ZA200208311B - Expression-regulating sequences and expression products in the field of filamentous fungi chrysosporium. - Google Patents

Expression-regulating sequences and expression products in the field of filamentous fungi chrysosporium. Download PDF

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Publication number: ZA200208311B
Authority: ZA; South Africa
Prior art keywords: chrysosporium; strain; polypeptide; expression; strains
Prior art date: 2000-04-13

Application number

ZA200208311A

Other languages

English (en)

Inventor

Mark Aaron Emalfarb

Peter Jan Punt

Cornelia Maria Johanna V Zeijl

Original Assignee

Mark Aaron Emalfarb

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-13

Filing date

2002-10-15

Publication date

2003-10-15

2002-10-15 Application filed by Mark Aaron Emalfarb filed Critical Mark Aaron Emalfarb

2003-10-15 Publication of ZA200208311B publication Critical patent/ZA200208311B/en

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Classifications

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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2477—Hemicellulases not provided in a preceding group
- C12N9/248—Xylanases
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01004—Cellulase (3.2.1.4), i.e. endo-1,4-beta-glucanase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01008—Endo-1,4-beta-xylanase (3.2.1.8)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01091—Cellulose 1,4-beta-cellobiosidase (3.2.1.91)

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Chemical & Material Sciences (AREA)
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Life Sciences & Earth Sciences (AREA)
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Wood Science & Technology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
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Microbiology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
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ZA200208311A 2000-04-13 2002-10-15 Expression-regulating sequences and expression products in the field of filamentous fungi chrysosporium. ZA200208311B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP00201343		2000-04-13

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ZA200208311B true ZA200208311B (en)	2003-10-15

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ZA200208311A ZA200208311B (en)	2000-04-13	2002-10-15	Expression-regulating sequences and expression products in the field of filamentous fungi chrysosporium.

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US (2)	US7906309B2 (cs)
EP (2)	EP1276876B1 (cs)
JP (3)	JP4922524B2 (cs)
KR (1)	KR100903780B1 (cs)
CN (1)	CN100420753C (cs)
AT (1)	ATE358724T1 (cs)
AU (1)	AU782105B2 (cs)
BR (1)	BR0110090A (cs)
CA (1)	CA2405954C (cs)
CZ (1)	CZ303980B6 (cs)
DE (1)	DE60127661T2 (cs)
DK (1)	DK1276876T3 (cs)
ES (1)	ES2283402T3 (cs)
HU (1)	HUP0300469A2 (cs)
IL (1)	IL152272A (cs)
MX (1)	MXPA02010155A (cs)
NO (1)	NO20024945L (cs)
NZ (1)	NZ521990A (cs)
PL (1)	PL207374B1 (cs)
RU (1)	RU2272835C2 (cs)
WO (1)	WO2001079507A2 (cs)
ZA (1)	ZA200208311B (cs)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5811381A (en) *	1996-10-10	1998-09-22	Mark A. Emalfarb	Cellulase compositions and methods of use
US7883872B2 (en)	1996-10-10	2011-02-08	Dyadic International (Usa), Inc.	Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose
EA005682B1 (ru) *	1998-10-06	2005-04-28	Марк Аарон Эмалфарб	Трансформированные грибы, в частности рода chrysosporium, способные к синтезу гетерологичных полипептидов
CZ303980B6 (cs) *	2000-04-13	2013-07-31	Dyadic International (Usa), Inc.	Expresi regulující sekvence nukleové kyseliny a produkty exprese v oblasti vláknitých plísní
ES2397267T3 (es)	2001-06-26	2013-03-05	Novozymes A/S	Polipéptidos con actividad de celobiohidrolasa I y polinucleótidos que codifican los mismos
WO2006012904A1 (en) *	2004-08-06	2006-02-09	Novozymes A/S	Polypeptides of botryosphaeria rhodina
DK1989302T3 (en) *	2006-02-14	2018-07-23	Bp Corp North America Inc	XYLANASES, NUCLEIC ACID CODING THEM AND PROCEDURES FOR THEIR PREPARATION AND USE
US9862956B2 (en)	2006-12-10	2018-01-09	Danisco Us Inc.	Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi
EP2505651A3 (en)	2006-12-10	2013-01-09	Dyadic International, Inc.	Isolated fungus with reduced protease activity
CN101855345A (zh)	2007-05-10	2010-10-06	诺维信股份有限公司	用于增强含纤维素材料的降解或转化的组合物和方法
US8551751B2 (en)	2007-09-07	2013-10-08	Dyadic International, Inc.	BX11 enzymes having xylosidase activity
US7923236B2 (en) *	2007-08-02	2011-04-12	Dyadic International (Usa), Inc.	Fungal enzymes
EP2408910B1 (en)	2009-03-16	2018-04-25	Danisco US Inc.	Chrysosporium lucknowense protein production system
AU2010241099A1 (en) *	2009-04-22	2011-10-27	Dsm Ip Assets B.V.	Process for the production of a recombinant polypeptide of interest
WO2010129287A2 (en)	2009-04-27	2010-11-11	The Board Of Trustees Of The University Of Illinois	Hemicellulose-degrading enzymes
DK2483415T3 (en)	2009-09-30	2015-02-09	Codexis Inc	RECOMBINANT C1 B-glucosidase FOR MANUFACTURE OF sugars from cellulosic BIOMASS
JP5735775B2 (ja) *	2009-10-21	2015-06-17	花王株式会社	改変プロモーター
CN101831448A (zh) *	2010-03-26	2010-09-15	武汉大学	一种植物三磷酸甘油醛脱氢酶基因及制备方法和应用
US9493802B2 (en)	2010-08-20	2016-11-15	Codexis, Inc.	Use of glycohydrolase 61 protein variants with improved thermostability for processing cellulose
WO2012024662A2 (en)	2010-08-20	2012-02-23	Codexis, Inc.	Expression constructs comprising fungal promoters
JP2013539971A (ja) *	2010-09-15	2013-10-31	ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア	Ｔｒｉｃｈｏｄｅｒｍａｒｅｅｓｅｉのエンドグルカナーゼｉの好熱性変異体
US9868958B2 (en) *	2011-04-22	2018-01-16	Danisco Us Inc.	Filamentous fungi having an altered viscosity phenotype
CN103517916B (zh) *	2011-04-22	2017-05-10	丹尼斯科美国公司	具有粘度改变表型的丝状真菌
WO2013048661A1 (en)	2011-09-30	2013-04-04	Codexis, Inc.	Fungal proteases
US9249418B2 (en)	2011-10-31	2016-02-02	Bp Corporation North America Inc.	Use of plant promoters in filamentous fungi
CA2851308A1 (en)	2011-10-31	2013-05-10	Bp Corporation North America Inc.	Use of mammalian promoters in filamentous fungi
WO2014070856A2 (en)	2012-11-02	2014-05-08	Bp Corporation North America Inc.	Thermotolerant beta-glucosidase variants
WO2014145768A2 (en)	2013-03-15	2014-09-18	Bp Corporation North America Inc.	Use of non-fungal 5' utrs in filamentous fungi
KR101598824B1 (ko)	2015-09-25	2016-03-02	경인엔지니어링 주식회사	역 v형 루버 구조를 이용한 배전반 방열장치
EP3672630A4 (en) *	2017-08-21	2021-06-02	Dyadic International Inc.	MANUFACTURING OF A FLU VACCINE IN MYCELIOPHTHORA THERMOPHILA
WO2024132947A1 (en) *	2022-12-19	2024-06-27	Basf Se	New cellulase promoters for fungal protein production

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK115890D0 (da) *	1990-05-09	1990-05-09	Novo Nordisk As	Enzym
GB9400623D0 (en) *	1994-01-14	1994-03-09	Univ Leeds	Exploitation of the cellulase enzyme complex of neurospora
GB2289218A (en) *	1994-05-06	1995-11-15	Merck & Co Inc	Inhibition of TNFalpha production with agonists of the A2b subtype of the adenosine receptor
US5550020A (en) *	1994-07-08	1996-08-27	Visible Genetics Inc.	Method, reagents and kit for diagnosis and targeted screening for retinoblastoma
JP3107977B2 (ja) *	1994-08-29	2000-11-13	明治製菓株式会社	新規セルラーゼおよびその遺伝子
WO1997013853A2 (en) *	1995-10-13	1997-04-17	Gist-Brocades B.V.	Protein detection
DE69704845T2 (de)	1996-01-26	2001-12-20	Novozymes A/S, Bagsvaerd	Herstellung von toilettenpapier
US5811381A (en) *	1996-10-10	1998-09-22	Mark A. Emalfarb	Cellulase compositions and methods of use
US6001595A (en) *	1996-11-29	1999-12-14	Rohm Enzyme GmbH	Promoters and uses thereof
WO1999025735A1 (en) *	1997-11-19	1999-05-27	Microbia, Inc.	Chimeric pre-activated transcription factors
EA005682B1 (ru) *	1998-10-06	2005-04-28	Марк Аарон Эмалфарб	Трансформированные грибы, в частности рода chrysosporium, способные к синтезу гетерологичных полипептидов
US6121034A (en) *	1999-05-13	2000-09-19	Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food	Coniothyrium minitans xylanase gene Cxy1
WO2001025468A1 (en) *	1999-10-06	2001-04-12	Mark Aaron Emalfarb	High-throughput screening of expressed dna libraries in filamentous fungi
CZ303980B6 (cs) *	2000-04-13	2013-07-31	Dyadic International (Usa), Inc.	Expresi regulující sekvence nukleové kyseliny a produkty exprese v oblasti vláknitých plísní
DK3219806T3 (da) *	2004-03-25	2020-07-13	Novozymes Inc	Fremgangsmåder til nedbrydning eller omdannelse af plantecellevægspolysaccharider

