PL375782A1 - Cząsteczki opłaszczone kwasem nukleinowym - Google Patents

Cząsteczki opłaszczone kwasem nukleinowym

Info

Publication number
PL375782A1
PL375782A1 PL03375782A PL37578203A PL375782A1 PL 375782 A1 PL375782 A1 PL 375782A1 PL 03375782 A PL03375782 A PL 03375782A PL 37578203 A PL37578203 A PL 37578203A PL 375782 A1 PL375782 A1 PL 375782A1
Authority
PL
Poland
Prior art keywords
nucleic acid
coated particles
acid coated
particles
nucleic
Prior art date
Application number
PL03375782A
Other languages
English (en)
Other versions
PL212483B1 (pl
Inventor
Chris Robert Lively
Robert Delong
Original Assignee
Powderject Research Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32043345&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL375782(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Powderject Research Limited filed Critical Powderject Research Limited
Publication of PL375782A1 publication Critical patent/PL375782A1/pl
Publication of PL212483B1 publication Critical patent/PL212483B1/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
    • C12N15/895Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091Purification or manufacturing processes for gene therapy compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1611Inorganic compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00Reverse transcribing DNA viruses
    • C12N2730/00011Details
    • C12N2730/10011Hepadnaviridae
    • C12N2730/10111Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Ceramic Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL375782A 2002-09-27 2003-09-29 Sposób wytwarzania czasteczek, czasteczki odpowiednie do dostarczania, pojemnik, urzadzenie do dostarczania czasteczek i zastosowanie tych czasteczek PL212483B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41409702P 2002-09-27 2002-09-27

Publications (2)

Publication Number Publication Date
PL375782A1 true PL375782A1 (pl) 2005-12-12
PL212483B1 PL212483B1 (pl) 2012-10-31

Family

ID=32043345

Family Applications (1)

Application Number Title Priority Date Filing Date
PL375782A PL212483B1 (pl) 2002-09-27 2003-09-29 Sposób wytwarzania czasteczek, czasteczki odpowiednie do dostarczania, pojemnik, urzadzenie do dostarczania czasteczek i zastosowanie tych czasteczek

Country Status (17)

Country Link
US (1) US8349364B2 (pl)
EP (1) EP1545593A1 (pl)
JP (1) JP4791730B2 (pl)
KR (1) KR101152561B1 (pl)
CN (1) CN100542605C (pl)
AU (1) AU2003269213B2 (pl)
BR (1) BR0314751A (pl)
CA (1) CA2500215C (pl)
EA (1) EA010881B1 (pl)
GB (1) GB2410497B (pl)
HK (1) HK1073797A1 (pl)
IL (1) IL167635A (pl)
MX (1) MXPA05003222A (pl)
NZ (1) NZ539107A (pl)
PL (1) PL212483B1 (pl)
WO (1) WO2004028560A1 (pl)
ZA (1) ZA200503380B (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1585974B1 (en) 2003-01-24 2013-02-27 University of Utah Methods of predicting mortality risk by determining telomere length
JP4793956B2 (ja) * 2005-12-29 2011-10-12 ニチコン株式会社 アルミニウム電解コンデンサの駆動用電解液、およびこれを用いたアルミニウム電解コンデンサ
CN102439171B (zh) 2008-12-22 2017-07-14 犹他大学研究基金会 单色多重定量pcr
GB0918679D0 (en) 2009-10-23 2009-12-09 Iqur Ltd Influenza vaccine
GB0918782D0 (en) 2009-10-26 2009-12-09 St Georges Hosp Medical School A protein as an adjuvant for a vaccine
WO2014195713A1 (en) 2013-06-06 2014-12-11 David J Rowlands Single domain antibody display
CN103736090B (zh) * 2014-01-27 2016-03-02 中国医学科学院医学生物学研究所 甲磺酸去铁胺佐剂及含甲磺酸去铁胺佐剂的疫苗
EP3164156A1 (en) * 2014-07-04 2017-05-10 BioNTech AG Stabilised formulations of rna
WO2016108954A1 (en) 2014-12-30 2016-07-07 Telomere Diagnostics, Inc. Multiplex quantitative pcr
WO2021061192A1 (en) * 2019-09-29 2021-04-01 Wjwu & Lynn Institute For Stem Cell Research Novel trimethylglycylglycerin compositions and their use in developing anti-cancer drugs and rna vaccines

