YU64691A - Poboljšani ergolin-8-karboksamidi - Google Patents

Poboljšani ergolin-8-karboksamidi

Info

Publication number
YU64691A
YU64691A YU64691A YU64691A YU64691A YU 64691 A YU64691 A YU 64691A YU 64691 A YU64691 A YU 64691A YU 64691 A YU64691 A YU 64691A YU 64691 A YU64691 A YU 64691A
Authority
YU
Yugoslavia
Prior art keywords
carboxamides
ergolin
improved
provides
disorders
Prior art date
Application number
YU64691A
Other languages
English (en)
Other versions
YU47809B (sr
Inventor
M.L. Cohen
D.W. Robertson
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of YU64691A publication Critical patent/YU64691A/sh
Publication of YU47809B publication Critical patent/YU47809B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Power Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

POBOLJŠANI ERGOLIN-8-KARBOKSAMIDI, opisani su N-(2-hidroksiciklopentil)-1-izopropil-6-metilergolin-8-karboksamidi korisni za blokiranje 5HT2 receptora u sisara koji imaju višak serotonina centralno ili periferalno; metode za tretiranje seksualnih disfunkcija, hipertenzije, migrene, vazospazma, tromboze, ishemije, depresije, anksioznosti, poremećaja sna i poremećaja apetita sa jedinjenjem prema ovom pronalasku.
YU64691A 1990-04-11 1991-04-10 Novi ergolin-8-karboksamidi i postupak za njihovo dobijanje YU47809B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/508,324 US5043341A (en) 1990-04-11 1990-04-11 N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides

Publications (2)

Publication Number Publication Date
YU64691A true YU64691A (sh) 1994-01-20
YU47809B YU47809B (sr) 1996-01-09

Family

ID=24022297

Family Applications (1)

Application Number Title Priority Date Filing Date
YU64691A YU47809B (sr) 1990-04-11 1991-04-10 Novi ergolin-8-karboksamidi i postupak za njihovo dobijanje

Country Status (24)

Country Link
US (1) US5043341A (sh)
EP (1) EP0452074B1 (sh)
JP (1) JPH04224578A (sh)
KR (1) KR0165124B1 (sh)
CN (1) CN1038937C (sh)
AT (1) ATE133414T1 (sh)
AU (1) AU634374B2 (sh)
CA (1) CA2040170A1 (sh)
CZ (1) CZ279745B6 (sh)
DE (1) DE69116590T2 (sh)
DK (1) DK0452074T3 (sh)
ES (1) ES2082923T3 (sh)
FI (1) FI96604C (sh)
GR (1) GR3019416T3 (sh)
HU (1) HU206113B (sh)
IE (1) IE72084B1 (sh)
IL (1) IL97808A (sh)
NO (1) NO177709C (sh)
NZ (1) NZ237753A (sh)
PT (1) PT97299B (sh)
RU (2) RU2002746C1 (sh)
TW (1) TW199859B (sh)
YU (1) YU47809B (sh)
ZA (1) ZA912628B (sh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141944A (en) * 1990-04-11 1992-08-25 Eli Lilly And Company N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
JPH0613145U (ja) * 1992-07-23 1994-02-18 日新電機株式会社 基板収納カセット
US5441961A (en) * 1992-08-27 1995-08-15 Eli Lilly And Company Substituted cyclo or bicycloalkylamides of (8β)-6-(substituted) ergolines
US5516943A (en) * 1993-09-14 1996-05-14 Sepracor, Inc. Process for preparing cyclic CIS-1-amino-2-alkanols
US5599985A (en) * 1993-09-14 1997-02-04 Sepracor, Inc. Optically pure 1-amido-2-indanols
AU5317996A (en) * 1995-04-18 1996-11-07 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-ht7 receptor
US5880134A (en) * 1996-03-20 1999-03-09 Eli Lilly And Company Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor
US6385208B1 (en) * 1998-06-02 2002-05-07 Cisco Technology, Inc. Serial media independent interface
PT1401863E (pt) * 2001-06-08 2009-07-23 Ipsen Pharma Análogos quiméricos da somatostatina-dopamina
DE10212564B4 (de) * 2002-03-12 2007-04-19 Neurobiotec Gmbh 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
JP2005220081A (ja) * 2004-02-06 2005-08-18 Toray Fine Chemicals Co Ltd ｃｉｓ−４−アミノ−１−ベンジル−３−ピロリジノールの製造方法およびピロリジン誘導体
WO2014070965A2 (en) 2012-11-01 2014-05-08 Ipsen Pharma S.A.S Somatostatin analogs and dimers thereof
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997470A (en) * 1956-03-05 1961-08-22 Lilly Co Eli Lysergic acid amides
CA1339661C (en) * 1987-06-15 1998-02-10 Kathlenn Rose Whitten Cycloalkylamides of (8b)-1alkyl-6 (substituted)ergolines
US4931447A (en) * 1987-06-15 1990-06-05 Eli Lilly And Company Cycloalkylamides of (8β)-1-alkyl-6-(substituted) ergolines

