AR002273A1 - Derivados de la 4-amino-benzoilguanidina, un procedimiento para prepararlos, el empleo de los mismos para preparar un medicamento, laspreparaciones farmaceuticas que las contienen y un procedimiento para preparar estas preparaciones farmaceuticas. - Google Patents
Derivados de la 4-amino-benzoilguanidina, un procedimiento para prepararlos, el empleo de los mismos para preparar un medicamento, laspreparaciones farmaceuticas que las contienen y un procedimiento para preparar estas preparaciones farmaceuticas.Info
- Publication number
- AR002273A1 AR002273A1 ARP960101165A AR10116596A AR002273A1 AR 002273 A1 AR002273 A1 AR 002273A1 AR P960101165 A ARP960101165 A AR P960101165A AR 10116596 A AR10116596 A AR 10116596A AR 002273 A1 AR002273 A1 AR 002273A1
- Authority
- AR
- Argentina
- Prior art keywords
- prepare
- pharmaceutical preparations
- procedure
- atoms
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
El invento se refiere a las 4-amino-benzoilguanidinas de fórmula (I) en la que R1 representa A, CF3, CH2F, CHF2 o C2F5; R2 y R3 representan,independientemente uno del otro, respectivamente H, A, cicloalquilo de 3 a 7 átomos de C, Ph o Het; R2 y R3 juntos también representan alquileno de 4 a 5átomos de C; Het representa un heterociclo de uno o dos núcleos, saturado, insaturado o aromático, con 1 a 4 átomos de N, O y/o S, unido a través de N oC, que puede estar no sustituido o sustituidouna, dos o tres veces con Hal, CF3, A, OH, OA, SH, SA, NH2, NHA, NA2, CN, NO2 y/o carbonilo-oxígeno, A esalquilo de 1 a 6 átomos de C; Hal es F, Cl, Br ó I y Ph representa fenilo no sustituido o sustituido una, dos o tres veces con A, OA, NH2,NHA, NA2, F, Cl,Br y/o CF3; y a sus sales aceptables desde el punto de vista fisiológico. También se refiere a un procedimiento para preparar dichos compuesto, apreparaciones farmacéuticas que los contienen y al empleo de los mismos para eltratamiento de las arritmias, de la angina de pecho, infartos y también parael tratamiento preventivo de estas enfermedades. Los nuevos compuestos del invento poseen propiedades antiarrítmicas y un efecto inhibidor del mecanismode intercambio deNa(+)/H(+) de las células.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19502644A DE19502644A1 (de) | 1995-01-28 | 1995-01-28 | 4-Amino-benzoylguanidin-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002273A1 true AR002273A1 (es) | 1998-03-11 |
Family
ID=7752517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960101165A AR002273A1 (es) | 1995-01-28 | 1996-01-26 | Derivados de la 4-amino-benzoilguanidina, un procedimiento para prepararlos, el empleo de los mismos para preparar un medicamento, laspreparaciones farmaceuticas que las contienen y un procedimiento para preparar estas preparaciones farmaceuticas. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5739142A (es) |
| EP (1) | EP0723963B1 (es) |
| JP (1) | JP3770946B2 (es) |
| KR (1) | KR100521853B1 (es) |
| CN (1) | CN1057999C (es) |
| AR (1) | AR002273A1 (es) |
| AT (1) | ATE202093T1 (es) |
| AU (1) | AU705632B2 (es) |
| BR (1) | BR9600217A (es) |
| CA (1) | CA2168192C (es) |
| CO (1) | CO4700428A1 (es) |
| CZ (1) | CZ289922B6 (es) |
| DE (2) | DE19502644A1 (es) |
| DK (1) | DK0723963T3 (es) |
| ES (1) | ES2158153T3 (es) |
| FI (1) | FI960376A (es) |
| GR (1) | GR3036572T3 (es) |
| HU (1) | HUP9600173A3 (es) |
| NO (1) | NO305793B1 (es) |
| PL (1) | PL182219B1 (es) |
| PT (1) | PT723963E (es) |
| RU (1) | RU2160728C2 (es) |
| SI (1) | SI0723963T1 (es) |
| SK (1) | SK281198B6 (es) |
| TR (1) | TR199600064A2 (es) |
