AR015512A1 - Derivados ciclicos n-acilo amina, un procedimiento para su preparacion, un intermediario y una composicion farmaceutica - Google Patents
Derivados ciclicos n-acilo amina, un procedimiento para su preparacion, un intermediario y una composicion farmaceuticaInfo
- Publication number
- AR015512A1 AR015512A1 ARP990100449A ARP990100449A AR015512A1 AR 015512 A1 AR015512 A1 AR 015512A1 AR P990100449 A ARP990100449 A AR P990100449A AR P990100449 A ARP990100449 A AR P990100449A AR 015512 A1 AR015512 A1 AR 015512A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- lower alkyl
- substitutable
- combined
- alkyl group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Derivados cíclicos N-acilo de amina, caracterizado porque comprende compuestos representados por la formula general (I) y además las salesfarmacéuticamente aceptables, en la cual Ar significa un grupo arilo o un grupo heteroarilo que puede tener un grupo substituyente seleccionado del grupo queconsiste en un átomo de halogeno, un grupo alquilo inferior y un grupo alcoxi inferior; R1 significa un grupo cicloalquilo C3-6 que es substituible con unátomo de fluor; R2 significa un átomo de hidrogenoo un grupo representado por -(A1)m-NH-B; o, combinado con R3, significa un grupo representado por =A2-NH-B;o, conjuntamente con un átomo adyacente de los átomos de C del anillo, significa un grupo heterocíclico alifático C2-8 que contiene nitrogeno,que contiene ungrupo imino, que es substituible con un grupo alquilo inferior, o un grupo carbocíclico alifático C3-8 que tiene en el anillo, un grupo representado por-(A1)m-NH-B, que es substituible con un grupo alquilo inferior; o, combinado con R4, conjuntamente con los 2 átomos de C adyacentes en el anillo, significa ungrupo heterocíclico alifático C2-8 que contiene nitrogeno que tiene un grupo imino que es substituible con un grupo alquilo inferior; R3 significa un átomo dehidrogeno o un grupo hidrocarbonado alifático C1-6 que es substituible con un grupo alquilo inferior; o combinado con R5, significa un enlace simple; ocombinado con R2, significa el mismo que el precedente; R4 significa un átomo de hidrogeno o un grupo representadopor -(A1)m-NH-B, o combinado con R5,significa un grupo representado por =A2-NH-B o, conjuntamente con uno de los átomos de C adyacentes en el anillo, significa un grupo heterocíclico alifáticoC2-8 que contiene nitrogeno que tiene un grupo imino que es substituible con un grupo alquilo inferior, o un grupo carbocíclico alifático C3-8 que tiene en elanillo un grupo representado por -(A1)m-NH-B, que es substituible con un grupo alquilo inferior; o, combinado con R2, significa lo mismo que anteriormente; R5significa un átomo de hidrogeno o un grupo hidrocarbonado alifático C1-6 que es substituible con un grupo alquilo inferior; o, combinado con R3 o R4, significa
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3806398 | 1998-02-04 | ||
JP22872698 | 1998-07-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR015512A1 true AR015512A1 (es) | 2001-05-02 |
Family
ID=26377245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990100449A AR015512A1 (es) | 1998-02-04 | 1999-02-03 | Derivados ciclicos n-acilo amina, un procedimiento para su preparacion, un intermediario y una composicion farmaceutica |
Country Status (24)
Country | Link |
---|---|
US (1) | US6140333A (es) |
EP (1) | EP1061076B1 (es) |
JP (1) | JP3613179B2 (es) |
KR (1) | KR20010040693A (es) |
CN (1) | CN1290251A (es) |
AR (1) | AR015512A1 (es) |
AT (1) | ATE284389T1 (es) |
AU (1) | AU745995B2 (es) |
BG (1) | BG104663A (es) |
BR (1) | BR9908351A (es) |
CA (1) | CA2317444C (es) |
DE (1) | DE69922494T2 (es) |
EE (1) | EE200000458A (es) |
ES (1) | ES2235458T3 (es) |
HR (1) | HRP20000495B1 (es) |
HU (1) | HUP0102404A2 (es) |
IL (1) | IL137166A0 (es) |
IS (1) | IS5580A (es) |
PE (1) | PE20000263A1 (es) |