2001
- 2001-04-17 CZ CZ20023435A patent/CZ303980B6/cs not_active IP Right Cessation
- 2001-04-17 HU HU0300469A patent/HUP0300469A2/hu unknown
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- 2001-04-17 US US10/257,629 patent/US7906309B2/en not_active Expired - Fee Related
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- 2001-04-17 MX MXPA02010155A patent/MXPA02010155A/es active IP Right Grant
- 2001-04-17 AT AT01923991T patent/ATE358724T1/de not_active IP Right Cessation
- 2001-04-17 EP EP01923991A patent/EP1276876B1/en not_active Expired - Lifetime
- 2001-04-17 PL PL358491A patent/PL207374B1/pl not_active IP Right Cessation
- 2001-04-17 WO PCT/NL2001/000301 patent/WO2001079507A2/en active IP Right Grant
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- 2001-04-17 CN CNB018110681A patent/CN100420753C/zh not_active Expired - Fee Related
- 2001-04-17 NZ NZ521990A patent/NZ521990A/en unknown
- 2001-04-17 JP JP2001577490A patent/JP4922524B2/ja not_active Expired - Fee Related
- 2001-04-17 EP EP07102273A patent/EP1854888A3/en not_active Withdrawn
- 2001-04-17 RU RU2002130278/13A patent/RU2272835C2/ru not_active IP Right Cessation
- 2001-04-17 ES ES01923991T patent/ES2283402T3/es not_active Expired - Lifetime
- 2001-04-17 DE DE60127661T patent/DE60127661T2/de not_active Expired - Lifetime
- 2001-04-17 BR BR0110090-4A patent/BR0110090A/pt not_active IP Right Cessation
- 2001-04-17 DK DK01923991T patent/DK1276876T3/da active
2002
- 2002-10-14 NO NO20024945A patent/NO20024945L/no not_active Application Discontinuation
- 2002-10-15 ZA ZA200208311A patent/ZA200208311B/en unknown
2011
- 2011-03-14 US US13/046,772 patent/US20130143271A1/en not_active Abandoned
- 2011-07-15 JP JP2011156864A patent/JP2011234729A/ja active Pending
2014
- 2014-06-19 JP JP2014126246A patent/JP2014236730A/ja active Pending

Also Published As

Publication number	Publication date
AU5066301A (en)	2001-10-30
JP2011234729A (ja)	2011-11-24
DE60127661T2 (de)	2007-12-06
EP1854888A2 (en)	2007-11-14
PL207374B1 (pl)	2010-12-31
KR100903780B1 (ko)	2009-06-19
PL358491A1 (en)	2004-08-09
DK1276876T3 (da)	2007-07-16
CZ303980B6 (cs)	2013-07-31
CZ20023435A3 (cs)	2003-05-14
JP4922524B2 (ja)	2012-04-25
EP1276876A2 (en)	2003-01-22
CA2405954A1 (en)	2001-10-25
IL152272A0 (en)	2003-05-29
US7906309B2 (en)	2011-03-15
ATE358724T1 (de)	2007-04-15
HUP0300469A2 (hu)	2003-06-28
NO20024945L (no)	2002-12-12
RU2272835C2 (ru)	2006-03-27
JP2004504012A (ja)	2004-02-12
US20030187243A1 (en)	2003-10-02
ES2283402T3 (es)	2007-11-01
BR0110090A (pt)	2003-02-18
DE60127661D1 (de)	2007-05-16
CN100420753C (zh)	2008-09-24
IL152272A (en)	2011-05-31
NZ521990A (en)	2004-11-26
MXPA02010155A (es)	2004-08-19
AU782105B2 (en)	2005-07-07
EP1854888A3 (en)	2009-10-07
EP1276876B1 (en)	2007-04-04
KR20020093932A (ko)	2002-12-16
WO2001079507A3 (en)	2002-02-07
CA2405954C (en)	2015-06-30
WO2001079507A2 (en)	2001-10-25
US20130143271A1 (en)	2013-06-06
JP2014236730A (ja)	2014-12-18
NO20024945D0 (no)	2002-10-14
CN1436242A (zh)	2003-08-13

Publication	Publication Date	Title
ZA200208311B (en)	2003-10-15	Expression-regulating sequences and expression products in the field of filamentous fungi chrysosporium.
US8871493B2 (en)	2014-10-28	Transformation system in the field of filamentous fungal hosts
EP1272669B1 (en)	2009-06-10	High-throughput screening of expressed dna libraries in filamentous fungi
WO2001025468A1 (en)	2001-04-12	High-throughput screening of expressed dna libraries in filamentous fungi
CN107109424A (zh)	2017-08-29	真菌宿主菌株、dna构建体及使用方法
RU2238974C2 (ru)	2004-10-27	Фрагмент днк мицелиального гриба penicillium verruculosum, кодирующий синтез секретируемой эндоглюканазы iii и группа штаммов penicillium canescens, синтезирующих эндоглюканазу iii penicillium verruculosum, сконструированных методами трансформации и генетической инженерии на основе этого фрагмента днк
MXPA01003462A (en)	2002-06-05	Transformation system in the field of filamentous fungal hosts
BRPI0110090B1 (pt)	2017-08-15	Construction of nucleic acid, process for producing a polipeptde, and microbial recombinant cepa