ZA944686B - Process for producing hydrophobic polypeptides proteins or peptides - Google Patents

Process for producing hydrophobic polypeptides proteins or peptides

Info

Publication number
ZA944686B
ZA944686B ZA944686A ZA944686A ZA944686B ZA 944686 B ZA944686 B ZA 944686B ZA 944686 A ZA944686 A ZA 944686A ZA 944686 A ZA944686 A ZA 944686A ZA 944686 B ZA944686 B ZA 944686B
Authority
ZA
South Africa
Prior art keywords
peptides
proteins
hydrophobic polypeptides
producing hydrophobic
polypeptides proteins
Prior art date
Application number
ZA944686A
Other languages
English (en)
Inventor
Heinz Doebili
Nicholas Draeger
Gerda Huber Trottman
Peter Jakob
Dietrich Stueber
Original Assignee
Hoffman La Roche A G F
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffman La Roche A G F filed Critical Hoffman La Roche A G F
Publication of ZA944686B publication Critical patent/ZA944686B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA944686A 1993-07-06 1994-06-29 Process for producing hydrophobic polypeptides proteins or peptides ZA944686B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93110755 1993-07-06

Publications (1)

Publication Number Publication Date
ZA944686B true ZA944686B (en) 1995-01-06

Family

ID=8213046

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA944686A ZA944686B (en) 1993-07-06 1994-06-29 Process for producing hydrophobic polypeptides proteins or peptides

Country Status (14)

