AP2473A - Macrocyclic inhibitors of hepatitis C virus - Google Patents

Macrocyclic inhibitors of hepatitis C virus

Info

Publication number: AP2473A
Authority: AP; ARIPO
Prior art keywords: hepatitis; virus; macrocyclic inhibitors; macrocyclic; inhibitors
Prior art date: 2005-07-29

Application number

AP2008004305A

Other languages

English (en)

Inventor

Pierre Jean-Marie Bernard Raboisson

Herman Augustinus De Kock

Sandrine Marie Helene Vendeville

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-29

Filing date

2006-07-28

Publication date

2012-09-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37036843&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2473(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-07-28 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2012-09-24 Application granted granted Critical

2012-09-24 Publication of AP2473A publication Critical patent/AP2473A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AP2008004305A 2005-07-29 2006-07-28 Macrocyclic inhibitors of hepatitis C virus AP2473A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05107067		2005-07-29
EP05107413		2005-08-11

Publications (1)

Publication Number	Publication Date
AP2473A true AP2473A (en)	2012-09-24

Family

ID=37036843

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2008004305A AP2473A (en)	2005-07-29	2006-07-28	Macrocyclic inhibitors of hepatitis C virus

Country Status (28)

Country	Link
US (1)	US7989471B2 (zh)
EP (1)	EP1912995B1 (zh)
JP (1)	JP5426163B2 (zh)
KR (1)	KR101074673B1 (zh)
CN (1)	CN101233137B (zh)
AP (1)	AP2473A (zh)
AR (1)	AR055104A1 (zh)
AT (1)	ATE517902T1 (zh)
AU (1)	AU2006274858B2 (zh)
BR (1)	BRPI0614670A2 (zh)
CA (1)	CA2617095C (zh)
DK (1)	DK1912995T3 (zh)
EA (1)	EA014646B1 (zh)
GT (1)	GT200600341A (zh)
HK (1)	HK1116772A1 (zh)
IL (1)	IL188283A (zh)
JO (1)	JO2768B1 (zh)
MX (1)	MX2008001395A (zh)
MY (1)	MY152153A (zh)
NO (1)	NO20081071L (zh)
NZ (1)	NZ564541A (zh)
PE (1)	PE20070221A1 (zh)
SG (1)	SG163613A1 (zh)
SI (1)	SI1912995T1 (zh)
SV (1)	SV2008002639A (zh)
TW (1)	TWI412534B (zh)
UY (1)	UY29705A1 (zh)
WO (1)	WO2007014919A1 (zh)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY140680A (en)	2002-05-20	2010-01-15	Bristol Myers Squibb Co	Hepatitis c virus inhibitors
ES2336009T3 (es)	2004-01-30	2010-04-07	Medivir Ab	Inhibidores de la ns-3 serina proteasa del vhc.
PE20070211A1 (es)	2005-07-29	2007-05-12	Medivir Ab	Compuestos macrociclicos como inhibidores del virus de hepatitis c
US7741281B2 (en)	2005-11-03	2010-06-22	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
RU2008152171A (ru) *	2006-07-05	2010-08-10	Интермьюн, Инк. (Us)	Новые ингибиторы вирусной репликации гепатита с
US7935670B2 (en)	2006-07-11	2011-05-03	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
JP5517614B2 (ja)	2006-07-13	2014-06-11	アキリオンファーマシューティカルズ，インコーポレーテッド	ウイルス複製阻害剤としての４−アミノ−４−オキソブタノイルペプチド類
US8343477B2 (en)	2006-11-01	2013-01-01	Bristol-Myers Squibb Company	Inhibitors of hepatitis C virus
US7772180B2 (en)	2006-11-09	2010-08-10	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8003604B2 (en)	2006-11-16	2011-08-23	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7763584B2 (en)	2006-11-16	2010-07-27	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
WO2008070358A2 (en) *	2006-11-16	2008-06-12	Phenomix Corporation	N-cyclopropyl-hydroxyproline-based tripeptidic hepatitis c serine protease inhibitors containing an isoindole, pyrrolopyridine, pyrrolopyrimidine or pyrrolopyrazine heterocycle in the side chain
US7888464B2 (en)	2006-11-16	2011-02-15	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
CA2679563A1 (en) *	2007-01-08	2008-07-17	Phenomix Corporation	Macrocyclic hepatitis c protease inhibitors
MX2009008540A (es) *	2007-02-08	2009-08-18	Tibotec Pharm Ltd	Inhibidores de virus de hepatitis c macrociclicos sustituidos con pirimidina.
WO2008096002A1 (en) *	2007-02-08	2008-08-14	Tibotec Pharmaceuticals Ltd.	Hcv inhibiting macrocyclic phosphonates and amidophosphates
US8383583B2 (en)	2007-10-26	2013-02-26	Enanta Pharmaceuticals, Inc.	Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