| TW (1) | TW325463B (es) |
| UA (1) | UA56983C2 (es) |
| ZA (1) | ZA96629B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4328352A1 (de) | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19737463A1 (de) * | 1997-08-28 | 1999-03-04 | Hoechst Marion Roussel De Gmbh | Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden |
| HUP0101482A3 (en) * | 1998-03-23 | 2002-12-28 | Aventis Pharm Prod Inc | Piperidinyl and n-amidinopiperidinyl derivatives, use of them for producing pharmaceutical compositions and pharmaceutical compositions containing the same |
| JP2002530325A (ja) * | 1998-11-26 | 2002-09-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 非インスリン依存型真性糖尿病の治療へのベンゾイルグアニジンの使用 |
| DE19859727A1 (de) | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung |
| DE10023405A1 (de) * | 2000-05-12 | 2001-11-15 | Merck Patent Gmbh | Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen |
| SA04250283B1 (ar) * | 2003-09-26 | 2008-05-26 | سولفاي فارماسيتيكالز جي أم بي أتش | مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid |
| DE102005030400A1 (de) * | 2005-06-27 | 2006-12-28 | Archimica Gmbh | Verfahren zur Herstellung von Arylaminen, Arylethern und Arylthioethern |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| ATE147375T1 (de) * | 1992-09-22 | 1997-01-15 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, sowie ihre verwendung als antiarrhythmika |
| DE4328869A1 (de) * | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1995
- 1995-01-28 DE DE19502644A patent/DE19502644A1/de not_active Withdrawn
-
1996
- 1996-01-05 UA UA96010053A patent/UA56983C2/uk unknown
- 1996-01-19 DE DE59607054T patent/DE59607054D1/de not_active Expired - Lifetime
- 1996-01-19 EP EP96100763A patent/EP0723963B1/de not_active Expired - Lifetime
- 1996-01-19 DK DK96100763T patent/DK0723963T3/da active
- 1996-01-19 AT AT96100763T patent/ATE202093T1/de not_active IP Right Cessation
- 1996-01-19 SI SI9630328T patent/SI0723963T1/xx unknown
- 1996-01-19 ES ES96100763T patent/ES2158153T3/es not_active Expired - Lifetime
- 1996-01-19 PT PT96100763T patent/PT723963E/pt unknown
- 1996-01-22 AU AU42112/96A patent/AU705632B2/en not_active Ceased
- 1996-01-25 CO CO96003094A patent/CO4700428A1/es unknown
- 1996-01-25 BR BR9600217A patent/BR9600217A/pt not_active Application Discontinuation
- 1996-01-26 FI FI960376A patent/FI960376A/fi unknown
- 1996-01-26 NO NO960353A patent/NO305793B1/no not_active IP Right Cessation
- 1996-01-26 SK SK122-96A patent/SK281198B6/sk unknown
- 1996-01-26 TR TR96/00064A patent/TR199600064A2/xx unknown
- 1996-01-26 US US08/592,660 patent/US5739142A/en not_active Expired - Lifetime
- 1996-01-26 TW TW085100970A patent/TW325463B/zh active
- 1996-01-26 CN CN96101244A patent/CN1057999C/zh not_active Expired - Fee Related
- 1996-01-26 HU HU9600173A patent/HUP9600173A3/hu unknown
- 1996-01-26 ZA ZA96629A patent/ZA96629B/xx unknown
- 1996-01-26 JP JP03122196A patent/JP3770946B2/ja not_active Expired - Fee Related
- 1996-01-26 CZ CZ1996252A patent/CZ289922B6/cs not_active IP Right Cessation
- 1996-01-26 RU RU96101810/04A patent/RU2160728C2/ru not_active IP Right Cessation
- 1996-01-26 AR ARP960101165A patent/AR002273A1/es unknown
- 1996-01-26 CA CA002168192A patent/CA2168192C/en not_active Expired - Fee Related
- 1996-01-26 PL PL96312490A patent/PL182219B1/pl not_active IP Right Cessation
- 1996-01-27 KR KR1019960002014A patent/KR100521853B1/ko not_active IP Right Cessation
-
2001
- 2001-09-10 GR GR20010401429T patent/GR3036572T3/el not_active IP Right Cessation
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