DK0736039T3 - Forbindelser med væksthormon-frigivende egenskaber - Google Patents

Forbindelser med væksthormon-frigivende egenskaber

Info

Publication number: DK0736039T3
Authority: DK; Denmark
Prior art keywords: growth hormone; compounds; pct; releasing properties; date jun
Prior art date: 1993-12-23

Application number

DK95903774T

Other languages

English (en)

Inventor

Nils Langeland Johansen

Behrend Friedrich Lundt

Jesper Lau

Kjeld Madsen

Gersen Henning Th

Birgit Sehested Hansen

Bernd Peschke

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-23

Filing date

1994-12-22

Publication date

2001-02-12

1993-12-23 Priority claimed from DK143993A external-priority patent/DK143993D0/da

1994-12-22 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2001-02-12 Application granted granted Critical

2001-02-12 Publication of DK0736039T3 publication Critical patent/DK0736039T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

DK95903774T 1993-12-23 1994-12-22 Forbindelser med væksthormon-frigivende egenskaber DK0736039T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DK143993A DK143993D0 (da)	1993-12-23	1993-12-23
DK12194		1994-01-28
DK119194		1994-10-14
PCT/DK1994/000485 WO1995017423A1 (en)	1993-12-23	1994-12-22	Compounds with growth hormone releasing properties

Publications (1)

Publication Number	Publication Date
DK0736039T3 true DK0736039T3 (da)	2001-02-12

Family

ID=27220421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95903774T DK0736039T3 (da)	1993-12-23	1994-12-22	Forbindelser med væksthormon-frigivende egenskaber

Country Status (27)

Country	Link
US (1)	US5767085A (da)
EP (1)	EP0736039B1 (da)
JP (1)	JP3181918B2 (da)
KR (1)	KR100354897B1 (da)
CN (1)	CN1052731C (da)
AT (1)	ATE197158T1 (da)
AU (1)	AU689181B2 (da)
BR (1)	BR9408377A (da)
CA (1)	CA2179597A1 (da)
CZ (1)	CZ293113B6 (da)
DE (1)	DE69426206T2 (da)
DK (1)	DK0736039T3 (da)
ES (1)	ES2153469T3 (da)
FI (1)	FI962584A (da)
GR (1)	GR3035150T3 (da)
HU (1)	HU224345B1 (da)
IL (1)	IL112112A (da)
MX (1)	MX9500072A (da)
NO (1)	NO315561B1 (da)
NZ (1)	NZ277486A (da)
PL (1)	PL181280B1 (da)
PT (1)	PT736039E (da)
RO (1)	RO115635B1 (da)
SG (1)	SG55069A1 (da)
SK (1)	SK281963B6 (da)
UA (1)	UA42747C2 (da)
WO (1)	WO1995017423A1 (da)

Families Citing this family (55)

