UA72948C2 - Заміщені похідні фенілпіперазину, фармацевтична композиція та спосіб лікування афективних або неврологічних захворювань і розладів - Google Patents

Заміщені похідні фенілпіперазину, фармацевтична композиція та спосіб лікування афективних або неврологічних захворювань і розладів

Info

Publication number
UA72948C2
UA72948C2 UA2002065260A UA200265260A UA72948C2 UA 72948 C2 UA72948 C2 UA 72948C2 UA 2002065260 A UA2002065260 A UA 2002065260A UA 200265260 A UA200265260 A UA 200265260A UA 72948 C2 UA72948 C2 UA 72948C2
Authority
UA
Ukraine
Prior art keywords
phenylpiperazine
affective
disorders
treatment
pharmaceutical composition
Prior art date
Application number
UA2002065260A
Other languages
English (en)
Russian (ru)
Inventor
Томас Рухланд
Крістіан Крог-Єнсен
Кристиан Крог-Енсен
Маріо Роттлондер
Марио Роттлондер
Гітте Міккельсен
Кім Андерсен
Айнер Кнуд Мольтсен
Айнэр Кнуд Мольтсен
Original Assignee
Х. Луннбек А/С
X. Луннбек A/C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Луннбек А/С, X. Луннбек A/C filed Critical Х. Луннбек А/С
Publication of UA72948C2 publication Critical patent/UA72948C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Запропоновано сполуки формули (І): , де R1-R8, X, Y, Ζ, n та m приймають значення, як визначено в описі. Сполуки цього винаходу мають спорідненість до 5-НТ1А-рецептора.
UA2002065260A 1999-12-30 2000-12-20 Заміщені похідні фенілпіперазину, фармацевтична композиція та спосіб лікування афективних або неврологічних захворювань і розладів UA72948C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199901885 1999-12-30
PCT/DK2000/000721 WO2001049678A1 (en) 1999-12-30 2000-12-20 Substituted phenyl-piperazine derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
UA72948C2 true UA72948C2 (uk) 2005-05-16

Family

ID=8108803

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2002065260A UA72948C2 (uk) 1999-12-30 2000-12-20 Заміщені похідні фенілпіперазину, фармацевтична композиція та спосіб лікування афективних або неврологічних захворювань і розладів

Country Status (28)

Country Link
US (1) US6699864B2 (uk)
EP (1) EP1246816B1 (uk)
JP (1) JP2003519224A (uk)
KR (1) KR100790916B1 (uk)
CN (1) CN1230432C (uk)
AR (1) AR029428A1 (uk)
AT (1) ATE261959T1 (uk)
AU (1) AU2152101A (uk)
BG (1) BG65262B1 (uk)
BR (1) BR0016952A (uk)
CA (1) CA2395705C (uk)
CZ (1) CZ20022319A3 (uk)
DE (1) DE60009155T2 (uk)
EA (1) EA006071B1 (uk)
ES (1) ES2213634T3 (uk)
HU (1) HUP0203722A3 (uk)
IL (2) IL150241A0 (uk)
IS (1) IS2174B (uk)
MX (1) MXPA02006223A (uk)
NO (1) NO322666B1 (uk)
NZ (1) NZ519647A (uk)
PL (1) PL199351B1 (uk)
PT (1) PT1246816E (uk)
SK (1) SK9442002A3 (uk)
TR (2) TR200400645T4 (uk)
UA (1) UA72948C2 (uk)
WO (1) WO2001049678A1 (uk)
ZA (1) ZA200204814B (uk)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
DE10259244A1 (de) * 2002-12-17 2004-07-01 Merck Patent Gmbh N-(Indolethyl-)cycloamin-Verbindungen
UA81300C2 (en) * 2003-04-04 2007-12-25 Lundbeck & Co As H Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture
WO2004087156A1 (en) 2003-04-04 2004-10-14 H. Lundbeck A/S 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors
WO2005061455A1 (en) 2003-12-23 2005-07-07 H. Lundbeck A/S 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri
SE0400441D0 (sv) 2004-02-25 2004-02-25 Active Biotech Ab Novel Benzofurans and Indols
AR052308A1 (es) 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
AR061481A1 (es) 2006-06-16 2008-08-27 Lundbeck & Co As H Compuestos con actividad combinada sobre sert, 5-ht3 y 5-ht1a
US20090093513A1 (en) * 2007-10-09 2009-04-09 Hamann Mark T Method to Use Compositions Having Antidepressant Anxiolytic and Other Neurological Activity and Compositions of Matter
EA201001425A1 (ru) * 2008-03-14 2011-06-30 Мерк Патент Гмбх Азаиндольные соединения для лечения заболеваний центральной нервной системы
EP2981520B1 (en) 2013-04-04 2019-03-06 LEK Pharmaceuticals d.d. New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
CN105085482B (zh) * 2014-05-04 2018-08-10 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
CN105085491B (zh) * 2014-05-05 2019-06-25 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
CN106795160B (zh) * 2015-07-23 2019-04-19 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
AU2018340376B2 (en) * 2017-09-29 2022-09-01 Sunshine Lake Pharma Co., Ltd. Substituted pyrimidine piperazine compound and use thereof
CN111518012A (zh) * 2020-05-27 2020-08-11 中国药科大学 含苯硫醚结构的化合物或其药学上可接受的盐、制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2138865A1 (de) * 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
US5814644A (en) * 1993-04-15 1998-09-29 Merck Sharp & Dohme, Ltd. Indole derivatives as dopamine D4 antagonists
FR2712591B1 (fr) 1993-11-19 1996-02-09 Pf Medicament Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
AU7564296A (en) 1995-11-17 1997-06-11 Ciba-Geigy Ag Solid phase synthesis of heterocyclic compounds and combinatorial compound library
USH2007H1 (en) * 1996-01-19 2001-12-04 Fmc Corporation Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines
ES2128266B1 (es) * 1997-07-08 2000-01-16 Vita Invest Sa Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.
AU5486600A (en) 1999-06-15 2001-01-02 Aventis Pharmaceuticals Products Inc. Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
EP1246819A1 (en) * 1999-12-30 2002-10-09 H. Lundbeck A/S A method for the preparation of substituted benzene derivatives

