ZA200204429B - New P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases. - Google Patents
New P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases. Download PDFInfo
- Publication number
- ZA200204429B ZA200204429B ZA200204429A ZA200204429A ZA200204429B ZA 200204429 B ZA200204429 B ZA 200204429B ZA 200204429 A ZA200204429 A ZA 200204429A ZA 200204429 A ZA200204429 A ZA 200204429A ZA 200204429 B ZA200204429 B ZA 200204429B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzoxazin
- piperidin
- nitro
- benzamide
- apci
- Prior art date
Links
- 230000002757 inflammatory effect Effects 0.000 title description 4
- 239000002464 receptor antagonist Substances 0.000 title description 4
- 229940044551 receptor antagonist Drugs 0.000 title description 4
- 208000024172 Cardiovascular disease Diseases 0.000 title description 3
- 102100037602 P2X purinoceptor 7 Human genes 0.000 title description 2
- 101710189965 P2X purinoceptor 7 Proteins 0.000 title description 2
- 208000026278 immune system disease Diseases 0.000 title description 2
- 208000027866 inflammatory disease Diseases 0.000 title description 2
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9904652A SE9904652D0 (sv) | 1999-12-17 | 1999-12-17 | Novel Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200204429B true ZA200204429B (en) | 2003-09-03 |
Family
ID=20418188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200204429A ZA200204429B (en) | 1999-12-17 | 2002-06-03 | New P2X7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6812226B2 (fr) |
| EP (1) | EP1242396B1 (fr) |
| JP (1) | JP2003516978A (fr) |
| KR (1) | KR20020067554A (fr) |
| CN (1) | CN1304382C (fr) |
| AT (1) | ATE250590T1 (fr) |
| AU (1) | AU775741B2 (fr) |
| BR (1) | BR0016396A (fr) |
| CA (1) | CA2392894A1 (fr) |
| DE (1) | DE60005560T2 (fr) |
| IL (1) | IL150085A0 (fr) |
| MX (1) | MXPA02005788A (fr) |
| NO (1) | NO323538B1 (fr) |
| SE (1) | SE9904652D0 (fr) |
| WO (1) | WO2001044213A1 (fr) |
| ZA (1) | ZA200204429B (fr) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9904505D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Pharma Prod | Novel compounds |
| TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
| SE9904738D0 (sv) * | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
| HUP0401333A3 (en) | 2001-04-18 | 2004-11-29 | Euro Celtique Sa | Spiropyrazole compounds and pharmaceutical compositions containing them |
| WO2002085354A1 (fr) | 2001-04-18 | 2002-10-31 | Euro-Celtique S.A. | Composes spiro-indene et spiro-indane |
| PT1385518E (pt) | 2001-04-18 | 2008-10-07 | Euro Celtique Sa | Compostos de benzimidazolona |
| MXPA03009602A (es) | 2001-04-18 | 2004-04-02 | Euro Celtique Sa | Analogos de nociceptina. |
| HUP0401109A3 (en) | 2001-04-18 | 2007-12-28 | Euro Celtique Sa | Nociceptin analogs, their use and pharmaceutical compositions containing them |
| WO2003042190A1 (fr) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | Derives de n-adamantylalkyle benzamide en tant qu'antagonistes du recepteur p2x7 |
| PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
| ATE375980T1 (de) * | 2002-02-12 | 2007-11-15 | Smithkline Beecham Corp | Nicotinamide und deren verwendung als p38 inhibitoren |
| US7176310B1 (en) | 2002-04-09 | 2007-02-13 | Ucb Sa | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents |