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CA2176140A1 (en) *	1993-11-24	1995-06-01	Meng Hsin Chen	Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s)
US5854211A (en) *	1993-12-23	1998-12-29	Novo Nordisk A/S	Compounds with growth hormone releasing properties
US5798337A (en) *	1994-11-16	1998-08-25	Genentech, Inc.	Low molecular weight peptidomimetic growth hormone secretagogues
US20020111461A1 (en) *	1999-05-21	2002-08-15	Todd C. Somers	Low molecular weight peptidomimetic growth hormone secretagogues
ATE272069T1 (de) *	1995-01-27	2004-08-15	Novo Nordisk As	Verbindungen mit wachstumshormon-freisetzenden eigenschaften
AU711104B2 (en) *	1995-06-22	1999-10-07	Novo Nordisk A/S	Compounds with growth hormone releasing properties
ATE334394T1 (de)	1995-12-13	2006-08-15	Merck & Co Inc	Testverfahren für die sekretionsrezeptoren von wachstumshormonen
US6531314B1 (en)	1996-12-10	2003-03-11	Merck & Co., Inc.	Growth hormone secretagogue receptor family
GB2308362A (en) *	1995-12-19	1997-06-25	Lilly Industries Ltd	Pharmaceutical indole derivatives
EP0869974B1 (en) *	1995-12-22	2009-03-04	Novo Nordisk A/S	Compounds with growth hormone releasing properties
US6451970B1 (en)	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives
US5919777A (en) *	1996-04-24	1999-07-06	Novo Nordisk A/S	Compounds with growth hormone releasing properties
CZ291982B6 (cs) *	1996-04-24	2003-06-18	Novo Nordisk A/S	Diamidový derivát uvolňující růstový hormon, jeho použití, farmaceutické prostředky ho obsahující a způsob stimulace uvolňování růstového hormonu
DE69734215T2 (de) *	1996-07-22	2006-06-29	Novo Nordisk A/S	Verbindungen mit Wachstumshormon-freisetzenden Eigenschaften
WO1998008492A1 (en) *	1996-08-29	1998-03-05	Novo Nordisk A/S	Transdermal delivery of peptides
US6420518B1 (en)	1997-04-04	2002-07-16	Genetech, Inc.	Insulin-like growth factor agonist molecules
US6121416A (en)	1997-04-04	2000-09-19	Genentech, Inc.	Insulin-like growth factor agonist molecules
EP1005484A1 (en)	1997-06-20	2000-06-07	Novo Nordisk A/S	Compounds with growth hormone releasing properties
US6127341A (en) *	1997-06-20	2000-10-03	Novo Nordisk A/S	Compounds with growth hormone releasing properties
JP4382279B2 (ja)	1998-01-16	2009-12-09	サファイアセラピューティクス，インコーポレイティド	成長ホルモン放出特性を有する化合物
US6919315B1 (en)	1998-06-30	2005-07-19	Novo Nordisk A/S	Compounds with growth hormone releasing properties
US6682908B1 (en)	1998-07-10	2004-01-27	Merck & Co., Inc.	Mouse growth hormone secretagogue receptor
EP1097170A1 (en)	1998-07-13	2001-05-09	Merck & Co., Inc.	Growth hormone secretagogue related receptors and nucleic acids
CA2340095A1 (en)	1998-08-10	2000-02-24	Merck & Co., Inc.	Canine growth hormone secretagogue receptor
US6696063B1 (en) *	1998-12-30	2004-02-24	Applied Research Systems Ars Holding N.V.	Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
PT1141014E (pt)	1999-01-06	2005-04-29	Genentech Inc	Variante mutante do factor de crescimento semelhante a insulina (igf-i)
AU759022B2 (en) *	1999-02-18	2003-04-03	Kaken Pharmaceutical Co., Ltd.	Novel amide derivatives as growth hormone secretagogues
CA2375148A1 (en) *	1999-06-04	2000-12-14	Novo Nordisk A/S	Compositions for the treatment of the catabolic state of prolonged critical illness
EP1282437B1 (en)	2000-05-16	2008-03-19	Genentech, Inc.	Treatment of cartilage disorders
ATE446758T1 (de)	2000-05-31	2009-11-15	Pfizer Prod Inc	Verwendung von wachstumshormonsekretagoga zur förderung der beweglichkeit des verdauungstrakts
TWI331922B (en)	2002-08-09	2010-10-21	Ipsen Pharma Sas	Growth hormone releasing peptides
CN1791387A (zh) *	2003-05-19	2006-06-21	沃尼尔·朗伯有限责任公司	含有控制粒径二氧化钛的硬明胶胶囊及其生产方法
US7476653B2 (en)	2003-06-18	2009-01-13	Tranzyme Pharma, Inc.	Macrocyclic modulators of the ghrelin receptor
DK2274978T3 (da)	2003-09-12	2015-06-15	Ipsen Biopharmaceuticals Inc	Fremgangsmåder til behandling af en insulin-lignende vækstfaktor-I(IGF-I)-mangel
WO2005027913A1 (en) *	2003-09-19	2005-03-31	Pfizer Products Inc.	Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue
EP1735055A1 (en) *	2004-03-30	2006-12-27	Sapphire Therapeutics, Inc.	Method of reducing c-reactive protein using growth hormone secretagogues
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
ES2388501T3 (es) *	2004-08-12	2012-10-16	Helsinn Healthcare S.A.	Uso de secretagogos de la hormona de crecimiento para estimular la motilidad del sistema gastrointestinal
CU23558A1 (es)	2006-02-28	2010-07-20	Ct Ingenieria Genetica Biotech	Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
WO2007127457A2 (en) *	2006-04-28	2007-11-08	The Administrators Of The Tulane Educational Fund	Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof
JP2010518090A (ja)	2007-02-09	2010-05-27	トランザイム・ファーマ，インコーポレイテッド	大環状グレリン受容体修飾因子およびその使用方法
MX2009008561A (es) *	2007-02-13	2010-01-15	Helsinn Therapeutics Us Inc	Metodo para tratar trastornos proliferativos celulares utilizando secretagogos.
TWI429436B (zh) *	2007-04-10	2014-03-11	Helsinn Therapeutics Us Inc	使用生長激素促泌素治療或預防嘔吐之方法
US20100099640A1 (en)	2007-05-04	2010-04-22	Joannes Geuns	Tissue degeneration protection
EP2225226B1 (en)	2007-12-26	2016-08-17	Critical Outcome Technologies, Inc.	Compounds and their use in a method for treatment of cancer
CA2730890C (en)	2008-07-17	2018-05-15	Critical Outcome Technologies Inc.	Thiosemicarbazone inhibitor compounds and cancer treatment methods
UA105657C2 (uk)	2009-02-27	2014-06-10	Хелсінн Терапьютікс (Ю.Ес.), Інк.	Поліпшені способи лікування мігрені на основі анамореліну
US9724381B2 (en)	2009-05-12	2017-08-08	The Administrators Of The Tulane Educational Fund	Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
EP2440180B1 (en)	2009-06-12	2014-08-27	Helsinn Healthcare S.A.	Ipamorelin diacetate injection and infusion solutions
EP3235818A3 (en)	2010-04-01	2018-03-14	Critical Outcome Technologies, Inc.	Compounds for the treatment of hiv
WO2013190520A2 (en)	2012-06-22	2013-12-27	The General Hospital Corporation	Gh-releasing agents in the treatment of vascular stenosis and associated conditions
US9119832B2 (en)	2014-02-05	2015-09-01	The Regents Of The University Of California	Methods of treating mild brain injury
KR20160147007A (ko)	2014-05-30	2016-12-21	화이자 인코포레이티드	선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체
WO2017075535A1 (en)	2015-10-28	2017-05-04	Oxeia Biopharmaceuticals, Inc.	Methods of treating neurodegenerative conditions
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators

Family Cites Families (10)

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US4228156A (en) *	1979-03-30	1980-10-14	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4223020A (en) *	1979-03-30	1980-09-16	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4223019A (en) *	1979-03-30	1980-09-16	Beckman Instruments, Inc.	Synthetic peptides having pituitary growth hormone releasing activity
US4410512A (en) *	1981-12-28	1983-10-18	Beckman Instruments, Inc.	Combinations having synergistic pituitary growth hormone releasing activity
WO1983002272A1 (en) *	1981-12-28	1983-07-07	Beckman Instruments Inc	Synthetic peptides having pituitary growth hormone releasing activity
US4803261A (en) *	1986-06-27	1989-02-07	The Administrators Of The Tulane Educational Fund	Method for synthesizing a peptide containing a non-peptide
IL98910A0 (en) *	1990-07-24	1992-07-15	Polygen Holding Corp	Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them
US5663146A (en) *	1991-08-22	1997-09-02	Administrators Of The Tulane Educational Fund	Polypeptide analogues having growth hormone releasing activity
WO1994007519A1 (en) *	1992-09-25	1994-04-14	Smithkline Beecham Corporation	Growth hormone releasing peptides
CA2176140A1 (en) *	1993-11-24	1995-06-01	Meng Hsin Chen	Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s)

