌啶基、芳基)-3-氨基苯酚类衍生物及其药物组合物和其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091096A (en) | 1976-03-19 | 1978-05-23 | Eli Lilly And Company | Dinitroanilines for the control of phytopathogens |
| EG12406A (en) | 1976-08-12 | 1979-03-31 | Janssen Pharmaceutica Nv | Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides |
| SE441448B (sv) | 1977-05-23 | 1985-10-07 | Pfizer | Sett att framstella hexahydro-gamma-karbolinforeningar |
| US4252812A (en) | 1977-05-23 | 1981-02-24 | Pfizer Inc. | 2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles |
| DE3200304A1 (de) | 1981-01-16 | 1982-08-26 | Sandoz-Patent-GmbH, 7850 Lörrach | 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel |
| DE3563964D1 (en) | 1984-10-16 | 1988-09-01 | Synthelabo | Piperidine derivatives, their preparation and their therapeutical application |
| YU150489A (sh) | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
| KR940003491B1 (ko) | 1989-08-10 | 1994-04-23 | 리히터 게데온 베기에스제티 기아르 알.티 | 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물 |
| US5854245A (en) | 1996-06-28 | 1998-12-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| WO1999033806A1 (en) | 1997-12-24 | 1999-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor |
| EP1061919A4 (en) | 1998-03-10 | 2002-09-04 | Res Triangle Inst | NEW OPIATES, METHOD FOR THE PRODUCTION AND USE THEREOF |
| SE9904675D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| JP2003525938A (ja) * | 2000-03-03 | 2003-09-02 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ３−（ジアリールメチレン）−８−アザビシクロ［３．２．１］オクタン誘導体 |
| SE0001207D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
-
2001
- 2001-05-18 SE SE0101773A patent/SE0101773D0/xx unknown
-
2002
- 2002-05-16 EE EEP200300526A patent/EE200300526A/xx unknown
- 2002-05-16 BR BR0209665-0A patent/BR0209665A/pt not_active Application Discontinuation
- 2002-05-16 KR KR10-2003-7014951A patent/KR20040000472A/ko not_active Application Discontinuation
- 2002-05-16 JP JP2002591458A patent/JP2005508291A/ja active Pending
- 2002-05-16 RU RU2003131963/04A patent/RU2003131963A/ru not_active Application Discontinuation
- 2002-05-16 PL PL02367246A patent/PL367246A1/xx not_active Application Discontinuation
- 2002-05-16 CN CNA028141687A patent/CN1527818A/zh active Pending
- 2002-05-16 US US10/477,636 patent/US7008952B2/en not_active Expired - Fee Related
- 2002-05-16 MX MXPA03010444A patent/MXPA03010444A/es unknown
- 2002-05-16 AR ARP020101818A patent/AR036231A1/es not_active Application Discontinuation
- 2002-05-16 IL IL15870002A patent/IL158700A0/xx unknown
- 2002-05-16 CA CA002446516A patent/CA2446516A1/en not_active Abandoned
- 2002-05-16 CZ CZ20033093A patent/CZ20033093A3/cs unknown
- 2002-05-16 SK SK1399-2003A patent/SK13992003A3/sk unknown
- 2002-05-16 WO PCT/SE2002/000957 patent/WO2002094785A1/en not_active Application Discontinuation
- 2002-05-16 EP EP02733713A patent/EP1395557A1/en not_active Withdrawn
- 2002-05-16 HU HU0401610A patent/HUP0401610A2/hu unknown
-
2003
- 2003-11-05 ZA ZA200308642A patent/ZA200308642B/en unknown
- 2003-11-07 BG BG108334A patent/BG108334A/bg unknown
- 2003-11-12 CO CO03100170A patent/CO5540320A2/es not_active Application Discontinuation
- 2003-11-13 IS IS7033A patent/IS7033A/is unknown
- 2003-11-17 NO NO20035119A patent/NO20035119D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EE200300526A (et) | 2004-02-16 |
| SK13992003A3 (sk) | 2004-04-06 |
| JP2005508291A (ja) | 2005-03-31 |
| NO20035119D0 (no) | 2003-11-17 |
| HUP0401610A2 (hu) | 2004-12-28 |
| KR20040000472A (ko) | 2004-01-03 |
| MXPA03010444A (es) | 2004-03-09 |
| RU2003131963A (ru) | 2005-05-10 |
| CA2446516A1 (en) | 2002-11-28 |
| IL158700A0 (en) | 2004-05-12 |
| SE0101773D0 (sv) | 2001-05-18 |
| US7008952B2 (en) | 2006-03-07 |
| BG108334A (bg) | 2004-12-30 |
| CN1527818A (zh) | 2004-09-08 |
| IS7033A (is) | 2003-11-13 |
| CZ20033093A3 (cs) | 2004-07-14 |
| PL367246A1 (en) | 2005-02-21 |
| BR0209665A (pt) | 2004-04-20 |
| WO2002094785A1 (en) | 2002-11-28 |
| EP1395557A1 (en) | 2004-03-10 |
| ZA200308642B (en) | 2005-02-07 |
| CO5540320A2 (es) | 2005-07-29 |
| US20040142966A1 (en) | 2004-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |