ZA200503380B - Nucleic acid coated particles - Google Patents

Nucleic acid coated particles Download PDF

Info

Publication number: ZA200503380B
Authority: ZA; South Africa
Prior art keywords: particles; antigen; nucleic acid; process according; dna
Prior art date: 2002-09-27

Application number

ZA200503380A

Other languages

English (en)

Inventor

Lively Chris Robert

Delong Robert

Original Assignee

Powderject Res Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-27

Filing date

2005-04-26

Publication date

2007-11-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32043345&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200503380(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-04-26 Application filed by Powderject Res Ltd filed Critical Powderject Res Ltd

2007-11-28 Publication of ZA200503380B publication Critical patent/ZA200503380B/en

Links

239000002245 particle Substances 0.000 title claims description 200
150000007523 nucleic acids Chemical class 0.000 title claims description 112
102000039446 nucleic acids Human genes 0.000 title claims description 105
108020004707 nucleic acids Proteins 0.000 title claims description 105
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 109
239000000203 mixture Substances 0.000 claims description 88
238000000034 method Methods 0.000 claims description 71
150000003839 salts Chemical class 0.000 claims description 55
239000000427 antigen Substances 0.000 claims description 49
108091007433 antigens Proteins 0.000 claims description 49
102000036639 antigens Human genes 0.000 claims description 49
230000008569 process Effects 0.000 claims description 45
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 44
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 42
HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 41
HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 40
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 38
239000010931 gold Substances 0.000 claims description 34
229910052737 gold Inorganic materials 0.000 claims description 33
239000002738 chelating agent Substances 0.000 claims description 31
235000019441 ethanol Nutrition 0.000 claims description 31
235000000346 sugar Nutrition 0.000 claims description 30
230000001404 mediated effect Effects 0.000 claims description 27
229920001519 homopolymer Polymers 0.000 claims description 25
239000004475 Arginine Substances 0.000 claims description 24
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 24
229930006000 Sucrose Natural products 0.000 claims description 21
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 21
229910052751 metal Inorganic materials 0.000 claims description 21
239000002184 metal Substances 0.000 claims description 21
239000005720 sucrose Substances 0.000 claims description 21
QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims description 17
229960003330 pentetic acid Drugs 0.000 claims description 17
229910021645 metal ion Inorganic materials 0.000 claims description 15
108090000765 processed proteins & peptides Proteins 0.000 claims description 15
238000002360 preparation method Methods 0.000 claims description 13
150000008163 sugars Chemical class 0.000 claims description 13
MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims description 12
MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims description 12
SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims description 12
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims description 12
239000003963 antioxidant agent Substances 0.000 claims description 11
235000006708 antioxidants Nutrition 0.000 claims description 11
102000004196 processed proteins & peptides Human genes 0.000 claims description 11
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 claims description 10
230000003078 antioxidant effect Effects 0.000 claims description 10
238000000151 deposition Methods 0.000 claims description 9
KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims description 8
YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Chemical compound [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 claims description 8
-1 trisaccharide sugars Chemical class 0.000 claims description 8
WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 8
229910052721 tungsten Inorganic materials 0.000 claims description 8
239000010937 tungsten Substances 0.000 claims description 8
229940099217 desferal Drugs 0.000 claims description 7
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GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 6
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GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 6
150000002016 disaccharides Chemical class 0.000 claims description 6
239000008101 lactose Substances 0.000 claims description 6
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 6
235000011056 potassium acetate Nutrition 0.000 claims description 6
230000003612 virological effect Effects 0.000 claims description 6
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 5
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 5
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 5
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 5
229930003268 Vitamin C Natural products 0.000 claims description 5
229930003427 Vitamin E Natural products 0.000 claims description 5
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 5
239000001110 calcium chloride Substances 0.000 claims description 5
229910001628 calcium chloride Inorganic materials 0.000 claims description 5
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 5
235000019155 vitamin A Nutrition 0.000 claims description 5
239000011719 vitamin A Substances 0.000 claims description 5
235000019154 vitamin C Nutrition 0.000 claims description 5
239000011718 vitamin C Substances 0.000 claims description 5
235000019165 vitamin E Nutrition 0.000 claims description 5
239000011709 vitamin E Substances 0.000 claims description 5
229940045997 vitamin a Drugs 0.000 claims description 5
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 4
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 4
239000001632 sodium acetate Substances 0.000 claims description 4
235000017281 sodium acetate Nutrition 0.000 claims description 4
239000001509 sodium citrate Substances 0.000 claims description 4
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 4
239000001488 sodium phosphate Substances 0.000 claims description 4
229910000162 sodium phosphate Inorganic materials 0.000 claims description 4
230000001225 therapeutic effect Effects 0.000 claims description 4
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 4
241000712461 unidentified influenza virus Species 0.000 claims description 4
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241000700588 Human alphaherpesvirus 1 Species 0.000 claims description 3
241000701074 Human alphaherpesvirus 2 Species 0.000 claims description 3
IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 3
IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims description 3
JHFZWTMEVGPUTE-UHFFFAOYSA-L dilithium;2-hydroxybutanedioate Chemical compound [Li+].[Li+].[O-]C(=O)C(O)CC([O-])=O JHFZWTMEVGPUTE-UHFFFAOYSA-L 0.000 claims description 3
CVOQYKPWIVSMDC-UHFFFAOYSA-L dipotassium;butanedioate Chemical compound [K+].[K+].[O-]C(=O)CCC([O-])=O CVOQYKPWIVSMDC-UHFFFAOYSA-L 0.000 claims description 3
WPUMTJGUQUYPIV-JIZZDEOASA-L disodium (S)-malate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](O)CC([O-])=O WPUMTJGUQUYPIV-JIZZDEOASA-L 0.000 claims description 3
229960004756 ethanol Drugs 0.000 claims description 3
229910052741 iridium Inorganic materials 0.000 claims description 3
GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims description 3
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MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 claims description 3
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235000019832 sodium triphosphate Nutrition 0.000 claims description 3
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Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
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Genetics & Genomics (AREA)
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Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Immunology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