| ES2193875B2 (es) * | 2002-04-09 | 2005-03-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. |
| EP1388535A1 (fr) * | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Arylcycloalkylamines acylés et leurs utilisations comme produits pharmaceutiques |
| GB0228410D0 (en) | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
| US7071223B1 (en) * | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
| PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
| ATE371738T1 (de) | 2003-04-17 | 2007-09-15 | Affectis Pharmaceuticals Ag | Mittel und verfahren zur diagnose und behandlung affektiver störungen |
| JP4731468B2 (ja) * | 2003-05-12 | 2011-07-27 | ファイザー・プロダクツ・インク | Ｐ２ｘ７受容体のベンズアミド阻害剤 |
| GB0324498D0 (en) | 2003-07-21 | 2003-11-26 | Aventis Pharma Inc | Heterocyclic compounds as P2X7 ion channel blockers |
| ES2232292B1 (es) * | 2003-07-30 | 2006-11-01 | Laboratorios Del Dr. Esteve, S.A. | Compuestos sulfonamidicos derivados de benzoxazinona, su preparacion y uso como medicamentos. |
| JP4717876B2 (ja) * | 2004-03-05 | 2011-07-06 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐ２ｘ３およびｐ２ｘ２／３アンタゴニストとしてのジアミノピリミジン |
| JPWO2005107804A1 (ja) * | 2004-05-06 | 2008-03-21 | 小野薬品工業株式会社 | 呼吸器疾患治療剤 |
| EP1763353A1 (fr) * | 2004-06-29 | 2007-03-21 | Warner-Lambert Company LLC | THERAPIES COMBINATOIRES DANS LESQUELLES SONT UTILISES DES INHIBITEURS DE BENZAMIDE DU RECEPTEUR P2X<SB>7</SB> |
| CN1980902A (zh) * | 2004-06-29 | 2007-06-13 | 辉瑞产品有限公司 | 通过对羟基保护前体去保护而制备5－4－(2－羟基－丙基)－3，5－二氧代－4，5－二氢－3h－[1，2，4]三嗪－2－基－苯甲酰胺衍生物的方法 |
| EP2266569A3 (fr) | 2004-09-20 | 2011-03-09 | Xenon Pharmaceuticals Inc. | Dérivés hétérocycliques et leur utilisation en tant qu'inhibiteurs de la stearoyl-coa desaturase |
| US7592343B2 (en) * | 2004-09-20 | 2009-09-22 | Xenon Pharmaceuticals Inc. | Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors |
| US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| EP1814551A2 (fr) | 2004-09-20 | 2007-08-08 | Xenon Pharmaceuticals Inc. | Derives de pyridazine destines a l'inhibition du desaturase-coa-stearoyl de l'humain |
| TW200626592A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
| EP1799667B1 (fr) | 2004-09-20 | 2013-03-20 | Xenon Pharmaceuticals Inc. | Derives heterocycliques et leur utilisation comme agents therapeutiques |
| EP2540296A1 (fr) | 2005-06-03 | 2013-01-02 | Xenon Pharmaceuticals Inc. | Dérivés d'arminothiazole utilisés comme inhibiteurs de la stéaroyl-coa désaturase humaine |
| WO2006136791A1 (fr) * | 2005-06-21 | 2006-12-28 | Astrazeneca Ab | Polymorphismes et haplotypes dans le gene p2x7 et utilisation de ceux-ci dans la determination de la susceptibilite a developper des maladies induites par l'atherosclerose |
| CA2625940A1 (fr) * | 2005-08-29 | 2007-03-08 | Irma Bernatchez-Lemaire | Utilisation de composes histogranine et du type histogranine comme inhibiteurs de la fonction du recepteur p2x7 et comme agents anti-arthritiques |
| CA2619919C (fr) * | 2005-09-01 | 2014-04-01 | F. Hoffmann-La Roche Ag | Diaminopyrimidines en tant que modulateurs de p2x3 et p2x2/3 |
| CA2620129C (fr) * | 2005-09-01 | 2014-12-23 | F. Hoffmann-La Roche Ag | Diaminopyrimidines comme modulateurs p2x3 et p2x2/3 |
