ZA200501894B - Dual component dental composition containing enzyme - Google Patents

Dual component dental composition containing enzyme Download PDF

Info

Publication number: ZA200501894B
Authority: ZA; South Africa
Prior art keywords: enzyme; dentifrice; components; composition; component
Prior art date: 2002-08-28

Application number

ZA200501894A

Other languages

English (en)

Inventor

Malcolm Williams

James G Masters

Michael Prencipe

Original Assignee

Colgate Palmolive Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-28

Filing date

2005-03-04

Publication date

2006-05-31

2005-03-04 Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co

2006-05-31 Publication of ZA200501894B publication Critical patent/ZA200501894B/en

Links

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PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
239000002280 amphoteric surfactant Substances 0.000 description 1
229940011037 anethole Drugs 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
230000002882 anti-plaque Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
238000003556 assay Methods 0.000 description 1
238000013096 assay test Methods 0.000 description 1
230000010065 bacterial adhesion Effects 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
239000000440 bentonite Substances 0.000 description 1
229910000278 bentonite Inorganic materials 0.000 description 1
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
229960003237 betaine Drugs 0.000 description 1
239000007844 bleaching agent Substances 0.000 description 1
235000019835 bromelain Nutrition 0.000 description 1
235000019846 buffering salt Nutrition 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 description 1
235000019402 calcium peroxide Nutrition 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
229920001525 carrageenan Polymers 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
229960002376 chymotrypsin Drugs 0.000 description 1
235000017803 cinnamon Nutrition 0.000 description 1
MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
229940073507 cocamidopropyl betaine Drugs 0.000 description 1
239000008119 colloidal silica Substances 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
208000002925 dental caries Diseases 0.000 description 1
210000003298 dental enamel Anatomy 0.000 description 1
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
229940038472 dicalcium phosphate Drugs 0.000 description 1
IPGANOYOHAODGA-UHFFFAOYSA-N dilithium;dimagnesium;dioxido(oxo)silane Chemical compound [Li+].[Li+].[Mg+2].[Mg+2].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O IPGANOYOHAODGA-UHFFFAOYSA-N 0.000 description 1
USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 1
TVQLLNFANZSCGY-UHFFFAOYSA-N disodium;dioxido(oxo)tin Chemical compound [Na+].[Na+].[O-][Sn]([O-])=O TVQLLNFANZSCGY-UHFFFAOYSA-N 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
229940043264 dodecyl sulfate Drugs 0.000 description 1
229960001484 edetic acid Drugs 0.000 description 1
235000014103 egg white Nutrition 0.000 description 1
210000000969 egg white Anatomy 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
125000004494 ethyl ester group Chemical group 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
239000003925 fat Substances 0.000 description 1
235000019197 fats Nutrition 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
150000002193 fatty amides Chemical class 0.000 description 1
POTUGHMKJGOKRI-UHFFFAOYSA-N ficin Chemical compound FI=CI=N POTUGHMKJGOKRI-UHFFFAOYSA-N 0.000 description 1
235000019836 ficin Nutrition 0.000 description 1
150000004673 fluoride salts Chemical class 0.000 description 1
150000002222 fluorine compounds Chemical class 0.000 description 1
235000013569 fruit product Nutrition 0.000 description 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
208000007565 gingivitis Diseases 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
229910001506 inorganic fluoride Inorganic materials 0.000 description 1
239000004816 latex Substances 0.000 description 1
229920000126 latex Polymers 0.000 description 1
PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 description 1
229940048848 lauryl glucoside Drugs 0.000 description 1
239000004571 lime Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
229950006780 n-acetylglucosamine Drugs 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
229920001542 oligosaccharide Polymers 0.000 description 1
RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
238000005192 partition Methods 0.000 description 1
229940023462 paste product Drugs 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
208000028169 periodontal disease Diseases 0.000 description 1
201000001245 periodontitis Diseases 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
229920001992 poloxamer 407 Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920000151 polyglycol Polymers 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
235000013824 polyphenols Nutrition 0.000 description 1
239000001205 polyphosphate Substances 0.000 description 1
235000011176 polyphosphates Nutrition 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
235000003270 potassium fluoride Nutrition 0.000 description 1
239000011698 potassium fluoride Substances 0.000 description 1
OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
229940099402 potassium metaphosphate Drugs 0.000 description 1
235000010333 potassium nitrate Nutrition 0.000 description 1
239000004323 potassium nitrate Substances 0.000 description 1
235000011151 potassium sulphates Nutrition 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
239000011369 resultant mixture Substances 0.000 description 1
235000002020 sage Nutrition 0.000 description 1
108700004121 sarkosyl Proteins 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
239000000176 sodium gluconate Substances 0.000 description 1
235000012207 sodium gluconate Nutrition 0.000 description 1
229940005574 sodium gluconate Drugs 0.000 description 1
235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
235000019983 sodium metaphosphate Nutrition 0.000 description 1
229940079864 sodium stannate Drugs 0.000 description 1
UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000001119 stannous chloride Substances 0.000 description 1
235000011150 stannous chloride Nutrition 0.000 description 1
ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
229960002799 stannous fluoride Drugs 0.000 description 1
229940080728 steareth-30 Drugs 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
AGGIJOLULBJGTQ-UHFFFAOYSA-N sulfoacetic acid Chemical class OC(=O)CS(O)(=O)=O AGGIJOLULBJGTQ-UHFFFAOYSA-N 0.000 description 1
235000018553 tannin Nutrition 0.000 description 1
229920001864 tannin Polymers 0.000 description 1
239000001648 tannin Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical class [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
229940034610 toothpaste Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
229960003500 triclosan Drugs 0.000 description 1
AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Birds (AREA)
Epidemiology (AREA)
Oral & Maxillofacial Surgery (AREA)
Cosmetics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Dental Preparations (AREA)

ZA200501894A 2002-08-28 2005-03-04 Dual component dental composition containing enzyme ZA200501894B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10/229,551 US6927053B2 (en)	2002-08-28	2002-08-28	Dual component dental composition containing enzyme

Publications (1)

Publication Number	Publication Date
ZA200501894B true ZA200501894B (en)	2006-05-31

Family

ID=31976251

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200501894A ZA200501894B (en)	2002-08-28	2005-03-04	Dual component dental composition containing enzyme

Country Status (15)

Country	Link
US (3)	US6927053B2 (pt)
EP (2)	EP2172187A1 (pt)
CN (1)	CN100435776C (pt)
AT (1)	ATE487467T1 (pt)
AU (1)	AU2003262883B2 (pt)
BR (1)	BR0313951A (pt)
CA (1)	CA2496807C (pt)
DE (1)	DE60334914D1 (pt)
DK (1)	DK1536761T3 (pt)
ES (1)	ES2354422T3 (pt)
MX (1)	MXPA05002289A (pt)
PL (1)	PL211957B1 (pt)
RU (1)	RU2292870C2 (pt)
WO (1)	WO2004019899A1 (pt)
ZA (1)	ZA200501894B (pt)

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BR112019012103B1 (pt) *	2016-12-20	2023-03-14	Colgate-Palmolive Company	Composições de higiene bucal bifásicas para clareamento e método de clareamento dental
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US6447758B1 (en)	2001-05-02	2002-09-10	Colgate Palmolive Company	Cationic antibacterial dentifrice exhibiting superior foaming properties
US7402416B2 (en)	2002-05-10	2008-07-22	Colgate-Palmolive Company	Antibacterial dentifrice exhibiting antiplaque and breath freshening properties
US6652841B1 (en) *	2002-08-28	2003-11-25	Colgate Palmolive Company	Antiplaque enzyme containing dual component composition
US6927053B2 (en) *	2002-08-28	2005-08-09	Colgate-Palmolive Company	Dual component dental composition containing enzyme

2002
- 2002-08-28 US US10/229,551 patent/US6927053B2/en not_active Expired - Fee Related
2003
- 2003-08-26 WO PCT/US2003/026737 patent/WO2004019899A1/en not_active Application Discontinuation
- 2003-08-26 PL PL375605A patent/PL211957B1/pl unknown
- 2003-08-26 RU RU2005108606/15A patent/RU2292870C2/ru not_active IP Right Cessation
- 2003-08-26 MX MXPA05002289A patent/MXPA05002289A/es active IP Right Grant
- 2003-08-26 AU AU2003262883A patent/AU2003262883B2/en not_active Ceased
- 2003-08-26 ES ES03791804T patent/ES2354422T3/es not_active Expired - Lifetime
- 2003-08-26 EP EP09177393A patent/EP2172187A1/en not_active Withdrawn
- 2003-08-26 DE DE60334914T patent/DE60334914D1/de not_active Expired - Lifetime
- 2003-08-26 CA CA2496807A patent/CA2496807C/en not_active Expired - Fee Related
- 2003-08-26 DK DK03791804.2T patent/DK1536761T3/da active
- 2003-08-26 AT AT03791804T patent/ATE487467T1/de not_active IP Right Cessation
- 2003-08-26 BR BR0313951-4A patent/BR0313951A/pt not_active IP Right Cessation
- 2003-08-26 EP EP03791804A patent/EP1536761B1/en not_active Expired - Lifetime
- 2003-08-26 CN CNB038245795A patent/CN100435776C/zh not_active Expired - Fee Related
2005
- 2005-03-04 ZA ZA200501894A patent/ZA200501894B/en unknown
- 2005-07-28 US US11/191,501 patent/US20060029554A1/en not_active Abandoned
2008
- 2008-03-05 US US12/042,870 patent/US20100266514A9/en not_active Abandoned

Also Published As

Publication number	Publication date
US20040042977A1 (en)	2004-03-04
BR0313951A (pt)	2005-07-19
US6927053B2 (en)	2005-08-09
AU2003262883B2 (en)	2009-11-12
CN1688282A (zh)	2005-10-26
EP1536761B1 (en)	2010-11-10
US20060029554A1 (en)	2006-02-09
RU2005108606A (ru)	2005-09-20
CA2496807C (en)	2011-08-02
PL211957B1 (pl)	2012-07-31
US20080152601A1 (en)	2008-06-26
AU2003262883A1 (en)	2004-03-19
MXPA05002289A (es)	2005-06-08
ATE487467T1 (de)	2010-11-15
WO2004019899A1 (en)	2004-03-11
CN100435776C (zh)	2008-11-26
EP2172187A1 (en)	2010-04-07
EP1536761A1 (en)	2005-06-08
RU2292870C2 (ru)	2007-02-10
ES2354422T3 (es)	2011-03-14
PL375605A1 (en)	2005-12-12
US20100266514A9 (en)	2010-10-21
DE60334914D1 (de)	2010-12-23
CA2496807A1 (en)	2004-03-11
DK1536761T3 (da)	2011-02-14

Publication	Publication Date	Title
US20080152601A1 (en)	2008-06-26	Dual Component Dental Composition Containing Enzyme
ZA200502420B (en)	2006-05-31	Antiplaque enzyme containing dual component composition
US7939306B2 (en)	2011-05-10	Antibacterial dentifrice exhibiting antiplaque and breath freshening properties
ZA200303469B (en)	2004-05-06	Oral composition providing enhanced tooth stain removal.
ZA200409987B (en)	2006-08-30	Antibacterial dentrifice exhibiting enhanced antiplaque and breath freshening properties
US20060008425A1 (en)	2006-01-12	Antiplaque oral composition containing enzymes and cyclodextrins