PE20090621A1 - Pirrolidina-aril-eteres como antagonistas de receptores de nk3 - Google Patents
Pirrolidina-aril-eteres como antagonistas de receptores de nk3Info
- Publication number
- PE20090621A1 PE20090621A1 PE2008001420A PE2008001420A PE20090621A1 PE 20090621 A1 PE20090621 A1 PE 20090621A1 PE 2008001420 A PE2008001420 A PE 2008001420A PE 2008001420 A PE2008001420 A PE 2008001420A PE 20090621 A1 PE20090621 A1 PE 20090621A1
- Authority
- PE
- Peru
- Prior art keywords
- aryl
- piperazin
- pyrrolidin
- phenyl
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRROLIDINA-ARIL-ETERES DE FORMULA (I) DONDE Ar ES ARILO O HETEROARILO DE 5 O 6 MIEMBROS; (i) ES UN RESTO MONO O BIHETEROCICLICO DE 6 A 9 ESLABONES, EN DONDE X ES C, SO2, N U O; R1 ES H, OH, CN, S(O)2-ALQUILO INFERIOR, ENTRE OTROS; R2 ES H, HALOGENO, ALQUILO INFERIOR, CN, ENTRE OTROS; R3 ES H O HALOGENO; R4 ES H O ALQUILO INFERIOR; n, o Y p SON CADA UNO 1 O 2; s ES DE 0 A 4. SON COMPUESTOS PREFERIDOS: {(3RS,4SR)-3-(3,4-DICLORO-FENIL)-4-[(RS)-1-(4-TRIFLUORMETIL-FENOXI)-ETIL]-PIRROLIDIN-1-IL}-(4-METANOSULFONIL-PIPERAZIN-1-IL)-METANONA, 2-(4-ACETIL-PIPERAZIN-1-IL)-1-{(3RS,4SR)-3-(3,4-DICLORO-FENIL)-4-[(RS)-1-(4-TRIFLUORMETIL-FENOXI)-ETIL]-PIRROLIDIN-1-IL}-ETANONA, [(3RS,4SR)-3-(3,4-DICLORO-FENIL)-4-((RS)-1-p-TOLILOXI-ETIL)-PIRROLIDIN-1-IL]-(4-METANOSULFONIL-PIPERAZIN-1-IL)-METANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES DE NEUROQUININAS 3 (NK-3) SIENDO UTILES EN EL TRATAMIENTO DE LA ANSIEDAD, DEPRESION, ESQUIZOFRENIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07114790 | 2007-08-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090621A1 true PE20090621A1 (es) | 2009-05-16 |
Family
ID=39870345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001420A PE20090621A1 (es) | 2007-08-22 | 2008-08-21 | Pirrolidina-aril-eteres como antagonistas de receptores de nk3 |
Country Status (18)
Country | Link |
---|---|
US (1) | US7812021B2 (es) |
EP (1) | EP2190815B1 (es) |
JP (1) | JP2010536818A (es) |
KR (1) | KR101194467B1 (es) |
CN (1) | CN101861302A (es) |
AR (1) | AR067991A1 (es) |
AT (1) | ATE519738T1 (es) |
AU (1) | AU2008290634B2 (es) |
BR (1) | BRPI0815674A2 (es) |
CA (1) | CA2697325A1 (es) |
CL (1) | CL2008002450A1 (es) |
ES (1) | ES2369955T3 (es) |
MX (1) | MX2010001774A (es) |
PE (1) | PE20090621A1 (es) |
RU (1) | RU2010108687A (es) |
TW (1) | TW200916462A (es) |
WO (1) | WO2009024502A1 (es) |
ZA (1) | ZA201001125B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8063075B2 (en) * | 2008-06-10 | 2011-11-22 | Hoffmann-La Roche Inc. | Pyrrolidine ether derivatives as NK3 receptor antagonists |
AU2009301212A1 (en) * | 2008-10-09 | 2010-04-15 | F. Hoffmann-La Roche Ag | Pyrrolidine n-benzyl derivatives |
EP2391615B1 (en) | 2009-01-30 | 2013-01-16 | F. Hoffmann-La Roche AG | Piperidine derivatives as nk3 receptor antagonists |
US8318759B2 (en) * | 2009-02-18 | 2012-11-27 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives as NK3 receptor antagonists |
SA110310332B1 (ar) | 2009-05-01 | 2013-12-10 | Astrazeneca Ab | مركبات ميثانون (3 استبدال -ازيتيدين -1-يل )(5- فينيل -1، 3، 4- أوكساديازول -2-يل ) |
US8394834B2 (en) * | 2009-08-25 | 2013-03-12 | Hoffman-La Roche Inc. | Pyrrolidines as NK3 receptor antagonists |
US20110144081A1 (en) | 2009-12-15 | 2011-06-16 | Henner Knust | Pyrrolidine derivatives |
US20110152233A1 (en) * | 2009-12-18 | 2011-06-23 | Henner Knust | Pyrrolidine compounds |
SG186275A1 (en) | 2010-07-06 | 2013-01-30 | Astrazeneca Ab | Therapeutic agents 976 |
US8507535B2 (en) * | 2010-07-07 | 2013-08-13 | Hoffmann-La Roche Inc. | Methyl-pyrrolidine ether derivatives |