| CN101253159B (zh) * | 2005-09-01 | 2011-12-07 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物 |
| ES2391107T3 (es) * | 2005-09-30 | 2012-11-21 | Glaxo Group Limited | Compuestos que tienen actividad en el receptor M1 y sus usos en medicina |
| CA2624504C (fr) * | 2005-09-30 | 2014-07-08 | Glaxo Group Limited | Composes de benzimidazolone qui presentent une activite au recepteur m1 et leurs utilisations en medecine |
| US8288413B2 (en) * | 2005-09-30 | 2012-10-16 | Glaxo Group Limited | Benzimidazolones which have activity at M1 receptor |
| FR2892722B1 (fr) * | 2005-11-02 | 2008-08-15 | Clinigenetics Sa | Composes de type methanone et leur utilisation dans des compositions pharmaceutiques notamment pour le traitement des maladies cardiovasculaires |
| US20070249666A1 (en) * | 2006-03-31 | 2007-10-25 | Bratcher Natalie A | P2X7 Antagonists to Treat Affective Disorders |
| TW200813018A (en) | 2006-06-09 | 2008-03-16 | Astrazeneca Ab | Novel compounds |
| EP1878721A1 (fr) * | 2006-07-13 | 2008-01-16 | Novo Nordisk A/S | 4-Piperidylbenzamides en tant qu'inhibiteurs de la 11-beta-hydroxysteroid dehydrogenase type 1 |
| WO2008060568A2 (fr) * | 2006-11-15 | 2008-05-22 | Neurogen Corporation | Arylpipéridines à substitution amide |
| CA2680275C (fr) * | 2007-03-09 | 2016-08-23 | Renovis, Inc. | Composes de bicycloheteroaryle utilises comme modulateurs de p2x7 et leurs utilisations |
| RU2460727C2 (ru) * | 2007-03-22 | 2012-09-10 | Астразенека Аб | Хинолиновые производные для лечения воспалительных заболеваний |
| US7932879B2 (en) * | 2007-05-08 | 2011-04-26 | Sony Ericsson Mobile Communications Ab | Controlling electroluminescent panels in response to cumulative utilization |
| US8119661B2 (en) | 2007-09-11 | 2012-02-21 | Astrazeneca Ab | Piperidine derivatives and their use as muscarinic receptor modulators |
| GB0718415D0 (en) * | 2007-09-20 | 2007-10-31 | Glaxo Group Ltd | Compounds |
| AU2008307195B2 (en) | 2007-10-04 | 2012-11-22 | F. Hoffmann-La Roche Ag | Cyclopropyl aryl amide derivatives and uses thereof |
| WO2009108551A2 (fr) * | 2008-02-25 | 2009-09-03 | H. Lundbeck A/S | Analogues d’hétéroarylamide |
| US8232290B2 (en) | 2008-03-25 | 2012-07-31 | Affectis Pharmaceuticals Ag | P2X7R antagonists and their use |
| US20090275574A1 (en) * | 2008-05-05 | 2009-11-05 | Astrazeneca Ab | Novel compounds-300 |
| EP3725775A1 (fr) * | 2009-02-17 | 2020-10-21 | Syntrix Biosystems, Inc. | Pyridine- et pyrimidinecarboxamides comme modulateurs du cxcr2 |
| SG175232A1 (en) | 2009-04-14 | 2011-12-29 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
| WO2011012592A1 (fr) * | 2009-07-30 | 2011-02-03 | F. Hoffmann-La Roche Ag | Amides de dihydropyrimidone utilisés comme modulateurs p2x7 |
| EP2322149A1 (fr) | 2009-11-03 | 2011-05-18 | Universidad del Pais Vasco | Procédés et compositions de traitement de l'ischémie |
| US8691556B2 (en) | 2009-12-08 | 2014-04-08 | Vanderbilt University | Methods and compositions for vein harvest and autografting |
| BR112012028850A2 (pt) | 2010-05-14 | 2015-09-15 | Affectis Pharmaceuticals Ag | métodos para a preparação de antagonistas de p2x7r |
| US8779149B2 (en) | 2010-08-23 | 2014-07-15 | Syntrix Biosystems, Inc. | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators |
| WO2012110190A1 (fr) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Nouveaux antagonistes p2x7r et leur utilisation |