US8304385B2 (en)	2007-11-14	2012-11-06	Enanta Pharmaceuticals, Inc.	Macrocyclic tetrazolyl hepatitis C serine protease inhibitors
US8273709B2 (en)	2007-12-14	2012-09-25	Enanta Pharmaceuticals, Inc.	Triazole-containing macrocyclic HCV serine protease inhibitors
US8202996B2 (en)	2007-12-21	2012-06-19	Bristol-Myers Squibb Company	Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
JP5490778B2 (ja)	2008-03-20	2014-05-14	エナンタファーマシューティカルズインコーポレイテッド	Ｃ型肝炎ウイルス阻害剤としてのフッ素化大環状化合物
US8163921B2 (en)	2008-04-16	2012-04-24	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
EP2300491B1 (en)	2008-05-29	2016-01-06	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
US7964560B2 (en)	2008-05-29	2011-06-21	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8207341B2 (en)	2008-09-04	2012-06-26	Bristol-Myers Squibb Company	Process or synthesizing substituted isoquinolines
UY32099A (es)	2008-09-11	2010-04-30	Enanta Pharm Inc	Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8563505B2 (en)	2008-09-29	2013-10-22	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8044087B2 (en)	2008-09-29	2011-10-25	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
ES2527166T3 (es)	2008-12-10	2015-01-21	Achillion Pharmaceuticals, Inc.	Nuevos péptidos de 4-amino-4-oxobutanoílo como inhibidores de la replicación viral
US8283310B2 (en)	2008-12-15	2012-10-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
CA2758072A1 (en) *	2009-04-08	2010-10-14	Idenix Pharmaceuticals, Inc.	Macrocyclic serine protease inhibitors
US8232246B2 (en)	2009-06-30	2012-07-31	Abbott Laboratories	Anti-viral compounds
CN101987825B (zh) *	2009-07-31	2014-04-02	上海开拓者医药发展有限公司	一种2-氨基-3-甲基-4-甲氧基苯乙酮的制备方法
WO2011017389A1 (en)	2009-08-05	2011-02-10	Idenix Pharmaceuticals, Inc.	Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv
US8937041B2 (en)	2010-12-30	2015-01-20	Abbvie, Inc.	Macrocyclic hepatitis C serine protease inhibitors
EP2658858A4 (en)	2010-12-30	2014-06-25	Enanta Pharm Inc	MACROCYCLIC INHIBITORS OF HEPATITIS C SERINE PROTEASE PHENANTHRIDINE
US9353100B2 (en)	2011-02-10	2016-05-31	Idenix Pharmaceuticals Llc	Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections
US8957203B2 (en)	2011-05-05	2015-02-17	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US10201584B1 (en)	2011-05-17	2019-02-12	Abbvie Inc.	Compositions and methods for treating HCV
US8691757B2 (en)	2011-06-15	2014-04-08	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
WO2013106631A1 (en)	2012-01-11	2013-07-18	Abbvie Inc.	Processes for making hcv protease inhibitors
BR112015007887A2 (pt)	2012-10-08	2017-07-04	Abbvie Inc	compostos úteis para produzir inibidores hcv protease
SI2909205T1 (sl)	2012-10-19	2017-02-28	Bristol-Myers Squibb Company	9-metil substituiran heksadekahidrociklopropa(e)pirolo(1,2-A)(1,4)diazaciklopentadecinil karbamat derivati kot nestrukturalni 3 (NS3) proteazni inhibitorji za zdravljenje hepatitis C virusnih infekcij
WO2014070964A1 (en)	2012-11-02	2014-05-08	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
US9643999B2 (en)	2012-11-02	2017-05-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
WO2014071007A1 (en)	2012-11-02	2014-05-08	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
EP2914614B1 (en)	2012-11-05	2017-08-16	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
WO2014137869A1 (en)	2013-03-07	2014-09-12	Bristol-Myers Squibb Company	Hepatitis c virus inhibitors
EP2970195B1 (en)	2013-03-14	2017-08-02	Achillion Pharmaceuticals, Inc.	Processes for producing sovaprevir
US9085607B2 (en)	2013-03-15	2015-07-21	Achillion Pharmaceuticals, Inc.	ACH-0142684 sodium salt polymorph, composition including the same, and method of manufacture thereof
WO2014145507A1 (en)	2013-03-15	2014-09-18	Achillion Pharmaceuticals, Inc.	A process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof
KR20160005686A (ko)	2013-03-15	2016-01-15	아칠리온 파르마세우티칼스 인코포레이티드	소바프레비르 다형체들 및 이의 제조 방법
EP3089757A1 (en)	2014-01-03	2016-11-09	AbbVie Inc.	Solid antiviral dosage forms
MA41812A (fr) *	2015-03-27	2018-01-30	Janssen Pharmaceuticals Inc	Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000059929A1 (en) *	1999-04-06	2000-10-12	Boehringer Ingelheim (Canada) Ltd.	Macrocyclic peptides active against the hepatitis c virus

