ZA986095B - 6-azauracil derivatives as IL-5 inhibitors. - Google Patents
6-azauracil derivatives as IL-5 inhibitors.Info
- Publication number
- ZA986095B ZA986095B ZA9806095A ZA986095A ZA986095B ZA 986095 B ZA986095 B ZA 986095B ZA 9806095 A ZA9806095 A ZA 9806095A ZA 986095 A ZA986095 A ZA 986095A ZA 986095 B ZA986095 B ZA 986095B
- Authority
- ZA
- South Africa
- Prior art keywords
- inhibitors
- azauracil derivatives
- azauracil
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0461—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97202117 | 1997-07-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA986095B true ZA986095B (en) | 2000-01-10 |
Family
ID=8228530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9806095A ZA986095B (en) | 1997-07-10 | 1998-07-09 | 6-azauracil derivatives as IL-5 inhibitors. |
Country Status (20)
Country | Link |
---|---|
US (2) | US6743792B2 (hu) |
EP (1) | EP1003729A1 (hu) |
JP (1) | JP2002508001A (hu) |
KR (1) | KR20010012614A (hu) |
CN (1) | CN1261881A (hu) |
AU (1) | AU756637B2 (hu) |
BR (1) | BR9811499A (hu) |
CA (1) | CA2294533A1 (hu) |
EE (1) | EE9900585A (hu) |
HR (1) | HRP990333A2 (hu) |
HU (1) | HUP0002826A3 (hu) |
ID (1) | ID24224A (hu) |
IL (1) | IL133915A0 (hu) |
NO (1) | NO20000094L (hu) |
NZ (1) | NZ501627A (hu) |
PL (1) | PL337875A1 (hu) |
SK (1) | SK180999A3 (hu) |
TR (1) | TR199903249T2 (hu) |
WO (1) | WO1999002504A1 (hu) |
ZA (1) | ZA986095B (hu) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0987265A1 (en) * | 1998-09-18 | 2000-03-22 | Janssen Pharmaceutica N.V. | Interleukin-5 inhibiting 6-azauracil derivatives |
JP2002530391A (ja) * | 1998-11-23 | 2002-09-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Il−5阻害性6−アザウラシル誘導体 |
EE200100320A (et) | 1998-12-18 | 2002-10-15 | Janssen Pharmaceutica N.V. | 6-asauratsiili derivaadid, nende valmistamismeetod ja kasutamine, kompositsioon ja selle valmistamismeetod, retseptori märgistamismeetod ja organi visualiseerimismeetod |
CZ2002356A3 (cs) | 1999-08-06 | 2002-06-12 | Janssen Pharmaceutica N. V. | Deriváty 6-azauracilu inhibující interleukin-5 |
US8073380B2 (en) * | 2005-12-30 | 2011-12-06 | Nokia Corporation | Media content delivery and recording over broadcast network |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3883527A (en) | 1973-10-19 | 1975-05-13 | Pfizer | Process for preparation of 2-aryl-1,3,4-triazine-3,5(2H,4H)-diones |
US4631278A (en) * | 1984-08-01 | 1986-12-23 | Janssen Pharmaceutica N.V. | Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor |
GB8602342D0 (en) * | 1986-01-30 | 1986-03-05 | Janssen Pharmaceutica Nv | 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones |
CA1331757C (en) * | 1988-02-29 | 1994-08-30 | Janssen Pharmaceutica Naamloze Vennootschap | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
DE4120138A1 (de) * | 1991-06-19 | 1992-12-24 | Bayer Ag | Substituierte hexahydro-1,2,4-triazindione, verfahren zu ihrer herstellung, zwischenprodukte dafuer und ihre verwendung |
EP0476439A1 (de) * | 1990-09-18 | 1992-03-25 | Bayer Ag | Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung |
TW263495B (hu) * | 1992-12-23 | 1995-11-21 | Celltech Ltd | |
GB9304920D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
TW332201B (en) * | 1995-04-06 | 1998-05-21 | Janssen Pharmaceutica Nv | 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives |
DE69615601T2 (de) * | 1995-04-14 | 2002-07-11 | Takeda Schering Plough Animal | Verfahren zur Herstellung von Triazinderivate |
-
1998
- 1998-07-02 CN CN98806918A patent/CN1261881A/zh active Pending
- 1998-07-02 PL PL98337875A patent/PL337875A1/xx unknown
- 1998-07-02 TR TR1999/03249T patent/TR199903249T2/xx unknown
- 1998-07-02 IL IL13391598A patent/IL133915A0/xx unknown
- 1998-07-02 SK SK1809-99A patent/SK180999A3/sk unknown
- 1998-07-02 NZ NZ501627A patent/NZ501627A/en unknown
- 1998-07-02 CA CA002294533A patent/CA2294533A1/en not_active Abandoned
- 1998-07-02 EP EP98935022A patent/EP1003729A1/en not_active Withdrawn
- 1998-07-02 AU AU84413/98A patent/AU756637B2/en not_active Ceased
- 1998-07-02 HU HU0002826A patent/HUP0002826A3/hu unknown
- 1998-07-02 KR KR1019997010573A patent/KR20010012614A/ko not_active Application Discontinuation
- 1998-07-02 EE EEP199900585A patent/EE9900585A/xx unknown
- 1998-07-02 WO PCT/EP1998/004192 patent/WO1999002504A1/en not_active Application Discontinuation
- 1998-07-02 ID IDW20000004A patent/ID24224A/id unknown
- 1998-07-02 JP JP50812799A patent/JP2002508001A/ja not_active Withdrawn
- 1998-07-02 BR BR9811499-9A patent/BR9811499A/pt not_active IP Right Cessation
- 1998-07-09 ZA ZA9806095A patent/ZA986095B/xx unknown
-
1999
- 1999-10-29 HR HR97202117.4A patent/HRP990333A2/hr not_active Application Discontinuation
-
2000
- 2000-01-07 NO NO20000094A patent/NO20000094L/no unknown
-
2001
- 2001-05-14 US US09/855,068 patent/US6743792B2/en not_active Expired - Fee Related
-
2003
- 2003-05-09 US US10/434,896 patent/US6951857B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
TR199903249T2 (xx) | 2000-09-21 |
KR20010012614A (ko) | 2001-02-15 |
HUP0002826A3 (en) | 2003-01-28 |
US20020042416A1 (en) | 2002-04-11 |
PL337875A1 (en) | 2000-09-11 |
WO1999002504A1 (en) | 1999-01-21 |
BR9811499A (pt) | 2000-09-19 |
AU756637B2 (en) | 2003-01-16 |
EP1003729A1 (en) | 2000-05-31 |
NZ501627A (en) | 2002-02-01 |
NO20000094L (no) | 2000-03-08 |
HRP990333A2 (en) | 2000-04-30 |
CN1261881A (zh) | 2000-08-02 |
IL133915A0 (en) | 2001-04-30 |
US6951857B2 (en) | 2005-10-04 |
AU8441398A (en) | 1999-02-08 |
HUP0002826A2 (hu) | 2001-04-28 |
NO20000094D0 (no) | 2000-01-07 |
SK180999A3 (en) | 2000-10-09 |
JP2002508001A (ja) | 2002-03-12 |
US20030220331A1 (en) | 2003-11-27 |
CA2294533A1 (en) | 1999-01-21 |
EE9900585A (et) | 2000-08-15 |
ID24224A (id) | 2000-07-13 |
US6743792B2 (en) | 2004-06-01 |
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