ZA200100783B - Triazolopyridines for the treatment of thrombosis disorders. - Google Patents
Triazolopyridines for the treatment of thrombosis disorders. Download PDFInfo
- Publication number
- ZA200100783B ZA200100783B ZA200100783A ZA200100783A ZA200100783B ZA 200100783 B ZA200100783 B ZA 200100783B ZA 200100783 A ZA200100783 A ZA 200100783A ZA 200100783 A ZA200100783 A ZA 200100783A ZA 200100783 B ZA200100783 B ZA 200100783B
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- South Africa
- Prior art keywords
- alkyl
- compound
- hydrogen
- composition
- tetrahydro
- Prior art date
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- 229940032147 starch Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- WOEQSXAIPTXOPY-UHFFFAOYSA-N tert-butyl 4-methylsulfonyloxypiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(OS(C)(=O)=O)CC1 WOEQSXAIPTXOPY-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- OVCXRBARSPBVMC-UHFFFAOYSA-N triazolopyridine Chemical compound C=1N2C(C(C)C)=NN=C2C=CC=1C=1OC=NC=1C1=CC=C(F)C=C1 OVCXRBARSPBVMC-UHFFFAOYSA-N 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical compound C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9423198P | 1998-07-27 | 1998-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200100783B true ZA200100783B (en) | 2002-01-28 |
Family
ID=22243910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200100783A ZA200100783B (en) | 1998-07-27 | 2001-01-26 | Triazolopyridines for the treatment of thrombosis disorders. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6303625B1 (xx) |
| EP (1) | EP1102766B1 (xx) |
| JP (1) | JP2003527306A (xx) |
| KR (1) | KR20010079576A (xx) |
| CN (1) | CN1320125A (xx) |
| AR (1) | AR019477A1 (xx) |
| AT (1) | ATE263169T1 (xx) |
| AU (1) | AU757512B2 (xx) |
| BR (1) | BR9912556A (xx) |
| CA (1) | CA2338654A1 (xx) |
| CZ (1) | CZ2001347A3 (xx) |
| DE (1) | DE69916073T2 (xx) |
| ES (1) | ES2219042T3 (xx) |
| HU (1) | HUP0103832A3 (xx) |
| ID (1) | ID27214A (xx) |
| MX (1) | MXPA01001099A (xx) |
| NO (1) | NO20010456L (xx) |
| PL (1) | PL345769A1 (xx) |
| SK (1) | SK1342001A3 (xx) |
| WO (1) | WO2000006570A1 (xx) |
| ZA (1) | ZA200100783B (xx) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306909B1 (en) | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
| SK287075B6 (sk) * | 1999-08-13 | 2009-11-05 | Biogen Idec Ma Inc. | Inhibítory bunkovej adhézie a farmaceutické prostriedky, ktoré ich obsahujú |
| TWI290136B (en) * | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| CA2448160A1 (en) * | 2001-05-25 | 2002-12-05 | Queen's University At Kingston | Heterocyclic beta-amino acids and their use as anti-epileptogenic agents |
| WO2003000657A1 (fr) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Derives de diamine |
| CA2577648A1 (en) * | 2004-08-18 | 2006-02-23 | Pharmacia & Upjohn Company Llc | Triazolopyridine compounds useful for the treatment of inflammation |
| US7618983B2 (en) * | 2004-11-10 | 2009-11-17 | Janssen Pharmaceutica, N.V. | Bicyclic triazole α4 integrin inhibitors |
| US8686189B2 (en) * | 2005-09-16 | 2014-04-01 | Daiichi Sankyo Company, Limited | Optically active diamine derivative and process for producing the same |
| EP2086973B1 (en) * | 2006-10-11 | 2012-01-25 | Amgen Inc., | Imidazo- and triazolo-pyridine compounds and methods of use therof |
| WO2010117926A1 (en) * | 2009-04-07 | 2010-10-14 | Schering Corporation | Substituted triazolopyridines and analogs thereof |
