ZA200607752B - [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase - Google Patents

[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase Download PDF

Info

Publication number: ZA200607752B
Authority: ZA; South Africa
Prior art keywords: compound; pharmaceutical composition; inflammatory; pharmaceutically acceptable; arthritis
Prior art date: 2004-03-26

Application number

ZA200607752A

Other languages

English (en)

Inventor

Gao Zhongli

Levell Julian

Adam W Sledeski

Davis Larry

Czekaj Mark

Haddad El-Bdaoui

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-26

Filing date

2006-09-15

Publication date

2008-05-28

2006-09-15 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2008-05-28 Publication of ZA200607752B publication Critical patent/ZA200607752B/en

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Classifications

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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
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Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
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General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Diabetes (AREA)
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Immunology (AREA)
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Ophthalmology & Optometry (AREA)
Communicable Diseases (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Endocrinology (AREA)
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Neurosurgery (AREA)
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Emergency Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA200607752A 2004-03-26 2006-09-15 [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase ZA200607752B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US55692704P	2004-03-26	2004-03-26

Publications (1)

Publication Number	Publication Date
ZA200607752B true ZA200607752B (en)	2008-05-28

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ID=34964263

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ZA200607752A ZA200607752B (en)	2004-03-26	2006-09-15	[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(4-bromo-3-methyl-5-propoxy-thiophen-2-yl)-methanone hydrochloride as an inhibitor of mast cell tryptase

Country Status (25)

Country	Link
US (1)	US20070142435A1 (no)
EP (1)	EP1737848A1 (no)
JP (1)	JP2007530580A (no)
KR (1)	KR20060130682A (no)
CN (1)	CN1956978A (no)
AR (1)	AR048336A1 (no)
AU (1)	AU2005230934A1 (no)
BR (1)	BRPI0509245A (no)
CA (1)	CA2560649A1 (no)
CR (1)	CR8603A (no)
DO (1)	DOP2005000039A (no)
EC (1)	ECSP066878A (no)
IL (1)	IL178031A0 (no)
MA (1)	MA28547B1 (no)
MX (1)	MXPA06010610A (no)
NO (1)	NO20064811L (no)
PA (1)	PA8627601A1 (no)
PE (1)	PE20060084A1 (no)
RU (1)	RU2330034C1 (no)
TN (1)	TNSN06278A1 (no)
TW (1)	TW200602035A (no)
UA (1)	UA83738C2 (no)
UY (1)	UY28821A1 (no)
WO (1)	WO2005097780A1 (no)
ZA (1)	ZA200607752B (no)

Families Citing this family (17)

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Publication number	Priority date	Publication date	Assignee	Title
PE20071148A1 (es) *	2006-03-29	2007-12-10	Sanofi Aventis	Mejoras en la preparacion de intermedios que conducen a hidrocloruro de [4-(5-aminometil-2-fluoro-fenil)-piperidin-1-il]-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona
AR065616A1 (es) *	2007-03-07	2009-06-17	Sanofi Aventis	Sintesis regioselectiva de ullmann de acido 4- bromo-3- metil-5- propoxi- tiofeno-2- carboxilico
WO2008115912A1 (en) *	2007-03-21	2008-09-25	Sanofi-Aventis	Regio-specific synthesis of 4-bromo-3-methyl-5-propoxy-thiophene-2-carboxylic acid
WO2008121669A1 (en) *	2007-03-29	2008-10-09	Sanofi-Aventis	4-bromo-3-methyl-5-propoxythiophene-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester, its regio-specific synthesis and intermediate thereto
AR065858A1 (es) *	2007-03-29	2009-07-08	Sanofi Aventis	Metodo para preparar el inhibidor de triptasa [ 4-(5-aminoetil-2-fluoro-fenil)-piperidin-1-il]-(4-bromo-3-metil-5-propoxi-tiofen-2-il)-metanona.
US8158792B2 (en)	2007-11-21	2012-04-17	Janssen Pharmaceutica N.V.	Spiropiperidines for use as tryptase inhibitors
CA2713131C (en) *	2008-01-24	2017-01-10	Soligenix, Inc.	Topically active steroids for use in interstitial pulmonary fibrosis
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Also Published As

Publication number	Publication date
CN1956978A (zh)	2007-05-02
AR048336A1 (es)	2006-04-19
RU2330034C1 (ru)	2008-07-27
UY28821A1 (es)	2005-10-31
NO20064811L (no)	2006-10-23
BRPI0509245A (pt)	2007-09-11
PE20060084A1 (es)	2006-03-09
IL178031A0 (en)	2006-12-31
UA83738C2 (en)	2008-08-11
DOP2005000039A (es)	2005-10-31
MXPA06010610A (es)	2006-12-15
EP1737848A1 (en)	2007-01-03
CA2560649A1 (en)	2005-10-20
TNSN06278A1 (en)	2007-12-03
ECSP066878A (es)	2006-11-24
KR20060130682A (ko)	2006-12-19
US20070142435A1 (en)	2007-06-21
AU2005230934A1 (en)	2005-10-20
MA28547B1 (fr)	2007-04-03
JP2007530580A (ja)	2007-11-01
RU2006137717A (ru)	2008-05-10
CR8603A (es)	2007-06-08
WO2005097780A1 (en)	2005-10-20
PA8627601A1 (es)	2006-01-23
TW200602035A (en)	2006-01-16

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US20120245199A1 (en)	2012-09-27	[4 [4-(aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1h-pyrrolo-pyridin-yl)-methanones and synthesis thereof
EP2516418B1 (en)	2014-05-14	Prodrugs of [4[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1h-pyrrolo-pyridin-yl)-methanones and synthesis thereof
US20040192734A1 (en)	2004-09-30	4-(3-aminomethylphenyl)piperidin-1-yl]-[5-(2-fluorophenylethynyl)furan-2-yl]-methanone as an inhibitor of mast cell tryptase