1994
- 1994-12-22 WO PCT/DK1994/000485 patent/WO1995017423A1/en active IP Right Grant
- 1994-12-22 US US08/448,623 patent/US5767085A/en not_active Expired - Lifetime
- 1994-12-22 DE DE69426206T patent/DE69426206T2/de not_active Expired - Lifetime
- 1994-12-22 JP JP51710995A patent/JP3181918B2/ja not_active Expired - Lifetime
- 1994-12-22 IL IL11211294A patent/IL112112A/xx not_active IP Right Cessation
- 1994-12-22 AU AU12724/95A patent/AU689181B2/en not_active Ceased
- 1994-12-22 CZ CZ19961834A patent/CZ293113B6/cs not_active IP Right Cessation
- 1994-12-22 DK DK95903774T patent/DK0736039T3/da active
- 1994-12-22 NZ NZ277486A patent/NZ277486A/en unknown
- 1994-12-22 SK SK820-96A patent/SK281963B6/sk unknown
- 1994-12-22 PL PL94315113A patent/PL181280B1/pl not_active IP Right Cessation
- 1994-12-22 KR KR1019960703336A patent/KR100354897B1/ko not_active IP Right Cessation
- 1994-12-22 PT PT95903774T patent/PT736039E/pt unknown
- 1994-12-22 CA CA002179597A patent/CA2179597A1/en not_active Abandoned
- 1994-12-22 EP EP95903774A patent/EP0736039B1/en not_active Expired - Lifetime
- 1994-12-22 ES ES95903774T patent/ES2153469T3/es not_active Expired - Lifetime
- 1994-12-22 HU HU9501947A patent/HU224345B1/hu not_active IP Right Cessation
- 1994-12-22 SG SG1996004604A patent/SG55069A1/en unknown
- 1994-12-22 BR BR9408377A patent/BR9408377A/pt not_active Application Discontinuation
- 1994-12-22 RO RO96-01293A patent/RO115635B1/ro unknown
- 1994-12-22 AT AT95903774T patent/ATE197158T1/de not_active IP Right Cessation
- 1994-12-22 UA UA96062486A patent/UA42747C2/uk unknown
- 1994-12-22 CN CN94194590A patent/CN1052731C/zh not_active Expired - Fee Related
1995
- 1995-01-02 MX MX9500072A patent/MX9500072A/es unknown
1996
- 1996-06-20 FI FI962584A patent/FI962584A/fi not_active IP Right Cessation
- 1996-06-21 NO NO19962665A patent/NO315561B1/no not_active IP Right Cessation
2000
- 2000-12-27 GR GR20000402838T patent/GR3035150T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
SK82096A3 (en)	1997-01-08
UA42747C2 (uk)	2001-11-15
JPH09507217A (ja)	1997-07-22
CZ183496A3 (en)	1997-02-12
CA2179597A1 (en)	1995-06-29
SG55069A1 (en)	1998-12-21
FI962584A0 (fi)	1996-06-20
NZ277486A (en)	1997-03-24
HUT73497A (en)	1996-08-28
JP3181918B2 (ja)	2001-07-03
GR3035150T3 (en)	2001-04-30
NO962665D0 (no)	1996-06-21
EP0736039B1 (en)	2000-10-25
MX9500072A (es)	1997-05-31
PL181280B1 (pl)	2001-07-31
PL315113A1 (en)	1996-10-14
DE69426206T2 (de)	2001-05-17
NO315561B1 (no)	2003-09-22
CZ293113B6 (cs)	2004-02-18
CN1052731C (zh)	2000-05-24
ATE197158T1 (de)	2000-11-15
SK281963B6 (sk)	2001-09-11
US5767085A (en)	1998-06-16
WO1995017423A1 (en)	1995-06-29
RO115635B1 (ro)	2000-04-28
EP0736039A1 (en)	1996-10-09
FI962584A (fi)	1996-06-20
DE69426206D1 (de)	2000-11-30
IL112112A (en)	2000-06-29
AU1272495A (en)	1995-07-10
HU9501947D0 (en)	1995-11-28
ES2153469T3 (es)	2001-03-01
PT736039E (pt)	2001-04-30
NO962665L (no)	1996-08-23
HU224345B1 (hu)	2005-08-29
BR9408377A (pt)	1997-08-19
IL112112A0 (en)	1995-03-15
KR100354897B1 (ko)	2003-01-06
CN1138335A (zh)	1996-12-18
AU689181B2 (en)	1998-03-26

Publication	Publication Date	Title
DK0736039T3 (da)	2001-02-12	Forbindelser med væksthormon-frigivende egenskaber
KR960701051A (ko)	1996-02-24	이미다조피리딘 및 이를 위장 질환의 치료에 사용하는 방법(imidazopyridines and their use in treating castrointestinal diseases)
DK0804223T3 (da)	2000-01-24	Farmaceutiske præparater indeholdende hGH
IL126235A (en)	2003-02-12	Compounds with growth hormone releasing properties, pharmaceutical compositions comprising them and their use
BR9906975A (pt)	2000-10-17	Composto, uso do mesmo, composição farmacêutica, e, processo para estimular a liberação do hormÈnio do crescimento pela pituitária de um mamìfero
AU6722498A (en)	1998-09-22	Disubstituted biphenyloxazolines
GB9015774D0 (en)	1990-09-05	Novel treatment
MX9710377A (es)	1998-03-29	Compuestos con propiedades de liberacion de la hormona de crecimiento.
NO306343B1 (no)	1999-10-25	Difluorstaton-analoger
PL309339A1 (en)	1995-10-02	Novel triazoquinazolines, methods of obtaining them and their application
NO950114L (no)	1995-03-10	Amylin-antagonister og agonister
MY106292A (en)	1995-04-29	(alpha)-adrenergic receptor antagonists.