| US8871760B2 (en) * | 2009-09-21 | 2014-10-28 | Roche Palo Alto Llc | [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators |
| UY34329A (es) | 2011-09-15 | 2013-04-30 | Novartis Ag | Compuestos de triazolopiridina |
| EP3004095A1 (de) * | 2013-06-03 | 2016-04-13 | Bayer Pharma Aktiengesellschaft | Triazolopyridine als thrombininhibitoren zur behandlung von thromboembolischen erkrankungen |
| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3050525A (en) | 1960-12-14 | 1962-08-21 | John B Bicking | Certain derivatives of s-triazolo [4, 3-a]-pyridine |
| NZ262664A (en) | 1993-02-22 | 1997-04-24 | Merck & Co Inc | Heterocyclic substituted derivatives, and medicaments thereof |
| DE4326758A1 (de) * | 1993-08-10 | 1995-02-16 | Basf Ag | [1,3,4]Triazolo[1,5-a]pyridine |
| CA2134192A1 (en) | 1993-11-12 | 1995-05-13 | Michael L. Denney | 5, 6-bicyclic glycoprotein iib/iiia antagonists |
-
1999
- 1999-07-15 US US09/354,032 patent/US6303625B1/en not_active Expired - Lifetime
- 1999-07-21 MX MXPA01001099A patent/MXPA01001099A/es unknown
- 1999-07-21 PL PL99345769A patent/PL345769A1/xx not_active Application Discontinuation
- 1999-07-21 CN CN99811380A patent/CN1320125A/zh active Pending
- 1999-07-21 CZ CZ2001347A patent/CZ2001347A3/cs unknown
- 1999-07-21 KR KR1020017001183A patent/KR20010079576A/ko not_active Application Discontinuation
- 1999-07-21 CA CA002338654A patent/CA2338654A1/en not_active Abandoned
- 1999-07-21 EP EP99937373A patent/EP1102766B1/en not_active Expired - Lifetime
- 1999-07-21 AU AU52218/99A patent/AU757512B2/en not_active Ceased
- 1999-07-21 HU HU0103832A patent/HUP0103832A3/hu unknown
- 1999-07-21 ES ES99937373T patent/ES2219042T3/es not_active Expired - Lifetime
- 1999-07-21 SK SK134-2001A patent/SK1342001A3/sk unknown
- 1999-07-21 AT AT99937373T patent/ATE263169T1/de not_active IP Right Cessation
- 1999-07-21 WO PCT/US1999/016572 patent/WO2000006570A1/en not_active Application Discontinuation
- 1999-07-21 JP JP2000562372A patent/JP2003527306A/ja active Pending
- 1999-07-21 BR BR9912556-0A patent/BR9912556A/pt not_active Application Discontinuation
- 1999-07-21 DE DE69916073T patent/DE69916073T2/de not_active Expired - Fee Related
- 1999-07-21 ID IDW20010365A patent/ID27214A/id unknown
- 1999-07-26 AR ARP990103671A patent/AR019477A1/es unknown
-
2001
- 2001-01-26 NO NO20010456A patent/NO20010456L/no not_active Application Discontinuation
- 2001-01-26 ZA ZA200100783A patent/ZA200100783B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA01001099A (es) | 2002-04-24 |
| US6303625B1 (en) | 2001-10-16 |
| HUP0103832A3 (en) | 2002-12-28 |
| KR20010079576A (ko) | 2001-08-22 |
| CZ2001347A3 (cs) | 2001-12-12 |
| CA2338654A1 (en) | 2000-02-10 |
| ATE263169T1 (de) | 2004-04-15 |
| AU757512B2 (en) | 2003-02-20 |
| JP2003527306A (ja) | 2003-09-16 |
| CN1320125A (zh) | 2001-10-31 |
| ES2219042T3 (es) | 2004-11-16 |
| DE69916073T2 (de) | 2004-12-30 |
| AU5221899A (en) | 2000-02-21 |
| DE69916073D1 (de) | 2004-05-06 |
| BR9912556A (pt) | 2002-01-15 |
| EP1102766B1 (en) | 2004-03-31 |
| AR019477A1 (es) | 2002-02-20 |
| PL345769A1 (en) | 2002-01-02 |
| WO2000006570A1 (en) | 2000-02-10 |
| ID27214A (id) | 2001-03-08 |
| NO20010456L (no) | 2001-03-26 |
| HUP0103832A2 (hu) | 2002-04-29 |
| NO20010456D0 (no) | 2001-01-26 |
| EP1102766A1 (en) | 2001-05-30 |
| SK1342001A3 (en) | 2002-04-04 |
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