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT727419E (pt)	1992-12-29	2002-08-30	Abbott Lab	Compostos intermediarios para a preparacao de inibidores da protease retroviral
IL110752A (en)	1993-09-13	2000-07-26	Abbott Lab	Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
US5559158A (en)	1993-10-01	1996-09-24	Abbott Laboratories	Pharmaceutical composition
IL111991A (en)	1994-01-28	2000-07-26	Abbott Lab	Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
US6037157A (en)	1995-06-29	2000-03-14	Abbott Laboratories	Method for improving pharmacokinetics
US5807876A (en)	1996-04-23	1998-09-15	Vertex Pharmaceuticals Incorporated	Inhibitors of IMPDH enzyme
US6054472A (en)	1996-04-23	2000-04-25	Vertex Pharmaceuticals, Incorporated	Inhibitors of IMPDH enzyme
CN1116288C (zh)	1996-04-23	2003-07-30	沃泰克斯药物股份有限公司	用作肌苷－5'－一磷酸脱氢酶抑制剂的脲衍生物
HU227742B1 (en)	1996-10-18	2012-02-28	Vertex Pharma	Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
GB9623908D0 (en)	1996-11-18	1997-01-08	Hoffmann La Roche	Amino acid derivatives
PT966465E (pt)	1997-03-14	2003-11-28	Vertex Pharma	Inibidores do enzima imfdh
WO1999007734A2 (en)	1997-08-11	1999-02-18	Boehringer Ingelheim (Canada) Ltd.	Hepatitis c inhibitor peptide analogues
GB9818731D0 (en) *	1998-08-27	1998-10-21	Univ Portsmouth	Compounds
CZ301802B6 (cs)	1999-03-19	2010-06-30	Vertex Pharmaceuticals Incorporated	Deriváty mocoviny jako inhibitory IMPDH a farmaceutické prostredky s jejich obsahem
SV2003000617A (es)	2000-08-31	2003-01-13	Lilly Co Eli	Inhibidores de la proteasa peptidomimetica ref. x-14912m
TW200403236A (en) *	2002-04-11	2004-03-01	Vertex Pharma	Inhibitors or serine proteases, particularly HCV NS3-NS4A protease
EP1629000B1 (en) *	2003-04-16	2009-02-18	Bristol-Myers Squibb Company	Macrocyclic isoquinoline peptide inhibitors of hepatitis c virus
US7125845B2 (en) *	2003-07-03	2006-10-24	Enanta Pharmaceuticals, Inc.	Aza-peptide macrocyclic hepatitis C serine protease inhibitors
ES2336009T3 (es)	2004-01-30	2010-04-07	Medivir Ab	Inhibidores de la ns-3 serina proteasa del vhc.
KR101381387B1 (ko) *	2005-07-29	2014-04-11	메디비르 아베	Ｃ형 간염 바이러스의 마크로사이클릭 억제제
PE20070343A1 (es) *	2005-07-29	2007-05-12	Medivir Ab	Inhibidores macrociclicos del virus de la hepatitis c

