ZA888734B - Stabilized medicinal substances,a process for the preparation thereof,and stable medicinal formulations - Google Patents
Stabilized medicinal substances,a process for the preparation thereof,and stable medicinal formulationsInfo
- Publication number
- ZA888734B ZA888734B ZA888734A ZA888734A ZA888734B ZA 888734 B ZA888734 B ZA 888734B ZA 888734 A ZA888734 A ZA 888734A ZA 888734 A ZA888734 A ZA 888734A ZA 888734 B ZA888734 B ZA 888734B
- Authority
- ZA
- South Africa
- Prior art keywords
- medicinal
- preparation
- stabilized
- stable
- formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G59/00—Polycondensates containing more than one epoxy group per molecule; Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups
- C08G59/18—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing
- C08G59/40—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing characterised by the curing agents used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873739690 DE3739690A1 (de) | 1987-11-24 | 1987-11-24 | Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA888734B true ZA888734B (en) | 1989-07-26 |
Family
ID=6341084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA888734A ZA888734B (en) | 1987-11-24 | 1988-11-22 | Stabilized medicinal substances,a process for the preparation thereof,and stable medicinal formulations |
Country Status (21)
Country | Link |
---|---|
US (2) | US5151433A (es) |
EP (1) | EP0317878B1 (es) |
JP (1) | JPH0768140B2 (es) |
KR (1) | KR970004908B1 (es) |
CN (1) | CN1028962C (es) |
AT (1) | ATE74513T1 (es) |
AU (1) | AU615495B2 (es) |
CA (1) | CA1338344C (es) |
DE (2) | DE3739690A1 (es) |
DK (1) | DK168423B1 (es) |
ES (1) | ES2033400T3 (es) |
FI (1) | FI93693C (es) |
GR (1) | GR3004925T3 (es) |
HU (1) | HU202100B (es) |
IE (1) | IE61173B1 (es) |
IL (1) | IL88460A0 (es) |
NO (1) | NO176550C (es) |
NZ (1) | NZ227032A (es) |
PH (1) | PH27416A (es) |
PT (1) | PT89061B (es) |
ZA (1) | ZA888734B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6300361B1 (en) | 1990-07-25 | 2001-10-09 | Novartis Ag | Stabilized pharmaceutical compositions comprising acid donors |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
TW483763B (en) * | 1994-09-02 | 2002-04-21 | Astra Ab | Pharmaceutical composition comprising of ramipril and dihydropyridine compound |
DE69615704T2 (de) * | 1995-12-27 | 2002-07-11 | Janssen Pharmaceutica N.V., Beerse | Bioadhesive feste arzneimittelform |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
KR20020040795A (ko) * | 1999-08-30 | 2002-05-30 | 로버트 흐라이탁, 미쉘 베스트 | 심혈관 사고 예방용 레닌-안지오텐신 시스템 억제제의 용도 |
US20030225124A1 (en) * | 1999-08-31 | 2003-12-04 | Spiridon Spireas | Stable formulations of ACE inhibitors, and methods for preparation thereof |
FR2824477B1 (fr) * | 2001-05-09 | 2005-09-09 | Ethypharm Lab Prod Ethiques | Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'anfiotensine, leur procede de preparation et comprimes orodispersibles contenant les granules enrobes |
CA2357982A1 (en) * | 2001-09-28 | 2003-03-28 | Bernard Charles Sherman | Solid compositions comprising ramipril |
EP1467717A1 (en) * | 2002-01-15 | 2004-10-20 | Ranbaxy Laboratories Limited | Stable pharmaceutical compositions comprising ace inhibitor(s) |
US20060177498A1 (en) * | 2003-01-22 | 2006-08-10 | Ramaswami Bharatrajan | Solid pharmaceutical composition comprising ramipril |
GB0301471D0 (en) * | 2003-01-22 | 2003-02-19 | Biochemie Gmbh | Organic compounds |
PL1635792T3 (pl) * | 2003-06-26 | 2009-08-31 | Teva Pharmaceutical Industries Ltd | Stabilne kompozycje farmaceutyczne pochodnych kwasu 2-aza-bicyklo[3.3.0]-oktano-3-karboksylowego |
US6869963B2 (en) * | 2003-07-11 | 2005-03-22 | Sandoz Ag | Stable pharmaceutical compositions containing an ACE inhibitor |
EP1694308A1 (en) * | 2003-10-30 | 2006-08-30 | Lupin Ltd. | Stable formulations of ace inhibitors and methods for preparation thereof |
GB2394660A (en) * | 2003-12-17 | 2004-05-05 | Niche Generics Ltd | Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide |
GB2411355B (en) * | 2004-02-27 | 2006-02-22 | Niche Generics Ltd | Pharmaceutical composition |
