ZA200300056B - Anthelmintic agents for preventing parasitic infections in humans and animals III. - Google Patents

Anthelmintic agents for preventing parasitic infections in humans and animals III. Download PDF

Info

Publication number: ZA200300056B
Authority: ZA; South Africa
Prior art keywords: optionally substituted; alkyl; formula; compositions; deterring
Prior art date: 2000-07-06

Application number

ZA200300056A

Other languages

English (en)

Inventor

Achim Harder

Georg Von Samson-Himmelstjerna

Bernd-Wieland Krueger

Heinz Mehlhorn

Juergen Schmidt

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-06

Filing date

2003-01-03

Publication date

2004-01-21

2003-01-03 Application filed by Bayer Ag filed Critical Bayer Ag

2004-01-21 Publication of ZA200300056B publication Critical patent/ZA200300056B/en

Links

241001465754 Metazoa Species 0.000 title description 9
229940124339 anthelmintic agent Drugs 0.000 title description 4
239000000921 anthelmintic agent Substances 0.000 title description 4
208000030852 Parasitic disease Diseases 0.000 title description 2
239000000203 mixture Substances 0.000 claims description 44
150000001875 compounds Chemical class 0.000 claims description 41
244000045947 parasite Species 0.000 claims description 15
-1 pentamethylene, hexamethylene Chemical group 0.000 claims description 12
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
239000001257 hydrogen Substances 0.000 claims description 8
229910052739 hydrogen Inorganic materials 0.000 claims description 8
125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 8
125000000547 substituted alkyl group Chemical group 0.000 claims description 6
125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 6
125000005017 substituted alkenyl group Chemical group 0.000 claims description 5
125000006193 alkinyl group Chemical group 0.000 claims description 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
241000238876 Acari Species 0.000 claims description 3
241000238631 Hexapoda Species 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
238000000034 method Methods 0.000 claims description 3
239000004094 surface-active agent Substances 0.000 claims description 3
239000004606 Fillers/Extenders Substances 0.000 claims description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
125000002837 carbocyclic group Chemical group 0.000 claims description 2
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims description 2
125000005842 heteroatom Chemical group 0.000 claims description 2
239000001301 oxygen Substances 0.000 claims description 2
229910052760 oxygen Inorganic materials 0.000 claims description 2
229920001281 polyalkylene Polymers 0.000 claims description 2
125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims 1
239000000126 substance Substances 0.000 description 17
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230000035515 penetration Effects 0.000 description 3
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241000255925 Diptera Species 0.000 description 2
241000237858 Gastropoda Species 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
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241000242683 Schistosoma haematobium Species 0.000 description 2
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PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
238000003287 bathing Methods 0.000 description 2
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229920001577 copolymer Polymers 0.000 description 2
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DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
238000007598 dipping method Methods 0.000 description 2
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150000002430 hydrocarbons Chemical class 0.000 description 1
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WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
239000000077 insect repellent Substances 0.000 description 1
239000002563 ionic surfactant Substances 0.000 description 1
230000001678 irradiating effect Effects 0.000 description 1
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150000002576 ketones Chemical class 0.000 description 1
TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
230000001665 lethal effect Effects 0.000 description 1
230000008818 liver damage Effects 0.000 description 1
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239000000314 lubricant Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
201000004792 malaria Diseases 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
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XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
229940105132 myristate Drugs 0.000 description 1
229920005615 natural polymer Polymers 0.000 description 1
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239000007764 o/w emulsion Substances 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical class CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
239000003883 ointment base Substances 0.000 description 1
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229940055577 oleyl alcohol Drugs 0.000 description 1
XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
230000003071 parasitic effect Effects 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
229960005323 phenoxyethanol Drugs 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
229920000151 polyglycol Polymers 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
RWPGFSMJFRPDDP-UHFFFAOYSA-L potassium metabisulfite Chemical compound [K+].[K+].[O-]S(=O)S([O-])(=O)=O RWPGFSMJFRPDDP-UHFFFAOYSA-L 0.000 description 1
235000010263 potassium metabisulphite Nutrition 0.000 description 1
239000004297 potassium metabisulphite Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000008569 process Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
239000003223 protective agent Substances 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
230000005855 radiation Effects 0.000 description 1
235000003441 saturated fatty acids Nutrition 0.000 description 1
150000004671 saturated fatty acids Chemical class 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
JNYAEWCLZODPBN-CTQIIAAMSA-N sorbitan Polymers OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
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239000000600 sorbitol Substances 0.000 description 1
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239000000454 talc Substances 0.000 description 1
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235000012222 talc Nutrition 0.000 description 1
TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
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239000003860 topical agent Substances 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Fodder In General (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)

ZA200300056A 2000-07-06 2003-01-03 Anthelmintic agents for preventing parasitic infections in humans and animals III. ZA200300056B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10032877A DE10032877A1 (de)	2000-07-06	2000-07-06	Anthelmintika zur Verhinderung von parasitären Infektionen bei Mensch und Tier III

Publications (1)

Publication Number	Publication Date
ZA200300056B true ZA200300056B (en)	2004-01-21

Family

ID=7648011

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200300056A ZA200300056B (en)	2000-07-06	2003-01-03	Anthelmintic agents for preventing parasitic infections in humans and animals III.

Country Status (16)

Country	Link
US (1)	US20030186980A1 (es)
EP (1)	EP1301188B1 (es)
JP (1)	JP2004501960A (es)
KR (1)	KR20030009549A (es)
CN (1)	CN1440289A (es)
AT (1)	ATE279195T1 (es)
AU (1)	AU2001279693A1 (es)
BR (1)	BR0112195A (es)
CA (1)	CA2414678A1 (es)
DE (2)	DE10032877A1 (es)
DK (1)	DK1301188T3 (es)
ES (1)	ES2230348T3 (es)
HU (1)	HUP0300800A3 (es)
PL (1)	PL359649A1 (es)
WO (1)	WO2002002088A2 (es)
ZA (1)	ZA200300056B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2012104865A1 (en) *	2011-01-28	2012-08-09	Director General, Defence Research & Development Organisation (Drdo)	N, n- dialkyl -morpholin- 4 - carboxamide compounds as insect repelling agents and a process for their preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2050522A5 (en) *	1969-06-17	1971-04-02	Aries Robert	Pesticidal carbamoyl morpholines
US5371239A (en) *	1989-12-22	1994-12-06	American Cyanamid Company	Methods and compositions for protecting animals against attack and infestation by helminth, acarid and arthropod endo- and ectoparasites
DE4018070A1 (de) *	1990-06-06	1991-12-12	Bayer Ag	Morpholinoharnstoff-derivate

2000
- 2000-07-06 DE DE10032877A patent/DE10032877A1/de not_active Withdrawn
2001
- 2001-06-26 AT AT01957894T patent/ATE279195T1/de not_active IP Right Cessation
- 2001-06-26 KR KR1020027017593A patent/KR20030009549A/ko not_active Application Discontinuation
- 2001-06-26 AU AU2001279693A patent/AU2001279693A1/en not_active Abandoned
- 2001-06-26 PL PL01359649A patent/PL359649A1/xx not_active Application Discontinuation
- 2001-06-26 CN CN01812383A patent/CN1440289A/zh active Pending
- 2001-06-26 HU HU0300800A patent/HUP0300800A3/hu unknown
- 2001-06-26 DE DE2001504130 patent/DE50104130D1/de not_active Expired - Fee Related
- 2001-06-26 EP EP01957894A patent/EP1301188B1/de not_active Expired - Lifetime
- 2001-06-26 WO PCT/EP2001/007294 patent/WO2002002088A2/de active IP Right Grant
- 2001-06-26 ES ES01957894T patent/ES2230348T3/es not_active Expired - Lifetime
- 2001-06-26 BR BR0112195-2A patent/BR0112195A/pt not_active IP Right Cessation
- 2001-06-26 CA CA002414678A patent/CA2414678A1/en not_active Abandoned
- 2001-06-26 DK DK01957894T patent/DK1301188T3/da active
- 2001-06-26 US US10/311,483 patent/US20030186980A1/en not_active Abandoned
- 2001-06-26 JP JP2002506710A patent/JP2004501960A/ja active Pending
2003
- 2003-01-03 ZA ZA200300056A patent/ZA200300056B/en unknown

Also Published As

Publication number	Publication date
PL359649A1 (en)	2004-08-23
KR20030009549A (ko)	2003-01-29
HUP0300800A3 (en)	2005-10-28
AU2001279693A1 (en)	2002-01-14
BR0112195A (pt)	2003-07-01
HUP0300800A2 (hu)	2003-08-28
JP2004501960A (ja)	2004-01-22
US20030186980A1 (en)	2003-10-02
CN1440289A (zh)	2003-09-03
WO2002002088A3 (de)	2002-05-10
DE10032877A1 (de)	2002-02-07
EP1301188A2 (de)	2003-04-16
DK1301188T3 (da)	2005-01-10
WO2002002088A2 (de)	2002-01-10
CA2414678A1 (en)	2002-01-03
EP1301188B1 (de)	2004-10-13
ES2230348T3 (es)	2005-05-01
DE50104130D1 (de)	2004-11-18
ATE279195T1 (de)	2004-10-15

Publication	Publication Date	Title
SU724077A3 (ru)	1980-03-25	Способ приготовлени антигельминтного препарата тетрамизола2,3,5,5-тетрагидро-6-фенил-имидазо -/2,1-в/-тиазола
US8501775B2 (en)	2013-08-06	Anthelmintics for preventing parasitic infections in humans and animals
US20040014813A1 (en)	2004-01-22	Anthelminthic agents for the prevention of parasitic infections in humans and animals II
US20030186980A1 (en)	2003-10-02	Anthelmintic agents for preventing parasitic infections in humans and animals III
US20040006136A1 (en)	2004-01-08	Anthelmintics for preventing parasitic infections in human and animals
US6753298B2 (en)	2004-06-22	Agents for combating Neospora spec
JP2001524518A (ja)	2001-12-04	ネオスポラｓｐｅｃの防除のための薬剤