PL (1) | PL342735A1 (es) |
SK (1) | SK11402000A3 (es) |
TR (1) | TR200002241T2 (es) |
WO (1) | WO1999040070A1 (es) |
YU (1) | YU41100A (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000031078A1 (fr) * | 1998-11-20 | 2000-06-02 | Banyu Pharmaceutical Co., Ltd. | Derives de 1-acetylazetidine |
US6476046B1 (en) | 2000-12-04 | 2002-11-05 | Sepracor, Inc. | Diazabicyclo[4.3.0]nonanes, and methods of use thereof |
WO2002070523A1 (en) * | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
SE0202133D0 (sv) | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
SE0302811D0 (sv) * | 2003-10-23 | 2003-10-23 | Astrazeneca Ab | Novel compounds |
SE0303090D0 (sv) | 2003-11-20 | 2003-11-20 | Astrazeneca Ab | Novel compounds |
SE0303541D0 (sv) | 2003-12-22 | 2003-12-22 | Astrazeneca Ab | New compounds |
CN1980929A (zh) * | 2004-02-24 | 2007-06-13 | 比奥阿克松医疗技术股份有限公司 | 4-取代哌啶衍生物 |
EP2146957B1 (en) | 2007-04-24 | 2013-06-12 | Theravance, Inc. | Quaternary ammonium compounds useful as muscarinic receptor antagonists |
BRPI0816219B8 (pt) | 2007-09-07 | 2021-05-25 | Theravance Biopharma R&D Ip Llc | compostos contendo guanidina úteis como antagonistas de receptor muscarínico, composição farmacêutica e uso |
US8017617B2 (en) * | 2007-12-14 | 2011-09-13 | Theravance, Inc. | Amidine-containing compounds useful as muscarinic receptor antagonists |
RU2010140613A (ru) * | 2008-03-05 | 2012-04-10 | Таргасепт, Инк. (Us) | Амиды диазабициклоалканов, селективные в отношении подтипа никотиновых ацетилхолиновых рецепторов |
US8278313B2 (en) | 2008-03-11 | 2012-10-02 | Abbott Laboratories | Macrocyclic spiro pyrimidine derivatives |
US8436005B2 (en) | 2008-04-03 | 2013-05-07 | Abbott Laboratories | Macrocyclic pyrimidine derivatives |
US8796297B2 (en) | 2009-06-30 | 2014-08-05 | Abbvie Inc. | 4-substituted-2-amino-pyrimidine derivatives |
PT2861566T (pt) | 2012-06-13 | 2017-02-08 | Hoffmann La Roche | Novos diazaspirocicloalcanos e azaspirocicloalcanos |
UA116547C2 (uk) | 2012-09-25 | 2018-04-10 | Ф. Хоффманн-Ля Рош Аг | Біциклічні похідні |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
JP2016512511A (ja) | 2013-03-13 | 2016-04-28 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | ヒト免疫不全ウイルス複製の阻害剤 |
DK3074400T3 (en) | 2013-11-26 | 2018-01-15 | Hoffmann La Roche | Octahydro-cyclobuta [1,2-c; 3,4-c '] dipyrrole derivatives as autotaxin inhibitors |
UA119347C2 (uk) | 2014-03-26 | 2019-06-10 | Ф. Хоффманн-Ля Рош Аг | Конденсовані [1,4]діазепінові сполуки як інгібітори продукції аутотаксину (atх) та лізофосфатидилової кислоти (lpa) |
MA50635A (fr) | 2014-03-26 | 2020-08-12 | Hoffmann La Roche | Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique |
US10149856B2 (en) | 2015-01-26 | 2018-12-11 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors |
US10857157B2 (en) | 2015-01-26 | 2020-12-08 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors |
US9687483B2 (en) | 2015-01-26 | 2017-06-27 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with Rho kinase inhibitors |
US10106525B2 (en) | 2015-01-26 | 2018-10-23 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
KR20180043837A (ko) | 2015-09-04 | 2018-04-30 | 에프. 호프만-라 로슈 아게 | 페녹시메틸 유도체 |
CA2983782A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
WO2017050791A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
CN107922412B (zh) | 2015-09-24 | 2021-02-23 | 豪夫迈·罗氏有限公司 | 作为atx抑制剂的二环化合物 |
CA2984585A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
US11198680B2 (en) | 2016-12-21 | 2021-12-14 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ.ホフマン-ラ ロシュ アーゲー | Atxインヒビターとしての新規二環式化合物 |
CR20190423A (es) | 2017-03-16 | 2019-11-01 | Hoffmann La Roche | Nuevos compuestos biciclícos como inhibidores dobles de atx/ca |
US10537567B2 (en) | 2017-07-11 | 2020-01-21 | BioAxone BioSciences, Inc. | Kinase inhibitors for treatment of disease |