ZA200503380A 2002-09-27 2005-04-26 Nucleic acid coated particles ZA200503380B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US41409702P	2002-09-27	2002-09-27

Publications (1)

Publication Number	Publication Date
ZA200503380B true ZA200503380B (en)	2007-11-28

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ID=32043345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200503380A ZA200503380B (en)	2002-09-27	2005-04-26	Nucleic acid coated particles

Country Status (17)

Country	Link
US (1)	US8349364B2 (pl)
EP (1)	EP1545593A1 (pl)
JP (1)	JP4791730B2 (pl)
KR (1)	KR101152561B1 (pl)
CN (1)	CN100542605C (pl)
AU (1)	AU2003269213B2 (pl)
BR (1)	BR0314751A (pl)
CA (1)	CA2500215C (pl)
EA (1)	EA010881B1 (pl)
GB (1)	GB2410497B (pl)
HK (1)	HK1073797A1 (pl)
IL (1)	IL167635A (pl)
MX (1)	MXPA05003222A (pl)
NZ (1)	NZ539107A (pl)
PL (1)	PL212483B1 (pl)
WO (1)	WO2004028560A1 (pl)
ZA (1)	ZA200503380B (pl)

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JP4793956B2 (ja) *	2005-12-29	2011-10-12	ニチコン株式会社	アルミニウム電解コンデンサの駆動用電解液、およびこれを用いたアルミニウム電解コンデンサ
CN102439171B (zh)	2008-12-22	2017-07-14	犹他大学研究基金会	单色多重定量pcr
GB0918679D0 (en)	2009-10-23	2009-12-09	Iqur Ltd	Influenza vaccine
GB0918782D0 (en)	2009-10-26	2009-12-09	St Georges Hosp Medical School	A protein as an adjuvant for a vaccine
WO2014195713A1 (en)	2013-06-06	2014-12-11	David J Rowlands	Single domain antibody display
CN103736090B (zh) *	2014-01-27	2016-03-02	中国医学科学院医学生物学研究所	甲磺酸去铁胺佐剂及含甲磺酸去铁胺佐剂的疫苗
EP3164156A1 (en) *	2014-07-04	2017-05-10	BioNTech AG	Stabilised formulations of rna
WO2016108954A1 (en)	2014-12-30	2016-07-07	Telomere Diagnostics, Inc.	Multiplex quantitative pcr
WO2021061192A1 (en) *	2019-09-29	2021-04-01	Wjwu & Lynn Institute For Stem Cell Research	Novel trimethylglycylglycerin compositions and their use in developing anti-cancer drugs and rna vaccines

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2003
- 2003-09-29 JP JP2004539249A patent/JP4791730B2/ja not_active Expired - Fee Related
- 2003-09-29 CN CNB038251353A patent/CN100542605C/zh not_active Expired - Fee Related
- 2003-09-29 PL PL375782A patent/PL212483B1/pl unknown
- 2003-09-29 WO PCT/GB2003/004202 patent/WO2004028560A1/en active Application Filing
- 2003-09-29 US US10/529,010 patent/US8349364B2/en not_active Expired - Fee Related
- 2003-09-29 BR BR0314751-7A patent/BR0314751A/pt not_active Application Discontinuation
- 2003-09-29 MX MXPA05003222A patent/MXPA05003222A/es active IP Right Grant
- 2003-09-29 CA CA2500215A patent/CA2500215C/en not_active Expired - Fee Related
- 2003-09-29 NZ NZ539107A patent/NZ539107A/en not_active IP Right Cessation
- 2003-09-29 EA EA200500546A patent/EA010881B1/ru not_active IP Right Cessation
- 2003-09-29 EP EP03750990A patent/EP1545593A1/en not_active Withdrawn
- 2003-09-29 AU AU2003269213A patent/AU2003269213B2/en not_active Ceased
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- 2003-09-29 KR KR1020057005212A patent/KR101152561B1/ko not_active IP Right Cessation
2005
- 2005-03-24 IL IL167635A patent/IL167635A/en active IP Right Grant
- 2005-04-26 ZA ZA200503380A patent/ZA200503380B/en unknown
- 2005-08-10 HK HK05106899A patent/HK1073797A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB0508549D0 (en)	2005-06-01
EA200500546A1 (ru)	2005-10-27
EA010881B1 (ru)	2008-12-30
NZ539107A (en)	2008-11-28
CN100542605C (zh)	2009-09-23
EP1545593A1 (en)	2005-06-29
AU2003269213A1 (en)	2004-04-19
PL375782A1 (pl)	2005-12-12
IL167635A (en)	2011-07-31
GB2410497B (en)	2006-11-22
JP2006503063A (ja)	2006-01-26
WO2004028560A1 (en)	2004-04-08
MXPA05003222A (es)	2005-07-26
BR0314751A (pt)	2005-07-26
US20060153804A1 (en)	2006-07-13
CA2500215C (en)	2012-02-28
AU2003269213B2 (en)	2008-11-13
KR101152561B1 (ko)	2012-06-01
US8349364B2 (en)	2013-01-08
KR20050070008A (ko)	2005-07-05
GB2410497A (en)	2005-08-03
CA2500215A1 (en)	2004-04-08
HK1073797A1 (en)	2005-10-21
JP4791730B2 (ja)	2011-10-12
CN1694721A (zh)	2005-11-09
PL212483B1 (pl)	2012-10-31

Publication	Publication Date	Title
ZA200503380B (en)	2007-11-28	Nucleic acid coated particles
JP4814099B2 (ja)	2011-11-09	核酸構築物
US6893664B1 (en)	2005-05-17	Particle delivery techniques
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US20050175584A1 (en)	2005-08-11	Functionalized colloidal metal compositions and methods
EP1150918A2 (en)	2001-11-07	Therapeutic calcium phosphate particles and methods of manufacture and use
US20060280798A1 (en)	2006-12-14	Nanoparticles for delivery of a pharmacologically active agent
AU2008302035A1 (en)	2009-03-26	Nanotherapeutic colloidal metal compositions and methods
AU775939B2 (en)	2004-08-19	Nucleic acid constructs for genetic immunization
EP0928190B1 (en)	2004-11-17	Nucleic acid particle delivery
JP2009215319A (ja)	2009-09-24	コロイド状金属組成物および方法
ZA200503377B (en)	2007-11-28	Nucleic acid constructs for gene expression
WO2006073503A1 (en)	2006-07-13	Therapeutic calcium phosphate particles for use in inhibiting expression of a gene
US6881723B1 (en)	2005-04-19	Nucleic acid constructs
JP2004522403A (ja)	2004-07-29	抗原発現を駆動する哺乳動物ｃｄ８０／ｃｄ８６遺伝子プロモーターを有する核酸ワクチン組成物