YU81692A - Postupak za proizvodnju cefalosporinskog antibiotika - Google Patents
Postupak za proizvodnju cefalosporinskog antibiotikaInfo
- Publication number
- YU81692A YU81692A YU81692A YU81692A YU81692A YU 81692 A YU81692 A YU 81692A YU 81692 A YU81692 A YU 81692A YU 81692 A YU81692 A YU 81692A YU 81692 A YU81692 A YU 81692A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- production
- procedure
- cephalosporin antibiotics
- methyl
- cephalosporin
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- -1 (1-Methyl-1-pyrrolidinyl) methyl Chemical group 0.000 abstract 1
- YLBRJSVEBVCFCN-UHFFFAOYSA-N 2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl chloride;hydrochloride Chemical compound Cl.CON=C(C(Cl)=O)C1=CSC(N)=N1 YLBRJSVEBVCFCN-UHFFFAOYSA-N 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Revetment (AREA)
- Artificial Fish Reefs (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
POSTUPAK ZA PROIZVODNJU CEFALOSPORINSKOG ANTIBIOTIKA, ovim pronalaskom omogućen je postupak anhidridnog acilovanja za proizvodnju antibiotika cefepim dihidrohlorid hidrata koji u suštini ne sadrži anti-izomer niti izomer delta2, koji je postupak naznačen time što obuhvata N-acilovanje sililovanog derivata 7-amino-3-((1-metil-1-pirolidinio)metil)cef-3-em-4-karbok-silata sa sin-izomerom 2-(2-aminotiazol-4-il)-2-metoksiimino acetilhlorid hidrohlorida.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75710491A | 1991-09-10 | 1991-09-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU81692A true YU81692A (sh) | 1995-03-27 |
Family
ID=25046366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU81692A YU81692A (sh) | 1991-09-10 | 1992-09-04 | Postupak za proizvodnju cefalosporinskog antibiotika |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0531981B1 (sh) |
| JP (1) | JP3434840B2 (sh) |
| KR (1) | KR0178280B1 (sh) |
| CN (2) | CN1036587C (sh) |
| AT (1) | ATE209209T1 (sh) |
| AU (1) | AU655838B2 (sh) |
| BG (1) | BG61189B1 (sh) |
| CA (1) | CA2077836A1 (sh) |
| CZ (2) | CZ71996A3 (sh) |
| DE (1) | DE69232216T2 (sh) |
| DK (1) | DK0531981T3 (sh) |
| EG (1) | EG20184A (sh) |
| ES (1) | ES2165351T3 (sh) |
| FI (2) | FI109127B (sh) |
| HU (1) | HU212782B (sh) |
| IL (1) | IL103109A (sh) |
| MX (1) | MX9205147A (sh) |
| NO (1) | NO301930B1 (sh) |
| NZ (1) | NZ244295A (sh) |
| OA (1) | OA09764A (sh) |
| PH (1) | PH31206A (sh) |
| PL (1) | PL174820B1 (sh) |
| PT (1) | PT531981E (sh) |
| RO (1) | RO109651B1 (sh) |
| RU (1) | RU2042681C1 (sh) |
| SK (2) | SK33698A3 (sh) |
| UY (1) | UY23475A1 (sh) |
| YU (1) | YU81692A (sh) |
| ZA (1) | ZA926866B (sh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY108872A (en) * | 1991-09-10 | 1996-11-30 | Bristol Myers Squibb Co | Preparation of a cephalosporin antibiotic using the syn-isomer of a thiazolyl intermediate. |
| CA2101571A1 (en) * | 1992-09-08 | 1994-03-09 | Elizabeth A. Garofalo | Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof |
| KR19980019860A (ko) * | 1996-09-04 | 1998-06-25 | 김윤배 | 세팔로스포린 중간체의 신규한 제조방법 |
| US7847093B2 (en) | 2003-04-16 | 2010-12-07 | Sandoz Ag | Processes for the preparations of cefepime |
| PL1618114T3 (pl) * | 2003-04-16 | 2010-12-31 | Sandoz Ag | Sposoby otrzymywania cefepimy |
| GB0416379D0 (en) * | 2004-07-22 | 2004-08-25 | Sandoz Ag | Organic compounds |
| ITMI20051684A1 (it) * | 2005-09-13 | 2007-03-14 | Harvest Lodge Ltd | Procedimento per la produzione del dicloridrato di amminoacidi |
| RU2469040C1 (ru) * | 2011-12-07 | 2012-12-10 | Общество с ограниченной ответственностью "КОМПАНИЯ "ДЕКО" | Способ получения 7-[2-(2-аминотиазол-4-ил)-2(z)-метоксииминоацетамидо]-3-[(1-метил-1-пирролидино)метил]-цеф-3-ем-4-карбоксилата дигидрохлорида моногидрата (цефепима дигидрохлорида моногидрата) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1213882A (en) * | 1982-03-04 | 1986-11-12 | Jun Okumura | Cephalosporins |