Also Published As

Publication number Publication date
BG106930A (en) 2003-04-30
WO2001049678A1 (en) 2001-07-12
KR20020063287A (ko) 2002-08-01
ES2213634T3 (es) 2004-09-01
CN1437597A (zh) 2003-08-20
HUP0203722A2 (hu) 2003-03-28
WO2001049678A9 (en) 2002-10-10
BR0016952A (pt) 2002-10-08
ZA200204814B (en) 2003-08-27
TR200201683T2 (tr) 2002-12-23
IL150241A0 (en) 2002-12-01
EP1246816A1 (en) 2002-10-09
US20030125320A1 (en) 2003-07-03
DE60009155D1 (de) 2004-04-22
IS2174B (is) 2006-11-15
NZ519647A (en) 2004-02-27
EA006071B1 (ru) 2005-08-25
KR100790916B1 (ko) 2008-01-03
NO322666B1 (no) 2006-11-13
TR200400645T4 (tr) 2004-06-21
ATE261959T1 (de) 2004-04-15
HUP0203722A3 (en) 2005-03-29
EP1246816B1 (en) 2004-03-17
AR029428A1 (es) 2003-06-25
CN1230432C (zh) 2005-12-07
PT1246816E (pt) 2004-08-31
MXPA02006223A (es) 2002-12-05
JP2003519224A (ja) 2003-06-17
IS6420A (is) 2002-06-13
CA2395705A1 (en) 2001-07-12
NO20023146D0 (no) 2002-06-28
IL150241A (en) 2008-12-29
CZ20022319A3 (cs) 2002-10-16
NO20023146L (no) 2002-06-28
EA200200732A1 (ru) 2003-02-27
SK9442002A3 (en) 2002-11-06
AU2152101A (en) 2001-07-16
PL355539A1 (en) 2004-05-04
US6699864B2 (en) 2004-03-02
BG65262B1 (bg) 2007-10-31
CA2395705C (en) 2006-10-17
PL199351B1 (pl) 2008-09-30
DE60009155T2 (de) 2005-01-05

Similar Documents

Publication Publication Date Title
UA72948C2 (uk) Заміщені похідні фенілпіперазину, фармацевтична композиція та спосіб лікування афективних або неврологічних захворювань і розладів
MY140767A (en) Compounds, methods and compositions
WO2003103575A3 (en) COMPOUNDS, COMPOSITIONS AND METHODS
IL134089A0 (en) 1-(n-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of the phenyl ring
MXPA02012271A (es) Nuevos compuestos que poseen actividad antibacteriana, antifungal o antitumor.
EP1353672A4 (en) SYNTHESIS OF 3-AMINOTHALIDOMIDE AND ITS ENANTIOMER
PT1200412E (pt) Agentes anti-proliferativos de imidazole
DE60006280D1 (de) Beta 2 -adrenergische rezeptor-agonisten
BR9917038A (pt) Composto, composição farmacêutica, método de modulação da atividade receptora de quimocinas, método de tratamento ou prevenção de doenças inflamatórias, método de tratamento ou prevenção de asma e método de tratamento ou prevenção de disfunções inflamatórias
MXPA04007470A (es) Piridinonas sustituidas.
WO2004018058A3 (en) Compounds, compositions, and methods
MY140169A (en) Compounds, compositions, and methods
PL367682A1 (en) Dolastatin 10 derivatives
MXPA04005847A (es) Compuestos derivados de 4-sulfuro/sulfoxido/sulfonil-1h-pirazolilo, para uso en enfermedades asociadas con el receptor 5-ht2c.
UA66865C2 (uk) Інденопіролокарбазоли, фармацевтична композиція, спосіб інгібування кіназної активності та спосіб лікування (варіанти)
NO20052267L (no) Forbindelser, Preparater og Metoder
MY141528A (en) Anilinopyrazole derivatives useful for the treatment of diabetes
WO2004009036A3 (en) Compounds compositions and methods
IL147149A0 (en) Novel diphenyl-piperidine derivate
TW200640944A (en) VGF polypeptides and methods of treating VGF-related disorders
AU2003252025A8 (en) Compounds, compositions, and methods
HRP20010969B1 (en) Novel piperazinylalkylthiopyrimidine derivatives,
AP2001002188A0 (en) 5HT1 antagonists for antidepressant therapy.
WO2004034972A3 (en) Compounds, compositions, and methods
MXPA02001204A (es) Compuestos calciliticos.