ZA201001125B - Pyrrolidine Aryl-Ether as NK3 receptor antagonists - Google Patents

Pyrrolidine Aryl-Ether as NK3 receptor antagonists

Info

Publication number
ZA201001125B
ZA201001125B ZA201001125A ZA201001125A ZA201001125B ZA 201001125 B ZA201001125 B ZA 201001125B ZA 201001125 A ZA201001125 A ZA 201001125A ZA 201001125 A ZA201001125 A ZA 201001125A ZA 201001125 B ZA201001125 B ZA 201001125B
Authority
ZA
South Africa
Prior art keywords
ether
receptor antagonists
pyrrolidine
aryl
pyrrolidine aryl
Prior art date
Application number
ZA201001125A
Other languages
English (en)
Inventor
Philippe Jablonski
Kenichi Kawasaki
Henner Knust
Anja Limberg
Matthias Nettekoven
Hasane Ratni
Claus Riemer
Xihan Wu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA201001125B publication Critical patent/ZA201001125B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA201001125A 2007-08-22 2010-02-16 Pyrrolidine Aryl-Ether as NK3 receptor antagonists ZA201001125B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07114790 2007-08-22

Publications (1)

Publication Number Publication Date
ZA201001125B true ZA201001125B (en) 2010-10-27

Family

ID=39870345

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA201001125A ZA201001125B (en) 2007-08-22 2010-02-16 Pyrrolidine Aryl-Ether as NK3 receptor antagonists

Country Status (18)

Country Link
US (1) US7812021B2 (xx)
EP (1) EP2190815B1 (xx)
JP (1) JP2010536818A (xx)
KR (1) KR101194467B1 (xx)
CN (1) CN101861302A (xx)
AR (1) AR067991A1 (xx)
AT (1) ATE519738T1 (xx)
AU (1) AU2008290634B2 (xx)
BR (1) BRPI0815674A2 (xx)
CA (1) CA2697325A1 (xx)
CL (1) CL2008002450A1 (xx)
ES (1) ES2369955T3 (xx)
MX (1) MX2010001774A (xx)
PE (1) PE20090621A1 (xx)
RU (1) RU2010108687A (xx)
TW (1) TW200916462A (xx)
WO (1) WO2009024502A1 (xx)
ZA (1) ZA201001125B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8063075B2 (en) * 2008-06-10 2011-11-22 Hoffmann-La Roche Inc. Pyrrolidine ether derivatives as NK3 receptor antagonists
MX2011003312A (es) * 2008-10-09 2011-04-26 Hoffmann La Roche Derivados de pirrolidina n-bencilo.
CN102282139B (zh) 2009-01-30 2014-06-18 弗·哈夫曼-拉罗切有限公司 作为nk3受体拮抗剂的哌啶衍生物
US8318759B2 (en) * 2009-02-18 2012-11-27 Hoffmann-La Roche Inc. Pyrrolidine derivatives as NK3 receptor antagonists
SA110310332B1 (ar) 2009-05-01 2013-12-10 Astrazeneca Ab مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل )
US8394834B2 (en) * 2009-08-25 2013-03-12 Hoffman-La Roche Inc. Pyrrolidines as NK3 receptor antagonists
US20110144081A1 (en) * 2009-12-15 2011-06-16 Henner Knust Pyrrolidine derivatives
US20110152233A1 (en) 2009-12-18 2011-06-23 Henner Knust Pyrrolidine compounds
MX2012015102A (es) 2010-07-06 2013-05-01 Astrazeneca Ab Agentes terapeuticos 976.
US8507535B2 (en) 2010-07-07 2013-08-13 Hoffmann-La Roche Inc. Methyl-pyrrolidine ether derivatives
US8618303B2 (en) * 2011-01-07 2013-12-31 Hoffmann-La Roche Inc. Pyrrolidine derivatives
UY34194A (es) 2011-07-15 2013-02-28 Astrazeneca Ab ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
JP7185633B2 (ja) 2017-02-17 2022-12-07 トレベナ・インコーポレイテッド ７員アザ複素環を含有するデルタ－オピオイド受容体調節化合物、その使用方法及び製造方法
EP3582779B1 (en) 2017-02-17 2024-04-17 Trevena, Inc. 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN148482B (xx) 1977-06-03 1981-03-07 Pfizer
GB9321557D0 (en) 1992-11-03 1993-12-08 Zeneca Ltd Carboxamide derivatives
EP0714891A1 (en) * 1994-11-22 1996-06-05 Eli Lilly And Company Heterocyclic tachykinin receptor antagonists
JP4195512B2 (ja) 1996-12-19 2008-12-10 アベンティス・ファーマスーティカルズ・インコーポレイテッド 新規な複素環置換ピロリジンアミド誘導体
CN1859914A (zh) * 2003-09-30 2006-11-08 默克公司 苯基吡咯烷醚速激肽受体拮抗剂
US7138423B2 (en) * 2004-07-20 2006-11-21 Bristol-Myers Squibb Company Arylpyrrolidine derivatives as NK-1 /SSRI antagonists
EP1817302A4 (en) * 2004-11-22 2009-07-01 Merck & Co Inc PIPERIDINYLPIPERIDIN-tachykinin receptor Antagonist
CA2587195A1 (en) * 2004-11-22 2006-07-13 Merck & Co., Inc. Cycloalkyl keto piperidine tachykinin receptor antagonists
BRPI0815658A2 (pt) * 2007-08-07 2015-02-18 Hoffmann La Roche Aril-éter pirrolidina como antagonistas do receptor nk3