| DE3419015A1 (de) * | 1984-05-22 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von cephalosporinen |
| GB2165245B (en) * | 1984-10-01 | 1988-05-25 | Glaxo Group Ltd | Chemical compounds |
| US4910301A (en) * | 1985-08-05 | 1990-03-20 | Bristol-Myers Company | Cefepime cephalosporin salts |
| US4714760A (en) * | 1985-08-20 | 1987-12-22 | Bristol-Myers Company | Cephalosporin intermediates |
| MY108872A (en) * | 1991-09-10 | 1996-11-30 | Bristol Myers Squibb Co | Preparation of a cephalosporin antibiotic using the syn-isomer of a thiazolyl intermediate. |
-
1992
- 1992-09-04 YU YU81692A patent/YU81692A/sh unknown
- 1992-09-08 IL IL103109A patent/IL103109A/xx not_active IP Right Cessation
- 1992-09-09 PL PL92295873A patent/PL174820B1/pl not_active IP Right Cessation
- 1992-09-09 PH PH44905A patent/PH31206A/en unknown
- 1992-09-09 KR KR1019920016595A patent/KR0178280B1/ko not_active IP Right Cessation
- 1992-09-09 HU HU9202884A patent/HU212782B/hu not_active IP Right Cessation
- 1992-09-09 RU SU925052816A patent/RU2042681C1/ru active
- 1992-09-09 UY UY23475A patent/UY23475A1/es not_active IP Right Cessation
- 1992-09-09 CZ CZ96719A patent/CZ71996A3/cs not_active IP Right Cessation
- 1992-09-09 AT AT92115443T patent/ATE209209T1/de active
- 1992-09-09 EP EP92115443A patent/EP0531981B1/en not_active Expired - Lifetime
- 1992-09-09 DE DE69232216T patent/DE69232216T2/de not_active Expired - Lifetime
- 1992-09-09 CN CN92110242A patent/CN1036587C/zh not_active Expired - Lifetime
- 1992-09-09 AU AU22844/92A patent/AU655838B2/en not_active Expired
- 1992-09-09 EG EG52692A patent/EG20184A/xx active
- 1992-09-09 OA OA60269A patent/OA09764A/fr unknown
- 1992-09-09 NO NO923495A patent/NO301930B1/no not_active IP Right Cessation
- 1992-09-09 SK SK336-98A patent/SK33698A3/sk not_active IP Right Cessation
- 1992-09-09 DK DK92115443T patent/DK0531981T3/da active
- 1992-09-09 PT PT92115443T patent/PT531981E/pt unknown
- 1992-09-09 RO RO92-01175A patent/RO109651B1/ro unknown
- 1992-09-09 MX MX9205147A patent/MX9205147A/es unknown
- 1992-09-09 ZA ZA926866A patent/ZA926866B/xx unknown
- 1992-09-09 SK SK2780-92A patent/SK280933B6/sk not_active IP Right Cessation
- 1992-09-09 CZ CS922780A patent/CZ282160B6/cs not_active IP Right Cessation
- 1992-09-09 FI FI924031A patent/FI109127B/fi not_active IP Right Cessation
- 1992-09-09 JP JP28213592A patent/JP3434840B2/ja not_active Expired - Lifetime
- 1992-09-09 CA CA002077836A patent/CA2077836A1/en not_active Abandoned
- 1992-09-09 ES ES92115443T patent/ES2165351T3/es not_active Expired - Lifetime
- 1992-09-10 NZ NZ244295A patent/NZ244295A/en not_active IP Right Cessation
- 1992-09-10 BG BG96859A patent/BG61189B1/bg unknown
-
1996
- 1996-12-05 CN CN96121883A patent/CN1059438C/zh not_active Expired - Lifetime
-
2001
- 2001-10-01 FI FI20011921A patent/FI119811B/fi not_active IP Right Cessation
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
| PH23284A (en) | 7-/2-(2-aminothiazol-4-yl)-2-(syn)-methoxyimino acetamido/ cephalosporin derivative | |
| YU81692A (sh) | Postupak za proizvodnju cefalosporinskog antibiotika | |
| EP0723965A4 (en) | NEW CEPHALOSPORINE DERIVATIVES | |
| BG96858A (bg) | Метод за получаване на цефалоспоринов антибиотик при използване на син-изомер на тиазолилов междинен продукт | |
| EP0780393A4 (en) | NEW CRYSTAL OF A CEPHALOSPORINE COMPOUND | |
| ES2043687T3 (es) | Nuevo derivado cristalino de cefalosporina. | |
| YU48092A (sh) | Postupak za dobijanje dvostruko blokiranih 1 karba(1-delta)-3-cefem-4-karboksilnih kiselina |