AR018472A1 - Compuesto, composicion y metodo para el tratamiento de la perdida de cabello - Google Patents
Compuesto, composicion y metodo para el tratamiento de la perdida de cabelloInfo
- Publication number
- AR018472A1 AR018472A1 ARP000100917A ARP000100917A AR018472A1 AR 018472 A1 AR018472 A1 AR 018472A1 AR P000100917 A ARP000100917 A AR P000100917A AR P000100917 A ARP000100917 A AR P000100917A AR 018472 A1 AR018472 A1 AR 018472A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heteroalkynyl
- heteroalkenyl
- heteroalkyl
- alkynyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/90—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Abstract
Compuestos y composiciones particularmente utiles para tratar la pérdida del cabello en mamíferos, incluyendo detener y/o revertir y estimularel crecimiento de éste. Los compuestos tienen una estructura bifenílica (I) y, preferiblemente, no afectan al corazon, en donde: R1, R2, R5, R7 y R10 son cadauno de manera independiente, seleccionados entre hidrogeno, halogeno, alquilo, alquenilo, alquinilo, heteroalquilo, heteroalquenilo y heteroalquinilo;R4 es seleccionado entre el grupo consistente en halogeno, alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, arilo, arilalquilo, heteroalquilo,heteroalquenilo, heteroalquinilo, heterocicloalquilo, heterocicloalquenilo, heteroarilo, heteroarilalquilo, y heteroarilalquenilo; con lacondicionde que cuando R2 es hidrogeno, Y es -CH2CHK1, X es seleccionado entre -NZ- y -NH- y R12 es alquilo C1-4, en donde K1 es seleccionada entrehidrogeno y alquilo C1-4 y Z es alquilo C1-4, entonces R4 no sea arilalquilo; R8 y R9 son cada uno de manera independiente, seleccionados entre hidrogeno,halogeno, alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, arilo, arilalquilo, heteroalquilo, heteroalquenilo, heteroalquinilo, heterocicloalquilo,heterocicloalquenilo, heteroarilo, heteroarilalquilo y heteroarilalquenilo; con la condicion que por lo menos uno, entre R8 y R9, no sea hidrogeno; R3 esseleccionado entre hidrogeno, alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, arilo, arilalquilo, heteroalquilo, heteroalquenilo, heteroalquinilo,heterocicloalquilo, heterocicloalquenilo, heteroarilo, heteroarilalquilo y heteroarilalquenilo; Y es seleccionado entre un enlace, alquilo, alquenilo,alquinilo, heteroalquilo, heteroalquenilo y heteroalquinilo; X es seleccionado entre -NZ-, -NH- y -O-; R11 es seleccionado entre un enlace y -C(O)-; con lacondicion que cuando Y es un enlace y X es -O-, luego R11 será -C(O)-; y cuando Y es alquilo y X es -O- entonces R11 no será -C(O)-; R12 es seleccionado entrealquilo, alquenilo, alquinilo, heteroalquilo, heteroalquenilo, heteroalquinilo, cicloalquilo, cicloalquenilo, heterocicloalquilo, heterocicloalquenilo, arilo,
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13695899P | 1999-06-01 | 1999-06-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR018472A1 true AR018472A1 (es) | 2001-11-14 |
Family
ID=22475200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000100917A AR018472A1 (es) | 1999-06-01 | 2000-03-01 | Compuesto, composicion y metodo para el tratamiento de la perdida de cabello |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1183074A1 (es) |
JP (1) | JP2003500459A (es) |
AR (1) | AR018472A1 (es) |
AU (1) | AU3507600A (es) |
CA (1) | CA2375822A1 (es) |
MX (1) | MXPA01012491A (es) |
WO (1) | WO2000072920A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6664291B2 (en) | 2000-03-31 | 2003-12-16 | Pfizer, Inc. | Malonamic acids and derivatives thereof as thyroid receptor ligands |
DK1262177T3 (da) * | 2001-05-31 | 2006-11-20 | Pfizer Prod Inc | Medicinsk brug af thyromimetiske forbindelser til behandling af hårtab og kompositioner |
US7169564B1 (en) | 2001-06-26 | 2007-01-30 | Anaderm Research Corporation | FKBP51/52 and CyP40-mediated mammalian hair growth |
DE10131462A1 (de) * | 2001-06-29 | 2003-01-09 | Bayer Ag | Phenol-Derivate |
ES2253495T3 (es) | 2001-09-26 | 2006-06-01 | Pfizer Products Inc. | Acidos indol carboxilicos como ligandos de receptores tiroideos. |
US8741966B2 (en) | 2007-11-09 | 2014-06-03 | Pronova Biopharma Norge As | Lipid compounds for use in cosmetic products, as food supplement or as a medicament |
EP2147910A1 (en) | 2008-07-15 | 2010-01-27 | Pronova BioPharma Norge AS | Novel lipid compounds |
JP5843755B2 (ja) | 2009-05-08 | 2016-01-13 | プロノヴァ・バイオファーマ・ノルゲ・アーエスPronova BioPharma Norge AS | 心血管性、代謝性および炎症性疾患領域に関する疾患の処置のための多価不飽和脂肪酸 |
SG190114A1 (en) | 2010-11-05 | 2013-07-31 | Pronova Biopharma Norge As | Methods of treatment using lipid compounds |
DK2695611T3 (en) | 2012-08-06 | 2015-01-05 | Wolff August Gmbh & Co Kg Arzneimittel Dr | Eprotirome for use in the prevention and / or treatment of hair disorders and their compositions |
MX2015011074A (es) | 2013-02-28 | 2016-03-09 | Pronova Biopharma Norge As | Composicion que comprende un compuesto lipido, un triglicerido y un tensioactivo, y metodos de uso de la misma. |
JP6784696B2 (ja) | 2015-04-28 | 2020-11-11 | プロノヴァ バイオファーマ ノルゲ エーエス | 硫黄を含有する構造的に強化された脂肪酸の非アルコール性脂肪性肝炎の予防及び/又は治療のための使用 |
KR20200096791A (ko) | 2017-12-06 | 2020-08-13 | 바스프 에이에스 | 비알콜성 지방간염 치료용 지방산 유도체 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69314718T2 (de) * | 1992-07-21 | 1998-02-26 | Ciba Geigy Ag | Oxamidsäure-Derivate als hypocholesterämische Mittel |
EP0812210A4 (en) * | 1995-02-23 | 1998-08-19 | Life Medical Sciences Inc | COMPOSITIONS AND METHODS FOR INCREASING HAIR GROWTH AND MAINTAINING THE HAIR COLOR |
-
2000
- 2000-03-01 MX MXPA01012491A patent/MXPA01012491A/es unknown
- 2000-03-01 CA CA002375822A patent/CA2375822A1/en not_active Abandoned
- 2000-03-01 AU AU35076/00A patent/AU3507600A/en not_active Abandoned
- 2000-03-01 EP EP00913676A patent/EP1183074A1/en not_active Withdrawn
- 2000-03-01 WO PCT/US2000/005251 patent/WO2000072920A1/en not_active Application Discontinuation
- 2000-03-01 JP JP2000621024A patent/JP2003500459A/ja active Pending
- 2000-03-01 AR ARP000100917A patent/AR018472A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA01012491A (es) | 2002-07-02 |
AU3507600A (en) | 2000-12-18 |
CA2375822A1 (en) | 2000-12-07 |
WO2000072920A1 (en) | 2000-12-07 |
JP2003500459A (ja) | 2003-01-07 |
EP1183074A1 (en) | 2002-03-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |