ZA200410102B - Use of nefopam for the treatment of nausea or emesis - Google Patents

Use of nefopam for the treatment of nausea or emesis Download PDF

Info

Publication number: ZA200410102B
Authority: ZA; South Africa
Prior art keywords: use according; condition; nefopam; induced; emesis
Prior art date: 2002-06-17

Application number

ZA200410102A

Other languages

English (en)

Inventor

Robin M Bannister

Michael H Lyne

Original Assignee

Arakis Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-17

Filing date

2004-12-14

Publication date

2006-07-26

2004-12-14 Application filed by Arakis Ltd filed Critical Arakis Ltd

2006-07-26 Publication of ZA200410102B publication Critical patent/ZA200410102B/en

Links

RGPDEAGGEXEMMM-UHFFFAOYSA-N Nefopam Chemical compound C12=CC=CC=C2CN(C)CCOC1C1=CC=CC=C1 RGPDEAGGEXEMMM-UHFFFAOYSA-N 0.000 title claims description 24
229960000751 nefopam Drugs 0.000 title claims description 23
206010047700 Vomiting Diseases 0.000 title claims description 16
206010028813 Nausea Diseases 0.000 title claims description 4
230000008693 nausea Effects 0.000 title claims description 4
LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims description 6
239000003814 drug Substances 0.000 claims description 5
208000002193 Pain Diseases 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 4
230000036407 pain Effects 0.000 claims description 4
230000002980 postoperative effect Effects 0.000 claims description 4
229940044551 receptor antagonist Drugs 0.000 claims description 4
239000002464 receptor antagonist Substances 0.000 claims description 4
229960001076 chlorpromazine Drugs 0.000 claims description 3
ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 claims description 3
229960003878 haloperidol Drugs 0.000 claims description 3
230000002829 reductive effect Effects 0.000 claims description 3
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 2
FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 claims description 2
239000003148 4 aminobutyric acid receptor blocking agent Substances 0.000 claims description 2
108060003345 Adrenergic Receptor Proteins 0.000 claims description 2
102000017910 Adrenergic receptor Human genes 0.000 claims description 2
206010013935 Dysmenorrhoea Diseases 0.000 claims description 2
229940098788 GABA receptor antagonist Drugs 0.000 claims description 2
206010061974 Gastrointestinal obstruction Diseases 0.000 claims description 2
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical class NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims description 2
208000027601 Inner ear disease Diseases 0.000 claims description 2
PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 claims description 2
208000019695 Migraine disease Diseases 0.000 claims description 2
229940121948 Muscarinic receptor antagonist Drugs 0.000 claims description 2
108010040718 Neurokinin-1 Receptors Proteins 0.000 claims description 2
RGCVKNLCSQQDEP-UHFFFAOYSA-N Perphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 RGCVKNLCSQQDEP-UHFFFAOYSA-N 0.000 claims description 2
208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 2
102100037346 Substance-P receptor Human genes 0.000 claims description 2
206010047513 Vision blurred Diseases 0.000 claims description 2
230000001154 acute effect Effects 0.000 claims description 2
208000029650 alcohol withdrawal Diseases 0.000 claims description 2
239000005557 antagonist Substances 0.000 claims description 2
230000000454 anti-cipatory effect Effects 0.000 claims description 2
230000001387 anti-histamine Effects 0.000 claims description 2
229940125715 antihistaminic agent Drugs 0.000 claims description 2
239000000739 antihistaminic agent Substances 0.000 claims description 2
UUQMNUMQCIQDMZ-UHFFFAOYSA-N betahistine Chemical compound CNCCC1=CC=CC=N1 UUQMNUMQCIQDMZ-UHFFFAOYSA-N 0.000 claims description 2
229960004536 betahistine Drugs 0.000 claims description 2
229930003827 cannabinoid Natural products 0.000 claims description 2
239000003557 cannabinoid Substances 0.000 claims description 2
229940065144 cannabinoids Drugs 0.000 claims description 2
UKTAZPQNNNJVKR-KJGYPYNMSA-N chembl2368925 Chemical compound C1=CC=C2C(C(O[C@@H]3C[C@@H]4C[C@H]5C[C@@H](N4CC5=O)C3)=O)=CNC2=C1 UKTAZPQNNNJVKR-KJGYPYNMSA-N 0.000 claims description 2
238000002512 chemotherapy Methods 0.000 claims description 2
239000000812 cholinergic antagonist Substances 0.000 claims description 2
239000003246 corticosteroid Substances 0.000 claims description 2
229960001334 corticosteroids Drugs 0.000 claims description 2
229960003564 cyclizine Drugs 0.000 claims description 2
UVKZSORBKUEBAZ-UHFFFAOYSA-N cyclizine Chemical group C1CN(C)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 UVKZSORBKUEBAZ-UHFFFAOYSA-N 0.000 claims description 2
230000003247 decreasing effect Effects 0.000 claims description 2
230000003111 delayed effect Effects 0.000 claims description 2
208000002173 dizziness Diseases 0.000 claims description 2
229960003413 dolasetron Drugs 0.000 claims description 2
229960001253 domperidone Drugs 0.000 claims description 2
FGXWKSZFVQUSTL-UHFFFAOYSA-N domperidone Chemical compound C12=CC=CC=C2NC(=O)N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2NC1=O FGXWKSZFVQUSTL-UHFFFAOYSA-N 0.000 claims description 2
239000003210 dopamine receptor blocking agent Substances 0.000 claims description 2
229960000394 droperidol Drugs 0.000 claims description 2
RMEDXOLNCUSCGS-UHFFFAOYSA-N droperidol Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CC=C(N2C(NC3=CC=CC=C32)=O)CC1 RMEDXOLNCUSCGS-UHFFFAOYSA-N 0.000 claims description 2
229960003727 granisetron Drugs 0.000 claims description 2
MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 claims description 2
238000007917 intracranial administration Methods 0.000 claims description 2
206010025482 malaise Diseases 0.000 claims description 2
229960004503 metoclopramide Drugs 0.000 claims description 2
TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 claims description 2
206010027599 migraine Diseases 0.000 claims description 2
229960002967 nabilone Drugs 0.000 claims description 2
GECBBEABIDMGGL-RTBURBONSA-N nabilone Chemical compound C1C(=O)CC[C@H]2C(C)(C)OC3=CC(C(C)(C)CCCCCC)=CC(O)=C3[C@@H]21 GECBBEABIDMGGL-RTBURBONSA-N 0.000 claims description 2
229960002715 nicotine Drugs 0.000 claims description 2
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 2
229960005343 ondansetron Drugs 0.000 claims description 2
239000000014 opioid analgesic Substances 0.000 claims description 2
229960000762 perphenazine Drugs 0.000 claims description 2
150000002990 phenothiazines Chemical group 0.000 claims description 2
230000035935 pregnancy Effects 0.000 claims description 2
229960003111 prochlorperazine Drugs 0.000 claims description 2
WIKYUJGCLQQFNW-UHFFFAOYSA-N prochlorperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 WIKYUJGCLQQFNW-UHFFFAOYSA-N 0.000 claims description 2
229960003910 promethazine Drugs 0.000 claims description 2
230000005855 radiation Effects 0.000 claims description 2
238000001356 surgical procedure Methods 0.000 claims description 2
XCTYLCDETUVOIP-UHFFFAOYSA-N thiethylperazine Chemical compound C12=CC(SCC)=CC=C2SC2=CC=CC=C2N1CCCN1CCN(C)CC1 XCTYLCDETUVOIP-UHFFFAOYSA-N 0.000 claims description 2
229960004869 thiethylperazine Drugs 0.000 claims description 2
239000003053 toxin Substances 0.000 claims description 2
231100000765 toxin Toxicity 0.000 claims description 2
108700012359 toxins Proteins 0.000 claims description 2
229960003688 tropisetron Drugs 0.000 claims description 2
UIVFDCIXTSJXBB-ITGUQSILSA-N tropisetron Chemical compound C1=CC=C[C]2C(C(=O)O[C@H]3C[C@H]4CC[C@@H](C3)N4C)=CN=C21 UIVFDCIXTSJXBB-ITGUQSILSA-N 0.000 claims description 2
208000027491 vestibular disease Diseases 0.000 claims description 2
208000009935 visceral pain Diseases 0.000 claims description 2
206010028980 Neoplasm Diseases 0.000 claims 1
230000003474 anti-emetic effect Effects 0.000 claims 1
201000011510 cancer Diseases 0.000 claims 1
230000002496 gastric effect Effects 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
241001465754 Metazoa Species 0.000 description 7
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 6
RGPDEAGGEXEMMM-KRWDZBQOSA-N (S)-nefopam Chemical compound C1([C@@H]2OCCN(CC3=CC=CC=C32)C)=CC=CC=C1 RGPDEAGGEXEMMM-KRWDZBQOSA-N 0.000 description 5
230000000202 analgesic effect Effects 0.000 description 5
229960004316 cisplatin Drugs 0.000 description 5
RGPDEAGGEXEMMM-QGZVFWFLSA-N (1r)-5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine Chemical compound C1([C@H]2OCCN(CC3=CC=CC=C32)C)=CC=CC=C1 RGPDEAGGEXEMMM-QGZVFWFLSA-N 0.000 description 4
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 4
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 4
229960005181 morphine Drugs 0.000 description 4
-1 trazadone Chemical compound 0.000 description 4
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
241000282339 Mustela Species 0.000 description 3
206010038776 Retching Diseases 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
229940079593 drug Drugs 0.000 description 3
230000000694 effects Effects 0.000 description 3
230000008673 vomiting Effects 0.000 description 3
WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 description 2
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
230000003187 abdominal effect Effects 0.000 description 2
RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 2
239000000730 antalgic agent Substances 0.000 description 2
230000003502 anti-nociceptive effect Effects 0.000 description 2
229960001653 citalopram Drugs 0.000 description 2
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
230000008602 contraction Effects 0.000 description 2
235000005911 diet Nutrition 0.000 description 2
230000037213 diet Effects 0.000 description 2
229960003638 dopamine Drugs 0.000 description 2
239000002895 emetic Substances 0.000 description 2
229940005483 opioid analgesics Drugs 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 1
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 description 1
FPVKHBSQESCIEP-UHFFFAOYSA-N (8S)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Natural products C1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 FPVKHBSQESCIEP-UHFFFAOYSA-N 0.000 description 1
FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 1
RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 1
KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 1
102000035037 5-HT3 receptors Human genes 0.000 description 1
108091005477 5-HT3 receptors Proteins 0.000 description 1
USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 1
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
206010002091 Anaesthesia Diseases 0.000 description 1
DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 1
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
108010092160 Dactinomycin Proteins 0.000 description 1
HCYAFALTSJYZDH-UHFFFAOYSA-N Desimpramine Chemical compound C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 HCYAFALTSJYZDH-UHFFFAOYSA-N 0.000 description 1
208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 description 1
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
PLDUPXSUYLZYBN-UHFFFAOYSA-N Fluphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 PLDUPXSUYLZYBN-UHFFFAOYSA-N 0.000 description 1
GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 1
XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 description 1
206010022773 Intracranial pressure increased Diseases 0.000 description 1
WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 description 1
DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 description 1
FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 description 1
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
102000003840 Opioid Receptors Human genes 0.000 description 1
108090000137 Opioid Receptors Proteins 0.000 description 1
BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 description 1
AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 1
241000700159 Rattus Species 0.000 description 1
244000000188 Vaccinium ovalifolium Species 0.000 description 1
RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
229960005310 aldesleukin Drugs 0.000 description 1
108700025316 aldesleukin Proteins 0.000 description 1
229960000473 altretamine Drugs 0.000 description 1
DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
229960003805 amantadine Drugs 0.000 description 1
229960000836 amitriptyline Drugs 0.000 description 1
KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 description 1
230000037005 anaesthesia Effects 0.000 description 1
238000001949 anaesthesia Methods 0.000 description 1
239000002269 analeptic agent Substances 0.000 description 1
230000036592 analgesia Effects 0.000 description 1
229940035676 analgesics Drugs 0.000 description 1
238000010171 animal model Methods 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
229940125681 anticonvulsant agent Drugs 0.000 description 1
239000001961 anticonvulsive agent Substances 0.000 description 1
239000000935 antidepressant agent Substances 0.000 description 1
229940005513 antidepressants Drugs 0.000 description 1
239000002111 antiemetic agent Substances 0.000 description 1
229940125683 antiemetic agent Drugs 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
229940125688 antiparkinson agent Drugs 0.000 description 1
239000000164 antipsychotic agent Substances 0.000 description 1
229940005529 antipsychotics Drugs 0.000 description 1
239000002249 anxiolytic agent Substances 0.000 description 1
230000000949 anxiolytic effect Effects 0.000 description 1
229940005530 anxiolytics Drugs 0.000 description 1
229960004046 apomorphine Drugs 0.000 description 1
VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 description 1
VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 1
230000036772 blood pressure Effects 0.000 description 1
229960002802 bromocriptine Drugs 0.000 description 1
OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 description 1
229960001736 buprenorphine Drugs 0.000 description 1
RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 description 1
QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 description 1
229960002495 buspirone Drugs 0.000 description 1
FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 description 1
229960004562 carboplatin Drugs 0.000 description 1
229960005243 carmustine Drugs 0.000 description 1
230000002057 chronotropic effect Effects 0.000 description 1
229940105442 cisplatin injection Drugs 0.000 description 1
229960004170 clozapine Drugs 0.000 description 1
QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 description 1
229960004126 codeine Drugs 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
229960004397 cyclophosphamide Drugs 0.000 description 1
229960000640 dactinomycin Drugs 0.000 description 1
229960000975 daunorubicin Drugs 0.000 description 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
229960003914 desipramine Drugs 0.000 description 1
229960002069 diamorphine Drugs 0.000 description 1
229960003668 docetaxel Drugs 0.000 description 1
230000028436 dopamine uptake Effects 0.000 description 1
229960004679 doxorubicin Drugs 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
229960001904 epirubicin Drugs 0.000 description 1
229960002428 fentanyl Drugs 0.000 description 1
PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
229960002949 fluorouracil Drugs 0.000 description 1
229960002464 fluoxetine Drugs 0.000 description 1
229960002690 fluphenazine Drugs 0.000 description 1
229960002870 gabapentin Drugs 0.000 description 1
230000005176 gastrointestinal motility Effects 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
230000036449 good health Effects 0.000 description 1
UUVWYPNAQBNQJQ-UHFFFAOYSA-N hexamethylmelamine Chemical compound CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1 UUVWYPNAQBNQJQ-UHFFFAOYSA-N 0.000 description 1
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
229960000908 idarubicin Drugs 0.000 description 1
229960001101 ifosfamide Drugs 0.000 description 1
HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 1
BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 description 1
229960004801 imipramine Drugs 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
229940090044 injection Drugs 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000001057 ionotropic effect Effects 0.000 description 1
229960001848 lamotrigine Drugs 0.000 description 1
PYZRQGJRPPTADH-UHFFFAOYSA-N lamotrigine Chemical compound NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl PYZRQGJRPPTADH-UHFFFAOYSA-N 0.000 description 1
229960004502 levodopa Drugs 0.000 description 1
239000011344 liquid material Substances 0.000 description 1
229960002247 lomustine Drugs 0.000 description 1
229960004391 lorazepam Drugs 0.000 description 1
229960000423 loxapine Drugs 0.000 description 1
XJGVXQDUIWGIRW-UHFFFAOYSA-N loxapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2OC2=CC=C(Cl)C=C12 XJGVXQDUIWGIRW-UHFFFAOYSA-N 0.000 description 1
239000000463 material Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
229960004961 mechlorethamine Drugs 0.000 description 1
HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical compound ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 description 1
229960001924 melphalan Drugs 0.000 description 1
SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
229960001797 methadone Drugs 0.000 description 1
229960000485 methotrexate Drugs 0.000 description 1
229960001344 methylphenidate Drugs 0.000 description 1
229960004584 methylprednisolone Drugs 0.000 description 1
229960001156 mitoxantrone Drugs 0.000 description 1
KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
JCSREICEMHWFAY-HUUCEWRRSA-N naxagolide Chemical compound C1=C(O)C=C2[C@H]3OCCN(CCC)[C@@H]3CCC2=C1 JCSREICEMHWFAY-HUUCEWRRSA-N 0.000 description 1
229950005651 naxagolide Drugs 0.000 description 1
229960001800 nefazodone Drugs 0.000 description 1
VRBKIVRKKCLPHA-UHFFFAOYSA-N nefazodone Chemical compound O=C1N(CCOC=2C=CC=CC=2)C(CC)=NN1CCCN(CC1)CCN1C1=CC=CC(Cl)=C1 VRBKIVRKKCLPHA-UHFFFAOYSA-N 0.000 description 1
229960002748 norepinephrine Drugs 0.000 description 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
230000012154 norepinephrine uptake Effects 0.000 description 1
230000000945 opiatelike Effects 0.000 description 1
229960002085 oxycodone Drugs 0.000 description 1
229960002296 paroxetine Drugs 0.000 description 1
229960002340 pentostatin Drugs 0.000 description 1
FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 description 1
229960004851 pergolide Drugs 0.000 description 1
YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
229960000624 procarbazine Drugs 0.000 description 1
CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
230000035485 pulse pressure Effects 0.000 description 1
230000001020 rhythmical effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
230000013275 serotonin uptake Effects 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000011343 solid material Substances 0.000 description 1
229960001052 streptozocin Drugs 0.000 description 1
ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
229960004688 venlafaxine Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/5545—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having eight-membered rings not containing additional condensed or non-condensed nitrogen-containing 3-7 membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

ZA200410102A 2002-06-17 2004-12-14 Use of nefopam for the treatment of nausea or emesis ZA200410102B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0213869.1A GB0213869D0 (en)	2002-06-17	2002-06-17	The treatment of pain

Publications (1)

Publication Number	Publication Date
ZA200410102B true ZA200410102B (en)	2006-07-26

Family

ID=9938718

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200410102A ZA200410102B (en)	2002-06-17	2004-12-14	Use of nefopam for the treatment of nausea or emesis

Country Status (15)

Country	Link
US (2)	US20060040905A1 (fr)
EP (2)	EP1513518A1 (fr)
JP (2)	JP2005533784A (fr)
CN (1)	CN100482221C (fr)
AU (2)	AU2003240113B2 (fr)
BR (1)	BR0311874A (fr)
CA (2)	CA2489306A1 (fr)
GB (1)	GB0213869D0 (fr)
IL (1)	IL165773A0 (fr)
MX (1)	MXPA04012826A (fr)
NO (1)	NO20045496L (fr)
NZ (1)	NZ537197A (fr)
PL (1)	PL374418A1 (fr)
WO (2)	WO2003105832A1 (fr)
ZA (1)	ZA200410102B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0330049D0 (en) *	2003-12-24	2004-02-04	Arakis Ltd	The treatment of neuropathic pain conditions
GB0408864D0 (en) *	2004-04-21	2004-05-26	Arakis Ltd	Novel benzoxazocines
GB0515703D0 (en) *	2005-07-29	2005-09-07	Arakis Ltd	Therapeutic use of nefopam
WO2009002933A1 (fr) *	2007-06-22	2008-12-31	Hydra Biosciences, Inc.	Procédés et compositions pour le traitement de troubles
GB0721013D0 (en)	2007-10-25	2007-12-05	Sosei R & D Ltd	New Salts
PT2293794E (pt)	2008-05-27	2013-07-10	Univ Melbourne	Métodos de tratamento de mamíferos com disfunções da trompa de eustáquio
US20110092493A1 (en) *	2008-09-24	2011-04-21	Clark Levi	Dose-controlled transdermal promethazine compositions and methods of use
CN102458400B (zh)	2009-05-20	2014-10-08	国立健康与医学研究所	用于治疗病灶性前庭功能障碍的血清素5-ht3受体拮抗剂
US8957107B2 (en) *	2009-12-15	2015-02-17	The Hospital For Sick Children	Method of treating scars and β-catenin-mediated disorders using Nefopam compounds
EP4335508A3 (fr)	2016-04-14	2024-07-10	Sensorion	(+)-azasetron destiné à être utilisé dans le traitement de troubles de l'oreille
US10736905B1 (en)	2016-09-09	2020-08-11	Shahin Fatholahi	Nefopam dosage forms and methods of treatment
US10736874B1 (en)	2017-09-08	2020-08-11	Shahin Fatholahi	Methods for treating pain associated with sickle cell disease
US11446311B2 (en)	2017-09-08	2022-09-20	Shahin Fatholahi	Methods for treating pain associated with sickle cell disease
RS65140B1 (sr) *	2019-05-06	2024-02-29	Chemcom Sa	Upotreba kompozicije protiv neprijatnih mirisa i povezani postupak

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2234266T3 (es) *	1998-07-24	2005-06-16	Jago Research Ag	Formulaciones medicas para aerosoles.
US20020013331A1 (en) *	2000-06-26	2002-01-31	Williams Robert O.	Methods and compositions for treating pain of the mucous membrane

2002
- 2002-06-17 GB GBGB0213869.1A patent/GB0213869D0/en not_active Ceased
2003
- 2003-06-17 WO PCT/GB2003/002586 patent/WO2003105832A1/fr active Application Filing
- 2003-06-17 EP EP03740737A patent/EP1513518A1/fr not_active Withdrawn
- 2003-06-17 CA CA002489306A patent/CA2489306A1/fr not_active Abandoned
- 2003-06-17 CN CNB038167050A patent/CN100482221C/zh not_active Expired - Fee Related
- 2003-06-17 US US10/517,882 patent/US20060040905A1/en not_active Abandoned
- 2003-06-17 WO PCT/GB2003/002618 patent/WO2003105833A1/fr active Application Filing
- 2003-06-17 MX MXPA04012826A patent/MXPA04012826A/es unknown
- 2003-06-17 EP EP03732727A patent/EP1513517A1/fr not_active Withdrawn
- 2003-06-17 NZ NZ537197A patent/NZ537197A/en unknown
- 2003-06-17 US US10/517,881 patent/US20060063753A1/en not_active Abandoned
- 2003-06-17 AU AU2003240113A patent/AU2003240113B2/en not_active Ceased
- 2003-06-17 BR BR0311874-6A patent/BR0311874A/pt not_active IP Right Cessation
- 2003-06-17 JP JP2004512736A patent/JP2005533784A/ja active Pending
- 2003-06-17 CA CA002489315A patent/CA2489315A1/fr not_active Abandoned
- 2003-06-17 JP JP2004512737A patent/JP2005531612A/ja active Pending
- 2003-06-17 AU AU2003277077A patent/AU2003277077B2/en not_active Ceased
- 2003-06-17 PL PL03374418A patent/PL374418A1/xx not_active Application Discontinuation
2004
- 2004-12-14 IL IL16577304A patent/IL165773A0/xx unknown
- 2004-12-14 ZA ZA200410102A patent/ZA200410102B/en unknown
- 2004-12-16 NO NO20045496A patent/NO20045496L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NZ537197A (en)	2007-10-26
AU2003240113A1 (en)	2003-12-31
PL374418A1 (en)	2005-10-17
MXPA04012826A (es)	2005-03-31
JP2005531612A (ja)	2005-10-20
WO2003105833A1 (fr)	2003-12-24
JP2005533784A (ja)	2005-11-10
US20060040905A1 (en)	2006-02-23
IL165773A0 (en)	2006-01-15
AU2003277077A1 (en)	2003-12-31
CA2489306A1 (fr)	2003-12-24
EP1513517A1 (fr)	2005-03-16
NO20045496L (no)	2005-01-12
AU2003277077B2 (en)	2006-11-02
CA2489315A1 (fr)	2003-12-24
EP1513518A1 (fr)	2005-03-16
CN1668294A (zh)	2005-09-14
GB0213869D0 (en)	2002-07-31
AU2003240113B2 (en)	2006-11-16
BR0311874A (pt)	2005-05-10
CN100482221C (zh)	2009-04-29
US20060063753A1 (en)	2006-03-23
WO2003105832A1 (fr)	2003-12-24

Publication	Publication Date	Title
AU2003277077B2 (en)	2006-11-02	Use of nefopam for the treatment of nausea or emesis
JP5744947B2 (ja)	2015-07-08	流涎症の治療のためのアルファ−２受容体アゴニスト（クロニジン）と抗ムスカリン剤（オキシブチニン）との組み合わせ
JP2001525359A (ja)	2001-12-11	アミノチオール化合物を用いた、神経及び腎障害ならびに治療に伴う毒性の治療方法
WO2016105449A1 (fr)	2016-06-30	Composés destinés à être utilisés en tant qu'agents thérapeutiques contre la douleur
JP7041166B2 (ja)	2022-03-23	トリアリールポリアミンを含む組成物および方法
EP3389655A2 (fr)	2018-10-24	Utilisation de stimulateurs de la sgc pour le traitement d'un dysfonctionnement du sphincter gastro-intestinal
CA2781436A1 (fr)	2011-06-03	Analogues de l'acide arachidonique et procedes pour un traitement analgesique l'utilisant
US20030008892A1 (en)	2003-01-09	Pharmaceutical composition and method of modulating cholinergic function in a mammal
AU2016218950C1 (en)	2022-11-03	Analgesic formulation
WO2004006903A1 (fr)	2004-01-22	Traitement des vomissements
US10646457B2 (en)	2020-05-12	Emesis treatment
WO2017066729A1 (fr)	2017-04-20	Nouveaux procédés
JP2019509321A (ja)	2019-04-04	疼痛を処置するための組み合わせ
WO2005011665A1 (fr)	2005-02-10	Utilisation de proglumide pour le traitement des vomissements
US20210393553A1 (en)	2021-12-23	Pharmaceutical combinations for the treatment of pain
WO2007093587A1 (fr)	2007-08-23	Utilisation de r-(-)-2,4-diamino-5-(2,3-dichlorophényl)-6-fluorométhylpyrimidine dans le traitement de troubles psychotiques
WO2023224960A1 (fr)	2023-11-23	Compositions de cannabinoïde à pénétration rapide, procédés de fabrication et méthodes d'utilisation
WO2022265984A1 (fr)	2022-12-22	Utilisation d'inhibiteurs de nep pour le traitement de troubles du sphincter gastro-intestinal
TW201204352A (en)	2012-02-01	Use of flavones for treating psychiatric disorders with sensorimotor gating deficits
CZ284327B6 (cs)	1998-10-14	Použití riluzolu pro výrobu léčiv přijatelných jako antidota proti škodlivým účinkům ozáření
AU2002258088A1 (en)	2003-01-29	A pharmaceutical composition comprising a nicotinic receptor partial antagonist and an antiemetic agent of modulating cholinergic function
WO2007105929A1 (fr)	2007-09-20	Composition pharmaceutique synergique à base de tramadol et de clonixinate de lysine