US8618303B2 (en) * | 2011-01-07 | 2013-12-31 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives |
UY34194A (es) | 2011-07-15 | 2013-02-28 | Astrazeneca Ab | ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad? |
WO2018152286A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
BR112019016827A2 (pt) | 2017-02-17 | 2020-04-07 | Trevena Inc | compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 5 membros, métodos de uso e produção dos mesmos |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN148482B (es) | 1977-06-03 | 1981-03-07 | Pfizer | |
GB9321557D0 (en) * | 1992-11-03 | 1993-12-08 | Zeneca Ltd | Carboxamide derivatives |
CA2162786A1 (en) * | 1994-11-22 | 1996-05-23 | Philip Arthur Hipskind | Heterocyclic tachykinin receptor antagonists |
BR9714057A (pt) | 1996-12-19 | 2000-05-09 | Hoechst Marion Roussel Inc | Derivados heterocìclicos de pirrolidina amida substituìda. |
US7468437B2 (en) * | 2003-09-30 | 2008-12-23 | Merck & Co., Inc. | Phenyl pyrrolidine ether tachykinin receptor antagonists |
US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
CN101061096A (zh) * | 2004-11-22 | 2007-10-24 | 默克公司 | 环烷基酮基哌啶速激肽受体拮抗剂 |
EP1817302A4 (en) * | 2004-11-22 | 2009-07-01 | Merck & Co Inc | PIPERIDINYLPIPERIDIN-tachykinin receptor Antagonist |
MX2010001080A (es) * | 2007-08-07 | 2010-03-01 | Hoffmann La Roche | Pirrolidin-aril-eteres como antagonistas de receptor de nk3. |
-
2008
- 2008-08-12 CN CN200880103704A patent/CN101861302A/zh active Pending
- 2008-08-12 CA CA2697325A patent/CA2697325A1/en not_active Abandoned
- 2008-08-12 AU AU2008290634A patent/AU2008290634B2/en not_active Expired - Fee Related
- 2008-08-12 KR KR1020107006058A patent/KR101194467B1/ko not_active IP Right Cessation
- 2008-08-12 EP EP08787130A patent/EP2190815B1/en not_active Not-in-force
- 2008-08-12 AT AT08787130T patent/ATE519738T1/de active
- 2008-08-12 BR BRPI0815674-3A2A patent/BRPI0815674A2/pt not_active IP Right Cessation
- 2008-08-12 WO PCT/EP2008/060566 patent/WO2009024502A1/en active Application Filing
- 2008-08-12 MX MX2010001774A patent/MX2010001774A/es active IP Right Grant
- 2008-08-12 JP JP2010521396A patent/JP2010536818A/ja active Pending
- 2008-08-12 RU RU2010108687/04A patent/RU2010108687A/ru not_active Application Discontinuation
- 2008-08-12 ES ES08787130T patent/ES2369955T3/es active Active
- 2008-08-20 CL CL2008002450A patent/CL2008002450A1/es unknown
- 2008-08-21 AR ARP080103635A patent/AR067991A1/es unknown
- 2008-08-21 US US12/195,545 patent/US7812021B2/en not_active Expired - Fee Related
- 2008-08-21 PE PE2008001420A patent/PE20090621A1/es not_active Application Discontinuation
- 2008-08-21 TW TW097131984A patent/TW200916462A/zh unknown
-
2010
- 2010-02-16 ZA ZA201001125A patent/ZA201001125B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CL2008002450A1 (es) | 2009-07-31 |
BRPI0815674A2 (pt) | 2015-02-18 |
KR20100043105A (ko) | 2010-04-27 |
WO2009024502A1 (en) | 2009-02-26 |
AR067991A1 (es) | 2009-10-28 |
US7812021B2 (en) | 2010-10-12 |
MX2010001774A (es) | 2010-03-10 |
CA2697325A1 (en) | 2009-02-26 |
TW200916462A (en) | 2009-04-16 |
ES2369955T3 (es) | 2011-12-09 |
EP2190815B1 (en) | 2011-08-10 |
ATE519738T1 (de) | 2011-08-15 |
AU2008290634B2 (en) | 2012-12-06 |
US20090054644A1 (en) | 2009-02-26 |
CN101861302A (zh) | 2010-10-13 |
RU2010108687A (ru) | 2011-09-27 |
ZA201001125B (en) | 2010-10-27 |
AU2008290634A1 (en) | 2009-02-26 |
JP2010536818A (ja) | 2010-12-02 |
KR101194467B1 (ko) | 2012-10-24 |
EP2190815A1 (en) | 2010-06-02 |
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