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5120657A (en) 1986-12-05 1992-06-09 Agracetus, Inc. Apparatus for genetic transformation
KR900007952B1 (ko) 1988-11-18 1990-10-23 주식회사 녹십자 신규의 한탄바이러스 rok84/105 균주 및 이를 이용한 한탄바이러스 백신의 제조방법
US5204253A (en) * 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5149655A (en) 1990-06-21 1992-09-22 Agracetus, Inc. Apparatus for genetic transformation
CA2051092C (en) * 1990-09-12 2002-07-23 Stephen A. Livesey Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions
JP3605411B2 (ja) * 1991-05-15 2004-12-22 モンサント・カンパニー 形質転換された稲植物の製法
TW360548B (en) * 1993-04-08 1999-06-11 Powderject Res Ltd Products for therapeutic use
GB2284208A (en) * 1993-11-25 1995-05-31 Pna Diagnostics As Nucleic acid analogues with a chelating functionality for metal ions
ATE300609T1 (de) 1994-01-21 2005-08-15 Powderject Vaccines Inc Gasbetätigtes element zum austragen von genmaterial
GB9416663D0 (en) 1994-08-17 1994-10-12 Oxford Bioscience Limited Particle delivery
WO1996012513A1 (en) 1994-10-24 1996-05-02 Oxford Biosciences Limited Particle delivery
GB9426379D0 (en) 1994-12-23 1995-03-01 Oxford Biosciences Ltd Particle delivery
FR2730637B1 (fr) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
AU727306B2 (en) 1996-04-26 2000-12-07 Merck Sharp & Dohme Corp. DNA vaccine formulations
IN184589B (pl) 1996-10-16 2000-09-09 Alza Corp
WO2000002591A1 (en) 1998-07-09 2000-01-20 Merck & Co., Inc. Polynucleotide vaccine formulations
PT1119630E (pt) * 1998-11-05 2006-05-31 Powderject Vaccines Inc Construcoes de acido nucleico para imunizacao genetica
WO2000072908A1 (en) * 1999-06-02 2000-12-07 Microheart, Inc. Devices and methods for delivering a drug
EP1282640A2 (en) 2000-05-01 2003-02-12 Powderject Vaccines, Inc. Nucleic acid immunization
JP2003535122A (ja) * 2000-06-02 2003-11-25 ザイコス インク. 生物活性物質のための送達システム

Also Published As

Publication number Publication date
GB0508549D0 (en) 2005-06-01
EA200500546A1 (ru) 2005-10-27
EA010881B1 (ru) 2008-12-30
NZ539107A (en) 2008-11-28
CN100542605C (zh) 2009-09-23
EP1545593A1 (en) 2005-06-29
AU2003269213A1 (en) 2004-04-19
IL167635A (en) 2011-07-31
GB2410497B (en) 2006-11-22
JP2006503063A (ja) 2006-01-26
WO2004028560A1 (en) 2004-04-08
MXPA05003222A (es) 2005-07-26
BR0314751A (pt) 2005-07-26
US20060153804A1 (en) 2006-07-13
CA2500215C (en) 2012-02-28
AU2003269213B2 (en) 2008-11-13
KR101152561B1 (ko) 2012-06-01
US8349364B2 (en) 2013-01-08
KR20050070008A (ko) 2005-07-05
GB2410497A (en) 2005-08-03
ZA200503380B (en) 2007-11-28
CA2500215A1 (en) 2004-04-08
HK1073797A1 (en) 2005-10-21
JP4791730B2 (ja) 2011-10-12
CN1694721A (zh) 2005-11-09
PL212483B1 (pl) 2012-10-31

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