ZA903139B - Derivatives of 4-phenylmethyl-1h-indole,process and intermediates of preparation,application as medicaments and compositions containing them - Google Patents

Derivatives of 4-phenylmethyl-1h-indole,process and intermediates of preparation,application as medicaments and compositions containing them

Info

Publication number
ZA903139B
ZA903139B ZA903139A ZA903139A ZA903139B ZA 903139 B ZA903139 B ZA 903139B ZA 903139 A ZA903139 A ZA 903139A ZA 903139 A ZA903139 A ZA 903139A ZA 903139 B ZA903139 B ZA 903139B
Authority
ZA
South Africa
Prior art keywords
phenylmethyl
indole
medicaments
intermediates
derivatives
Prior art date
Application number
ZA903139A
Other languages
English (en)
Inventor
Francois Clemence
Clemence Francois
Jacques Guillaume
Guillaume Jacques
Gilles Hamon
Hamon Gilles
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of ZA903139B publication Critical patent/ZA903139B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA903139A 1989-04-28 1990-04-25 Derivatives of 4-phenylmethyl-1h-indole,process and intermediates of preparation,application as medicaments and compositions containing them ZA903139B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8905650A FR2646349B1 (fr) 1989-04-28 1989-04-28 Derives du 4-phenylmethyl lh-indole, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant

Publications (1)

Publication Number Publication Date
ZA903139B true ZA903139B (en) 1991-06-26

Family

ID=9381227

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA903139A ZA903139B (en) 1989-04-28 1990-04-25 Derivatives of 4-phenylmethyl-1h-indole,process and intermediates of preparation,application as medicaments and compositions containing them

Country Status (16)

Country Link
US (1) US5086070A (ja)
EP (1) EP0395528B1 (ja)
JP (1) JPH0368554A (ja)
AT (1) ATE124685T1 (ja)
AU (1) AU628968B2 (ja)
CA (1) CA2015669A1 (ja)
DE (1) DE69020632T2 (ja)
DK (1) DK0395528T3 (ja)
ES (1) ES2074144T3 (ja)
FR (1) FR2646349B1 (ja)
HU (1) HUT54642A (ja)
MX (1) MX20482A (ja)
NZ (1) NZ233478A (ja)
PT (1) PT93915B (ja)
RU (1) RU2067576C1 (ja)
ZA (1) ZA903139B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908367A (en) * 1985-07-11 1990-03-13 Roussel Uclaf N-(1H-indole-4-yl)-benzamides
CH687764A5 (de) * 1992-07-02 1997-02-14 Lonza Ag Gampel Wallis Geschof Verfahren zur Herstellung von 7-Acylindolen.
CA2186947A1 (en) 1994-04-01 1995-10-12 Kazuo Ueda Oxime derivative and bactericide containing the same as active ingredients
US6268312B1 (en) 1994-04-01 2001-07-31 Shionogi & Co., Ltd. Oxime derivative and bactericide containing the same as active ingredient
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6391907B1 (en) 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
AU2009272900B2 (en) * 2008-07-15 2012-04-19 F. Hoffmann-La Roche Ag Substituted indolyl and indazolyl derivatives and uses thereof
US10538512B2 (en) 2016-05-23 2020-01-21 The Rockefeller University Aminoacylindazole immunomodulators for treatment of autoimmune diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2584070B1 (fr) * 1985-06-27 1987-08-28 Roussel Uclaf Nouveaux derives de l'hydroxy alkoxy 4-phenyl propyl indole, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant.
FR2584713B1 (fr) * 1985-07-11 1988-09-09 Roussel Uclaf Nouveaux derives de l'indole carboxamide, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant

Also Published As

Publication number Publication date
DK0395528T3 (da) 1995-10-30
HU902612D0 (en) 1990-09-28
EP0395528A2 (fr) 1990-10-31
JPH0368554A (ja) 1991-03-25
US5086070A (en) 1992-02-04
FR2646349A1 (fr) 1990-11-02
PT93915A (pt) 1990-11-20
PT93915B (pt) 1996-10-31
HUT54642A (en) 1991-03-28
ATE124685T1 (de) 1995-07-15
NZ233478A (en) 1992-08-26
EP0395528B1 (fr) 1995-07-05
EP0395528A3 (fr) 1991-11-21
FR2646349B1 (fr) 1994-04-01
DE69020632T2 (de) 1996-01-11
ES2074144T3 (es) 1995-09-01
AU628968B2 (en) 1992-09-24
AU5393190A (en) 1990-11-01
RU2067576C1 (ru) 1996-10-10
DE69020632D1 (de) 1995-08-10
CA2015669A1 (fr) 1990-10-28
MX20482A (es) 1993-11-01

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