AR004677A1 - Derivados de la 4-sulfonilbenzoilguanidina o 4-sulfinilbenzoilguanidina, procedimiento para prepararlos y composiciones farmaceuticas que los contienen - Google Patents

Derivados de la 4-sulfonilbenzoilguanidina o 4-sulfinilbenzoilguanidina, procedimiento para prepararlos y composiciones farmaceuticas que los contienen

Info

Publication number
AR004677A1
AR004677A1 ARP960103933A AR10393396A AR004677A1 AR 004677 A1 AR004677 A1 AR 004677A1 AR P960103933 A ARP960103933 A AR P960103933A AR 10393396 A AR10393396 A AR 10393396A AR 004677 A1 AR004677 A1 AR 004677A1
Authority
AR
Argentina
Prior art keywords
hal
carbon atoms
preparing
ch2f
chf2
Prior art date
Application number
ARP960103933A
Other languages
English (en)
Original Assignee
Merck Patent Ges Mit Beschränkter Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7769293&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR004677(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Ges Mit Beschränkter Haftung filed Critical Merck Patent Ges Mit Beschränkter Haftung
Publication of AR004677A1 publication Critical patent/AR004677A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Leads Or Probes (AREA)

Abstract

El invento se referie a las 4-sulfonilbenzoilguanidinas o 4- sulfinil benzoilguanidinas de fórmula (I), en la que R1 es A, CF3, CH2F, CHF2, C2F5, CN,NO2 o Hal, R2 es -SOnR6, -SO2NR4R5, NO2, ó CF3; R3es H, Hal, A, OH, OA, CN, NO2, CF3,CH2F, CHF2, C2F5 ó CH2CF3; R4 y R5 son independientemente H, A,cicloalquilo de 5 a 7 átomos de C, cicloalquilmetilo de 4 a 8 átomos de C, Ph ó -CH2-Ph; o bien R4 y R5 son juntos alquileno de 4 a 5 átomos de C, en dondeun grupo CH2 también puedeser reem plazado por O, S, NH, N-A ó N-CH2-Ph; R6 es A, PH, Het o cicloalquilo (C3-7), Het representa un heterociclo de uno o dosnúcleos, saturado, insaturado o aromático, con 1 a 4 átomos de N, O y/o S, unido a través del N ó C, que puedeestar no sust ituido o sustituido una, dos otres veces con Hal, SH, SA, NH2, NHA, NA2, CF3, A, OH, OA, CN, NO2, y/o carboniloxi; A es alquilo de 1 a 6 átomos de C; Hal es F, Cl, Br ó I; Phes fenilo no sustituido o sustituido una, dos o tresveces con A, OA , NR4R5, F, Cl, Br, I ó CF3 y n es 1 ó 2; y sus sales aceptables desde el punto devista fisiológico. También se refiere a un procedimiento para preparar dichos compuestos, a preparaciones farmacéuticas que los contienen y alempleo de losmismos para el tratamiento de las arritmias, de la angina de pecho, infartos y también para el tratamiento preventivo de estas enfermedades. Los nuevoscompuestos del invento poseen propiedades antiarrítmicas y un efecto inhibidor delmecanismo de intercam bio de Na+/H+ de la células
ARP960103933A 1995-08-11 1996-08-09 Derivados de la 4-sulfonilbenzoilguanidina o 4-sulfinilbenzoilguanidina, procedimiento para prepararlos y composiciones farmaceuticas que los contienen AR004677A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19529612A DE19529612A1 (de) 1995-08-11 1995-08-11 Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate

Publications (1)

Publication Number Publication Date
AR004677A1 true AR004677A1 (es) 1999-03-10

Family

ID=7769293

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103933A AR004677A1 (es) 1995-08-11 1996-08-09 Derivados de la 4-sulfonilbenzoilguanidina o 4-sulfinilbenzoilguanidina, procedimiento para prepararlos y composiciones farmaceuticas que los contienen

Country Status (25)