Also Published As

Publication number Publication date
ES2369955T3 (es) 2011-12-09
US20090054644A1 (en) 2009-02-26
BRPI0815674A2 (pt) 2015-02-18
KR101194467B1 (ko) 2012-10-24
TW200916462A (en) 2009-04-16
JP2010536818A (ja) 2010-12-02
CN101861302A (zh) 2010-10-13
KR20100043105A (ko) 2010-04-27
CL2008002450A1 (es) 2009-07-31
WO2009024502A1 (en) 2009-02-26
EP2190815A1 (en) 2010-06-02
RU2010108687A (ru) 2011-09-27
PE20090621A1 (es) 2009-05-16
AU2008290634A1 (en) 2009-02-26
EP2190815B1 (en) 2011-08-10
US7812021B2 (en) 2010-10-12
AU2008290634B2 (en) 2012-12-06
AR067991A1 (es) 2009-10-28
ATE519738T1 (de) 2011-08-15
CA2697325A1 (en) 2009-02-26
MX2010001774A (es) 2010-03-10

Similar Documents

Publication Publication Date Title
ZA201001125B (en) Pyrrolidine Aryl-Ether as NK3 receptor antagonists
ZA201000676B (en) Pyrrolidine aryl-ether as NK3 receptor antagonists
EP2244575A4 (en) ANTAGONISTS OF THE ANGIOTENSIN II RECEPTOR
EP2214676A4 (en) OXININE RECEPTOR ANTAGONISTS SUBSTITUTED DIAZEPAN TYPE
EP2150115A4 (en) RECEPTOR ANTAGONISTS OF CYCLOPROPYLPYRROLIDINE OREXINE
EP2099454A4 (en) AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS
EP2001485A4 (en) ANTAGONISTS OF OREXIN RECEPTORS IN THE FORM OF DIAZEPAN COMPOUNDS
HK1128691A1 (en) Substituted diazepan compounds as orexin receptor antagonists
EP2203051A4 (en) OCTAHYDROPENTAL COMPOUNDS AS CHEMOKIN RECEPTOR ANTAGONISTS
ZA201007126B (en) Isoquinolinone derivatives as nk3 antagonists
EP2184278A4 (en) P2X4 RECEIVER ANTAGONIST
IL201165A0 (en) CRIg ANTAGONISTS
IL212545A0 (en) Toll-like receptor 3 antagonists
ZA200903334B (en) Substituted diazepan compounds as orexin receptor antagonists
IL213982A0 (en) Piperidine derivatives as nk3 receptor antagonists
ZA201103119B (en) Isoquinolinone derivatives as nk3 antagonists
IL212107A0 (en) Isoquinolinone derivatives as nk3 antagonists
IL209663A0 (en) Isoquinolinone derivatives as nk3 antagonists
IL207577A0 (en) Pyrrolidine ether derivatives as nk3 receptor antagonists
IL209266A0 (en) Pyrrolidine derivatives as nk2 receptor antagonists
IL217759A0 (en) Pyrrolidine derivatives as nk3 receptor antagonists
EP2365748A4 (en) IMIDAZOISOINDOLA ANTAGONISTS OF NEUROPEPTIDE S RECEPTORS
IL202454A0 (en) Urotensin ii receptor antagonists
HK1169992A1 (en) Pyrrolidine derivatives as nk - 3 receptor antagonists nk-3
IL213763A0 (en) Pyrrolidine derivatives as nk3 receptor antagonists