US11918581B2 (en) | 2021-01-11 | 2024-03-05 | Incyte Corporation | Combination therapy comprising JAK pathway inhibitor and rock inhibitor |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9000301D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Piperidine & pyrrolidine derivatives |
GB9202443D0 (en) * | 1992-02-05 | 1992-03-18 | Fujisawa Pharmaceutical Co | A novel substituted-acetamide compound and a process for the preparation thereof |
WO1995021820A1 (fr) * | 1994-02-10 | 1995-08-17 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveau derive du carbamate et composition correspondante |
JPH07258250A (ja) * | 1994-03-25 | 1995-10-09 | Yamanouchi Pharmaceut Co Ltd | エステル誘導体 |
JPH08198751A (ja) * | 1995-01-19 | 1996-08-06 | Yamanouchi Pharmaceut Co Ltd | カルバメート誘導体 |
JPH08291141A (ja) * | 1995-04-21 | 1996-11-05 | Kotobuki Seiyaku Kk | ジフェニル酢酸誘導体及びその製造法 |
JPH09278749A (ja) * | 1996-04-10 | 1997-10-28 | Taisho Pharmaceut Co Ltd | 複素環誘導体 |
JPH09278751A (ja) * | 1996-04-12 | 1997-10-28 | Taisho Pharmaceut Co Ltd | ピペラジン誘導体 |
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1999
- 1999-02-03 EE EEP200000458A patent/EE200000458A/xx unknown
- 1999-02-03 AT AT99902825T patent/ATE284389T1/de not_active IP Right Cessation
- 1999-02-03 TR TR2000/02241T patent/TR200002241T2/xx unknown
- 1999-02-03 CN CN99802687A patent/CN1290251A/zh active Pending
- 1999-02-03 CA CA002317444A patent/CA2317444C/en not_active Expired - Fee Related
- 1999-02-03 JP JP2000530500A patent/JP3613179B2/ja not_active Expired - Fee Related
- 1999-02-03 SK SK1140-2000A patent/SK11402000A3/sk unknown
- 1999-02-03 AR ARP990100449A patent/AR015512A1/es unknown
- 1999-02-03 BR BR9908351-5A patent/BR9908351A/pt not_active Application Discontinuation
- 1999-02-03 IL IL13716699A patent/IL137166A0/xx unknown
- 1999-02-03 WO PCT/JP1999/000462 patent/WO1999040070A1/ja active IP Right Grant
- 1999-02-03 KR KR1020007008571A patent/KR20010040693A/ko not_active Application Discontinuation
- 1999-02-03 PL PL99342735A patent/PL342735A1/xx unknown
- 1999-02-03 YU YU41100A patent/YU41100A/sh unknown
- 1999-02-03 HU HU0102404A patent/HUP0102404A2/hu unknown
- 1999-02-03 DE DE69922494T patent/DE69922494T2/de not_active Expired - Lifetime
- 1999-02-03 EP EP99902825A patent/EP1061076B1/en not_active Expired - Lifetime
- 1999-02-03 ES ES99902825T patent/ES2235458T3/es not_active Expired - Lifetime
- 1999-02-03 AU AU22986/99A patent/AU745995B2/en not_active Ceased
- 1999-02-04 US US09/244,985 patent/US6140333A/en not_active Expired - Fee Related
- 1999-02-04 PE PE1999000093A patent/PE20000263A1/es not_active Application Discontinuation
-
2000
- 2000-07-21 HR HR20000495A patent/HRP20000495B1/xx not_active IP Right Cessation
- 2000-08-02 IS IS5580A patent/IS5580A/is unknown
- 2000-08-04 BG BG104663A patent/BG104663A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2317444A1 (en) | 1999-08-12 |
HRP20000495A2 (en) | 2003-06-30 |
YU41100A (sh) | 2002-06-19 |
TR200002241T2 (tr) | 2000-11-21 |
IS5580A (is) | 2000-08-02 |
EP1061076A1 (en) | 2000-12-20 |
EE200000458A (et) | 2002-02-15 |
HUP0102404A2 (hu) | 2001-11-28 |
AU745995B2 (en) | 2002-04-11 |
WO1999040070A1 (fr) | 1999-08-12 |
KR20010040693A (ko) | 2001-05-15 |
PL342735A1 (en) | 2001-07-02 |
PE20000263A1 (es) | 2000-04-25 |
EP1061076B1 (en) | 2004-12-08 |
BR9908351A (pt) | 2001-11-20 |
AU2298699A (en) | 1999-08-23 |
DE69922494T2 (de) | 2005-05-25 |
HRP20000495B1 (en) | 2005-12-31 |
IL137166A0 (en) | 2001-07-24 |
ES2235458T3 (es) | 2005-07-01 |
EP1061076A4 (en) | 2001-05-02 |
US6140333A (en) | 2000-10-31 |
CN1290251A (zh) | 2001-04-04 |
BG104663A (en) | 2001-09-28 |
SK11402000A3 (sk) | 2001-03-12 |
ATE284389T1 (de) | 2004-12-15 |
DE69922494D1 (de) | 2005-01-13 |
CA2317444C (en) | 2008-12-02 |
JP3613179B2 (ja) | 2005-01-26 |
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