2006
- 2006-07-19 JO JO2006237A patent/JO2768B1/en active
- 2006-07-26 PE PE2006000917A patent/PE20070221A1/es not_active Application Discontinuation
- 2006-07-28 AP AP2008004305A patent/AP2473A/xx active
- 2006-07-28 JP JP2008523375A patent/JP5426163B2/ja not_active Expired - Fee Related
- 2006-07-28 AU AU2006274858A patent/AU2006274858B2/en not_active Ceased
- 2006-07-28 EA EA200800484A patent/EA014646B1/ru not_active IP Right Cessation
- 2006-07-28 SI SI200631129T patent/SI1912995T1/sl unknown
- 2006-07-28 US US11/995,573 patent/US7989471B2/en not_active Expired - Fee Related
- 2006-07-28 MX MX2008001395A patent/MX2008001395A/es active IP Right Grant
- 2006-07-28 CA CA2617095A patent/CA2617095C/en not_active Expired - Fee Related
- 2006-07-28 SG SG201005107-6A patent/SG163613A1/en unknown
- 2006-07-28 WO PCT/EP2006/064813 patent/WO2007014919A1/en active Application Filing
- 2006-07-28 AR ARP060103306A patent/AR055104A1/es unknown
- 2006-07-28 BR BRPI0614670-8A patent/BRPI0614670A2/pt not_active Application Discontinuation
- 2006-07-28 KR KR1020087003833A patent/KR101074673B1/ko not_active IP Right Cessation
- 2006-07-28 GT GT200600341A patent/GT200600341A/es unknown
- 2006-07-28 UY UY29705A patent/UY29705A1/es unknown
- 2006-07-28 CN CN200680027654.7A patent/CN101233137B/zh not_active Expired - Fee Related
- 2006-07-28 TW TW095127588A patent/TWI412534B/zh not_active IP Right Cessation
- 2006-07-28 DK DK06764264.5T patent/DK1912995T3/da active
- 2006-07-28 MY MYPI20063671 patent/MY152153A/en unknown
- 2006-07-28 EP EP06764264A patent/EP1912995B1/en active Active
- 2006-07-28 NZ NZ564541A patent/NZ564541A/en not_active IP Right Cessation
- 2006-07-28 AT AT06764264T patent/ATE517902T1/de active
- 2006-07-29 SV SV2006002639A patent/SV2008002639A/es unknown
2007
- 2007-12-20 IL IL188283A patent/IL188283A/en not_active IP Right Cessation
2008
- 2008-02-29 NO NO20081071A patent/NO20081071L/no not_active Application Discontinuation
- 2008-06-18 HK HK08106769.8A patent/HK1116772A1/xx not_active IP Right Cessation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000059929A1 (en) *	1999-04-06	2000-10-12	Boehringer Ingelheim (Canada) Ltd.	Macrocyclic peptides active against the hepatitis c virus

Also Published As

Publication number	Publication date
US20100240698A1 (en)	2010-09-23
CN101233137B (zh)	2014-05-07
MY152153A (en)	2014-08-15
US7989471B2 (en)	2011-08-02
KR20080041651A (ko)	2008-05-13
KR101074673B1 (ko)	2011-10-19
SI1912995T1 (sl)	2011-11-30
EP1912995B1 (en)	2011-07-27
IL188283A0 (en)	2008-04-13
ATE517902T1 (de)	2011-08-15
SV2008002639A (es)	2008-07-23
UY29705A1 (es)	2007-05-31
PE20070221A1 (es)	2007-04-16
CA2617095C (en)	2014-05-13
MX2008001395A (es)	2008-04-16
NO20081071L (no)	2008-04-25
AU2006274858A1 (en)	2007-02-08
GT200600341A (es)	2007-02-26
BRPI0614670A2 (pt)	2011-04-12
SG163613A1 (en)	2010-08-30
IL188283A (en)	2016-12-29
WO2007014919A1 (en)	2007-02-08
AU2006274858B2 (en)	2012-05-24
AR055104A1 (es)	2007-08-08
NZ564541A (en)	2010-03-26
CN101233137A (zh)	2008-07-30
DK1912995T3 (da)	2011-10-24
EA200800484A1 (ru)	2008-06-30
JP5426163B2 (ja)	2014-02-26
HK1116772A1 (en)	2009-01-02
EP1912995A1 (en)	2008-04-23
JO2768B1 (en)	2014-03-15
EA014646B1 (ru)	2010-12-30
JP2009502882A (ja)	2009-01-29
CA2617095A1 (en)	2007-02-08
TW200745165A (en)	2007-12-16
TWI412534B (zh)	2013-10-21

Publication	Publication Date	Title
IL240244A0 (en)	2015-09-24	Macrocyclic inhibitors of hepatitis c virus
AP2585A (en)	2013-02-04	Macrocyclic inhibitors of hepatitis C virus
AP2473A (en)	2012-09-24	Macrocyclic inhibitors of hepatitis C virus
SI1912997T1 (sl)	2012-02-29	Makrociklični inhibitorji virusa hepatitis C
PL1919904T3 (pl)	2014-06-30	Makrocykliczne inhibitory wirusa zapalenia wątroby typu C
SI1919898T1 (sl)	2011-05-31	Makrociklični inhibitorji virusa hepatitisa C
SI1919899T1 (sl)	2011-05-31	Makrociklični inhibitorji virusa hepatitisa C
PL1913015T3 (pl)	2014-04-30	Makrocykliczne inhibitory wirusa zapalenia wątroby typu C
HK1116503A1 (en)	2008-12-24	Macrocyclic inhibitors of hepatitis c virus
HK1136824A1 (zh)	2010-07-09	丙型肝炎病毒的大環化合物抑制劑
IL221361A0 (en)	2012-09-24	Novel macrocyclic inhibitors of hepatitis c virus replication
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