Also Published As

Publication number Publication date
CA2040170A1 (en) 1991-10-12
IE72084B1 (en) 1997-03-12
IL97808A (en) 1994-12-29
NO911398L (no) 1991-10-14
AU7433791A (en) 1991-10-17
RU2086551C1 (ru) 1997-08-10
DE69116590D1 (de) 1996-03-07
FI911713A (fi) 1991-10-12
KR910018381A (ko) 1991-11-30
FI96604B (fi) 1996-04-15
HUT56841A (en) 1991-10-28
FI96604C (fi) 1996-07-25
YU47809B (sr) 1996-01-09
ATE133414T1 (de) 1996-02-15
CZ99091A3 (en) 1995-03-15
FI911713A0 (fi) 1991-04-10
JPH04224578A (ja) 1992-08-13
KR0165124B1 (ko) 1999-03-20
AU634374B2 (en) 1993-02-18
CN1038937C (zh) 1998-07-01
PT97299A (pt) 1992-01-31
CZ279745B6 (cs) 1995-06-14
EP0452074A2 (en) 1991-10-16
HU206113B (en) 1992-08-28
DE69116590T2 (de) 1996-07-04
IE911205A1 (en) 1991-10-23
PT97299B (pt) 1998-08-31
GR3019416T3 (en) 1996-06-30
CN1056496A (zh) 1991-11-27
IL97808A0 (en) 1992-06-21
RU2002746C1 (ru) 1993-11-15
ES2082923T3 (es) 1996-04-01
EP0452074A3 (en) 1992-03-04
NZ237753A (en) 1993-02-25
TW199859B (sh) 1993-02-11
NO177709C (no) 1995-11-08
DK0452074T3 (da) 1996-02-19
EP0452074B1 (en) 1996-01-24
NO911398D0 (no) 1991-04-10
US5043341A (en) 1991-08-27
NO177709B (no) 1995-07-31
ZA912628B (en) 1992-12-30

Similar Documents

Publication Publication Date Title
YU64691A (sh) Poboljšani ergolin-8-karboksamidi
ATE163648T1 (de) Indole derivate als serotonin-antagonisten
FI910228A (fi) Heteroaromatiska foereningar med fem ringatomer och substituerade med indol.
MY131298A (en) 5-heteroyl indole derivatives
ATE236122T1 (de) N-(2-substituierte-3-(2-aminoethyl)-1h-indol-5- yl)-amide als 5-ht1f agonisten
ATE273970T1 (de) N-acyl und n-aroyl aralkylamide
EA200000561A1 (ru) Триазиновые соединения для лечения расстройств цнс
EA200001104A1 (ru) Аскорбат пароксетина
ATE256255T1 (de) Grundplatte zum befestigen eines elements
EA200001105A1 (ru) 10-камфорсульфонат пароксетина для лечения нарушений цнс
FR2453321A1 (fr) Ressort a lames
ES2099786T3 (es) Disposicion de fijacion de carriles.
FR2818747B1 (fr) Procede de criblage base sur l'interaction siah-numb
ES2156868T3 (es) Compuestos de arilalcoxifenoxi-imidazolina.
SE9201162D0 (sv) Bullerskydd, saerskilt foer jaernvaegar och spaarvaegar
ITPS920010U1 (it) Gruppo generatore di vibrazioni