| WO2012163792A1 (fr) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Nouveaux antagonistes de p2x7r et leur utilisation |
| WO2012163456A1 (fr) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Nouveaux antagonistes de p2x7r et leur utilisation |
| US9181226B2 (en) | 2011-07-18 | 2015-11-10 | Merck Patent Gmbh | Benzamides |
| US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| GB201508864D0 (en) * | 2015-05-22 | 2015-07-01 | Glaxosmithkline Ip Dev Ltd | Compounds |
| CN109136361A (zh) * | 2018-08-01 | 2019-01-04 | 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） | P2x7受体在诊断和治疗类风湿关节炎方面的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL106507A (en) * | 1992-08-07 | 1997-11-20 | Merck & Co Inc | Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type |
| CA2200468A1 (fr) * | 1994-10-27 | 1996-05-09 | Wayne J. Thompson | Antagonistes de muscarine |
| US5756497A (en) * | 1996-03-01 | 1998-05-26 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| SE9704546D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
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1999
- 1999-12-17 SE SE9904652A patent/SE9904652D0/xx unknown
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2000
- 2000-12-12 CA CA002392894A patent/CA2392894A1/fr not_active Abandoned
- 2000-12-12 US US10/149,760 patent/US6812226B2/en not_active Expired - Fee Related
- 2000-12-12 BR BR0016396-1A patent/BR0016396A/pt not_active IP Right Cessation
- 2000-12-12 DE DE60005560T patent/DE60005560T2/de not_active Expired - Lifetime
- 2000-12-12 CN CNB008189234A patent/CN1304382C/zh not_active Expired - Fee Related
- 2000-12-12 AU AU22443/01A patent/AU775741B2/en not_active Ceased
- 2000-12-12 WO PCT/SE2000/002504 patent/WO2001044213A1/fr active IP Right Grant
- 2000-12-12 AT AT00986154T patent/ATE250590T1/de not_active IP Right Cessation
- 2000-12-12 JP JP2001544703A patent/JP2003516978A/ja active Pending
- 2000-12-12 EP EP00986154A patent/EP1242396B1/fr not_active Expired - Lifetime
- 2000-12-12 IL IL15008500A patent/IL150085A0/xx unknown
- 2000-12-12 MX MXPA02005788A patent/MXPA02005788A/es active IP Right Grant
- 2000-12-12 KR KR1020027007697A patent/KR20020067554A/ko active IP Right Grant
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2002
- 2002-06-03 ZA ZA200204429A patent/ZA200204429B/en unknown
- 2002-06-14 NO NO20022857A patent/NO323538B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02005788A (es) | 2002-09-18 |
| NO20022857D0 (no) | 2002-06-14 |
| ATE250590T1 (de) | 2003-10-15 |
| JP2003516978A (ja) | 2003-05-20 |
| DE60005560D1 (de) | 2003-10-30 |
| KR20020067554A (ko) | 2002-08-22 |
| NO20022857L (no) | 2002-08-01 |
| AU775741B2 (en) | 2004-08-12 |
| CA2392894A1 (fr) | 2001-06-21 |
| BR0016396A (pt) | 2002-08-20 |
| SE9904652D0 (sv) | 1999-12-17 |
| DE60005560T2 (de) | 2004-07-15 |
| CN1434811A (zh) | 2003-08-06 |
| US6812226B2 (en) | 2004-11-02 |
| US20030040513A1 (en) | 2003-02-27 |
| EP1242396A1 (fr) | 2002-09-25 |
| EP1242396B1 (fr) | 2003-09-24 |
| WO2001044213A1 (fr) | 2001-06-21 |
| IL150085A0 (en) | 2002-12-01 |
| NO323538B1 (no) | 2007-06-04 |
| AU2244301A (en) | 2001-06-25 |
| CN1304382C (zh) | 2007-03-14 |
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