Country Link
US (1) US5750374A (xx)
EP (2) EP0641861B1 (xx)
JP (2) JP2947401B2 (xx)
CN (3) CN100439391C (xx)
AT (1) ATE236984T1 (xx)
AU (1) AU666274B2 (xx)
CA (1) CA2125467C (xx)
DE (1) DE69432449T2 (xx)
DK (1) DK0641861T3 (xx)
ES (1) ES2194017T3 (xx)
NZ (1) NZ260907A (xx)
PT (1) PT641861E (xx)
RU (1) RU94023251A (xx)
ZA (1) ZA944686B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817626A (en) * 1995-03-14 1998-10-06 Praecis Pharmaceuticals Incorporated Modulators of beta-amyloid peptide aggregation
US6303567B1 (en) 1995-03-14 2001-10-16 Praecis Pharmaceuticals, Inc . Modulators of β-amyloid peptide aggregation comprising D-amino acids
WO1996028471A1 (en) 1995-03-14 1996-09-19 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
US5854215A (en) * 1995-03-14 1998-12-29 Praecis Pharmaceuticals Incorporated Modulators of β-amyloid peptide aggregation
GB9618952D0 (en) 1996-09-11 1996-10-23 Sandoz Ltd Process
US5985242A (en) * 1995-10-27 1999-11-16 Praecis Pharmaceuticals, Inc. Modulators of β-amyloid peptide aggregation comprising D-amino acids
US6277826B1 (en) 1996-08-27 2001-08-21 Praecis Pharmaceuticals, Inc. Modulators of β-amyloid peptide aggregation comprising D-amino acids
CA2362834C (en) 1999-03-04 2005-12-06 Praecis Pharmaceuticals Incorporated Modulators of beta-amyloid peptide aggregation comprising d-amino acids
EP1187920A2 (en) 1999-06-09 2002-03-20 Arch Development Corporation Recombinant prion-like genes and proteins and materials and methods comprising same
EP1226241A1 (en) * 1999-10-21 2002-07-31 Panorama Research, Inc. A general method for optimizing the expression of heterologous proteins
US7799561B2 (en) * 2002-06-12 2010-09-21 Sigma-Aldrich, Co. Affinity peptides and method for purification of recombinant proteins
FR2859221B1 (fr) * 2003-08-28 2005-10-14 Centre Nat Rech Scient Vecteur de co-expression de domaines membranaires de proteines d'enveloppe d'un virus et utilisations
US7741053B2 (en) * 2005-05-13 2010-06-22 Sigma-Aldrich Co. Processes for purification of recombinant proteins
KR100621354B1 (ko) * 2005-06-14 2006-09-08 광주과학기술원 유비퀴틴을 이용한 아밀로이드-베타 펩티드의 제조방법
WO2010063460A1 (en) * 2008-12-02 2010-06-10 Universität Zürich Recombinant production of hydrophobic peptides and fusion proteins for use in producing same
US20170226159A1 (en) * 2014-09-26 2017-08-10 Kaneka Corporation Method for producing hydrophobic peptide
EP3227455B1 (en) 2014-12-01 2023-07-12 Pfenex Inc. Fusion partners for peptide production
CN105001307B (zh) 2015-07-31 2016-08-24 南京斯拜科生化实业有限公司 一种溶解难溶多肽的偶联肽链及其在液相色谱中分离纯化的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0207044A1 (en) * 1985-06-20 1986-12-30 Monsanto Company Release of peptides from polypeptides
ES2000859A6 (es) * 1985-08-12 1988-03-16 Syntex Inc Un metodo para producir un vector de expresion bacteriana para la expresion de proteinas de fusion
DE3788397T3 (de) * 1986-03-24 2003-11-27 Ortho Pharmaceutical Corp., Raritan Synthetische htlv-iii-peptid-zusammensetzungen und ihre verwendung.
US5047513A (en) * 1986-07-10 1991-09-10 Hoffmann-La Roche Inc. Metal chelate resins
CA1304886C (en) * 1986-07-10 1992-07-07 Heinz Dobeli Metal chelate resins
EP0289110A3 (en) * 1987-02-02 1990-01-24 Swiss Serum and Vaccine Institute Berne Conjugate malaria vaccine
CA1340522C (en) * 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
US5416007A (en) * 1987-03-20 1995-05-16 Creative Biomolecules, Inc. Enhanced proteolytic cleavage of recombinant fusion proteins
US5124255A (en) * 1988-03-11 1992-06-23 Abbott Laboratories CKS method of protein synthesis
IT1226728B (it) * 1988-08-05 1991-02-05 Eniricerche Spa Coniugato peptidico immunologicamente attivo utile come vaccino antimalaria e metodo di immunizzazione impiegante lo stesso
US5045190A (en) * 1988-11-08 1991-09-03 Carbonell Ruben G Chromatography apparatus
AU646877B2 (en) * 1990-06-15 1994-03-10 Scios Nova Inc. Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease
EP0546101A1 (en) * 1990-08-24 1993-06-16 The President And Fellows Of Harvard College METHOD OF INTERFERING WITH FORMATION OF $g(a)-ANTICHYMOTRYPSIN-$g(b)-PROTEIN COMPLEX AND SYNTHETIC PEPTIDES FOR USE THEREIN
EP0770679B2 (de) * 1990-11-03 2009-12-30 Siemens Healthcare Diagnostics Products GmbH HCV-spezifische Peptide, Mittel dazu und ihre Verwendung
NZ243636A (en) * 1991-07-29 1993-06-25 Iaf Biochem Int Immunoassay and kit for simultaneously detecting antibodies to hiv-1, hiv-2, htlv-1 and htlv-11
US5434050A (en) * 1991-08-13 1995-07-18 Regents Of The University Of Minnesota Labelled β-amyloid peptide and methods of screening for Alzheimer's disease

Also Published As

Publication number Publication date
ES2194017T3 (es) 2003-11-16
DK0641861T3 (da) 2003-07-28
PT641861E (pt) 2003-07-31
JP2947401B2 (ja) 1999-09-13
CN1227846A (zh) 1999-09-08
CA2125467C (en) 2001-02-06
EP1304381A2 (en) 2003-04-23
DE69432449T2 (de) 2004-04-08
EP0641861B1 (en) 2003-04-09
EP0641861A2 (en) 1995-03-08
NZ260907A (en) 1996-06-25
CN100439391C (zh) 2008-12-03
CA2125467A1 (en) 1995-01-07
AU666274B2 (en) 1996-02-01
ATE236984T1 (de) 2003-04-15
CN1916017A (zh) 2007-02-21
EP1304381A3 (en) 2003-05-02
EP0641861A3 (en) 1997-07-30
JPH07102000A (ja) 1995-04-18
RU94023251A (ru) 1996-05-10
JPH1143500A (ja) 1999-02-16
CN1098416A (zh) 1995-02-08
US5750374A (en) 1998-05-12
AU6612294A (en) 1995-01-27
CN1057535C (zh) 2000-10-18
DE69432449D1 (de) 2003-05-15

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