YU61398A - Derivati tiazola - Google Patents

Derivati tiazola

Info

Publication number
YU61398A
YU61398A YU61398A YU61398A YU61398A YU 61398 A YU61398 A YU 61398A YU 61398 A YU61398 A YU 61398A YU 61398 A YU61398 A YU 61398A YU 61398 A YU61398 A YU 61398A
Authority
YU
Yugoslavia
Prior art keywords
cell
tumors
well
thiazole derivatives
variopus
Prior art date
Application number
YU61398A
Other languages
English (en)
Inventor
Leo Alig
Kurt Hilpert
Thomas Weller
Albrecht Edenhofer
Original Assignee
F.Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of YU61398A publication Critical patent/YU61398A/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/48Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1024Tetrapeptides with the first amino acid being heterocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Abstract

Jedinjenja formule I kao i njihove farmaceutski korisne soli i estri, pri čemu R1, R2 i R3 imaju značenje dato u zahtevu 1, inhibirajući vezivanje adhezivnih proteina na površinu različitih tipova ćelija i u skladu sa tim utiču na ćelija-ćelija i ćelija-matrica interakcije. Mogu se koristiti u obliku farmaceutskih preparata za kontrolu ili prevenciju neoplazmi, metastaza tumora, rasta tumora, osteoporoze, Paget-ove bolesti, dijabetske retinopatije, makularne degeneracije, restenosisa koji prati vaskularnu intervenciju, psorijaze, artritisa, fibroze, otkazivanja bubrega kao i infekcija izazvanih virusima, bakterijama ili gljivicama.[Compounds of formula I as well as pharmaceutically useful salts and esters, whereas R1, R2 and R3 have the meaning given in claim 1, inhibit connection of adhesive proteins on the surface of variopus types of cells and in accordance with that they influence cell to cell and cell to matrix interactions. They can be used in the shape of pharmaceutical preparations for control or prevention of neoplasmus, methastasis of tumors, growth of tumors, osteoporosis, Paget s diseases, diabetic reinopatia, muscular degeneration, restenosis, following vascular intervention, psoriasis, arthritis, fibrosis, disfunction of kidneys as well as infections caused by viruses, bacterias and fungus.
YU61398A 1998-01-02 1998-12-30 Derivati tiazola YU61398A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98100006 1998-01-02

Publications (1)

Publication Number Publication Date
YU61398A true YU61398A (sh) 2001-12-26

Family

ID=8231229

Family Applications (1)

Application Number Title Priority Date Filing Date
YU61398A YU61398A (sh) 1998-01-02 1998-12-30 Derivati tiazola

Country Status (30)