EA011862B1 (ru) * | 2004-03-24 | 2009-06-30 | Актавис Груп Хф. | Композиции рамиприла |
US20060045911A1 (en) * | 2004-08-27 | 2006-03-02 | Sun Pharmaceutical Industries Ltd. | Stable pharmaceutical formulations |
ZA200704767B (en) * | 2004-11-05 | 2008-08-27 | King Pharmaceuticals Res & Dev | Stabilized individually coated ramipril particles, compositions and methods |
EP1809260B1 (en) * | 2004-11-08 | 2013-11-27 | Rubicon Research Private Limited | Aqueous pharmaceutical coating |
GB0518129D0 (en) * | 2005-09-06 | 2005-10-12 | Arrow Int Ltd | Ramipril formulation |
KR100679166B1 (ko) | 2005-10-04 | 2007-02-06 | 신풍제약주식회사 | 안정성이 증진된 약제학적 조성물 및 그의 제조방법 |
GB2431579A (en) * | 2005-10-28 | 2007-05-02 | Arrow Int Ltd | Ramipril formulations |
US20070098782A1 (en) * | 2005-10-28 | 2007-05-03 | Selamine Limited | Ramipril Formulation |
MX2008012248A (es) * | 2006-03-28 | 2009-02-20 | Gelesis Inc | Uso de materiales polimericos con otras sustancias para rendimiento mejorado. |
US20070232680A1 (en) * | 2006-04-04 | 2007-10-04 | Vijayabhaskar Bolugoddu | Preparation of ramipril and stable pharmaceutical compositions |
RU2008145115A (ru) * | 2006-04-19 | 2010-05-27 | Тева Фармасьютикл Индастриес Лтд. (Il) | Стабильные фармацевтические композиции производственных соединений 2-аза-бицикло[3.3.0]-октан-3-карбоновой кислоты |
BRPI0621739A2 (pt) * | 2006-06-02 | 2011-12-20 | Teva Pharma | formulação estável que consiste em drogas sensìveis à umectação e seu procedimento de fabricação |
PT1864677E (pt) * | 2006-06-02 | 2008-03-13 | Teva Pharma | Formulação estável compreendendo um fármaco sensível à humidade e processo para a sua produção |
US20070281000A1 (en) * | 2006-06-02 | 2007-12-06 | Michael Fox | Stable formulation comprising moisture sensitive drug/s and manufacturing procedure thereof |
AU2007264414A1 (en) * | 2006-06-30 | 2008-01-03 | Alphapharm Pty Ltd | A stabilised composition comprising ACE inhibitors |
CA2661598A1 (en) * | 2006-08-28 | 2008-03-06 | Sanofi-Aventis Deutschland Gmbh | Methods of lowering glucose levels |
GB0624090D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril amine salts |
GB0624084D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril amino acid salts |
GB0624087D0 (en) * | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril combination salt |
PL382311A1 (pl) * | 2007-04-27 | 2008-11-10 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Kompozycja farmaceutyczna o polepszonej stabilności zawierająca inhibitor acetylocholinoesterazy lub farmaceutycznie dopuszczalną jego sól oraz sposób jej wytwarzania |
EP2273985B1 (en) | 2008-03-28 | 2016-02-17 | Ferrer Internacional, S.A. | Capsule for the prevention of cardiovascular diseases |
WO2010030735A2 (en) * | 2008-09-11 | 2010-03-18 | Aethos Pharmaceuticals, Inc. | Stabilized coating for pharmaceutical formulations |
TR200906322A2 (tr) | 2009-08-17 | 2011-07-21 | Bi̇lgi̇ç Mahmut | Çözünürlük ve stabilite özellikleri geliştirilmiş granüller. |
ES2364011B1 (es) | 2009-11-20 | 2013-01-24 | Gp Pharm, S.A. | Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares. |
CA2864456A1 (en) | 2012-02-17 | 2013-08-22 | Egis Gyogyszergyar Zrt. | Pharmaceutical formulation having improved stability |
PL227900B1 (pl) | 2012-11-15 | 2018-01-31 | Adamed Spolka Z Ograniczona Odpowiedzialnoscia | Kompozycja farmaceutyczna zawierająca inhibitor ACE i bloker kanałów wapniowych, sposób jej wytwarzania i jednostka dawkowania zawierająca tę kompozycję |
HUP1300496A2 (hu) | 2013-08-16 | 2015-03-02 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Stabil kombinációs gyógyszerkészítmény |
TWI668285B (zh) * | 2015-12-31 | 2019-08-11 | 長興材料工業股份有限公司 | 可熱聚合之組合物、由此形成之組成液及其用途 |
EP3275432A1 (en) | 2016-07-25 | 2018-01-31 | H e x a l Aktiengesellschaft | Dosage form with ace inhibitor |
WO2021162562A2 (en) | 2020-02-10 | 2021-08-19 | Adamed Pharma S.A. | Stable ramipril composition and fixed dose composition comprising thereof |
CN115068434B (zh) * | 2022-08-03 | 2023-05-09 | 昆山龙灯瑞迪制药有限公司 | 一种雷米普利片的制备方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3565559A (en) * | 1968-03-11 | 1971-02-23 | Sumitomo Chemical Co | Process for making microcapsules |
IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
US4344949A (en) * | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
DE3039073A1 (de) * | 1980-10-16 | 1982-05-19 | Röhm GmbH, 6100 Darmstadt | Umhuelltes acetylsalicylsaeurepraeparat |
LU88621I2 (fr) * | 1980-10-23 | 1995-09-01 | Schering Corp | Sandopril |
US4425355A (en) * | 1981-02-17 | 1984-01-10 | Warner-Lambert Company | Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids |
DE3226768A1 (de) * | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
DE3586600T2 (de) * | 1984-02-10 | 1993-02-18 | Benzon Pharma As | Dosierungsform eine vielzahl mit einer diffusionshuelle ueberzogener einheiten enthaltend. |
DE3413710A1 (de) * | 1984-04-12 | 1985-10-24 | Hoechst Ag, 6230 Frankfurt | Verfahren zur behandlung der herzinsuffizienz |
AU4104085A (en) * | 1984-04-13 | 1985-10-17 | Macewans Machinery Ltd. | Steam-heated beater |
CA1259924A (en) * | 1985-03-25 | 1989-09-26 | Wallace E. Becker | Pharmaceutical tableting method |
DE3610391A1 (de) * | 1986-03-27 | 1987-10-08 | Hoechst Ag | Verbindungen mit nootroper wirkung, diese enthaltende mittel und deren verwendung bei der behandlung und prophylaxe cognitiver dysfunktionen |
GB8616669D0 (en) * | 1986-07-09 | 1986-08-13 | Merk Sharpe & Dohme Ltd | Pharmaceutical compositions |
US4743450A (en) * | 1987-02-24 | 1988-05-10 | Warner-Lambert Company | Stabilized compositions |
CA1323833C (en) * | 1987-04-28 | 1993-11-02 | Yatindra M. Joshi | Pharmaceutical compositions in the form of beadlets and method |
US4808413A (en) * | 1987-04-28 | 1989-02-28 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions in the form of beadlets and method |
US4898732A (en) * | 1988-05-04 | 1990-02-06 | The Clinipad Corporation | Inhibiting of tumor growth with an antagonist of the renin-angioten-sin system |
-
1987
- 1987-11-24 DE DE19873739690 patent/DE3739690A1/de not_active Withdrawn
-
1988
- 1988-11-15 DE DE8888119014T patent/DE3869919D1/de not_active Expired - Lifetime
- 1988-11-15 ES ES198888119014T patent/ES2033400T3/es not_active Expired - Lifetime
- 1988-11-15 EP EP88119014A patent/EP0317878B1/de not_active Expired - Lifetime
- 1988-11-15 AT AT88119014T patent/ATE74513T1/de not_active IP Right Cessation
- 1988-11-22 ZA ZA888734A patent/ZA888734B/xx unknown
- 1988-11-22 NZ NZ227032A patent/NZ227032A/en unknown
- 1988-11-22 FI FI885398A patent/FI93693C/fi not_active IP Right Cessation
- 1988-11-22 US US07/274,598 patent/US5151433A/en not_active Expired - Lifetime
- 1988-11-22 JP JP63293761A patent/JPH0768140B2/ja not_active Expired - Lifetime
- 1988-11-22 HU HU885992A patent/HU202100B/hu unknown
- 1988-11-22 PH PH37849A patent/PH27416A/en unknown
- 1988-11-23 NO NO885213A patent/NO176550C/no unknown
- 1988-11-23 KR KR1019880015400A patent/KR970004908B1/ko not_active IP Right Cessation
- 1988-11-23 IE IE350588A patent/IE61173B1/en not_active IP Right Cessation
- 1988-11-23 IL IL88460A patent/IL88460A0/xx not_active IP Right Cessation
- 1988-11-23 CA CA000583952A patent/CA1338344C/en not_active Expired - Lifetime
- 1988-11-23 AU AU25818/88A patent/AU615495B2/en not_active Expired
- 1988-11-23 DK DK653688A patent/DK168423B1/da not_active IP Right Cessation
- 1988-11-23 CN CN88108057A patent/CN1028962C/zh not_active Expired - Lifetime
- 1988-11-23 PT PT89061A patent/PT89061B/pt not_active IP Right Cessation
-
1992
- 1992-06-17 GR GR920401112T patent/GR3004925T3/el unknown
-
1994
- 1994-02-10 US US08/194,634 patent/US5442008A/en not_active Expired - Lifetime
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6300361B1 (en) | 1990-07-25 | 2001-10-09 | Novartis Ag | Stabilized pharmaceutical compositions comprising acid donors |
US6300362B1 (en) | 1990-07-25 | 2001-10-09 | Novartis Ag (Formerly Sandoz Ltd.) | Stabilized pharmaceutical compositions comprising acid donors |
US6509350B2 (en) | 1990-07-25 | 2003-01-21 | Novartis Ag | Stabilized pharmaceutical compositions comprising acid donors |
US6790861B2 (en) | 1990-07-25 | 2004-09-14 | Novartis Ag | Stabilized pharmaceutical compositions comprising acid donors |
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