Country Link
US (1) US5744641A (es)
EP (1) EP0758644B1 (es)
JP (1) JP3901766B2 (es)
KR (1) KR100447111B1 (es)
CN (1) CN1071743C (es)
AR (1) AR004677A1 (es)
AT (1) ATE252075T1 (es)
AU (1) AU709800B2 (es)
BR (1) BR9603377B1 (es)
CA (1) CA2183050C (es)
CZ (1) CZ292974B6 (es)
DE (2) DE19529612A1 (es)
DK (1) DK0758644T3 (es)
ES (1) ES2206534T3 (es)
HU (1) HU226134B1 (es)
MX (1) MX9603300A (es)
NO (1) NO306858B1 (es)
PL (1) PL184320B1 (es)
PT (1) PT758644E (es)
RU (1) RU2159232C2 (es)
SI (1) SI0758644T1 (es)
SK (1) SK281661B6 (es)
TW (1) TW432039B (es)
UA (1) UA45965C2 (es)
ZA (1) ZA966773B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4328352A1 (de) * 1993-08-24 1995-03-02 Hoechst Ag Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19833118C2 (de) * 1998-07-23 2000-07-27 Merck Patent Gmbh Verfahren zur Herstellung von orthoalkylierten Benzoesäurederivaten
DE19903275A1 (de) * 1999-01-28 2000-08-03 Merck Patent Gmbh Lyophilisate mit verbesserter Rekonstituierbarkeit
DE19951418A1 (de) * 1999-10-26 2001-05-03 Merck Patent Gmbh Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid
DE10001879A1 (de) * 2000-01-19 2001-07-19 Aventis Pharma Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10023405A1 (de) * 2000-05-12 2001-11-15 Merck Patent Gmbh Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen
KR100643561B1 (ko) * 2000-12-08 2006-11-10 엘지.필립스 엘시디 주식회사 액정표시장치용 어레이기판과 어레이기판의 제조방법
DE10305070A1 (de) * 2003-02-07 2004-08-26 Merck Patent Gmbh Verwendung von N-(4,5-Methansulfonyl-2-methyl-benzoyl)-guanidin
DE502004007841D1 (de) * 2003-05-06 2008-09-25 Merck Patent Gmbh Verfahren zur kristallisation von guanidinium-salzen
DE102004045825A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Lyophilisat enthaltend N-Diaminomethylen-2-methyl-4,5-di-(methylsulfonyl)-benzamid
ES2804574T3 (es) * 2008-05-09 2021-02-08 Merck Patent Gmbh Composición farmacéutica para tratar enfermedades asociadas con la resistencia a la insulina y la disfunción de células beta
MX2011001821A (es) 2008-09-02 2011-03-25 Sanofi Aventis Aminoindanos sustituidos y sus analogos, y el uso farmaceutico de los mismos.
FR2948028B1 (fr) 2009-07-17 2011-12-02 Merck Sante Sas Association d'un inhibiteur de l'echangeur sodium-proton et d'un derive amine de dihydro-1,3,5-triazine
RU2018131500A (ru) 2016-02-08 2020-03-10 Мерк Патент Гмбх Кристаллические модификации гидрохлорида n-(4,5-бисметансульфонил-2-метилбензоил)гуанидина и солей n-(4,5-бисметансульфонил-2-метилбензоил)гуанидина
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DE59305042D1 (de) * 1992-09-22 1997-02-20 Hoechst Ag Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
EP0604852A1 (de) * 1992-12-28 1994-07-06 Hoechst Aktiengesellschaft 2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters
DE4430916A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Alkyl-benzoylguanidin-Derivate

Also Published As

Publication number Publication date
ATE252075T1 (de) 2003-11-15
DE59610773D1 (de) 2003-11-20
JPH0952876A (ja) 1997-02-25
TW432039B (en) 2001-05-01
EP0758644A1 (de) 1997-02-19
CZ292974B6 (cs) 2004-01-14
DK0758644T3 (da) 2003-12-22
CA2183050C (en) 2008-09-30
CN1071743C (zh) 2001-09-26
PL315611A1 (en) 1997-02-17
AU709800B2 (en) 1999-09-09
CN1148590A (zh) 1997-04-30
SK103396A3 (en) 1997-03-05
JP3901766B2 (ja) 2007-04-04
SI0758644T1 (en) 2004-04-30
NO963340L (no) 1997-02-12
KR970010740A (ko) 1997-03-27
BR9603377A (pt) 1998-05-12
CA2183050A1 (en) 1997-02-12
PT758644E (pt) 2004-02-27
BR9603377B1 (pt) 2009-01-13
HUP9602196A3 (en) 1998-07-28
CZ231296A3 (en) 1997-02-12
AU6191796A (en) 1997-02-13
EP0758644B1 (de) 2003-10-15
PL184320B1 (pl) 2002-10-31
UA45965C2 (uk) 2002-05-15
ZA966773B (en) 1997-02-19
MX9603300A (es) 1997-03-29
HU226134B1 (en) 2008-05-28
DE19529612A1 (de) 1997-02-13
HUP9602196A2 (en) 1997-05-28
RU2159232C2 (ru) 2000-11-20
KR100447111B1 (ko) 2004-12-08
NO306858B1 (no) 2000-01-03
NO963340D0 (no) 1996-08-09
HU9602196D0 (en) 1996-10-28
US5744641A (en) 1998-04-28
ES2206534T3 (es) 2004-05-16
SK281661B6 (sk) 2001-06-11

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