Country Link
US (3) US6100282A (sh)
JP (1) JP3113237B2 (sh)
KR (1) KR100312901B1 (sh)
CN (1) CN1080720C (sh)
AR (1) AR014949A1 (sh)
AT (1) ATE233746T1 (sh)
AU (1) AU720618B2 (sh)
BR (1) BR9900006A (sh)
CA (1) CA2257328C (sh)
CO (1) CO4990934A1 (sh)
DE (1) DE69811844T2 (sh)
DK (1) DK0928790T3 (sh)
ES (1) ES2193471T3 (sh)
HK (1) HK1020953A1 (sh)
HR (1) HRP980645A2 (sh)
HU (1) HUP9803040A3 (sh)
ID (1) ID21936A (sh)
IL (1) IL127785A (sh)
MA (1) MA26591A1 (sh)
NO (1) NO312067B1 (sh)
NZ (2) NZ333591A (sh)
PE (1) PE20000061A1 (sh)
PL (1) PL330619A1 (sh)
PT (1) PT928790E (sh)
RU (1) RU2218337C2 (sh)
SG (1) SG74686A1 (sh)
TR (1) TR199802765A2 (sh)
UY (1) UY25334A1 (sh)
YU (1) YU61398A (sh)
ZA (1) ZA9811925B (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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US6911462B2 (en) * 1998-05-22 2005-06-28 Avanir Pharmaceuticals Benzimidazole compounds for regulating IgE
US6919366B2 (en) * 1998-05-22 2005-07-19 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
GB9826174D0 (en) * 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
WO2001004103A1 (en) 1999-07-13 2001-01-18 F. Hoffmann-La Roche Ag Benzazepinones and quinazolines
US6759425B2 (en) * 1999-10-21 2004-07-06 Avanir Pharmaceuticals Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
US6960605B2 (en) * 2000-01-19 2005-11-01 Alteon, Inc. Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging
ES2291455T3 (es) * 2001-03-12 2008-03-01 Avanir Pharmaceuticals Compuestos de bencimidazol para modular ige e inhibir la proliferacion celular.
PE20030968A1 (es) * 2002-02-28 2004-01-12 Novartis Ag Derivados de 5-feniltiazol como inhibidores de cinasas
TW200304820A (en) * 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
AU2003270426A1 (en) 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
TWI276631B (en) * 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
AU2004263190A1 (en) * 2003-08-08 2005-02-17 Avanir Pharmaceuticals Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases
US7652146B2 (en) * 2004-02-06 2010-01-26 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors
CA2580725A1 (en) * 2004-09-20 2006-03-30 4Sc Ag Novel heterocyclic nf-kb inhibitors
US8716320B2 (en) * 2006-07-21 2014-05-06 Replidyne, Inc. Antibacteriall heterocyclic ureas
US8148380B2 (en) 2007-07-23 2012-04-03 Crestone, Inc. Antibacterial amide and sulfonamide substituted heterocyclic urea compounds
US8293919B2 (en) * 2007-07-23 2012-10-23 Crestone, Inc. Antibacterial sulfone and sulfoxide substituted heterocyclic urea compounds
TWI504598B (zh) * 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
CN102936257B (zh) * 2012-08-30 2016-03-30 齐鲁工业大学 一类含银的噻唑西弗碱配合物的结构、制备和用途
WO2019002074A1 (en) 2017-06-29 2019-01-03 Bayer Aktiengesellschaft THIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF PRMT5

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Also Published As

Publication number Publication date
NZ333591A (en) 2000-05-26
TR199802765A3 (tr) 1999-07-21
CA2257328C (en) 2006-05-09
CA2257328A1 (en) 1999-07-02
SG74686A1 (en) 2000-08-22
IL127785A (en) 2004-09-27
HUP9803040A3 (en) 2001-04-28
HK1020953A1 (en) 2000-05-26
KR19990066925A (ko) 1999-08-16
AU9614498A (en) 1999-07-22
US6320054B1 (en) 2001-11-20
AR014949A1 (es) 2001-04-11
US6344562B1 (en) 2002-02-05
HU9803040D0 (en) 1999-02-01
HRP980645A2 (en) 1999-10-31
NO312067B1 (no) 2002-03-11
ATE233746T1 (de) 2003-03-15
NO986159L (no) 1999-07-05
HUP9803040A2 (hu) 2000-04-28
AU720618B2 (en) 2000-06-08
MA26591A1 (fr) 2004-12-20
DE69811844T2 (de) 2003-12-04
PL330619A1 (en) 1999-07-05
NO986159D0 (no) 1998-12-28
JP2000053664A (ja) 2000-02-22
KR100312901B1 (ko) 2002-01-15
UY25334A1 (es) 2001-01-31
ID21936A (id) 1999-08-12
PE20000061A1 (es) 2000-02-09
RU2218337C2 (ru) 2003-12-10
ZA9811925B (en) 2000-06-29
DE69811844D1 (de) 2003-04-10
JP3113237B2 (ja) 2000-11-27
TR199802765A2 (xx) 1999-07-21
ES2193471T3 (es) 2003-11-01
IL127785A0 (en) 1999-10-28
CN1224718A (zh) 1999-08-04
NZ333590A (en) 2000-05-26
CO4990934A1 (es) 2000-12-26
BR9900006A (pt) 2000-04-11
PT928790E (pt) 2003-07-31
DK0928790T3 (da) 2003-06-30
US6100282A (en) 2000-08-08
CN1080720C (zh) 2002-03-13
US20020010316A1 (en) 2002-01-24

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